| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Zhan Shi, Ying Su, Feng Wang, Ping Li. Downregulation of microRNA-181a attenuates hydrogen peroxide-induced human lens epithelial cell apoptosis in vitro. Molecular medicine reports. vol 17. issue 4. 2018-08-30. PMID:29484431. |
in addition, the downregulation of mir‑181a expression significantly decreased h2o2‑induced cell apoptosis, which was accompanied by a downregulation in casp3 and bax and cox‑2 expression. |
2018-08-30 |
2023-08-13 |
human |
| Peng Cao, Jinlu Sun, Mitchell A Sullivan, Xiao Huang, Hanxiang Wang, Yu Zhang, Na Wang, Kaiping Wan. Angelica sinensis polysaccharide protects against acetaminophen-induced acute liver injury and cell death by suppressing oxidative stress and hepatic apoptosis in vivo and in vitro. International journal of biological macromolecules. vol 111. 2018-08-29. PMID:29415408. |
specifically, serum and hepatic biochemical parameters including alanine aminotransferase (alt), aspartate transaminase (ast), glutathione (gsh), malondialdehyde (mda) and superoxide dismutase (sod) were evaluated, and key proteins involved in hepatic apoptosis, including cleaved caspase-3, bax and bcl-2 were quantified. |
2018-08-29 |
2023-08-13 |
rat |
| Xiaomei Wang, Pengda Zou, Yuanyuan He, Kai Meng, Fusheng Quan, Yong Zhan. Effect of luteinizing hormone on goat theca cell apoptosis and steroidogenesis through activation of the PI3K/AKT pathway. Animal reproduction science. vol 190. 2018-08-29. PMID:29422438. |
the apoptosis ratio and expression of the bax gene in tcs were less with lh treatment, and the extent of this inhibition was decreased by suppressing the pi3k/akt pathway. |
2018-08-29 |
2023-08-13 |
Not clear |
| Yan Feng, Li-Li Zu, Lei Zhan. MicroRNA-26b inhibits the tumor growth of human liver cancer through the PI3K/Akt and NF-κB/MMP-9/VEGF pathways. Oncology reports. vol 39. issue 5. 2018-08-29. PMID:29498407. |
forced upregulation of microrna-26b had anticancer effects, inhibited cell proliferation, induced apoptosis and promoted bax and caspase-3/-9 protein expression in a liver cancer cell line as determined by mtt assay, flow cytometry and western blot analysis. |
2018-08-29 |
2023-08-13 |
human |
| Yan Feng, Li-Li Zu, Lei Zhan. MicroRNA-26b inhibits the tumor growth of human liver cancer through the PI3K/Akt and NF-κB/MMP-9/VEGF pathways. Oncology reports. vol 39. issue 5. 2018-08-29. PMID:29498407. |
pi3k inhibitor significantly facilitated the effects of microrna-26b regarding the suppression of the pi3k/akt pathway, inhibition of cell proliferation, induction of apoptosis and increases in bax and caspase-3/-9 protein expression in the liver cancer cell line. |
2018-08-29 |
2023-08-13 |
human |
| Yan Feng, Li-Li Zu, Lei Zhan. MicroRNA-26b inhibits the tumor growth of human liver cancer through the PI3K/Akt and NF-κB/MMP-9/VEGF pathways. Oncology reports. vol 39. issue 5. 2018-08-29. PMID:29498407. |
nf-κb inhibitor also significantly enhanced the effects of microrna-26b regarding suppression of the nf-κb/mmp-9/vegf pathway, inhibition of cell proliferation, induction of apoptosis, and promotion of bax and caspase-3/-9 protein expression in the liver cancer cell line. |
2018-08-29 |
2023-08-13 |
human |
| Wensheng Zhang, Wanzhuo He, Xiaodong Shi, Xiao Li, Yuanyuan Wang, Minghua Hu, Fangli Ma, Ning Tao, Guiqin Wang, Zhihai Qi. An Asparagus polysaccharide fraction inhibits MDSCs by inducing apoptosis through toll-like receptor 4. Phytotherapy research : PTR. vol 32. issue 7. 2018-08-28. PMID:29532545. |
subsequent studies showed that the ap treatment enhanced the expression of bax and caspase-9 and inhibited the expression of bcl-2, suggesting that ap induced apoptosis in the mdscs via the intrinsic pathway. |
