| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Esther J Y Kim, Minna-Liisa Anko, Christoffer Flensberg, Ian J Majewski, Fan-Suo Geng, Jaber Firas, David C S Huang, Mark F van Delft, Joan K Heat. BAK/BAX-Mediated Apoptosis Is a Myc-Induced Roadblock to Reprogramming. Stem cell reports. vol 10. issue 2. 2019-01-17. PMID:29358089. |
to directly determine how extensively apoptosis limits reprogramming, we exploited mouse embryonic fibroblasts (mefs) lacking the two essential mediators of apoptosis, bak and bax. |
2019-01-17 |
2023-08-13 |
mouse |
| Jun-Xia Li, Yan-Ping Bi, Jing Wang, Xue Yang, Yan-Fang Tian, Zhong-Fang Su. JTC-801 inhibits the proliferation and metastasis of ovarian cancer cell SKOV3 through inhibition of the PI3K - AKT signaling pathway. Die Pharmazie. vol 73. issue 5. 2019-01-17. PMID:29724295. |
the apoptosis rate of skov3 cells treated with jtc-801 was significantly increased (p<0.05), and the expression results of relevant apoptosis proteins (bcl2, bax, active caspase-3) indicated the jtc-801 could induce the apoptosis of skov3. |
2019-01-17 |
2023-08-13 |
Not clear |
| Parisa Ghorbani, Farideh Namvar, Masoud Homayouni-Tabrizi, Mozhgan Soltani, Ehsan Karimi, Parichehreh Yaghmae. Apoptotic efficacy and antiproliferative potential of silver nanoparticles synthesised from aqueous extract of sumac ( IET nanobiotechnology. vol 12. issue 5. 2019-01-17. PMID:30095419. |
in addition, molecular analysis demonstrated that the apoptosis in mcf-7 cells exposed to agsu/nps was induced via up-regulation of bax and down-regulation of bcl-2. |
2019-01-17 |
2023-08-13 |
human |
| Chun-Hua Shan, Jianjun Guo, Xinsheng Sun, Nan Li, Xinyu Yang, Yuhong Gao, Dianrui Qiu, Xuemei Li, Yanan Wang, Man Feng, Chao Wang, Juan Juan Zha. Effects of fermented Chinese herbal medicines on milk performance and immune function in late-lactation cows under heat stress conditions. Journal of animal science. vol 96. issue 10. 2019-01-14. PMID:30032262. |
the immunity-related biochemistry and genes transcript responses involving cytokines (il-1, il-2, il-6, and il-12), apoptosis (bak, mcl-1, bax, bcl-2, bcl-xl, and p53), and immunoglobulins (iga, igg, and igm) were investigated. |
2019-01-14 |
2023-08-13 |
Not clear |
| Wenliang Zha, Yuting Bai, Ling Xu, Yuning Liu, Zhen Yang, Hui Gao, Jun L. Curcumin Attenuates Testicular Injury in Rats with Streptozotocin-Induced Diabetes. BioMed research international. vol 2018. 2019-01-14. PMID:30151389. |
moreover, testicular apoptosis and bax expression were much higher in diabetic rats than in control rats. |
2019-01-14 |
2023-08-13 |
rat |
| Alessandro de Souza Prestes, Matheus Mulling Dos Santos, Assis Ecker, Gabriel Teixeira de Macedo, Roselei Fachinetto, Getulio Nicola Bressan, João Batista Teixeira da Rocha, Nilda Vargas Barbos. Methylglyoxal disturbs the expression of antioxidant, apoptotic and glycation responsive genes and triggers programmed cell death in human leukocytes. Toxicology in vitro : an international journal published in association with BIBRA. vol 55. 2019-01-14. PMID:30447388. |
these phenomena were accompanied by morphological changes (increased size and granularity) and disruption in mrna expression of antioxidant, apoptotic and glycation-responsive genes, particularly: nrf2 (nuclear factor (erythroid-derived 2)-like 2), sod1 (cuzn-superoxide dismutase), sod2 (mn-superoxide dismutase), gsr (glutathione-s-reductase), bax (bax-associated x protein), bcl-2 (bcl-2-associated x protein), aif (apoptosis inducing factor), glo-1 (glyoxalase-1) and rage (receptor for advanced glycation end products). |
2019-01-14 |
2023-08-13 |
human |
| Xiaoqin Li, Yanqing Jia, Haijin Liu, Xiangwei Wang, Zhili Chu, Ruochen Hu, Juan Ren, Sa Xiao, Shuxia Zhang, Xinglong Wang, Zengqi Yan. High level expression of ISG12(1) promotes cell apoptosis via mitochondrial-dependent pathway and so as to hinder Newcastle disease virus replication. Veterinary microbiology. vol 228. 2019-01-14. PMID:30593361. |
