| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Tao Lin, Jae Eun Lee, Reza K Oqani, So Yeon Kim, Eun Seok Cho, Yong Dae Jeong, Jun Jong Baek, Dong Il Ji. Delayed blastocyst formation or an extra day culture increases apoptosis in pig blastocysts. Animal reproduction science. vol 185. 2018-05-25. PMID:28844338. |
delayed blastocyst collection/formation or an additional day of post-blastulation culture increased the frequencies of apoptosis, condensed nuclei, and low quality blastocysts (those showing a nuclear destruction that negated counting of the nuclei); increased the expression of the pro-apoptotic bax gene; and reduced the ratio of icm (inner cell mass) cells to te (trophectoderm) cells. |
2018-05-25 |
2023-08-13 |
Not clear |
| Jiaming Liu, Jindan Wang, Yilu Shi, Wei Su, Jie Chen, Zhengzheng Zhang, Guocan Wang, Fangyan Wan. Short Chain Fatty Acid Acetate Protects against Ethanol-Induced Acute Gastric Mucosal Lesion in Mice. Biological & pharmaceutical bulletin. vol 40. issue 9. 2018-05-24. PMID:28867726. |
with respect to gastric mucosal apoptosis, acetate suppressed caspase-3 activity and bax expression in favor of cell survival. |
2018-05-24 |
2023-08-13 |
mouse |
| Yang Jiao, Yan Wu, Dong D. Polydatin inhibits cell proliferation, invasion and migration, and induces cell apoptosis in hepatocellular carcinoma. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas. vol 51. issue 4. 2018-05-24. PMID:29513792. |
polydatin also induced cell apoptosis in a concentration-dependent manner possibly via increasing the caspase-3 activity, and up-regulating the protein expression of caspase-3, caspase-9, bax, and down-regulating the protein expression of bcl-2. |
2018-05-24 |
2023-08-13 |
mouse |
| Jiaqi Wang, Yixuan Pan, Jiacheng Hu, Qiang Ma, Yi Xu, Yijian Zhang, Fei Zhang, Yingbin Li. Tea polyphenols induce S phase arrest and apoptosis in gallbladder cancer cells. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas. vol 51. issue 4. 2018-05-24. PMID:29513793. |
tps also induced mitochondrial-related apoptosis in gbc cells by upregulating bax, cleaved caspase-3, and cleaved parp expressions and downregulating bcl-2, cyclin a, and cdk2 expressions. |
2018-05-24 |
2023-08-13 |
mouse |
| Olga Koval, Galina Kochneva, Anastasiya Tkachenko, Olga Troitskaya, Galina Sivolobova, Antonina Grazhdantseva, Anna Nushtaeva, Elena Kuligina, Vladimir Richte. Recombinant Vaccinia Viruses Coding Transgenes of Apoptosis-Inducing Proteins Enhance Apoptosis But Not Immunogenicity of Infected Tumor Cells. BioMed research international. vol 2017. 2018-05-23. PMID:28951871. |
we showed that both these recombinant vvs more considerably activated a set of critical apoptosis markers in infected cells than the recombinant vv coding gm-csf alone (vv-gmcsf-dgf): these were phosphatidylserine externalization, caspase-3 and caspase-7 activation, dna fragmentation, and upregulation of proapoptotic protein bax. |
2018-05-23 |
2023-08-13 |
human |
| Yanli Zhang, Le Han, Hua Yang, Jing Pang, Peizhen Li, Guomin Zhang, Fengzhe Li, Feng Wan. Bisphenol A affects cell viability involved in autophagy and apoptosis in goat testis sertoli cell. Environmental toxicology and pharmacology. vol 55. 2018-05-22. PMID:28846990. |
apoptosis with an increase in bax:bcl-2 ratio and higher rates of autophagy, such as autophagosome formation and increased expression of autophagy-related markers were also induced in gscs exposed to 500μm bpa. |
2018-05-22 |
2023-08-13 |
Not clear |
| Xiaohong Yang, Rui Yang, Xianli Li, Xiaohui Zhen. Danshensu attenuates aldosterone-induced cardiomyocytes injury through interfering p53 pathway. Molecular medicine reports. vol 16. issue 4. 2018-05-21. PMID:28765913. |
further research indicated that dss‑ and cellular tumor antigen p53 (p53)‑alone or combination treatment was able to decrease the expression levels of apoptosis regulator bax and caspase‑3, and increase the expression of apoptosis regulator b‑cell lymphoma (bcl)‑2 in ald‑stimulated cardiomyocytes. |
