| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xiuli Ding, Jiadong Chi, Xue Yang, Jian Hao, Chang Liu, Cuihong Zhu, Xiaodong Wang, Xiaohui Liu, Yangyang Niu, Wei Ji, Dan Chen, Xiongzhi W. Cucurbitacin B synergistically enhances the apoptosis-inducing effect of arsenic trioxide by inhibiting STAT3 phosphorylation in lymphoma Ramos cells. Leukemia & lymphoma. vol 58. issue 10. 2019-04-26. PMID:28278714. |
dramatically, cucurbitacin b (cub), an effective component of the dichloromethane extraction from trichosanthes kirilowii maxim, synergistically eliminated the apoptosis resistance of burkitt's lymphoma ramos cells to ato by inhibiting the phosphorylation of stat3, followed in turn by downregulation of bcl-2 and upregulation of bax. |
2019-04-26 |
2023-08-13 |
Not clear |
| Zhen-Zhen Jia, Jing-Wen Zhang, Di Zhou, Ding-Qi Xu, Xi-Zeng Fen. Deltamethrin exposure induces oxidative stress and affects meiotic maturation in mouse oocyte. Chemosphere. vol 223. 2019-04-26. PMID:30802836. |
the apoptosis of oocyte regulated by the expression of bax and bcl-2 protein was obviously affected by deltamethrin. |
2019-04-26 |
2023-08-13 |
mouse |
| Mansoureh Hashemi, Mahmoudreza Hadjighassem, Alireza Zali, Javad Hashem. Tumoricidal effect of human olfactory ensheathing cell mediated suicide gene therapy in human glioblastoma cells. Molecular biology reports. vol 45. issue 6. 2019-04-25. PMID:30242665. |
also, apoptosis hallmarks, including dna fragmentation in cell nuclear, expression increase of bax to bcl-2 ratio and increase of caspase3 activation were observed in this study. |
2019-04-25 |
2023-08-13 |
human |
| Wen-Ying Shi, Jie Yan, Xiao-Rong Chang, Bi-Dan Lou, Jin-Xiang Li, Jie Huang, Hua Lin, Chao Wang, Wei Zhan. [Observation of electroacupuncture intervention on cell apoptosis and Bax and Bcl-2 expression in cerebral and myocardial tissues in cerebral ischemia rats based on "heart-brain correlation" theory]. Zhen ci yan jiu = Acupuncture research. vol 44. issue 2. 2019-04-25. PMID:30945486. |
[observation of electroacupuncture intervention on cell apoptosis and bax and bcl-2 expression in cerebral and myocardial tissues in cerebral ischemia rats based on "heart-brain correlation" theory]. |
2019-04-25 |
2023-08-13 |
rat |
| Y Jiao, L Ji, Y Kuang, Q Yan. Cytotoxic effect of oxaloacetate on HepG2-human hepatic carcinoma cells via apoptosis and ROS accumulation. Neoplasma. vol 64. issue 2. 2019-04-23. PMID:28043145. |
caspase-3 activity was increased, the pro-apoptotic protein bax was up-regulated, and the anti-apoptotic protein bcl-2 was down-regulated in oa-treated hepg2 cells indicating that apoptosis through the intrinsic pathway was involved in the cell death. |
2019-04-23 |
2023-08-13 |
human |
| Guohua Hou, Maheen Mahwish Surhio, Hongling Ye, Xiaoming Gao, Ziyang Ye, Jinglei Li, Ming Y. Protective effects of a Lachnum polysaccharide against liver and kidney injury induced by lead exposure in mice. International journal of biological macromolecules. vol 124. 2019-04-23. PMID:30448488. |
for further studies, key proteins involved in hepatic and kidney apoptosis, including cleaved caspase-3, bax, bcl-2, tgf-β1 and α-sma, were quantified. |
2019-04-23 |
2023-08-13 |
mouse |
| Sen Wang, Guanghui Zhao, Wanzhen Shao, Huan Liu, Weizhuo Wang, Cuiyan Wu, Mikko J Lammi, Xiong Gu. The Importance of Se-Related Genes in the Chondrocyte of Kashin-Beck Disease Revealed by Whole Genomic Microarray and Network Analysis. Biological trace element research. vol 187. issue 2. 2019-04-22. PMID:29948913. |
the se-related gene insulin-like growth factor binding protein 2 (igfbp2), insulin-like growth factor binding protein 3 (igfbp3), interleukin 6 (il6), bcl2, apoptosis regulator (bcl2), and bcl2-associated x, apoptosis regulator (bax), which involved in many molecular functions, biological processes, and apoptosis pathway may play important roles in the pathogenesis of kbd. |
