| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xiaoli Ren, Bingbing Zhao, Hongjian Chang, Min Xiao, Yuhong Wu, Yun Li. Paclitaxel suppresses proliferation and induces apoptosis through regulation of ROS and the AKT/MAPK signaling pathway in canine mammary gland tumor cells. Molecular medicine reports. vol 17. issue 6. 2018-09-26. PMID:29658576. |
in addition, paclitaxel upregulated the expression of bax and cytochrome c, but reduced expression of apoptosis regulator bcl‑2, resulting in activation of caspase‑3, chromatin condensation, karyopyknosis, intracellular vacuolization, increased production of ros and mda, and decreased activity of sod. |
2018-09-26 |
2023-08-13 |
Not clear |
| Dan Gu, Lulin Huang, Xia Chen, Qianhu Wu, Kan Din. Structural characterization of a galactan from Ophiopogon japonicus and anti-pancreatic cancer activity of its acetylated derivative. International journal of biological macromolecules. vol 113. 2018-09-25. PMID:29518447. |
in addition, the cells apoptosis was triggered since cleaved caspase-3 and fasl were activated while p53, p21, bax expression were up-regulated by roh05a as well. |
2018-09-25 |
2023-08-13 |
Not clear |
| Min Yeong Kim, Hyun Hwang Bo, Eun Ok Choi, Da He Kwon, Hong Jae Kim, Kyu Im Ahn, Seon Yeong Ji, Jin-Woo Jeong, Shin-Hyung Park, Su-Hyun Hong, Gi-Young Kim, Cheol Park, Heui-Soo Kim, Sung-Kwon Moon, Seok-Joong Yun, Wun Jae Kim, Yung Hyun Cho. Induction of Apoptosis by Citrus unshiu Peel in Human Breast Cancer MCF-7 Cells: Involvement of ROS-Dependent Activation of AMPK. Biological & pharmaceutical bulletin. vol 41. issue 5. 2018-09-24. PMID:29709909. |
in contrast, compound c, an ampk inhibitor, significantly inhibited wecu-induced apoptosis, while inhibiting increased expression of bax and decreased expression of bcl-2 by wecu and inhibition of wecu-induced parp degradation. |
2018-09-24 |
2023-08-13 |
human |
| Jun Yang, Linna Li, Chengwang Xu, Dexuan Yang, Shanshan Wang, Shoujun Yua. CT‑1042, a novel anticancer agent, exhibits effects by activating p53 and inhibiting survivin. Oncology reports. vol 39. issue 6. 2018-09-21. PMID:29620221. |
in addition, ct‑1042 induced mitochondrial‑mediated apoptosis by activating p53 and bax, as well as inhibiting bcl‑2 and survivin. |
2018-09-21 |
2023-08-13 |
human |
| Likun Liu, Cuicui Han, Haitao Yu, Wenbin Zhu, Hongxia Cui, Lihong Zheng, Chunjing Zhang, Liling Yu. Chloroquine inhibits cell growth in human A549 lung cancer cells by blocking autophagy and inducing mitochondrial‑mediated apoptosis. Oncology reports. vol 39. issue 6. 2018-09-21. PMID:29658606. |
cq‑mediated growth inhibition in a549 cells was characterized by the targeting of the pi3k/akt pathway, thus, inducing mitochondria‑mediated apoptosis at relatively higher concentrations by downregulating bcl‑2 expression, increasing the expression level of bax, decreasing mitochondrial membrane potential, releasing cytochrome c from the mitochondria into the cytosol, activating caspase‑3 and cleaving parp. |
2018-09-21 |
2023-08-13 |
human |
| Linyu Zhou, Chunyan Bao, Xiao Hu, Yongqing Dai, Zhijun Ba. [LRIG1 promotes the apoptosis of pituitary tumor cells induced by cisplatin]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 34. issue 1. 2018-09-20. PMID:29595451. |
the cells of the two groups were induced by 20 g/ml ddp, and 48 hours later, the cell apoptosis was detected by flow cytometry; the proliferation capacity was tested by plate cloning experiment; and the relative expressions of apoptosis-related proteins bax, caspase-3 and bcl2 in the cells were examined by western blot analysis. |
2018-09-20 |
2023-08-13 |
human |
| Linyu Zhou, Chunyan Bao, Xiao Hu, Yongqing Dai, Zhijun Ba. [LRIG1 promotes the apoptosis of pituitary tumor cells induced by cisplatin]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 34. issue 1. 2018-09-20. PMID:29595451. |
