| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Peng Chen, Mingdao Hu, Feng Liu, Henghai Yu, Chen Che. S-allyl-l-cysteine (SAC) protects hepatocytes from alcohol-induced apoptosis. FEBS open bio. vol 9. issue 7. 2020-02-18. PMID:31161729. |
moreover, ethanol suppressed cellular anti-apoptotic protein b-cell lymphoma-2 (bcl-2) expression, increased pro-apoptotic protein bcl-2-associated x protein (bax) expression, induced mitochondrial cytochrome c release, and activated the caspase 3-dependent apoptosis pathway in brl-3a cells. |
2020-02-18 |
2023-08-13 |
rat |
| Jian-Fang Li, Liang-Jun Xie, Lu-Ping Qin, Yi-Fei Liu, Ting-Jie Zhang, Yong Huang, Mu-Hua Chen. Apoptosis gene reprograming of human peripheral blood mononuclear cells induced by radioiodine-131 ( The Indian journal of medical research. vol 149. issue 5. 2020-02-18. PMID:31417030. |
apoptosis gene reprograming of human peripheral blood mononuclear cells induced by radioiodine-131 ( the nature of adaptable change of b-cell lymphoma-2 (bcl-2) and/or bcl2-associated x protein (bax) gene expression in the human peripheral blood mononuclear cells (pbmcs) irradiated by radioiodine in thyroid diseases therapy is not fully understood. |
2020-02-18 |
2023-08-13 |
human |
| Bei Yang, Xinlu Wang, Yilin Ma, Lei Yan, Yuan Ren, Dainan Yu, Bo Qiao, Xin Shen, Hui Liu, Dalei Zhang, Haibin Kuan. Tri-ortho-cresyl phosphate (TOCP)-induced reproductive toxicity involved in placental apoptosis, autophagy and oxidative stress in pregnant mice. Environmental toxicology. vol 35. issue 1. 2020-02-18. PMID:31566301. |
moreover, tocp administration induced placental apoptosis and autophagy by upregulating p53, bax, beclin-1, ratio of lc3 ii/lc3 i and atg5 and downregulating bcl-2 protein. |
2020-02-18 |
2023-08-13 |
mouse |
| Yueqin Wang, Haohao Liu, Xiaohui Liu, Xiaofeng Zhang, Jinxia Wu, Le Yuan, Xingde Du, Rui Wang, Ya Ma, Xinghai Chen, Xuemin Cheng, Donggang Zhuang, Huizhen Zhan. Histone acetylation plays an important role in MC-LR-induced apoptosis and cycle disorder in SD rat testicular cells. Chemosphere. vol 241. 2020-02-18. PMID:31683423. |
meanwhile, mc-lr induced testicular tissue injury and increased the expressions of apoptosis-related genes, such as bax, caspase3 and caspase8, ultimately causing cells apoptosis in testicular tissues. |
2020-02-18 |
2023-08-13 |
rat |
| Manoj Paul, Mahadevappa Hemshekhar, Kempaiah Kemparaju, Kesturu S Giris. Berberine mitigates high glucose-potentiated platelet aggregation and apoptosis by modulating aldose reductase and NADPH oxidase activity. Free radical biology & medicine. vol 130. 2020-02-17. PMID:30391673. |
in addition, berberine inhibited p38-p53 mediated bax activation, mitochondrial dysfunction and platelet apoptosis induced by hg. |
2020-02-17 |
2023-08-13 |
Not clear |
| Debottam Sinha, Pascal H G Duijf, Kum Kum Khann. Mitotic slippage: an old tale with a new twist. Cell cycle (Georgetown, Tex.). vol 18. issue 1. 2020-02-17. PMID:30601084. |
abbreviations: apc/c: anaphase-promoting complex/cyclosome; bad: bcl2-associated agonist of cell death; bak1: bcl2 antagonist kinase1; bax: bcl2-associated x; bcl2: b-cell chronic lymphocytic leukaemia (cll)/lymphoma 2; bh: bcl2 homology domain; bid: bh3-interacting domain death agonist; bim: bcl2-interacting mediator of cell death; bub: budding uninhibited by benzimidazoles; cdc: cell division cycle; cdh1: cadherin-1; cdk1: cyclin-dependent kinase 1; cep55: centrosomal protein (55 kda): cin: chromosomal instability; cta: cancer testis antigen; egr1: early growth response protein 1; erk: extracellular signal-regulated kinase; escrt: endosomal sorting complexes required for transport; gin: genomic instability; mad2: mitotic arrest deficient 2; mcl1: myeloid cell leukemia sequence 1; mps1: monopolar spindle 1 kinase; myt1: myelin transcription factor 1; plk1: polo like kinase 1; puma: p53-upregulated mediator of apoptosis; sac: spindle assembly checkpoint; taa: tumor-associated antigen. |
