| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yanan Li, Xinran Li, Jinghua Zhao, Lina Li, Yuxin Wang, Yiming Zhang, Yu Chen, Wenhan Liu, Li Ga. Midazolam Attenuates Autophagy and Apoptosis Caused by Ketamine by Decreasing Reactive Oxygen Species in the Hippocampus of Fetal Rats. Neuroscience. vol 388. 2019-03-29. PMID:29634998. |
results showed that ketamine induced apoptosis through activation of the mitochondrial pathway by increasing the expression of c-caspase-3 and bax, and decreasing the expression of bcl-2 at the protein level. |
2019-03-29 |
2023-08-13 |
human |
| Fatemeh Khaki-Khatibi, Marjan Ghorbani, Mehdi Sabzichi, Fatemeh Ramezani, Jamal Mohammadia. Adjuvant therapy with stattic enriches the anti-proliferative effect of doxorubicin in human ZR-75-1 breast cancer cells via arresting cell cycle and inducing apoptosis. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 109. 2019-03-28. PMID:30551374. |
cell viability was investigated by mtt assay, the percentage of apoptosis by dapi staining, and annexin v. real time-pcr was applied to find out the correlation between mechanistic roles of the stat3 pathway and apoptotic signal in the modulation of bcl-2 and bax gene expressions axis. |
2019-03-28 |
2023-08-13 |
human |
| Da Lv, Yi Gu, Ming Guo, Ping Hou, Yan Li, Ronghui W. Perfluorooctanoic acid exposure induces apoptosis in SMMC-7721 hepatocellular cancer cells. Environmental pollution (Barking, Essex : 1987). vol 247. 2019-03-28. PMID:30703684. |
furthermore, we showed that pfoa-mediated induction of apoptosis involved inducing bax and decreasing bcl-2 expression as a molecular mechanism of its toxicological effects. |
2019-03-28 |
2023-08-13 |
Not clear |
| Ali A Shati, Fahmy G Elsai. Hepatotoxic effect of subacute vincristine administration activates necrosis and intrinsic apoptosis in rats: protective roles of broccoli and Indian mustard. Archives of physiology and biochemistry. vol 125. issue 1. 2019-03-25. PMID:29388444. |
vcr treatment induced hepatocyte apoptosis, shown by the up-regulation of mrna and protein levels of 53, increased protein levels of cleaved caspase-3 and bax, and reduced levels of intracellular atp and bcl-2mrna and protein. |
2019-03-25 |
2023-08-13 |
rat |
| Xiaozhu Tang, Jing Sun, Tao Ge, Kaiqi Zhang, Qiuyi Gui, Shantang Zhang, Weidong Che. PEGylated liposomes as delivery systems for Gambogenic acid: Characterization and in vitro/in vivo evaluation. Colloids and surfaces. B, Biointerfaces. vol 172. 2019-03-25. PMID:30125771. |
mechanistically, western blot analysis revealed that up-regulation of bax, down-regulation of bcl-2 and activation of caspase-3 contributed to apoptosis. |
2019-03-25 |
2023-08-13 |
Not clear |
| Jinpeng Ruan, Junde Chen, Jie Zeng, Zhenggang Yang, Chonggang Wang, Zhuan Hong, Zhenghong Zu. The protective effects of Nile tilapia (Oreochromis niloticus) scale collagen hydrolysate against oxidative stress induced by tributyltin in HepG2 cells. Environmental science and pollution research international. vol 26. issue 4. 2019-03-25. PMID:30523527. |
moreover, tsch decreased the expression of the proapoptotic protein bax, reducing apoptosis. |
2019-03-25 |
2023-08-13 |
Not clear |
| Junfeng Wang, Li Qin, Biqing Zhao, Liang Cai, Zhenping Zhong, Yonghong Liu, Xiaojiang Zho. Crotonols A and B, two rare tigliane diterpenoid derivatives against K562 cells from Croton tiglium. Organic & biomolecular chemistry. vol 17. issue 1. 2019-03-25. PMID:30534799. |
furthermore, crotonol a promoted the apoptosis of k562 cells through the cleavage of parp and the accumulation of bax as well as the degradation of bcl-2. |
2019-03-25 |
2023-08-13 |
Not clear |