compared with the control group, after lrig1 was over-expressed, the cell apoptosis rate significantly increased, the cell proliferation significantly decreased, and the levels of bax and caspase-3 increased as well, while the level of bcl2 decreased remarkably. |
2018-09-20 |
2023-08-13 |
human |
| Yan Zhen Zhang, Chun Feng Wang, Lian Feng Zhan. Cucurbitacin D impedes gastric cancer cell survival via activation of the iNOS/NO and inhibition of the Akt signalling pathway. Oncology reports. vol 39. issue 6. 2018-09-20. PMID:29658590. |
in addition, cud activated the mitochondrial apoptosis pathway, which increased the expression of bax and the release of cleaved caspace‑9 (c‑caspase‑9) and cytochrome c, decreased the expression of b‑cell lymphoma 2 (bcl‑2). |
2018-09-20 |
2023-08-13 |
human |
| Ying-Hui Kong, Su-Ping X. Salidroside prevents skin carcinogenesis induced by DMBA/TPA in a mouse model through suppression of inflammation and promotion of apoptosis. Oncology reports. vol 39. issue 6. 2018-09-20. PMID:29693192. |
consistently, p21, p53 upregulated modulator of apoptosis (puma), bax and caspase-3 were highly induced by sr to enhance the apoptotic response for preventing skin cancer. |
2018-09-20 |
2023-08-13 |
mouse |
| Jing Pang, Fengzhe Li, Xu Feng, Hua Yang, Le Han, Yixuan Fan, Haitao Nie, Zhen Wang, Feng Wang, Yanli Zhan. Influences of different dietary energy level on sheep testicular development associated with AMPK/ULK1/autophagy pathway. Theriogenology. vol 108. 2018-09-18. PMID:29304491. |
meanwhile, 15% er and 30% er diets induced testis autophagy and apoptosis through activating ampk-ulk1(ulk1, unc-51 like autophagy activating kinase) signal pathway with characterization of increased beclin-1 and light chain 3-Ⅱ/light chain 3-Ⅰ (lc3-ii/lc3-i) ratio, up-regulated the ratio of pro-apoptotic bcl-2-associated x protein (bax) and anti-apoptotic b-cell lymphoma 2 (bcl-2), as well as activated ampk, phosphorylated ampk(p-ampk) and ulk1. |
2018-09-18 |
2023-08-13 |
Not clear |
| Lili Zhang, Zhaomin Fan, Yuechen Han, Lei Xu, Wenwen Liu, Xiaohui Bai, Meijuan Zhou, Jianfeng Li, Haibo Wan. Valproic Acid Promotes Survival of Facial Motor Neurons in Adult Rats After Facial Nerve Transection: a Pilot Study. Journal of molecular neuroscience : MN. vol 64. issue 4. 2018-09-18. PMID:29532368. |
but treatment of vpa significantly reduced cell apoptosis by decreasing the expression of bax protein and increased neuronal survival by upregulating the level of brain-derived neurotrophic factor (bdnf) and growth associated protein-43 (gap-43) expression in injured fmns compared with group ns. |
2018-09-18 |
2023-08-13 |
rat |
| Mohamed A Dkhil, Rami B Kassab, Saleh Al-Quraishy, Mohamed M Abdel-Daim, Rafat Zrieq, Ahmed E Abdel Monei. Ziziphus spina-christi (L.) leaf extract alleviates myocardial and renal dysfunction associated with sepsis in mice. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 102. 2018-09-18. PMID:29549730. |
additionally, zscle reduced myocardial and renal apoptosis by inducing the downregulation of caspase-3 and bax mrna and upregulation of the expression of bcl-2. |
2018-09-18 |
2023-08-13 |
mouse |
| Yan Li, Haixu Wang, Dangxia Zhou, Ting Shuang, Haibo Zhao, Biliang Che. Up-Regulation of Long Noncoding RNA SRA Promotes Cell Growth, Inhibits Cell Apoptosis, and Induces Secretion of Estradiol and Progesterone in Ovarian Granular Cells of Mice. Medical science monitor : international medical journal of experimental and clinical research. vol 24. 2018-09-18. PMID:29674607. |
results we demonstrated that elevated lncrna sra stimulated cell growth, changed distribution of cell cycle phases with increase of cyclin b, cyclin e, and cyclin d1, and inhibited cell apoptosis with up-regulation of bcl2 and down-regulation of bax, cleaved-caspase 3, and cleaved-parp. |
2018-09-18 |
2023-08-13 |
mouse |
| Anna Tankiewicz-Kwedlo, Justyna Magdalena Hermanowicz, Krystyna Pawlak, Robert Czarnomysy, Krzysztof Bielawski, Izabela Prokop, Dariusz Pawla. Erythropoietin Intensifies the Proapoptotic Activity of LFM-A13 in Cells and in a Mouse Model of Colorectal Cancer. International journal of molecular sciences. vol 19. issue 4. 2018-09-17. PMID:29690619. |