2018-08-28 |
2023-08-13 |
mouse |
| Jun Wei, Chongling Sun, Chang Liu, Qimei Zhan. Effects of Rat Anti-mouse Interleukin-6 Receptor Antibody on the Recovery of Cognitive Function in Stroke Mice. Cellular and molecular neurobiology. vol 38. issue 2. 2018-08-27. PMID:28488007. |
furthermore, mr16-1 promoted the expression of bcl-2 and inhibited the expression of bax in stroke mice, which revealed the inhibitory effect of mr16-1 on neuronal apoptosis. |
2018-08-27 |
2023-08-13 |
mouse |
| Jun Wei, Chongling Sun, Chang Liu, Qimei Zhan. Effects of Rat Anti-mouse Interleukin-6 Receptor Antibody on the Recovery of Cognitive Function in Stroke Mice. Cellular and molecular neurobiology. vol 38. issue 2. 2018-08-27. PMID:28488007. |
mr16-1 ameliorated cognitive dysfunction and apoptosis in stroke mice, involving the inhibition of inflammatory response and pro-apoptotic bax, and the up-regulation of anti-apoptotic bcl-2. |
2018-08-27 |
2023-08-13 |
mouse |
| P Zhang, S-R Zhao, F Liu, X-J Sun, H Li. Oridonin Induces Apoptosis in Human Nasopharyngeal Carcinoma Cells Involving ROS Generation. Folia biologica. vol 63. issue 4. 2018-08-27. PMID:29256858. |
further, oridonin-induced apoptosis was mediated by the mitochondrial pathway in npc cells, which was confirmed by the loss of mmp, downregulation of anti-apoptotic bcl-2 family protein mcl-1 and bcl-2, upregulation of pro-apoptotic bcl-2 family member bax, and activation of caspase-3 and parp. |
2018-08-27 |
2023-08-13 |
human |
| Yanhua Huang, Ziyi Fu, Wei Dong, Zhenming Zhang, Jinquan Mu, Junfeng Zhan. Serum starvation-induces down-regulation of Bcl-2/Bax confers apoptosis in tongue coating-related cells in vitro. Molecular medicine reports. vol 17. issue 4. 2018-08-27. PMID:29393442. |
cellular proliferation and apoptosis were observed by using 3‑[4,5‑dimethyl‑2‑thiazolyl]‑2,5‑diphenyl‑2‑h‑tetrazolium bromide (mtt) assay, flow cytometry, hoechst staining, scanning electron microscope (sem), transmission electron microscope (tem), and by measuring the expression ratio of b‑cell lymphoma 2 apoptosis regulator (bcl‑2)/bcl‑2 associated protein x apoptosis regulator (bax) mrna and protein by reverse transcription‑quantitative polymerase chain reaction (rt‑qpcr) and western blotting, respectively. |
2018-08-27 |
2023-08-13 |
Not clear |
| Yin Jia, Qin Qin, Chao-Ping Fang, Wei Shen, Ting-Ting Sun, Yuan-Lan Huang, Wen-Jie Li, An-Mei Den. UVB induces apoptosis via downregulation of CALML3-dependent JNK1/2 and ERK1/2 pathways in cataract. International journal of molecular medicine. vol 41. issue 5. 2018-08-27. PMID:29436594. |
overexpression of calmodulin like 3 (calml3) reversed the effects of uvb irradiation on apoptosis, ros production and ca2+ concentration of hlecs, and decreased expressions of caspase‑3 and bax, with increased expressions of bcl‑2. |
2018-08-27 |
2023-08-13 |
human |
| Qipeng Zhao, Xiaobo Wang, Ailing Chen, Xiuli Cheng, Guoxin Zhang, Jianmin Sun, Yunsheng Zhao, Yu Huang, Yafei Zh. Rhein protects against cerebral ischemic‑/reperfusion‑induced oxidative stress and apoptosis in rats. International journal of molecular medicine. vol 41. issue 5. 2018-08-27. PMID:29436613. |
levels of b‑cell lymphoma-2 (bcl‑2), apoptosis regulator bax (bax), caspase-9, caspase‑3 and cleaved caspase‑3 expression were analyzed using western blot analysis. |
2018-08-27 |
2023-08-13 |
rat |
| Shijie Wen, Changyuan Wang, Xiaokui Huo, Qiang Meng, Zhihao Liu, Shilei Yang, Yanna Zhu, Huijun Sun, Xiaodong Ma, Kexin Li. JBP485 attenuates vancomycin-induced nephrotoxicity by regulating the expressions of organic anion transporter (Oat) 1, Oat3, organic cation transporter 2 (Oct2), multidrug resistance-associated protein 2 (Mrp2) and P-glycoprotein (P-gp) in rats. Toxicology letters. vol 295. 2018-08-27. PMID:29964132. |