2018-05-21 |
2023-08-13 |
Not clear |
| Xiaozhong Qiu, Ling Shi, Hanting Zhuang, Hongtao Zhang, Juan Wang, Lijun Wang, Peng Sun, Lili Yu, Longxi Li. Cerebrovascular Protective Effect of Boldine Against Neural Apoptosis via Inhibition of Mitochondrial Bax Translocation and Cytochrome C Release. Medical science monitor : international medical journal of experimental and clinical research. vol 23. 2018-05-21. PMID:28841638. |
cerebrovascular protective effect of boldine against neural apoptosis via inhibition of mitochondrial bax translocation and cytochrome c release. |
2018-05-21 |
2023-08-13 |
mouse |
| Gong Wang, Yun Wan, Jinyan Zhao, Zhenfeng Hon. Ethanol extract of Antrodia camphorata inhibits proliferation of HCT-8 human colorectal cancer cells by arresting cell cycle progression and inducing apoptosis. Molecular medicine reports. vol 16. issue 4. 2018-05-21. PMID:28849005. |
ac treatment induced hct‑8 cell apoptosis, upregulated expression of the apoptosis gene bax, and downregulated bcl‑2, cmyc, cyclin d1 and cdk4 protein expression levels. |
2018-05-21 |
2023-08-13 |
human |
| Rui-Fang Fan, Ying Lu, Zhi-Gang Fang, Xiao-Yan Guo, Yu-Xin Chen, Yi-Chuan Xu, Ya-Mei Lei, Ke-Fang Liu, Dong-Jun Lin, Ling-Ling Liu, Xiang-Fu Li. PIM-1 kinase inhibitor SMI-4a exerts antitumor effects in chronic myeloid leukemia cells by enhancing the activity of glycogen synthase kinase 3β. Molecular medicine reports. vol 16. issue 4. 2018-05-21. PMID:28849186. |
in addition, the downstream gene expression of apoptosis regulator bax and poly(adp‑ribose) polymerase‑1 was upregulated, and apoptosis regulator bcl‑2 and myc proto‑oncogene protein expression levels were downregulated. |
2018-05-21 |
2023-08-13 |
Not clear |
| Natalia Majewska, Ilona Zaręba, Arkadiusz Surażyński, Anna Galick. Methylparaben-induced decrease in collagen production and viability of cultured human dermal fibroblasts. Journal of applied toxicology : JAT. vol 37. issue 9. 2018-05-18. PMID:28382686. |
the increased expression and nuclear translocation of caspase-3 as well as increased bax and decreased bcl-2 expression may suggest mp-induced cell apoptosis. |
2018-05-18 |
2023-08-13 |
human |
| Silvia Carloni, Giulia Riparini, Giuseppe Buonocore, Walter Balduin. Rapid modulation of the silent information regulator 1 by melatonin after hypoxia-ischemia in the neonatal rat brain. Journal of pineal research. vol 63. issue 3. 2018-05-18. PMID:28708259. |
in parallel, we found a reduced activation of the early phases of intrinsic apoptosis, detected by reduced bax translocation to the mitochondria and preservation of the mitochondrial expression of cytochrome c, indicating a reduced outer mitochondrial membrane permeabilization in the melatonin-treated ischemic animals. |
2018-05-18 |
2023-08-13 |
rat |
| Homa Mollaei, Reza Safaralizadeh, Esmaeil Babaei, Mohamad Reza Abedini, Reyhane Hoshya. The anti-proliferative and apoptotic effects of crocin on chemosensitive and chemoresistant cervical cancer cells. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 94. 2018-05-18. PMID:28763753. |
moreover, the genetic mechanism of crocin-induced apoptosis was accomplished by studying the relative expressions of p53, bax, bcl2 and mir-365, an upstream regulator of the last two ones. |
2018-05-18 |
2023-08-13 |
human |
| Qiang Wan, Yu-Ping Yang, Zhong-Yong Li. [Puerarin attenuates PM2.5-induced vascular endothelial cells injury via ERK1/2 signaling pathway]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 41. issue 12. 2018-05-18. PMID:28901078. |
different concentrations of pm2.5 (0,20, 200, 400 mg•l⁻¹) were used to contaminate ea.hy926 cells for 24 h. the cells survival rate was detected by mtt assay; cells apoptosis of ea.hy926cells was detected by flow cytometry; the protein levels of p-erk1/2, bax and bcl-2 were detected by western blot; the contents of tumor necrosis factor-α (tnf-α), interleukin-6 (il-6), malonaldehyde (mda), and the activities of superoxide dismutase (sod) and lactic dehydrogenase (ldh) were measured by elisa. |
