| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Qiang Wan, Zhongyong Liu, Yuping Yang, Xiaobing Cu. Suppressive effects of berberine on atherosclerosis via downregulating visfatin expression and attenuating visfatin-induced endothelial dysfunction. International journal of molecular medicine. vol 41. issue 4. 2018-08-21. PMID:29393413. |
in addition, in vitro experiments indicated that visfatin (100 µg/l) significantly increased apoptosis, the contents of il-6 and tnf-α, the protein levels of p-p38 mapk, p-jnk and bax in huvecs, which were reversed by bbr administration (50 µmol/l). |
2018-08-21 |
2023-08-13 |
mouse |
| Xing Zhang, Hong Lu, Weilong Hong, Leping Liu, Silu Wang, Mengtao Zhou, Bicheng Chen, Yongheng Ba. Tyrphostin B42 attenuates trichostatin A-mediated resistance in pancreatic cancer cells by antagonizing IL-6/JAK2/STAT3 signaling. Oncology reports. vol 39. issue 4. 2018-08-21. PMID:29393444. |
in addition, increased expression of bcl‑2 mrna and decreased expression of bax mrna in panc‑1‑tsa cells indicated that tsa induced the inhibition of mitochondrial-dependent apoptosis in pccs. |
2018-08-21 |
2023-08-13 |
Not clear |
| Buyun Kim, Byoungduck Par. Saffron carotenoids inhibit STAT3 activation and promote apoptotic progression in IL-6-stimulated liver cancer cells. Oncology reports. vol 39. issue 4. 2018-08-21. PMID:29393468. |
conversely, crocin increased the pro-apoptotic (bax) protein, which was correlated with the induction of apoptosis and inhibition of proliferation. |
2018-08-21 |
2023-08-13 |
Not clear |
| Jun Song, Sai-Jun Ma, Jian-Hua Luo, Hui Zhang, Ri-Xiong Wang, Hui Liu, Li Li, Zhi-Guang Zhang, Rui-Xiang Zho. Melatonin induces the apoptosis and inhibits the proliferation of human gastric cancer cells via blockade of the AKT/MDM2 pathway. Oncology reports. vol 39. issue 4. 2018-08-21. PMID:29484412. |
melatonin also induced upregulation of bax, downregulation of bcl-xl, an increase in cleaved caspase-9 level and activation of caspase-3, which confirmed the involvement of the mitochondria in melatonin‑induced apoptosis. |
2018-08-21 |
2023-08-13 |
human |
| Da Zhao, Xinyan Zhan. Selenium Antagonizes the Lead-Induced Apoptosis of Chicken Splenic Lymphocytes In Vitro by Activating the PI3K/Akt Pathway. Biological trace element research. vol 182. issue 1. 2018-08-20. PMID:28681127. |
however, se supplementation during pb exposure observably attenuated pb-induced apoptosis; increased the levels of the pi3k, akt, and bcl-2 mrnas and proteins; and decrease the levels of the p53, bax, cyt-c, caspase 3, and caspase 9 mrnas and proteins in the chicken spleen. |
2018-08-20 |
2023-08-13 |
cat |
| Liqiao Fan, Bibo Tan, Yong Li, Qun Zhao, Hufang Yuan, Yu Liu, Dong Wang, Zhidong Zhan. Upregulation of miR‑185 promotes apoptosis of the human gastric cancer cell line MGC803. Molecular medicine reports. vol 17. issue 2. 2018-08-20. PMID:29257260. |
post‑transfection, the following experiments were conducted: mtt assay was applied to test cell viability; flow cytometry (fcm) was used to determine the apoptotic rate of the cells; and qpcr and western blotting were conducted to detect the expression levels of the following apoptosis‑associated factors: b‑cell lymphoma 2 (bcl‑2), bcl‑2‑associated x protein (bax), survivin, x‑linked inhibitor of apoptosis protein (xiap), livin, caspase‑3 and caspase‑8. |
2018-08-20 |
2023-08-13 |
human |
| Xinyu Hu, Yidi Qu, Qiubo Chu, Wenshu Li, Jian H. Investigation of the neuroprotective effects of Lycium barbarum water extract in apoptotic cells and Alzheimer's disease mice. Molecular medicine reports. vol 17. issue 3. 2018-08-20. PMID:29257339. |
lb additionally normalized the expression levels of apoptosis regulator bcl‑2, apoptosis regulator bax, and cleaved caspase‑3, ‑8 and ‑9 in l‑glu exposed cells. |