2020-02-17 |
2023-08-13 |
Not clear |
| Meiyan Wu, Fengting Liu, Qinghui Gu. Quercetin attenuates hypoxia-ischemia induced brain injury in neonatal rats by inhibiting TLR4/NF-κB signaling pathway. International immunopharmacology. vol 74. 2020-02-17. PMID:31228815. |
treatment could clearly attenuate cortical cell apoptosis, as well as suppress apoptosis marker bax, and activate anti-apoptosis marker bcl-2. |
2020-02-17 |
2023-08-13 |
rat |
| Yeong-Seon Won, Kwon-Il Se. Lupiwighteone induces caspase-dependent and -independent apoptosis on human breast cancer cells via inhibiting PI3K/Akt/mTOR pathway. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 135. 2020-02-17. PMID:31604113. |
we also showed that treatment with lupiwighteone induced caspase-dependent apoptosis (up-regulation of caspase-3, -7, -8, -9, parp, and bax or down-regulation of bid, bcl-2), induction of caspase-independent apoptosis (up-regulation of aif and endo g on cytosol), and inhibition of the pi3k/akt/mtor signaling pathway (down-regulation of pi3k, p-akt, and p-mtor) in both mcf-7 and mda-mb-231 cells. |
2020-02-17 |
2023-08-13 |
human |
| Lu Wang, Peng Zhou, Ru Feng, Zhen Luo, Xiaoyu Li, Lili Ga. Anti-proliferation activities of Oryza sativa L. anthocyanins-Hohenbuehelia serotina polysaccharides complex after in vitro gastrointestinal digestion. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 135. 2020-02-17. PMID:31794802. |
hela cells treated with osa-hsp complex exhibited pro-apoptosis characteristics by triggering endogenous mitochondrial apoptosis pathway through activating the expressions of bax, cytochrome c and caspase-3 as well as inhibiting the expression of bcl-2. |
2020-02-17 |
2023-08-13 |
Not clear |
| Manqi Huang, Yizhou Zhong, Li Lin, Boxuan Liang, Jun Liu, Junying Jiang, Manjiang Hu, Yuji Huang, Xi Lin, Lvliang Lu, Ziwei Bian, Wenyu Zhong, Jiejiao Wu, Jiewei Zheng, Weifeng Rong, Yating Zhang, Liang Jiang, Jieling Wu, Xin Zhang, Xingfen Yang, Qiansheng Hu, Zhenlie Huan. 1,2-Dichloroethane induces cerebellum granular cell apoptosis via mitochondrial pathway in vitro and in vivo. Toxicology letters. vol 322. 2020-02-17. PMID:31935479. |
bax inhibitor peptide v5 rescued 1,2-dce-induced hcgc apoptosis. |
2020-02-17 |
2023-08-13 |
mouse |
| Tia A Arena, Bernice Chou, Peter D Harms, Athena W Won. An anti-apoptotic HEK293 cell line provides a robust and high titer platform for transient protein expression in bioreactors. mAbs. vol 11. issue 5. 2020-02-14. PMID:30907238. |
the hek293 bax bak double knock-out (hek293 dko) cell line exhibited resistance to apoptosis and shear stress. |
2020-02-14 |
2023-08-13 |
Not clear |
| Zhou Yun, Arunachalam Chinnathambi, Sulaiman Ali Alharbi, Zhu Ji. Biosynthesis of gold nanoparticles using Vetex negundo and evaluation of pro-apoptotic effect on human gastric cancer cell lines. Journal of photochemistry and photobiology. B, Biology. vol 203. 2020-02-13. PMID:31884347. |
moreover, the status of apoptosis gene such as caspase-3, bcl-2, bcl-xl, bax and caspase-9 expressions was analysed by using western and rt-pcr techniques. |
2020-02-13 |
2023-08-13 |
human |
| Zhou Yun, Arunachalam Chinnathambi, Sulaiman Ali Alharbi, Zhu Ji. Biosynthesis of gold nanoparticles using Vetex negundo and evaluation of pro-apoptotic effect on human gastric cancer cell lines. Journal of photochemistry and photobiology. B, Biology. vol 203. 2020-02-13. PMID:31884347. |
furthermore, molecular mechanisms also provoked apoptosis through modulating pro (caspase-3, bax, bid, caspase-9) and anti-apoptotic (bcl-2 and bcl-xl) mediators by western blotting and gene expression in ags cells. |