the induction of apoptosis by epo and lfm-a-13 in the cells was confirmed by phosphatidylserine externalization, loss of mitochondrial membrane potential, and modulation of the expression of apoptotic protein bax and antiapoptotic protein bcl-2 in colon adenocarcinoma cells. |
2018-09-17 |
2023-08-13 |
mouse |
| Elham Ahmadian, Ahmad Yari Khosroushahi, Aziz Eftekhari, Safar Farajnia, Hossein Babaei, Mohammad Ali Eghba. Novel angiotensin receptor blocker, azilsartan induces oxidative stress and NFkB-mediated apoptosis in hepatocellular carcinoma cell line HepG2. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 99. 2018-09-17. PMID:29710494. |
apoptosis was analyzed qualitatively by dapi staining and quantitatively through flow cytometry methodologies and bax and bcl-2 mrna and protein levels were assessed by real time pcr and elisa methods, respectively. |
2018-09-17 |
2023-08-13 |
Not clear |
| Rui Liu, Hui-Li Wang, Man-Jing Deng, Xiu-Jie Wen, Yuan-Yuan Mo, Fa-Ming Chen, Chun-Li Zou, Wei-Feng Duan, Lei Li, Xin Ni. Melatonin Inhibits Reactive Oxygen Species-Driven Proliferation, Epithelial-Mesenchymal Transition, and Vasculogenic Mimicry in Oral Cancer. Oxidative medicine and cellular longevity. vol 2018. 2018-09-17. PMID:29725496. |
in this study, we found that melatonin impaired the proliferation and apoptosis resistance of oral cancer cells by inactivating ros-dependent akt signaling, involving in downregulation of cyclin d1, pcna, and bcl-2 and upregulation of bax. |
2018-09-17 |
2023-08-13 |
Not clear |
| Subhadip Hajra, Arup Ranjan Patra, Abhishek Basu, Sudin Bhattachary. Prevention of doxorubicin (DOX)-induced genotoxicity and cardiotoxicity: Effect of plant derived small molecule indole-3-carbinol (I3C) on oxidative stress and inflammation. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 101. 2018-09-13. PMID:29494960. |
moreover, i3c attenuate dox-induced apoptosis by up-regulation of bcl2 and down-regulation of bax and caspase-3 expression in bone marrow cells. |
2018-09-13 |
2023-08-13 |
mouse |
| Zhao Fang, Wanjun Luo, Yanli Lu. Protective effect of α-mangostin against CoCl2-induced apoptosis by suppressing oxidative stress in H9C2 rat cardiomyoblasts. Molecular medicine reports. vol 17. issue 5. 2018-09-13. PMID:29512772. |
furthermore, treatment with cocl2 increased the cleavage of caspase‑9, caspase‑3 and apoptosis regulator bax, and reduced apoptosis regulator bcl‑2 in h9c2 cells, as measured by reverse transcription‑quantitative polymerase chain reaction and western blotting, which were significantly reversed by co‑treatment with α‑mg (0.06 and 0.3 mm). |
2018-09-13 |
2023-08-13 |
rat |
| Yahima Frión-Herrera, Alexis Díaz-García, Jenny Ruiz-Fuentes, Hermis Rodríguez-Sánchez, José Maurício Sforci. Mechanisms underlying the cytotoxic effect of propolis on human laryngeal epidermoid carcinoma cells. Natural product research. vol 32. issue 17. 2018-09-11. PMID:28783983. |
both samples induced apoptosis via activation of tp53, casp3, bax, p21 signalling, and downregulation of bcl2 and bcl-xl. |
2018-09-11 |
2023-08-13 |
human |
| Yan Zhang, Hui Li, Xiudong Yang, Gang Jin, Yang Zhan. Cognitive-enhancing effect of polysaccharides from Flammulina velutipes on Alzheimer's disease by compatibilizing with ginsenosides. International journal of biological macromolecules. vol 112. 2018-09-10. PMID:29428385. |
terminal deoxynucleotidyl transferase-mediated dutp biotin nick-end labeling (tunel), immunohistochemistry, and western blot analysis showed that the tunel apoptosis cell rate, bax, cytochrome c, caspase-3, caspase-9, and apoptosis-inducing factor expression levels were obviously decreased, and the bcl-2 expression levels were obviously increased in the hippocampi of rats treated with fvp and ginsenosides. |
2018-09-10 |
2023-08-13 |
rat |