2019-04-22 |
2023-08-13 |
Not clear |
| Ravi Sakthivel, Dicson Sheeja Malar, Govindaraju Archunan, Kasi Pandima Dev. Phytol ameliorated benzo(a)pyrene induced lung carcinogenesis in Swiss albino mice via inhibition of oxidative stress and apoptosis. Environmental toxicology. vol 34. issue 4. 2019-04-22. PMID:30520250. |
moreover, administration of b(a)p induced apoptosis, as observed by the highest expression of bax, caspase-3, and caspase-9 proteins in lung tissue of b(a)p alone treated animals. |
2019-04-22 |
2023-08-13 |
mouse |
| Duoduo Zhang, Jie Zhang, Jie Zeng, Zhubo Li, Hua Zuo, Chengzhi Huang, Xiaoyan Zha. Nano-Gold Loaded with Resveratrol Enhance the Anti-Hepatoma Effect of Resveratrol Journal of biomedical nanotechnology. vol 15. issue 2. 2019-04-22. PMID:30596551. |
res-gnps induced apoptosis in hepg2 cells by down-regulating pro-caspase-9, pro-caspase-3, pi3k and akt and upregulating caspase-8 and bax. |
2019-04-22 |
2023-08-13 |
Not clear |
| Guodong Cai, Mengxue Si, Xi Li, Hui Zou, Jianhong Gu, Yan Yuan, Xuezhong Liu, Zongping Liu, Jianchun Bia. Zearalenone induces apoptosis of rat Sertoli cells through Fas-Fas ligand and mitochondrial pathway. Environmental toxicology. vol 34. issue 4. 2019-04-22. PMID:30600648. |
the results revealed that zea induced apoptosis of rat sertoli cells, significantly reduced the transcription and expression of the anti-apoptotic protein bcl-2, increased the transcription and expression of pro-apoptotic proteins bax and tbid, and fas, fasl, fadd, and caspase-8. |
2019-04-22 |
2023-08-13 |
rat |
| Liping Wang, Ning Liu, Xiaoyan Xue, Shujun Zho. The Effect of Overexpression of the Enhancer of Zeste Homolog 1 (EZH1) Gene on Aristolochic Acid-Induced Injury in HK-2 Human Kidney Proximal Tubule Cells In Vitro. Medical science monitor : international medical journal of experimental and clinical research. vol 25. 2019-04-22. PMID:30688289. |
overexpression the ezh1 gene inhibited hk-2 cell apoptosis, reduced ros levels, and down-regulated the expressions of il-1β, il-6, tnf-α, bax and cyt c mrna and protein, and increased the expressions of bcl-2 and nfkbia, cxcl8 and cyclin d1, indicating that overexpression of ezh1 suppressed nf-κb signaling in aristolochic acid-injured hk-2 cells. |
2019-04-22 |
2023-08-13 |
human |
| Yuqian Wang, Hong Zhao, Dezhou Wang, Miao Hao, Chenfei Kong, Xiaoming Zhao, Yiyao Gao, Jing Li, Baocai Liu, Bai Yang, Hao Zhang, Jinlan Jian. Inhibition of Autophagy Promoted Apoptosis and Suppressed Growth of Hepatocellular Carcinoma Upon Photothermal Exposure. Journal of biomedical nanotechnology. vol 15. issue 4. 2019-04-22. PMID:30841973. |
apoptosis was evaluated based on flow cytometry, western blot analysis of apoptosis related proteins (bax, bcl2, caspase 3), hoechst staining, and tunel staining. |
2019-04-22 |
2023-08-13 |
Not clear |
| Marie Ménard, Clélia Costechareyre, Gabriel Ichim, Jonathan Blachier, David Neves, Loraine Jarrosson-Wuilleme, Reinhard Depping, Jan Koster, Pierre Saintigny, Patrick Mehlen, Servane Tauszig-Delamasur. Hey1- and p53-dependent TrkC proapoptotic activity controls neuroblastoma growth. PLoS biology. vol 16. issue 5. 2019-04-18. PMID:29750782. |
p53 transcriptionally regulates the expression of trkc-kf cytoplasmic and mitochondrial interactors cofactor of breast cancer 1 (cobra1) and b cell lymphoma 2-associated x (bax), which will subsequently trigger the intrinsic pathway of apoptosis. |
2019-04-18 |
2023-08-13 |
mouse |
| Lu Wang, Xiaoyu Li, Binbin Wan. The cytotoxicity activity of Hohenbuehelia serotina polyphenols on HeLa cells via induction of cell apoptosis and cell cycle arrest. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 124. 2019-04-18. PMID:30529121. |