in addition, we showed that isg12(1) localized to the mitochondria; promoted the redistribution of bax, a proapoptotic protein causing irreversible loss of mitochondrial function, from the cytoplasm to the mitochondria; and therefore induced cell apoptosis. |
2019-01-14 |
2023-08-13 |
chicken |
| Lili Jin, Qiuyu Wang, Hanyu Zhang, Sijia Tai, Hongsheng Liu, Dianbao Zhan. A Synthetic Peptide AWRK6 Alleviates Lipopolysaccharide-Induced Liver Injury. International journal of molecular sciences. vol 19. issue 9. 2019-01-11. PMID:30205524. |
by tunel assay on liver sections, awrk6 was proven to inhibit apoptosis induced by lps in mice livers, which was also verified by the protein levels of cleaved-caspase 9, bax and bcl-2. |
2019-01-11 |
2023-08-13 |
mouse |
| Olivier Boucherat, Sophie Chabot, Roxane Paulin, Isabelle Trinh, Alice Bourgeois, François Potus, Marie-Claude Lampron, Caroline Lambert, Sandra Breuils-Bonnet, Valérie Nadeau, Renée Paradis, Elena A Goncharova, Steeve Provencher, Sébastien Bonne. HDAC6: A Novel Histone Deacetylase Implicated in Pulmonary Arterial Hypertension. Scientific reports. vol 7. issue 1. 2019-01-10. PMID:28674407. |
mechanistically, we demonstrated that hdac6 maintains ku70 in a hypoacetylated state, blocking the translocation of bax to mitochondria and preventing apoptosis. |
2019-01-10 |
2023-08-13 |
mouse |
| Y Zhang, C Bao, Q Mu, J Chen, J Wang, Y Mi, A J Sayari, Y Chen, M Gu. Reversal of cisplatin resistance by inhibiting PI3K/Akt signal pathway in human lung cancer cells. Neoplasma. vol 63. issue 3. 2019-01-09. PMID:26925782. |
inhibition of pi3k/aktactivity in a549/ddp cells and h460/ddp cells could reverse cisplatin resistance by enhancing the effect of cisplatin on bax oligomerization and release of cytochrome c, allowing activation of the caspase-mediated apoptosis pathway. |
2019-01-09 |
2023-08-13 |
human |
| Mingzhen Zhang, Jie Zheng, Ruth Nussinov, Buyong M. Release of Cytochrome C from Bax Pores at the Mitochondrial Membrane. Scientific reports. vol 7. issue 1. 2019-01-09. PMID:28572603. |
how cytochrome c is released from the mitochondria to the cytosol via bax oligomeric pores, a process which is required for apoptosis, is still a mystery. |
2019-01-09 |
2023-08-13 |
Not clear |
| Eman M Mantawy, Ahmed Esmat, Wesam M El-Bakly, Rania A Salah ElDin, Ebtehal El-Demerdas. Mechanistic clues to the protective effect of chrysin against doxorubicin-induced cardiomyopathy: Plausible roles of p53, MAPK and AKT pathways. Scientific reports. vol 7. issue 1. 2019-01-09. PMID:28684738. |
moreover, chrysin attenuated dox-induced apoptosis via decreasing expression of p53, bax, puma, noxa, cytochrome c and caspase-3 while increasing expression of bcl-2. |
2019-01-09 |
2023-08-13 |
human |
| Xiong Zhang, Qi Ni, Ying Wang, Hongwei Fan, Yingbin L. Synergistic Anticancer Effects of Formononetin and Temozolomide on Glioma C6 Cells. Biological & pharmaceutical bulletin. vol 41. issue 8. 2019-01-09. PMID:29848900. |
drug combination enhanced the expression of bax, cleaved caspase-3, cleaved caspase-9, decreased the expression of bcl-2, and promoted tumor cells apoptosis. |
2019-01-09 |
2023-08-13 |
human |
| Zhaohui Dong, Lanying Zhang, Wei Xu, Gensheng Zhan. EGFR may participate in immune evasion through regulation of B7‑H5 expression in non‑small cell lung carcinoma. Molecular medicine reports. vol 18. issue 4. 2019-01-09. PMID:30106102. |
the expression levels of egfr, b7‑h5, survivin, apoptosis regulator bax, apoptosis regulator bcl‑2 (bcl‑2), tgf‑β, vascular endothelial growth factor (vegf), il‑10 and cyclooxygenase (cox)‑2 were assessed via quantitative pcr and western blotting. |
2019-01-09 |
2023-08-13 |
Not clear |
| Delong Tian, Yanhai Li, Xinxin Li, Zhenzhen Tia. Aloperine inhibits proliferation, migration and invasion and induces apoptosis by blocking the Ras signaling pathway in human breast cancer cells. Molecular medicine reports. vol 18. issue 4. 2019-01-09. PMID:30132540. |
