| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Giovanni Vitale, Alessandra Dicitore, Daniele Pepe, Davide Gentilini, Elisa S Grassi, Maria O Borghi, Giulia Gelmini, Maria C Cantone, Germano Gaudenzi, Gabriella Misso, Anna M Di Blasio, Leo J Hofland, Michele Caraglia, Luca Persan. Synergistic activity of everolimus and 5-aza-2'-deoxycytidine in medullary thyroid carcinoma cell lines. Molecular oncology. vol 11. issue 8. 2018-04-23. PMID:28453190. |
among these, the neurotrophin signaling pathway was most directly involved in apoptosis, through the overexpression of ngfr and bax genes. |
2018-04-23 |
2023-08-13 |
Not clear |
| Shi-Jie Zhang, Ting-Ting Xu, Lin Li, Yu-Min Xu, Zi-Ling Qu, Xin-Chen Wang, Shui-Qing Huang, Yi Luo, Na-Chuan Luo, Ping Lu, Ya-Fei Shi, Xin Yang, Qi Wan. Bushen-Yizhi formula ameliorates cognitive dysfunction through SIRT1/ER stress pathway in SAMP8 mice. Oncotarget. vol 8. issue 30. 2018-04-23. PMID:28521305. |
in addition, western blot results (bcl-2, bax and caspase-3) and tunel staining show that bsyz prevents neuron from apoptosis, and elevates the expression of neurotrophic factors, including nerve growth factor (ngf), postsynapticdensity 95 (psd95) and synaptophysin (syn), in both hippocampus and cortex. |
2018-04-23 |
2023-08-13 |
mouse |
| Zhi Cheng, Zhanqiang Du, Yingchun Shang, Yuling Zhang, Tao Zhan. A Preliminary Study: PS1 Increases U1 snRNA Expression Associated with AD. Journal of molecular neuroscience : MN. vol 62. issue 3-4. 2018-04-23. PMID:28577205. |
importantly, the increased levels of bax, bcl2, and bax/bcl2 ratio showed that the overexpression of u1 snrna could cause cell apoptosis. |
2018-04-23 |
2023-08-13 |
Not clear |
| C Ashley Barnes, Pushpa Mishra, James L Baber, Marie-Paule Strub, Nico Tjandr. Conformational Heterogeneity in the Activation Mechanism of Bax. Structure (London, England : 1993). vol 25. issue 8. 2018-04-23. PMID:28712810. |
bax is known for its pro-apoptotic role within the mitochondrial pathway of apoptosis. |
2018-04-23 |
2023-08-13 |
Not clear |
| Fei Guo, Wei Zhao, Lin Yang, Yang Yang, Saiqi Wang, Yingjun Wang, Zhaoming Li, Jiaxiang Wan. Truncated apolipoprotein C-I induces apoptosis in neuroblastoma by activating caspases in the extrinsic and intrinsic pathways. Oncology reports. vol 38. issue 3. 2018-04-23. PMID:28713944. |
bax, bim, and tbid upregulation, and bcl‑2 and bcl‑xl downregulation were associated with permeabilization of the mitochondrial membrane, as detected by the jc-1 assay and the release of cytochrome c and apoptosis. |
2018-04-23 |
2023-08-13 |
mouse |
| A Nanda, Qimuge Suyila, Li Xian, Su Xiula. Hepatoprotective Mongolian prescription II enhances the antitumor effects of chemotherapeutics in hepatocellular carcinoma xenografts. Pathology, research and practice. vol 213. issue 5. 2018-04-20. PMID:28416328. |
apoptotic genes (bcl-2 and bax) are up-regulated, suggesting that the ratio of bcl-2/bax was statistically significant, indicating that the drugs had affected the expression of apoptosis genes, especially on induce apoptosis gene bax. |
2018-04-20 |
2023-08-13 |
mouse |
| Kodandaram Sumalatha, Mohan Gowda, Sreepriya Meenakshisundara. ROS-mediated induction of apoptosis by benzoquinone embelin in human colon adenocarcinoma cells HT-29. Journal of complementary & integrative medicine. vol 14. issue 2. 2018-04-18. PMID:28306533. |
influence of embelin on the expression of genes regulating apoptosis (caspase 3 and 9, bcl-2, bax, cytochrome c and x-linked inhibitor of apoptosis protein) and migration/invasion (matrix metalloproteinase [mmp]-2 and mmp-9) was investigated by reverse transcription polymerase chain reaction (pcr). |
2018-04-18 |
2023-08-13 |
human |
| Lina Sun, Shuchun Chen, Haina Gao, Luping Ren, Guangyao Son. Visfatin induces the apoptosis of endothelial progenitor cells via the induction of pro-inflammatory mediators through the NF-κB pathway. International journal of molecular medicine. vol 40. issue 3. 2018-04-17. PMID:28677720. |
