| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Qiang Xia, Chunxiao Liu, Xia Zhen. N-acetylcysteine ameliorates contrast‑induced kidney injury in rats with unilateral hydronephrosis. Molecular medicine reports. vol 17. issue 2. 2018-07-23. PMID:29207099. |
following modeling, uuo+iohexol rats exhibited a significantly higher apoptosis rate of renal tubular cells, higher expression of bax mrna, and lower ratio of bcl‑2/bax (all p<0.05). |
2018-07-23 |
2023-08-13 |
rat |
| Qiang Xia, Chunxiao Liu, Xia Zhen. N-acetylcysteine ameliorates contrast‑induced kidney injury in rats with unilateral hydronephrosis. Molecular medicine reports. vol 17. issue 2. 2018-07-23. PMID:29207099. |
three weeks after obstruction relief, uuo+iohexol+nac rats exhibited a lower apoptosis rate, lower bax mrna expression, higher expression of bcl‑2 mrna and higher ratio of bcl‑2/bax (all p<0.05) compared with day 1 following drug administration. |
2018-07-23 |
2023-08-13 |
rat |
| Atif Zafar, Swarnendra Singh, Yatendra Kumar Satija, Daman Saluja, Imrana Nasee. Deciphering the molecular mechanism underlying anticancer activity of coumestrol in triple-negative breast cancer cells. Toxicology in vitro : an international journal published in association with BIBRA. vol 46. 2018-07-20. PMID:28986287. |
results demonstrated that coumestrol inhibited cell viability, induced ros generation, dna damage, g1/s cell cycle arrest, up-regulation of bax and apoptosis induction via caspase-dependent mitochondrial mediated pathway in mda-mb-231 cells. |
2018-07-20 |
2023-08-13 |
Not clear |
| Atif Zafar, Swarnendra Singh, Yatendra Kumar Satija, Daman Saluja, Imrana Nasee. Deciphering the molecular mechanism underlying anticancer activity of coumestrol in triple-negative breast cancer cells. Toxicology in vitro : an international journal published in association with BIBRA. vol 46. 2018-07-20. PMID:28986287. |
to account for coumestrol-mediated up-regulation of bax and apoptosis induction, direct binding potential between coumestrol and bax/bcl-2 was studied using in silico molecular docking studies. |
2018-07-20 |
2023-08-13 |
Not clear |
| Atif Zafar, Swarnendra Singh, Yatendra Kumar Satija, Daman Saluja, Imrana Nasee. Deciphering the molecular mechanism underlying anticancer activity of coumestrol in triple-negative breast cancer cells. Toxicology in vitro : an international journal published in association with BIBRA. vol 46. 2018-07-20. PMID:28986287. |
we propose that coumestrol directly enters cells and combines with bax/bcl-2 to alter their structures, thereby causing bax binding to the outer mitochondrial membrane and bcl-2 release from the mitochondria to initiate apoptosis. |
2018-07-20 |
2023-08-13 |
Not clear |
| Yali Zhang, Yucheng Guo, Mimi Wang, Huanhuan Dong, Jingfang Zhang, Liyu Zhan. Quercetrin from Toona sinensis leaves induces cell cycle arrest and apoptosis via enhancement of oxidative stress in human colorectal cancer SW620 cells. Oncology reports. vol 38. issue 6. 2018-07-20. PMID:29039609. |
qtl promoted apoptosis which was consistent with the upregulated expression of bax, cytochrome c, caspase-9, apaf-1 and caspase-3. |
2018-07-20 |
2023-08-13 |
human |
| Guanhua Qian, Li Wang, Xueling Zheng, Tinghe Y. Deactivation of cisplatin-resistant human lung/ovary cancer cells with pyropheophorbide-α methyl ester-photodynamic therapy. Cancer biology & therapy. vol 18. issue 12. 2018-07-20. PMID:29059002. |
western blot revealed an increase of caspase 3 and bax, and a decrease of bcl-2, demonstrating the occurrence of apoptosis. |