moreover, jbp485 decreased the number of apoptosis cells in tunel staining as well as reversed the decreased expression of b-cell lymphoma-2 (bcl-2) and the increased expressions of bcl-2-like protein 4 (bax) and caspase-3 in rat kidney. |
2018-08-27 |
2023-08-13 |
rat |
| Jie Peng, Bin Fu, Gan Fu, Xielan Zhao, Xiaolin Li, Fangping Che. Effect of NPM1 type B mutation on the proliferation, invasion and chemosensitivity of THP-1 leukemia cells. Die Pharmazie. vol 72. issue 10. 2018-08-24. PMID:29441887. |
in the present study, we found that overexpression of npm1 mutb enhanced the proliferation and invasion of thp-1 aml cells through the regulation of timp-2, mmp-2, ang-1, c-myc and ccnd1; led to no significant change of apoptosis rate with the absence of chemotherapy agents, while enhanced the chemosensitivity of thp-1 aml cells to chemotherapy agents dnr and ara-c through the regulation of bax, bcl-2 and caspase-3. |
2018-08-24 |
2023-08-13 |
Not clear |
| Simona Daniele, Deborah Pietrobono, Barbara Costa, Mariateresa Giustiniano, Valeria La Pietra, Chiara Giacomelli, Giuseppe La Regina, Romano Silvestri, Sabrina Taliani, Maria Letizia Trincavelli, Federico Da Settimo, Ettore Novellino, Claudia Martini, Luciana Marinell. Bax Activation Blocks Self-Renewal and Induces Apoptosis of Human Glioblastoma Stem Cells. ACS chemical neuroscience. vol 9. issue 1. 2018-08-23. PMID:28368610. |
bax activation blocks self-renewal and induces apoptosis of human glioblastoma stem cells. |
2018-08-23 |
2023-08-13 |
human |
| Lingxing Wang, Honghong Huang, Hongchao Cai, Yafang Che. Maternal hypoxia increases hippocampal cell susceptibility to ischemia after middle cerebral artery occlusion in rat offspring. Folia neuropathologica. vol 55. issue 4. 2018-08-23. PMID:29363906. |
conclusions: these findings suggest that maternal hypoxia may exacerbate hippocampal cell apoptosis in rat offspring after mcao via alterations in the expression of cytochrome c, caspase-3, bax, and bcl-2, which ultimately affects ischemic stroke prognosis. |
2018-08-23 |
2023-08-13 |
rat |
| Yanjie Guo, Jimin Yin, Mingjie Tang, Xingang Y. Downregulation of SOX3 leads to the inhibition of the proliferation, migration and invasion of osteosarcoma cells. International journal of oncology. vol 52. issue 4. 2018-08-23. PMID:29484385. |
sox3 knockdown-mediated cell cycle arrest and cell apoptosis were associated with decreased levels of cdc25a, cyclin d1, proliferating cell nuclear antigen (pcna) and bcl-2, as well as an increased bax expression. |
2018-08-23 |
2023-08-13 |
Not clear |
| Mingyang Kang, Peng Xia, Tingting Hou, Zhiping Qi, Shaojun Liao, Xiaoyu Yan. MicroRNA-190b inhibits tumor cell proliferation and induces apoptosis by regulating Bcl-2 in U2OS osteosarcoma cells. Die Pharmazie. vol 72. issue 5. 2018-08-22. PMID:29441873. |
additionally, cell-cycle regulators p27, p21 and apoptosis factors b-cell lymphoma-2 (bcl-2), bcl-2 associated x (bax), caspase-3 were examined by western blotting. |
2018-08-22 |
2023-08-13 |
human |
| Yan-Bo Ma, Chun-Jiao Lu, Muhammad Junaid, Pan-Pan Jia, Li Yang, Jing-Hui Zhang, De-Sheng Pe. Potential adverse outcome pathway (AOP) of silver nanoparticles mediated reproductive toxicity in zebrafish. Chemosphere. vol 207. 2018-08-22. PMID:29803881. |
to explore the mechanism of the apoptotic pathway, the transcription levels of various genes (bax, bcl-2, caspase-3, and caspase-9) associated with the mitochondrion-mediated apoptosis pathway were examined in zebrafish after exposure to agnps. |
2018-08-22 |
2023-08-13 |
zebrafish |