in addition, the mitochondrial apoptosis pathway in hela cells was initiated by hsp through activation of bax, cytochrome c and caspase-3, as well as inhibition of bcl-2. |
2019-04-18 |
2023-08-13 |
Not clear |
| A Štern, A Rotter, M Novak, M Filipič, B Žegur. Genotoxic effects of the cyanobacterial pentapeptide nodularin in HepG2 cells. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 124. 2019-04-18. PMID:30562542. |
moreover changes in the expression of selected genes from the p53 pathway, involved in the response to dna damage (p53, gadd45α, cdkn1a, mdm2), apoptosis (bax, bcl2) and oxidative stress (gpx1, gsr, gclc, cat, sod1) were determined using qpcr. |
2019-04-18 |
2023-08-13 |
human |
| Ya-Wei Li, Wei Zhang, Na Xu, Yan Li, Hong Zhang, Shi-Jie Lv, Wen-He Zh. [Dihydroartemisinin inhibits proliferation of pancreatic cancer JF-305 cells by regulating expression of apoptosis related proteins and production of reactive oxygen species]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 42. issue 15. 2019-04-16. PMID:29139274. |
western blot was used to detect the protein expression changes of bax, bcl-2, cleaved caspase-3, cleaved caspase-9 and cyto c. as compared with the control group, the jf-305 cells proliferation was inhibited significantly(p<0.05) after treatment with different concentrations of dihydroartemisimin for 48 h; cell cycle was blocked in the g2/m phase; apoptotic morphology of nuclear condensation, aggregation, and fragmentation was found, and the apoptosis ratio was increased(p<0.05). |
2019-04-16 |
2023-08-13 |
human |
| Cong Ma, Bo Wen, Qin Zhang, Peipei Shao, Wen Gu, Kun Qu, Yang Shi, Bei Wan. Polydatin Regulates the Apoptosis and Autophagy of Fibroblasts Obtained from Patients with Ankylosing Spondylitis. Biological & pharmaceutical bulletin. vol 42. issue 1. 2019-04-15. PMID:30333377. |
in the present study, the results revealed that polydatin induced the apoptosis of fibroblasts isolated from patients with as by upregulating the expression of active caspase-3 and bax, and downregulating the expression of bcl-2. |
2019-04-15 |
2023-08-13 |
Not clear |
| Pei-Guo Wang, Yu-Ting Li, Yi Pan, Zhen-Zhu Gao, Xu-Wen Guan, Li Jia, Feng-Ting Li. Lower expression of Bax predicts poor clinical outcome in patients with glioma after curative resection and radiotherapy/chemotherapy. Journal of neuro-oncology. vol 141. issue 1. 2019-04-15. PMID:30446901. |
the pro-apoptotic protein bax, a short-lived protein in cancers, plays important roles in the sensitivity of glioma cells to spontaneous and therapy-induced apoptosis but and its prognostic value in gliomas is unknown. |
2019-04-15 |
2023-08-13 |
Not clear |
| Jinxin Wang, Ruilin Li, Zhiyuan Deng, Zuoyan Sun, Lijuan Chai, Hong Guo, Hong Wang, Lu Chen, Limin Hu, Shaoxia Wan. Xueshuantong for Injection Ameliorates Diabetic Nephropathy in a Rat Model of Streptozotocin-Induced Diabetes. The Chinese journal of physiology. vol 61. issue 6. 2019-04-15. PMID:30580505. |
apoptosis related factors such as cleaved caspase-3, bcl-2, bax and inflammationrelated factors, including tumor necrosis factor-α (tnf-α), interleukin 6 (il-6), il-1β, induciblenitric oxide synthase (inos) and intercellular adhesion molecule-1 (icam-1) were detected by pcror western blot. |
2019-04-15 |
2023-08-13 |
rat |
| Feng Liang, Ligen Shi, Jingwei Zheng, Sheng Chen, Yangxin Wang, Jianmin Zhan. Neuroprotective Effects of CGP3466B on Apoptosis Are Modulated by Protein-L-isoaspartate (D-aspartate) O-methyltransferase/Mst1 Pathways after Traumatic Brain Injury in Rats. Scientific reports. vol 7. issue 1. 2019-04-11. PMID:28835703. |
cgp3466b alleviates neuronal apoptosis by increasing pcmt1 expression and subsequently inhibiting mst1 activation, resulting in changing the expression levels of bax, bcl-2 and active-caspase3. |
2019-04-11 |
2023-08-13 |
rat |