2018-07-20 |
2023-08-13 |
human |
| Yu Wang, Chunhui Xia, Zhiqiang Lun, Yanxin Lv, Wei Chen, Tao L. Crosstalk between p38 MAPK and caspase-9 regulates mitochondria-mediated apoptosis induced by tetra-α-(4-carboxyphenoxy) phthalocyanine zinc photodynamic therapy in LoVo cells. Oncology reports. vol 39. issue 1. 2018-07-20. PMID:29115534. |
the findings revealed that the tαpczn-pdt treatment of lovo cells resulted in the induction of apoptosis, the formation of p38 mapk/caspase-9 complexes, the activation of p38 mapk, caspase-9, caspase-3 and bid, the downregulation of bcl-2, the reduction of mitochondrial membrane potential (ΔΨm), the upregulation of bax and the release of apoptosis-inducing factor (aif) and cytochrome c (cyto c). |
2018-07-20 |
2023-08-13 |
human |
| Ting-An Wang, Shu-Lin Xian, Xing-Yu Guo, Xiao-Dong Zhang, Yun-Fei L. Combined 18F-FDG PET/CT imaging and a gastric orthotopic xenograft model in nude mice are used to evaluate the efficacy of glycolysis-targeted therapy. Oncology reports. vol 39. issue 1. 2018-07-20. PMID:29115645. |
in addition, apoptosis induced by 3-brpa and sct was initiated by the upregulation of bax and downregulation of bcl-2, which promote cytochrome c release and subsequently activate caspase-9 and -3, and ultimately execute mitochondria-mediated apoptosis. |
2018-07-20 |
2023-08-13 |
mouse |
| Yi Cheng, Wen Gu, Guorui Zhang, Xiaoming Li, Xuejun Gu. Activation of Notch1 signaling alleviates dysfunction of bone marrow-derived mesenchymal stem cells induced by cigarette smoke extract. International journal of chronic obstructive pulmonary disease. vol 12. 2018-07-20. PMID:29138545. |
n1icd overexpression equilibrated the expression of bax and bcl-2, and blocked caspase-3 cleavage, contributing to the inhibition of apoptosis. |
2018-07-20 |
2023-08-13 |
rat |
| Zhili Ni, Jingmei Y. Oxymatrine induces nasopharyngeal cancer cell death through inhibition of PI3K/AKT and NF‑κB pathways. Molecular medicine reports. vol 16. issue 6. 2018-07-20. PMID:29152662. |
oxymatrine treatment also induced apoptosis, induced the activities of caspase‑3 and caspase‑9, promoted p53 and bax protein expression, and suppressed cyclin d protein expression in these cells. |
2018-07-20 |
2023-08-13 |
Not clear |
| Wei Wang, Wenli H. Salvianolic acid B recovers cognitive deficits and angiogenesis in a cerebral small vessel disease rat model via the STAT3/VEGF signaling pathway. Molecular medicine reports. vol 17. issue 2. 2018-07-20. PMID:29257241. |
salvianolic acid b was identified to recover cognitive deficits and neurocytes, reduce inflammation, oxidative stress and neurocyte apoptosis (caspase‑3 and bax protein expression) in cerebral small vessel disease rats. |
2018-07-20 |
2023-08-13 |
rat |
| Liang Liu, Yingchao Ju, Jing Wang, Rongmiao Zho. Epigallocatechin-3-gallate promotes apoptosis and reversal of multidrug resistance in esophageal cancer cells. Pathology, research and practice. vol 213. issue 10. 2018-07-19. PMID:28964574. |
using flow cytometry, we determined the cellular apoptosis, bcl-2, bax and caspase-3 protein expression in eca109 and ec9706 cells following treatment with egcg for 24h. |
2018-07-19 |
2023-08-13 |
human |
| Liang Liu, Yingchao Ju, Jing Wang, Rongmiao Zho. Epigallocatechin-3-gallate promotes apoptosis and reversal of multidrug resistance in esophageal cancer cells. Pathology, research and practice. vol 213. issue 10. 2018-07-19. PMID:28964574. |