2018-05-18 |
2023-08-13 |
human |
| Fiona D'Souza, Shivanand M Pudakalakatti, Shubhashree Uppangala, Sachin Honguntikar, Sujith Raj Salian, Guruprasad Kalthur, Renu Pasricha, Divya Appajigowda, Hanudatta S Atreya, Satish Kumar Adig. Unraveling the association between genetic integrity and metabolic activity in pre-implantation stage embryos. Scientific reports. vol 6. 2018-05-17. PMID:27853269. |
further analysis revealed an association of apoptosis and micronuclei frequency with p53 and bax transcripts in idl embryos on the e4.5 owing to delayed induction of chromosome instability. |
2018-05-17 |
2023-08-13 |
mouse |
| Y He, D Tan, Y Mi, B Bai, D Jiang, X Zhou, S J. Effect of epigallocatechin-3-gallate on acrylamide-induced oxidative stress and apoptosis in PC12 cells. Human & experimental toxicology. vol 36. issue 10. 2018-05-17. PMID:27920337. |
egcg reduced the expression of bax mrna, decreased cytochrome c release, reduced intracellular calcium levels, inactivated caspase 3 and increased mitochondrial membrane potential, suggesting that egcg prevents acr-induced apoptosis through a mitochondrial-mediated pathway. |
2018-05-17 |
2023-08-13 |
Not clear |
| Xiao Tan, Xian-Zhe Dong, Dai-Hong Guo, Shi Wang, Mu-Han Li, Run-Qing Zhao, Ping Li. [Anti-radiation effect and mechanism studies of ethanol extracts from Spatholobus suberectus and its active component catechin]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 41. issue 9. 2018-05-17. PMID:28891624. |
the proliferation and differentiation of hematopoietic progenitor cells in bone marrow were promoted, the apoptosis of bone marrow cells was significantly up-regulated and the expression of cleaved caspase-3 and bax was significantly reduced in ssd and catechin group. |
2018-05-17 |
2023-08-13 |
mouse |
| Anna E Kowalczyk, Bartlomiej E Krazinski, Janusz Godlewski, Jolanta Kiewisz, Przemyslaw Kwiatkowski, Agnieszka Sliwinska-Jewsiewicka, Jacek Kiezun, Marian Sulik, Zbigniew Kmie. Expression of the EP300, TP53 and BAX genes in colorectal cancer: Correlations with clinicopathological parameters and survival. Oncology reports. vol 38. issue 1. 2018-05-15. PMID:28586030. |
e1a binding protein p300 (ep300), tumor protein p53 (tp53) and bcl2 associated x, apoptosis regulator (bax) genes encode proteins which cooperate to regulate important cellular processes. |
2018-05-15 |
2023-08-13 |
Not clear |
| Mohammed A El-Magd, Walied S Abdo, Mustafa El-Maddaway, Nasr M Nasr, Rasha A Gaber, Eman S El-Shetry, Ayman A Saleh, Faisal Abdulrahman Ali Alzahrani, Doaa H Abdelhad. High doses of S-methylcysteine cause hypoxia-induced cardiomyocyte apoptosis accompanied by engulfment of mitochondaria by nucleus. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 94. 2018-05-15. PMID:28783581. |
this centripetal movement of mitochondria accompanied by cardiomyocytes hypoxia-induced apoptosis as evident by increasing tunel positive cells as well as upregulation of apoptotic genes (caspase3 and bax), hypoxia inducible factor 1 alpha (hif1α), dynein light chain 1 (dynll1) and downregulation of the anti-apoptotic marker, bcl2. |
2018-05-15 |
2023-08-13 |
rat |
| Yonggang Lyu, Xin Xu, Jun Yun, Jun Yi, Xin Li, Xianghua Liu, Rui Ling, Ling Wang, Jing Fa. [TNF-α regulates the proliferation of human breast cancer cells via regulation of ceramide content]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 33. issue 10. 2018-05-15. PMID:29169412. |
mtt assay was used to determine the proliferation of the cancer cells and western blotting was performed to measure the protein expressions of acid sphingomyelinase (asm), sphk1 and apoptosis or proliferation relevant factors including bcl2, bax and proliferating cell nuclear antigen (pcna). |
2018-05-15 |
2023-08-13 |
human |