2020-02-13 |
2023-08-13 |
human |
| Daorui Qin, Yunman Tang, Xuejun Wang, Yu Mao, Zhichun Fen. Antagonistic Effect of Cuscuta chinensis on a Rat Model with Unilateral Cryptorchidism. Medical science monitor : international medical journal of experimental and clinical research. vol 25. 2020-02-12. PMID:31493333. |
after 90 days, all the rats were sacrificed and the testicles were separated and weighed, followed by tunel staining to detect germ cell apoptosis, flow cytometry to measure jc-1, ros, and mda, and western blot analysis to evaluate the expression of bax, bcl-2, and cleaved caspase3. |
2020-02-12 |
2023-08-13 |
rat |
| Yiping Yang, Fu Wei, Jian Wang, Rui Chen, Jie Zhang, Danni Li, Dong Gan, Xiaobo Yang, Yunfeng Zo. Manganese modifies Neurotrophin-3 (NT3) and its tropomyosin receptor kinase C (TrkC) in the cortex: Implications for manganese-induced neurotoxicity. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 135. 2020-02-10. PMID:31676349. |
we further found increased levels of bax, cleaved caspase-3, and the total apoptosis rate, and decreased levels of bcl 2, nt3, trkc, and ras/mapk and pi3/akt signaling in mn-treated primary cortical neurons. |
2020-02-10 |
2023-08-13 |
Not clear |
| Yangyang Han, Ming Lu, Jinsong Zho. Buforin IIb induces androgen-independent prostate cancer cells apoptosis though p53 pathway in vitro. Toxicon : official journal of the International Society on Toxinology. vol 168. 2020-02-07. PMID:31229626. |
in this study, we found buforin iib significantly inhibited the prostate cancer cells proliferation, furthermore, buforin iib-induced cell apoptosis through downregulation of pro-caspase 3/8/9, poly (adp-ribose) polymerase parp and anti-apoptotic bcl-2 and upregulation of pro-apoptotic bax. |
2020-02-07 |
2023-08-13 |
Not clear |
| Huimin Li, Lei Shen, Tingting Lv, Ru Wang, Na Zhang, Hao Peng, Wenxiu Dia. Salidroside attenuates dextran sulfate sodium-induced colitis in mice via SIRT1/FoxOs signaling pathway. European journal of pharmacology. vol 861. 2020-02-06. PMID:31401159. |
sal inhibited oxidative stress by upregulating sod, gsh-px and cat while suppressing colonic apoptosis by downregulating the expression of bax, caspase-3, and cleaved-caspase-3 and upregulating the expression of bcl-2. |
2020-02-06 |
2023-08-13 |
mouse |
| Ayman M Mahmoud, Omnia E Hussein, Sanaa M Abd El-Twab, Walaa G Hozaye. Ferulic acid protects against methotrexate nephrotoxicity via activation of Nrf2/ARE/HO-1 signaling and PPARγ, and suppression of NF-κB/NLRP3 inflammasome axis. Food & function. vol 10. issue 8. 2020-02-05. PMID:31289794. |
mtx caused apoptosis marked by increased expression of bax, cytochrome c and caspase-3, and suppressed bcl-2, effects that were significantly reversed in fa-treated groups. |
2020-02-05 |
2023-08-13 |
rat |
| . Retraction: Downregulation of uPAR and Cathepsin B Induces Apoptosis via Regulation of Bcl-2 and Bax and Inhibition of the PI3K/Akt Pathway in Gliomas. PloS one. vol 15. issue 1. 2020-02-05. PMID:31995620. |
retraction: downregulation of upar and cathepsin b induces apoptosis via regulation of bcl-2 and bax and inhibition of the pi3k/akt pathway in gliomas. |
2020-02-05 |
2023-08-13 |
Not clear |
| Fei Chen, Can-Can Zhou, Yin Yang, Jian-Wen Liu, Chong-Huai Ya. GM1 Ameliorates Lead-Induced Cognitive Deficits and Brain Damage Through Activating the SIRT1/CREB/BDNF Pathway in the Developing Male Rat Hippocampus. Biological trace element research. vol 190. issue 2. 2020-02-04. PMID:30414004. |
moreover, gm1 counteracted lead-induced apoptosis by decreasing the expression of bax, cleaved caspase-3, and by increasing the level of bcl-2 in a dose-dependent manner. |
2020-02-04 |
2023-08-13 |
rat |