| Lei Yu, Min Chen, Rui Zhang, Ting X. Antitumor Effects of Glychionide-A Flavonoid in Human Pancreatic Carcinoma Cells Are Mediated by Activation of Apoptotic and Autophagic Pathways, Cell Cycle Arrest, and Disruption of Mitochondrial Membrane Potential. Medical science monitor : international medical journal of experimental and clinical research. vol 25. 2019-03-22. PMID:30712054. |
glychionide-a prompted apoptosis and autophagy and was also associated with alteration in apoptosis- (bax, caspase 9 and bcl-2) and autophagy- (lc3i, ii, beclin 1 and p62) related protein expression. |
2019-03-22 |
2023-08-13 |
human |
| Edwin José Torres de Oliveira, Lucas Roberto Pessatto, Raquel Oliveira Nascimento de Freitas, Bruno Ivo Pelizaro, Ana Paula Maluf Rabacow, Juliana Miron Vani, Antônio Carlos Duenhas Monreal, Mário Sérgio Mantovani, Ricardo Bentes de Azevedo, Andréia Conceição Milan Brochado Antoniolli-Silva, Roberto da Silva Gomes, Rodrigo Juliano Oliveir. New Bis copper complex ((Z) -4 - ((4-chlorophenyl) amino) -4-oxobut-2-enoyl) oxy): Cytotoxicity in 4T1 cells and their toxicogenic potential in Swiss mice. Toxicology and applied pharmacology. vol 356. 2019-03-21. PMID:30092250. |
the compound demonstrated cytotoxicity and genotoxicity to 4 t1 cells, and after cell cycle arrest in g1, which occurred by the increase in atm and p21 expression, it induced the cells to apoptosis by increasing bax and caspase-7. |
2019-03-21 |
2023-08-13 |
mouse |
| Yu-Hong Liu, Qiong-Hui Huang, Xue Wu, Jia-Zhen Wu, Jia-Li Liang, Guo-Sheng Lin, Lie-Qiang Xu, Xiao-Ping Lai, Zi-Ren Su, Jian-Nan Che. Polydatin protects against acetaminophen-induced hepatotoxicity in mice via anti-oxidative and anti-apoptotic activities. Food & function. vol 9. issue 11. 2019-03-20. PMID:30375606. |
additionally, pd markedly arrests apoptosis by assuaging tunel-positive hepatocytes and the apoptotic index, decreasing the levels and expression of cytochrome c (cytc), cleaved-caspase-9, apoptotic protease activating factor 1 (apaf-1), cleaved-caspase-3, and bax and increasing the level and expression of bcl-2. |
2019-03-20 |
2023-08-13 |
mouse |
| G F Bomfim, G K F Merighe, S A de Oliveira, J A Negra. Effect of acute stressors, adrenocorticotropic hormone administration, and cortisol release on milk yield, the expression of key genes, proliferation, and apoptosis in goat mammary epithelial cells. Journal of dairy science. vol 101. issue 7. 2019-03-18. PMID:29706427. |
however, the addition of cortisol in vitro significantly increased the expression of the ghr and igf1r genes, which stimulate cell proliferation, and the bax gene, which causes apoptosis. |
2019-03-18 |
2023-08-13 |
Not clear |
| Han Chen, Yingshi Ji, Xin Yan, Guanfang Su, Li Chen, Jun Xia. Berberine attenuates apoptosis in rat retinal Müller cells stimulated with high glucose via enhancing autophagy and the AMPK/mTOR signaling. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 108. 2019-03-18. PMID:30372821. |
our results showed that bbr attenuated apoptosis, up regulated bcl-2 and down regulated bax and caspase-3 expression; enhanced the formation of autophagy, elevated the expression of beclin-1 and lc3ii and activated the ampk/mtor signaling pathway in müller cells under high glucose conditions compared with the control group. |
2019-03-18 |
2023-08-13 |
rat |
| Shuyun Ma, Xiaohong Deng, Yang Yang, Qingqing Zhang, Ting Zhou, Zi Li. The lncRNA LINC00675 regulates cell proliferation, migration, and invasion by affecting Wnt/β-catenin signaling in cervical cancer. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 108. 2019-03-18. PMID:30372871. |
in addition, overexpression of linc00675 inhibited cell apoptosis, increased the protein level of bcl-2, and decreased the protein level of bax in cervical cancer cells. |
2019-03-18 |
2023-08-13 |
Not clear |
