| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Bin Li, Cui-Min Ding, Yan-Xiao Li, Jing-Cui Peng, Nan Geng, Wen-Wen Qi. MicroRNA‑145 inhibits migration and induces apoptosis in human non‑small cell lung cancer cells through regulation of the EGFR/PI3K/AKT signaling pathway. Oncology reports. vol 40. issue 5. 2018-12-18. PMID:30226581. |
the downregulation of mir‑145 in a549 cells reduced lactate dehydrogenase (ldh) expression, apoptosis, caspase‑3/-9 levels and bax protein expression, while it increased cell proliferation. |
2018-12-18 |
2023-08-13 |
human |
| Bin Li, Cui-Min Ding, Yan-Xiao Li, Jing-Cui Peng, Nan Geng, Wen-Wen Qi. MicroRNA‑145 inhibits migration and induces apoptosis in human non‑small cell lung cancer cells through regulation of the EGFR/PI3K/AKT signaling pathway. Oncology reports. vol 40. issue 5. 2018-12-18. PMID:30226581. |
upregulation of mir‑145 in a459 cells increased ldh, apoptosis, caspase‑3/-9 levels and bax protein expression, while it inhibited cell proliferation. |
2018-12-18 |
2023-08-13 |
human |
| Anil Murat Ozturk, Murat Celal Sozbilen, Elvin Sevgili, Taner Dagci, Halit Özyalcin, Guliz Armaga. Epidermal growth factor regulates apoptosis and oxidative stress in a rat model of spinal cord injury. Injury. vol 49. issue 6. 2018-12-17. PMID:29602490. |
our experiment also suggests that alteration of the ratio of bcl-2 to bax may result from decreased apoptosis following egf treatment. |
2018-12-17 |
2023-08-13 |
rat |
| Qin Weilan, Yan Yan, Liu Xuemei, Shen Wei, Liu Xiaohan, Ma Qingke, Wang Ying, Jin Xiangla. Effect of medicated thread moxibustion on apoptosis of hippocampal neurons in rat models of chronic cerebral ischemic vascular dementia. Cellular and molecular biology (Noisy-le-Grand, France). vol 64. issue 13. 2018-12-17. PMID:30403605. |
changes in related indexes such as bax, bc1-2 and c-fos of neuron apoptosis in hippocampus ca1 area were determined by immunohistochemistry, while protein expression was semi-quantitatively assayed using imaging analysis technique. |
2018-12-17 |
2023-08-13 |
rat |
| Qin Weilan, Yan Yan, Liu Xuemei, Shen Wei, Liu Xiaohan, Ma Qingke, Wang Ying, Jin Xiangla. Effect of medicated thread moxibustion on apoptosis of hippocampal neurons in rat models of chronic cerebral ischemic vascular dementia. Cellular and molecular biology (Noisy-le-Grand, France). vol 64. issue 13. 2018-12-17. PMID:30403605. |
medicated thread moxibustion alleviates hippocampal neuronal necrosis, inhibits neuron apoptosis in hippocampus ca1 area, protects nerves, and maintains relative equilibrium inbax/bcl-2 through down-regulation of c-fos and bax and up-regulation of bcl-2. |
2018-12-17 |
2023-08-13 |
rat |
| Lihua Liu, Zhongfu Zuo, Sijing Lu, Lihua Wang, Aihua Liu, Xuezheng Li. Silencing of PINK1 represses cell growth, migration and induces apoptosis of lung cancer cells. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 106. 2018-12-14. PMID:29966978. |
furthermore, the apoptosis rate was enhanced by pink1 suppression, as evidenced by increased protein levels of bax, cleaved caspase-3 and cleaved poly (adp-ribose) polymerase (parp), and decreased level of bcl-2. |
2018-12-14 |
2023-08-13 |
Not clear |
| Amin Ghasemi, Taghi Khanzadeh, Milad Zadi Heydarabad, Arash Khorrami, Akram Jahanban Esfahlan, Somayeh Ghavipanjeh, Mahdi Gholipour Belverdi, Saghar Darvishani Fikouhi, Akbar Darbin, Malihe Najafpour, Ako Azim. Evaluation of BAX and BCL-2 Gene Expression and Apoptosis Induction in Acute Lymphoblastic Leukemia Cell Line CCRFCEM after High- Dose Prednisolone Treatment Asian Pacific journal of cancer prevention : APJCP. vol 19. issue 8. 2018-12-14. PMID:30141309. |