egcg induced apoptosis, decreased the bcl-2 protein expression and increased the expression of bax and caspase-3 protein. |
2018-07-19 |
2023-08-13 |
human |
| Sana Irfan Khan, Rajiv Kumar Malhotra, Neha Rani, Anil Kumar Sahu, Ameesha Tomar, Shanky Garg, Tapas Chandra Nag, Ruma Ray, Shreesh Ojha, Dharamvir Singh Arya, Jagriti Bhati. Febuxostat Modulates MAPK/NF- Oxidative medicine and cellular longevity. vol 2017. 2018-07-19. PMID:29138678. |
they also attenuated oxidative stress and apoptosis by suppressing the expression of proapoptotic proteins (bax and caspase-3), reducing tunel-positive cells, and increasing the level of antiapoptotic proteins (bcl-2). |
2018-07-19 |
2023-08-13 |
rat |
| Juedan Li, Lin Zhao, Xiaomeng Zhao, Peng Wang, Yan Liu, Jianping Rua. Foxo1 Attenuates NaF-Induced Apoptosis of LS8 Cells through the JNK and Mitochondrial Pathways. Biological trace element research. vol 181. issue 1. 2018-07-18. PMID:28429284. |
the expression levels of foxo1, c-jun n-terminal kinase (jnk), and some well-known regulators of the mitochondrial pathway of apoptosis (cytoplasmic cytochrome c, cleaved caspase-9, cleaved caspase-3, bcl-2, and bax) were detected by quantitative real-time pcr, western blot, and immunofluorescence assay. |
2018-07-18 |
2023-08-13 |
Not clear |
| Yanli Luo, Minxiang Le. α-Mangostin protects against high-glucose induced apoptosis of human umbilical vein endothelial cells. Bioscience reports. vol 37. issue 6. 2018-07-18. PMID:29054969. |
compared with huvecs cultured in 5 mm glucose, cells cultured in 30 mm glucose exhibited a higher apoptosis rate, up-regulation of cleaved caspase-3 and bax (proapoptotic proteins), down-regulation of bcl-2 (anti-apoptotic protein), increased ceramide concentration, and enhanced asm activity (all |
2018-07-18 |
2023-08-13 |
human |
| Charith Ub Wijerathne, Hee-Seon Park, Hye-Yun Jeong, Ji-Won Song, Og-Sung Moon, Young-Won Seo, Young-Suk Won, Hwa-Young Son, Jong-Hwan Lim, Sung-Hum Yeon, Hyo-Jung Kwu. Quisqualis indica Improves Benign Prostatic Hyperplasia by Regulating Prostate Cell Proliferation and Apoptosis. Biological & pharmaceutical bulletin. vol 40. issue 12. 2018-07-17. PMID:28943529. |
in addition, qi induced apoptosis by up-regulating caspase-3 and -9 activity and decreasing the b-cell lymphoma 2 (bcl-2)/bcl-2-associated x protein (bax) ratio in prostate tissues of bph rats. |
2018-07-17 |
2023-08-13 |
human |
| Jianmin Li, Changying Li, Hongjie Li, Ting Zhang, Xiaodong Hao, Jiwu Chang, Yong X. MicroRNA‑30a‑5p suppresses tumor cell proliferation of human renal cancer via the MTDH/PTEN/AKT pathway. International journal of molecular medicine. vol 41. issue 2. 2018-07-17. PMID:29207012. |
furthermore, overexpression of mirna‑30a‑5p suppressed cell proliferation, induced apoptosis, and promoted caspase‑3/9 activities and b‑cell lymphoma 2‑associated x protein (bax) protein expression in caki‑2 cells. |
2018-07-17 |
2023-08-13 |
human |
| Jianmin Li, Changying Li, Hongjie Li, Ting Zhang, Xiaodong Hao, Jiwu Chang, Yong X. MicroRNA‑30a‑5p suppresses tumor cell proliferation of human renal cancer via the MTDH/PTEN/AKT pathway. International journal of molecular medicine. vol 41. issue 2. 2018-07-17. PMID:29207012. |
furthermore, transfection with small interfering rna‑mtdh, increased the effects of mirna‑30a‑5p on the inhibition of cell proliferation, and promotion of apoptosis, caspase‑3/9 activities and bax protein expression levels in caki‑2 cells. |
2018-07-17 |
2023-08-13 |
human |