in addition, the results of confocal microscopy analysis and flow cytometry detection revealed that alo induced the apoptosis of mcf-7 and mda-mb-231 cells, and western blotting indicated that alo upregulated the protein levels of bax, caspase-3 and caspase-9, and downregulated the expression of bcl-2. |
2019-01-09 |
2023-08-13 |
human |
| Phuong M Le, Vanesa L Silvestri, Samuel C Redstone, Jordanne B Dunn, Julie T Millar. Cross-linking by epichlorohydrin and diepoxybutane correlates with cytotoxicity and leads to apoptosis in human leukemia (HL-60) cells. Toxicology and applied pharmacology. vol 352. 2019-01-08. PMID:29792945. |
quantitative reverse transcription polymerase chain reaction experiments revealed that treatment of hl-60 cells with deb and ech results in up-regulation of several genes involved in the intrinsic (mitochondrial) apoptosis pathway, including bax, bak1, casp-9, apaf-1, and bcl-2. |
2019-01-08 |
2023-08-13 |
human |
| Mao-Jian Chen, Li Wang, Wei-Ping Yang, Qing-Hong Qin, Qi-Xing Tan, Bin Lian, Chang-Yuan We. [Effects of FBI-1 silencing on proliferation and apoptosis of triple-negative breast cancer cell line MDA-MB-231]. Sheng li xue bao : [Acta physiologica Sinica]. vol 70. issue 5. 2019-01-08. PMID:30377688. |
fbi-1 gene silencing inhibited proliferation and induced apoptosis of mda-mb-231 cells in vitro, together with decreased bcl-2 and survivin protein expression, increased bax protein expression and activated caspase 3. |
2019-01-08 |
2023-08-13 |
mouse |
| Youxia Huang, Yingjian Cai, Ronggui Huang, Xingzhong Zhen. Rosmarinic Acid Combined with Adriamycin Induces Apoptosis by Triggering Mitochondria-Mediated Signaling Pathway in HepG2 and Bel-7402 Cells. Medical science monitor : international medical journal of experimental and clinical research. vol 24. 2019-01-07. PMID:30391993. |
cell viability, apoptosis, cell cycle, and bcl-2 and bax expression were changed with increased concentrations of rosa. |
2019-01-07 |
2023-08-13 |
human |
| Lin Zheng, Wei-Dan Jiang, Lin Feng, Pei Wu, Ling Tang, Sheng-Yao Kuang, Yun-Yun Zeng, Xiao-Qiu Zhou, Yang Li. Selenium deficiency impaired structural integrity of the head kidney, spleen and skin in young grass carp (Ctenopharyngodon idella). Fish & shellfish immunology. vol 82. 2019-01-03. PMID:30142391. |
results showed that selenium deficiency (1) caused oxidative damage in part by reducing the activities of antioxidant enzymes (such as sod, cat, gpx, gst and gr) and glutathione (gsh) content, down-regulating the transcript abundances of antioxidant enzymes (except gstp1) partly related to kelch-like-ech-associated protein 1a (keap1a)/nf-e2-related factor 2 (nrf2) signalling; (2) aggravated apoptosis in part by up-regulating the mrna levels of caspase-2, -3, -7, -8 and -9, which were partially related to p38mapk/fasl/caspase-8 signalling and jnk/(bax, bcl-2, mcl-1b, iap)/(apaf1, caspase-9) signalling; (3) damaged the tight junctions in part by down-regulating the mrna levels of zo-1 (except spleen), zo-2 (except spleen), claudin-c, -f, -7, -11 and claudin-15, and up-regulating the mrna levels of claudin-12, which were partially related to myosin light chain kinase (mlck) signalling. |
2019-01-03 |
2023-08-13 |
cat |
| Yunxia Lu, Yong Chen, Rui Li, Quan Liu, Nuojin Wang, Yi Zhang, Bao Li, Zhaohui Fan. Protective effects of Danzhi jiangtang capsule on vascular endothelial damages induced by high-fat diet and palmitic acid. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 107. 2019-01-03. PMID:30257381. |
djc therapy exhibited a potent antioxidant activity and effectively prevented the endothelial dysfunction (ed) manifested by promoting p-enos expression and enhancing no release, decreasing lipid deposition (oil-red o staining, cpt1b and acc) and inflammation (il-1β, tnfα, cd68 and p-jnk), alleviating oxidative and er stress, and decreasing the apoptosis of endothelial cells (tunel, bcl-2 and bax) induced by hfd and palmitic acid respectively. |
2019-01-03 |
2023-08-13 |
human |