2018-08-20 |
2023-08-13 |
mouse |
| Hui-Zhen Zheng, Xue-Kun Fu, Jiu-Long Shang, Rong-Xi Lu, Yong-Fang Ou, Chun-Ling Che. Ginsenoside Rg1 protects rat bone marrow mesenchymal stem cells against ischemia induced apoptosis through miR-494-3p and ROCK-1. European journal of pharmacology. vol 822. 2018-08-20. PMID:29307726. |
rbmscs treated with hypoxia and serum deprivation for 24h (h/sd-rbmscs) showed the up-regulated expression of ras homolog family member a (rhoa), rho associated coiled-coil containing protein kinase 1 (rock-1), myosin light chain 2 (mlc-2), bcl2 associated agonist of cell death (bad) and bcl2 associated x, apoptosis regulator (bax); while the expression of mir-148b-3p, mir-148b-5p and mir-494-3p was down-regulated. |
2018-08-20 |
2023-08-13 |
rat |
| Lei Shi, Zaizong Wang, Xianjin Liu, Mao Li, Shangfei Zhang, Xiaobin Son. Bax inhibitor-1 is required for resisting the Early Brain Injury induced by subarachnoid hemorrhage through regulating IRE1-JNK pathway. Neurological research. vol 40. issue 3. 2018-08-20. PMID:29334839. |
background and purpose bax inhibitor-1 (bi-1) has been identified as a suppressor of bax-mediated cell apoptosis by regulation of endoplasmic reticulum stress-induced cell death. |
2018-08-20 |
2023-08-13 |
rat |
| Mingjie Xing, Xiumin Chen, Xiaoxia Li, Yifeng Yang, Xiaoxu Wang, Xinyan Cao, Hailong Xue, Shiyong Wang, Yunfei Diao, Weigang Zhao, Meng Zhao, Xuezhe Cui, Tong Chang, Baozeng Xu, Haijun We. Histone deacetylase inhibitor stimulates E2 and P4 secretion in sika deer ovarian granulosa cells at a moderate dose. Cell biology international. vol 42. issue 3. 2018-08-17. PMID:29064603. |
it was found that tsa inhibited gcs proliferation and induced gcs apoptosis by upregulating expression of bax, meanwhile, downregulating expression of glut3, glut8, bcl-xl. |
2018-08-17 |
2023-08-13 |
Not clear |
| Lufang Wang, Yanyan Zhao, Qiong Wu, Yifu Guan, Xin W. Therapeutic effects of β-elemene via attenuation of the Wnt/β-catenin signaling pathway in cervical cancer cells. Molecular medicine reports. vol 17. issue 3. 2018-08-16. PMID:29363722. |
the expression levels of cyclin‑dependent kinase inhibitor 2b (p15), cyclin d1, cellular tumor antigen p53, apoptosis regulator bcl‑2 (bcl‑2), apoptosis regulator bax (bax), 72 kda type iv collagenase (mmp‑2), matrix metalloproteinase‑9 (mmp‑9), β‑catenin, transcription factor 7 (tcf7), and myc proto‑oncogene protein (c‑myc) were analyzed via western blotting. |
2018-08-16 |
2023-08-13 |
human |
| Lufang Wang, Yanyan Zhao, Qiong Wu, Yifu Guan, Xin W. Therapeutic effects of β-elemene via attenuation of the Wnt/β-catenin signaling pathway in cervical cancer cells. Molecular medicine reports. vol 17. issue 3. 2018-08-16. PMID:29363722. |
furthermore, the present study revealed that β‑elemene induced apoptosis in siha cells by enhancing the expression of p53 and bax, and suppressing the expression of bcl‑2. |
2018-08-16 |
2023-08-13 |
human |
| Rinaldo Florencio-Silva, Gisela R S Sasso, Estela Sasso-Cerri, Manuel J Simões, Paulo S Cerr. Effects of estrogen status in osteocyte autophagy and its relation to osteocyte viability in alveolar process of ovariectomized rats. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 98. 2018-08-15. PMID:29276969. |
autophagy was analyzed by immunohistochemical detections of beclin-1, map-lc3α and p62, whereas apoptosis was evaluated by immunohistochemical detections of cleaved caspase-3 and bax, tunel (terminal deoxynucleotidyl transferase dutp nick end labeling) method and by ultrastructural analysis. |
2018-08-15 |
2023-08-13 |
rat |