evaluation of bax and bcl-2 gene expression and apoptosis induction in acute lymphoblastic leukemia cell line ccrfcem after high- dose prednisolone treatment objective: glucocorticoids are one of the most important drugs in the treatment of acute lymphoblastic leukemiafor children. |
2018-12-14 |
2023-08-13 |
Not clear |
| Amin Ghasemi, Taghi Khanzadeh, Milad Zadi Heydarabad, Arash Khorrami, Akram Jahanban Esfahlan, Somayeh Ghavipanjeh, Mahdi Gholipour Belverdi, Saghar Darvishani Fikouhi, Akbar Darbin, Malihe Najafpour, Ako Azim. Evaluation of BAX and BCL-2 Gene Expression and Apoptosis Induction in Acute Lymphoblastic Leukemia Cell Line CCRFCEM after High- Dose Prednisolone Treatment Asian Pacific journal of cancer prevention : APJCP. vol 19. issue 8. 2018-12-14. PMID:30141309. |
the aim of this study was to evaluate the effect of high dose prednisolone on inductionof apoptosis and changes in bax and bcl-2 gene expression at different times. |
2018-12-14 |
2023-08-13 |
Not clear |
| Amin Ghasemi, Taghi Khanzadeh, Milad Zadi Heydarabad, Arash Khorrami, Akram Jahanban Esfahlan, Somayeh Ghavipanjeh, Mahdi Gholipour Belverdi, Saghar Darvishani Fikouhi, Akbar Darbin, Malihe Najafpour, Ako Azim. Evaluation of BAX and BCL-2 Gene Expression and Apoptosis Induction in Acute Lymphoblastic Leukemia Cell Line CCRFCEM after High- Dose Prednisolone Treatment Asian Pacific journal of cancer prevention : APJCP. vol 19. issue 8. 2018-12-14. PMID:30141309. |
conclusions: apoptosis induced by high-dose prednisolone in the ccrf-cem cells, which is almost resistant,and possibly mediated by reducing the expression of bcl-2 and bax up-regulation. |
2018-12-14 |
2023-08-13 |
Not clear |
| Shoumin Feng, Jian Zhu, Kaishun Xia, Wei Yu, Yitian Wang, Junjie Wang, Fangcai Li, Zhengming Yang, Xiaobo Yang, Bing Liu, Huimin Tao, Chengzhen Lian. Cantharidin Inhibits Anti-Apoptotic Bcl-2 Family Proteins and Induces Apoptosis in Human Osteosarcoma Cell Lines MG-63 and MNNG/HOS via Mitochondria-Dependent Pathway. Medical science monitor : international medical journal of experimental and clinical research. vol 24. 2018-12-12. PMID:30248086. |
in addition, cantharidin-induced apoptosis was accompanied by increased expression of bax and parp and decreased expression of bcl-2, p-akt, and p-cdc2. |
2018-12-12 |
2023-08-13 |
human |
| Chenlin Pei, Qun He, Shuai Liang, Xuejun Gon. Mahanimbine Exerts Anticancer Effects on Human Pancreatic Cancer Cells by Triggering Cell Cycle Arrest, Apoptosis, and Modulation of AKT/Mammalian Target of Rapamycin (mTOR) and Signal Transducer and Activator of Transcription 3 (STAT3) Signalling Pathways. Medical science monitor : international medical journal of experimental and clinical research. vol 24. 2018-12-12. PMID:30273298. |
mahanimbine prompted apoptosis was also associated with decline in bcl-2 and enhancement of the bax expression. |
2018-12-12 |
2023-08-13 |
human |
| Xiujuan Yan, Yingxiu Li, Yun Ho Choi, Chongyang Wang, Yihua Piao, Jing Ye, Jingzhi Jiang, Liangchang Li, Huixian Xu, Qingsong Cui, Guanghai Yan, Minggen Ji. Protective Effect and Mechanism of Alprostadil in Acute Respiratory Distress Syndrome Induced by Oleic Acid in Rats. Medical science monitor : international medical journal of experimental and clinical research. vol 24. 2018-12-12. PMID:30296789. |
alprostadil inhibited bax but increased bcl-2, indicating a suppressive role in apoptosis. |
2018-12-12 |
2023-08-13 |
rat |