following treatment with visfatin for 48 h, the epcs exhibited a dose-dependent increase in apoptosis and an upregulated expression of bax, caspase-3 and nf-κb at both the mrna and protein level, and a decreased protein expression of bcl-2. |
2018-04-17 |
2023-08-13 |
Not clear |
| Lina Sun, Shuchun Chen, Haina Gao, Luping Ren, Guangyao Son. Visfatin induces the apoptosis of endothelial progenitor cells via the induction of pro-inflammatory mediators through the NF-κB pathway. International journal of molecular medicine. vol 40. issue 3. 2018-04-17. PMID:28677720. |
compared with the untreated control group, the increase in epc apoptosis, as well as in bax and caspase-3 expression was significant following treatment with 150 ng/ml visfatin, which also induced a dose-dependent and significant increase in the protein expression of interleukin-6 (il-6) and intercellular adhesion molecule-1 (icam-1). |
2018-04-17 |
2023-08-13 |
Not clear |
| Lina Sun, Shuchun Chen, Haina Gao, Luping Ren, Guangyao Son. Visfatin induces the apoptosis of endothelial progenitor cells via the induction of pro-inflammatory mediators through the NF-κB pathway. International journal of molecular medicine. vol 40. issue 3. 2018-04-17. PMID:28677720. |
pre-incubation of the epcs with bay11 for 1 h followed by treatment with visfatin (150 ng/ml) for 48 h also abolished visfatin-induced apoptosis; it also abolished the promoting effects of visfatin on the expression of caspase-3, bax, icam-1 and il-6, and its suppressive effects on the protein expression of bcl-2. |
2018-04-17 |
2023-08-13 |
Not clear |
| Wan Liang, Likai Ji, Yu Zhang, Yueran Zhen, Qingde Zhang, Xuewen Xu, Bang Li. Transcriptome Differences in Porcine Alveolar Macrophages from Tongcheng and Large White Pigs in Response to Highly Pathogenic Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) Infection. International journal of molecular sciences. vol 18. issue 7. 2018-04-17. PMID:28704922. |
for tc pig, 549 specific degs were identified, including vav2, bcl2 and bax, which were enriched in activation of leukocyte extravasation and suppression of apoptosis. |
2018-04-17 |
2023-08-13 |
Not clear |
| Xin Guo, Nan Guo, Jianwen Zhao, Yunlang Ca. Active targeting co-delivery system based on hollow mesoporous silica nanoparticles for antitumor therapy in ovarian cancer stem-like cells. Oncology reports. vol 38. issue 3. 2018-04-17. PMID:28731164. |
igf‑1r was chosen as the drug target, apoptosis rate and expression of cyclin b1, bax, bcl-xl, p-akt were used to evaluate the antitumor effect of hmsn‑cooh@dox fluorescence nvp. |
2018-04-17 |
2023-08-13 |
Not clear |
| Jing Tan, Xianzhen Jiang, Guangming Yin, Leye He, Jianye Liu, Zhi Long, Zhiqiang Jiang, Kun Ya. Anacardic acid induces cell apoptosis of prostatic cancer through autophagy by ER stress/DAPK3/Akt signaling pathway. Oncology reports. vol 38. issue 3. 2018-04-17. PMID:28731173. |
in this study we found that anacardic acid inhibited cell proliferation, induced apoptosis and caspase-3/9 activities and bax protein expression of prostatic cancer. |
2018-04-17 |
2023-08-13 |
Not clear |
| Jing Tan, Xianzhen Jiang, Guangming Yin, Leye He, Jianye Liu, Zhi Long, Zhiqiang Jiang, Kun Ya. Anacardic acid induces cell apoptosis of prostatic cancer through autophagy by ER stress/DAPK3/Akt signaling pathway. Oncology reports. vol 38. issue 3. 2018-04-17. PMID:28731173. |
si-chop was used to inhibit er stress in prostatic cancer by anacardic acid, which showed that the cell proliferation was increased, apoptosis, and caspase-3/9 activities and bax protein expression was suppressed, autophagy, lc3, beclin-1, atg 7 and dapk3 protein expression was reduced, and p-akt and p-mtor protein expression was promoted. |
2018-04-17 |
2023-08-13 |
Not clear |