| Hassan A Elgebaly, Nermeen M Mosa, Mariam Allach, Khaled F El-Massry, Ahmed H El-Ghorab, Amir M Al Hroob, Ayman M Mahmou. Olive oil and leaf extract prevent fluoxetine-induced hepatotoxicity by attenuating oxidative stress, inflammation and apoptosis. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 98. 2018-08-15. PMID:29278855. |
in addition, olive oil and leaf extract prevented fluoxetine-induced apoptosis in the liver of rats as evidenced by decreased expression of bax and caspase-3, and up-regulated expression of bcl-2. |
2018-08-15 |
2023-08-13 |
rat |
| Yangang Cheng, Jinyan Tan, Huifeng Li, Xiangpeng Kong, Yan Liu, Rui Guo, Guoyan Li, Bingyou Yang, Miaorong Pe. Cardioprotective effects of total flavonoids from Jinhe Yangxin prescription by activating the PI3K/Akt signaling pathway in myocardial ischemia injury. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 98. 2018-08-14. PMID:29274587. |
furthermore, jhtf inhibited myocardial apoptosis, which may be related to downregulated caspase-3 and bax, upregulated bcl-2, and increased the protein levels of phosphorylated akt, gsk-3β and endothelial nitric oxide synthase (enos). |
2018-08-14 |
2023-08-13 |
rat |
| Runchen Miao, Xinsen Xu, Zhixin Wang, Sushun Liu, Kai Qu, Wei Chen, Chang Li. Synergistic effect of nutlin-3 combined with aspirin in hepatocellular carcinoma HepG2 cells through activation of Bcl-2/Bax signaling pathway. Molecular medicine reports. vol 17. issue 3. 2018-08-14. PMID:29286113. |
apoptosis markers, including b‑cell lymphoma 2 (bcl‑2), bcl‑2‑associated x protein (bax), caspase‑3, caspase‑8 and caspase‑9 were estimated by western blot analysis at various time points. |
2018-08-14 |
2023-08-13 |
mouse |
| Xing-He Xue, Zhen-Hua Feng, Zhen-Xing Li, Xiao-Yun Pa. Salidroside inhibits steroid-induced avascular necrosis of the femoral head via the PI3K/Akt signaling pathway: In vitro and in vivo studies. Molecular medicine reports. vol 17. issue 3. 2018-08-14. PMID:29286130. |
sal decreased the expression of cleaved caspase-3, cleaved caspase‑9, apoptosis regulator bax and cytochrome c, while it increased the expression of b cell lymphoma‑2 and phosphorylated‑akt in dex‑induced osteoblasts. |
2018-08-14 |
2023-08-13 |
rat |
| Chan-Min Liu, Wei Yang, Jie-Qiong Ma, Hui-Xin Yang, Zhao-Jun Feng, Jian-Mei Sun, Chao Cheng, Hong Jian. Dihydromyricetin Inhibits Lead-Induced Cognitive Impairments and Inflammation by the Adenosine 5'-Monophosphate-Activated Protein Kinase Pathway in Mice. Journal of agricultural and food chemistry. vol 66. issue 30. 2018-08-14. PMID:29975840. |
dhm suppressed pb-induced apoptosis, as indicated by the decreased levels of bax and cleaved caspase-3. |
2018-08-14 |
2023-08-13 |
mouse |
| Alessandra Russo, Venera Cardile, Adriana C E Graziano, Rosanna Avola, Maurizio Bruno, Daniela Rigan. Involvement of Bax and Bcl-2 in Induction of Apoptosis by Essential Oils of Three Lebanese Salvia Species in Human Prostate Cancer Cells. International journal of molecular sciences. vol 19. issue 1. 2018-08-13. PMID:29351194. |
involvement of bax and bcl-2 in induction of apoptosis by essential oils of three lebanese salvia species in human prostate cancer cells. |
2018-08-13 |
2023-08-13 |
human |
| J J Tong, I M Thompson, X Zhao, P Lacass. Effect of 17β-estradiol on milk production, hormone secretion, and mammary gland gene expression in dairy cows. Journal of dairy science. vol 101. issue 3. 2018-08-10. PMID:29274969. |
the mrna levels of genes encoding proteins related to mammary activity (α-lactalbumin, β-casein, and acetyl-coenzyme a carboxylase), apoptosis (bax, bcl2, and caspase-3), prl receptors (prlr; long and short forms), signal transducer and activator of transcription 5 (stat5a and stat5b), and suppressors of cytokine signaling (socs2 and socs3) were evaluated by real-time reverse transcription pcr using rna extracted from milk fat and mammary biopsies. |
2018-08-10 |
2023-08-13 |
Not clear |