| Swayamsiddha Kar, Dipta Sengupta, Moonmoon Deb, Nibedita Pradhan, Samir Kumar Patr. SOX2 function and Hedgehog signaling pathway are co-conspirators in promoting androgen independent prostate cancer. Biochimica et biophysica acta. Molecular basis of disease. vol 1863. issue 1. 2018-12-11. PMID:27816521. |
moreover, gene expression of emt markers such as e-cadherin and apoptosis related bcl-2 and bax was also investigated wherein decrease in e-cadherin and bcl-2 levels and increase in bax expression further substantiating our claim. |
2018-12-11 |
2023-08-13 |
human |
| Kohei Arasaki, Yumi Mikami, Stephanie R Shames, Hiroki Inoue, Yuichi Wakana, Mitsuo Tagay. Legionella effector Lpg1137 shuts down ER-mitochondria communication through cleavage of syntaxin 17. Nature communications. vol 8. 2018-12-11. PMID:28504273. |
cleavage of syntaxin 17 inhibits not only autophagy but also staurosporine-induced apoptosis occurring in a bax, drp1-dependent manner. |
2018-12-11 |
2023-08-13 |
Not clear |
| Aida Peña-Blanco, Ana J García-Sáe. Bax, Bak and beyond - mitochondrial performance in apoptosis. The FEBS journal. vol 285. issue 3. 2018-12-11. PMID:28755482. |
bax, bak and beyond - mitochondrial performance in apoptosis. |
2018-12-11 |
2023-08-13 |
Not clear |
| Aida Peña-Blanco, Ana J García-Sáe. Bax, Bak and beyond - mitochondrial performance in apoptosis. The FEBS journal. vol 285. issue 3. 2018-12-11. PMID:28755482. |
bax and bak are members of the bcl-2 family and core regulators of the intrinsic pathway of apoptosis. |
2018-12-11 |
2023-08-13 |
Not clear |
| Aida Peña-Blanco, Ana J García-Sáe. Bax, Bak and beyond - mitochondrial performance in apoptosis. The FEBS journal. vol 285. issue 3. 2018-12-11. PMID:28755482. |
a new perspective is emerging, in which the control of apoptosis by bax and bak goes beyond them and is highly influenced by additional mitochondrial components. |
2018-12-11 |
2023-08-13 |
Not clear |
| Gabriele Bonaventura, Rosario Iemmolo, Agata G D'Amico, Valentina La Cognata, Erminio Costanzo, Mario Zappia, Velia D'Agata, Francesca L Conforti, Eleonora Aronica, Sebastiano Cavallar. PACAP and PAC1R are differentially expressed in motor cortex of amyotrophic lateral sclerosis patients and support survival of iPSC-derived motor neurons. Journal of cellular physiology. vol 233. issue 4. 2018-12-11. PMID:28926110. |
treatment with 100 nm pacap was able to effectively rescue ipsc-derived motor neurons from apoptosis, as shown by cell viability assay and protein dosage of the apoptotic marker (bax). |
2018-12-11 |
2023-08-13 |
human |
| Biao Zhang, Dan-Dan Guo, Jia-Ying Zheng, Yan-An W. Expression of KLF6-SV2 in colorectal cancer and its impact on proliferation and apoptosis. European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP). vol 27. issue 1. 2018-12-11. PMID:29084019. |
klf6-sv2 plays a role as tumor suppressor by efficiently blocking cell proliferation, arresting cell cycle and inducing apoptosis in colorectal cancer, which may be related to increased expression of p21 and bax. |
2018-12-11 |
2023-08-13 |
Not clear |
| Bing-Gang Zhou, Chang-Sheng Wei, Song Zhang, Zhi Zhang, Huan-Min Ga. Matrine reversed multidrug resistance of breast cancer MCF-7/ADR cells through PI3K/AKT signaling pathway. Journal of cellular biochemistry. vol 119. issue 5. 2018-12-11. PMID:29130495. |
methyl thiazolyl tetrazolium (mtt) assay was used to detect the inhibitory action; annexin v to detect apoptosis; fluorospectrophotometry to examine intracellular adriamycin (adr) accumulation; and western blot to label the proteins of p-glycoprotein (p-gp), mrp1, pten, p-akt, bcl-2, bax, and caspase-3. |
2018-12-11 |
2023-08-13 |
Not clear |