| Sri Renukadevi Balusamy, Haribalan Perumalsamy, Md Amdad Huq, Balamuralikrishnan Balasubramania. Anti-proliferative activity of Origanum vulgare inhibited lipogenesis and induced mitochondrial mediated apoptosis in human stomach cancer cell lines. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 108. 2019-03-18. PMID:30372889. |
the increase of bax expression and downregulation of bcl2 expression indicated that oregano eo induced mitochondrial mediated apoptosis. |
2019-03-18 |
2023-08-13 |
human |
| Shirong Cao, Shu Li, Yating Wang, Jiani Shen, Yi Zhou, Huiyan Li, Xueqing Yu, Haiping Ma. Acetylation of HMGB1 by JNK1 Signaling Promotes LPS-Induced Peritoneal Mesothelial Cells Apoptosis. BioMed research international. vol 2018. 2019-03-18. PMID:30539006. |
overexpression of wild-type, but not hypoacetylation mutant of hmgb1, enhanced lps-induced apoptosis in hmrsv5 cells, which was accompanied by elevated protein levels of bax and cleaved-caspase 3 compared to the control. |
2019-03-18 |
2023-08-13 |
mouse |
| Emel Aksoy, Ahmet Kursat Azku. Schmallenberg virus induces apoptosis in Vero cell line via extrinsic and intrinsic pathways in a time and dose dependent manner. The Journal of veterinary medical science. vol 81. issue 2. 2019-03-18. PMID:30541984. |
expression analyses of pro-apoptotic (bax, bak and puma) and anti-apoptotic (bcl-2 and bcl-xl) genes revealed that sbv-induced apoptosis causes upregulation of pro-apoptotic genes, dominantly via puma gene, whereas bcl-2 and bcl-xl genes were downregulated. |
2019-03-18 |
2023-08-13 |
Not clear |
| Xiaofei Li, Lei Xu, Gaoying Sun, Xianmin Wu, Xiaohui Bai, Jianfeng Li, Jerome F Strauss, Zhibing Zhang, Haibo Wan. Spag6 Mutant Mice Have Defects in Development and Function of Spiral Ganglion Neurons, Apoptosis, and Higher Sensitivity to Paclitaxel. Scientific reports. vol 7. issue 1. 2019-03-15. PMID:28819108. |
increased bax expression, a disturbed distribution of cytochrome c, and cleaved caspase-3 positive staining indicated that increased apoptosis involved a mitochondrial pathway. |
2019-03-15 |
2023-08-13 |
mouse |
| Elias Wael Yousse. Age-Dependent Differential Expression of Apoptotic Markers in Rat Oral Mucosa Asian Pacific journal of cancer prevention : APJCP. vol 19. issue 11. 2019-03-15. PMID:30486627. |
results: our data showed a significant decrease in the proliferative activity of oral mucosa(gingiva and buccal mucosa) in old rats and an increase in the immunoreactivity of bax apoptotic proteins related toincreased susceptibility of cells to apoptosis. |
2019-03-15 |
2023-08-13 |
rat |
| Xing'ai Ju, Degang Xue, Tongyi Wang, Baiping Ge, Yu Zhang, Zhanquan L. Catalpol Promotes the Survival and VEGF Secretion of Bone Marrow-Derived Stem Cells and Their Role in Myocardial Repair After Myocardial Infarction in Rats. Cardiovascular toxicology. vol 18. issue 5. 2019-03-14. PMID:29752623. |
moreover, the apoptosis of bmscs induced by ogd was restrained by catalpol as evidenced by increased level of b-cell lymphoma-2 (bcl-2) and decreased levels of bcl2-associated x (bax) and cleaved caspase-3. |
2019-03-14 |
2023-08-13 |
rat |
| Jingyu Xu, Wei Shen, Bei Pei, Xiaowei Wang, Dazhi Sun, Yongjin Li, LiJuan Xiu, Xuan Liu, Ye Lu, Xuan Zhang, XiaoQiang Yu. Xiao Tan He Wei Decoction reverses MNNG-induced precancerous lesions of gastric carcinoma in vivo and vitro: Regulation of apoptosis through NF-κB pathway. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 108. 2019-03-14. PMID:30218863. |
our research founds that xiao tan he wei decoction could inhibit cell proliferation and increased apoptosis by increase the level of pro-apoptotic proteins like bax and caspase-3 and decreased the level of anti-apoptotic protein bcl-2, block the cells in g0/g1 phase simultaneously. |
2019-03-14 |
2023-08-13 |
rat |