| Chen Gao, Yinglu Zhou, Zhongling Jiang, Yuan Zhao, Dongjun Zhang, Xia Cong, Rongfeng Cao, Huatao Li, Wenru Tia. Cytotoxic and chemosensitization effects of Scutellarin from traditional Chinese herb Scutellaria altissima L. in human prostate cancer cells. Oncology reports. vol 38. issue 3. 2018-04-17. PMID:28737827. |
additionally, scutellarin altered the protein expression of cell cycle and apoptosis regulatory genes by downregulating cdc2, cyclin b1 and bcl-2 and upregulating caspase-3, caspase-9 and bax in prostate cancer cells. |
2018-04-17 |
2023-08-13 |
human |
| Donghe Han, Shurui Chen, Shiqiang Fang, Shiqiong Liu, Meihua Jin, Zhanpeng Guo, Yajiang Yuan, Yansong Wang, Chang Liu, Xifan Me. The Neuroprotective Effects of Muscle-Derived Stem Cells via Brain-Derived Neurotrophic Factor in Spinal Cord Injury Model. BioMed research international. vol 2017. 2018-04-17. PMID:28758111. |
an in vitro study demonstrated that mdscs attenuated neuron apoptosis, and the expression of antioxidants was upregulated as well as the ratio of bcl-2 and bax in the mnt (mdscs cocultured with injured neurons) group compared with the nt (injured neurons) group. |
2018-04-17 |
2023-08-13 |
rat |
| B Yeganeh, S Ghavami, Md N Rahim, T Klonisch, A J Halayko, K M Coomb. Autophagy activation is required for influenza A virus-induced apoptosis and replication. Biochimica et biophysica acta. Molecular cell research. vol 1865. issue 2. 2018-04-17. PMID:29108912. |
both bax knockout (ko) and bax/bak double knockout mefs displayed inhibition of virus-induced cytopathology and cell death and diminished virus-mediated caspase activation, suggesting that virus-induced apoptosis is bax/bak-dependent. |
2018-04-17 |
2023-08-13 |
mouse |
| Kate McArthur, Lachlan W Whitehead, John M Heddleston, Lucy Li, Benjamin S Padman, Viola Oorschot, Niall D Geoghegan, Stephane Chappaz, Sophia Davidson, Hui San Chin, Rachael M Lane, Marija Dramicanin, Tahnee L Saunders, Canny Sugiana, Romina Lessene, Laura D Osellame, Teng-Leong Chew, Grant Dewson, Michael Lazarou, Georg Ramm, Guillaume Lessene, Michael T Ryan, Kelly L Rogers, Mark F van Delft, Benjamin T Kil. BAK/BAX macropores facilitate mitochondrial herniation and mtDNA efflux during apoptosis. Science (New York, N.Y.). vol 359. issue 6378. 2018-04-17. PMID:29472455. |
mitochondrial apoptosis is mediated by bak and bax, two proteins that induce mitochondrial outer membrane permeabilization, leading to cytochrome c release and activation of apoptotic caspases. |
2018-04-17 |
2023-08-13 |
mouse |
| Chih-Hao Yang, Ting-Lin Yen, Chia-Yuan Hsu, Philip-Aloysius Thomas, Joen-Rong Sheu, Thanasekaran Jayakuma. Multi-Targeting Andrographolide, a Novel NF-κB Inhibitor, as a Potential Therapeutic Agent for Stroke. International journal of molecular sciences. vol 18. issue 8. 2018-04-16. PMID:28749412. |
the neuroprotective mechanisms of andrographolide are suggested as: (i) increasing nuclear factor e2-related factor 2-heme oxygenase (nrf2-ho-1) expression through p38-mitogen activated protein kinase (mapk) regulation, (ii) inducing cerebral endothelial cells (cec) apoptosis and caspase-3 activation, (iii) down regulating bax, inducible nitric oxide synthase (inos), and (iv) inhibiting hydroxyl radical (oh |
2018-04-16 |
2023-08-13 |
Not clear |
| Ting Zhang, Wan Hong He, Ling Lin Feng, Hao Guang Huan. Effect of doxorubicin-induced ovarian toxicity on mouse ovarian granulosa cells. Regulatory toxicology and pharmacology : RTP. vol 86. 2018-04-12. PMID:28219713. |
after granulosa cells were treated with doxorubicin at the final concentrations of 0, 0.4, 0.8, and 1.6 μg/ml for 24 h, cell apoptosis was detected by dapi staining or caspase-3/7 fluorescence probe; ros was determined by 2', 7'-dichlorodihydrofluorescin diacetate fluorescence probe; mitochondrial membrane potential was detected by rhodamine-123 fluorescence probe; and mrna expression levels of bax, bcl-2, p53, fshr, star, p450scc and p450arom were analyzed by rt-pcr. |
2018-04-12 |
2023-08-13 |
mouse |