| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Li Liu, Tian-Mei Li, Xue-Ru Liu, Yi-Ping Bai, Jie Li, Ni Tang, Xiao-Bin Wan. MicroRNA-140 inhibits skeletal muscle glycolysis and atrophy in endotoxin-induced sepsis in mice via the WNT signaling pathway. American journal of physiology. Cell physiology. vol 317. issue 2. 2020-03-23. PMID:31042421. |
the experimental results indicated that upregulated mir-140 or silenced wnt11 increased cross-sectional areas of muscle fiber while decreasing lactic acid production, skeletal muscle cell apoptosis [corresponding to downregulated b cell lymphoma 2 (bcl-2)-associated x protein (bax) and caspase-3 and upregulated bcl-2], and the proteolytic rate of tyr and 3-mh. |
2020-03-23 |
2023-08-13 |
mouse |
| Yun Zhang, Wei Huo, Yan Wen, Hai L. Silencing Nogo-B receptor inhibits penile corpus cavernosum vascular smooth muscle cell apoptosis of rats with diabetic erectile dysfunction by down-regulating ICAM-1. PloS one. vol 14. issue 8. 2020-03-23. PMID:31442237. |
reverse transcription quantitative polymerase chain reaction assay and western blot analysis were carried out for the assessment of ngbr, factors correlated to icam-1, including steroid receptor coactivator (src) and proline-rich tyrosine kinase2 (pyk2), and factors associated with apoptosis, including b-cell lymphoma-2 (bcl-2), bcl-2 associated protein x (bax), caspase 3 and cleaved-caspase 3. |
2020-03-23 |
2023-08-13 |
rat |
| Jun Lu, Nina Zhou, Ping Yang, Lanqiuzi Deng, Ganzhe Li. MicroRNA-27a-3p Downregulation Inhibits Inflammatory Response and Hippocampal Neuronal Cell Apoptosis by Upregulating Mitogen-Activated Protein Kinase 4 (MAP2K4) Expression in Epilepsy: In Vivo and In Vitro Studies. Medical science monitor : international medical journal of experimental and clinical research. vol 25. 2020-03-23. PMID:31710596. |
mir-27a-3p inhibitor also inhibited apoptosis of hippocampal neurons in epileptic rats, promoted bcl2 expression, and decreased bax and caspase3 expression. |
2020-03-23 |
2023-08-13 |
rat |
| Jun Lu, Nina Zhou, Ping Yang, Lanqiuzi Deng, Ganzhe Li. MicroRNA-27a-3p Downregulation Inhibits Inflammatory Response and Hippocampal Neuronal Cell Apoptosis by Upregulating Mitogen-Activated Protein Kinase 4 (MAP2K4) Expression in Epilepsy: In Vivo and In Vitro Studies. Medical science monitor : international medical journal of experimental and clinical research. vol 25. 2020-03-23. PMID:31710596. |
mir-27a-3p inhibitor significantly promoted the cell viability of ka-induced neurons, inhibited cell apoptosis, promoted the expression of bcl-2, and decreased bax and caspase3 expression, and all these changes were abolished by map2k4-sirna co-transfection. |
2020-03-23 |
2023-08-13 |
rat |
| Lu Gan, Menghuan Guo, Jing Si, Jinhua Zhang, Zhiyuan Liu, Jin Zhao, Fang Wang, Junfang Yan, Hongyan Li, Hong Zhan. Protective effects of phenformin on zebrafish embryonic neurodevelopmental toxicity induced by X-ray radiation. Artificial cells, nanomedicine, and biotechnology. vol 47. issue 1. 2020-03-23. PMID:31713449. |
in addition, expression levels of multiple genes related to neural development and apoptosis (sod2, bdnf, ache, p53, bax, and bcl-2) were compared by rt-pcr and associated protein expression levels by western blotting. |
2020-03-23 |
2023-08-13 |
cat |
| Jia Song, Chuchu Lin, Xuan Yang, Yanqi Xie, Ping Hu, Huatian Li, Wenbo Zhu, Haiyan H. Mitochondrial targeting nanodrugs self-assembled from 9-O-octadecyl substituted berberine derivative for cancer treatment by inducing mitochondrial apoptosis pathways. Journal of controlled release : official journal of the Controlled Release Society. vol 294. 2020-03-20. PMID:30445003. |
then, ha/peg/bd nds were investigated to induce apoptosis through dissipating mitochondria membrane potential, releasing cytochrome c, increasing the activities of caspase 9/3, activating the pro-apoptotic bax, suppressing the anti-apoptotic bcl-2 and upregulating ros levels. |
2020-03-20 |
2023-08-13 |
Not clear |
| Haifeng Yuan, Jinghua Zhang, Fuli Li, Wei Li, Haichao Wan. Sinomenine exerts antitumour effect in gastric cancer cells via enhancement of miR-204 expression. Basic & clinical pharmacology & toxicology. vol 125. issue 5. 2020-03-20. PMID:31243880. |
we found that sin memorably repressed cell proliferation, evoked apoptosis and affected cyclind1, bcl-2, bax and cleaved-caspase-3 expression in mkn45 and sgc-7901 cells. |
2020-03-20 |
2023-08-13 |
Not clear |
| Chao Huang, Xiao-Fen Wu, Xiu-Lian Wan. Trichostatin a inhibits phenotypic transition and induces apoptosis of the TAF-treated normal colonic epithelial cells through regulation of TGF-β pathway. The international journal of biochemistry & cell biology. vol 114. 2020-03-19. PMID:31278993. |
besides, tsa promoted the apoptosis rate (36.84 ± 6.52%) comparing with the ccd-18co-treated hcoepics (3.52 ± 0.85%, p < 0.05), with promotion of bax (0.5893±0.0498 in 2d and 0.8867±0.0916 in 3d) and reduction of bcl-2 (0.0476±0.0053 in 2d and 0.0294±0.0075 in 3d). |
2020-03-19 |
2023-08-13 |
Not clear |
| Esmail Nourmohammadi, Hoda Khoshdel-Sarkarizi, Reza Nedaeinia, Hamid Reza Sadeghnia, Leila Hasanzadeh, Majid Darroudi, Reza Kazemi Oskue. Evaluation of anticancer effects of cerium oxide nanoparticles on mouse fibrosarcoma cell line. Journal of cellular physiology. vol 234. issue 4. 2020-03-18. PMID:30187476. |
for apoptosis assay, the annexin v/pi test was done as well as measuring the mrna and protein expression levels of bax and bcl2 by real-time pcr and western blot method, respectively. |
2020-03-18 |
2023-08-13 |
mouse |
| Souvik Roy, Anweshan Sil, Tania Chakrabort. Potentiating apoptosis and modulation of p53, Bcl2, and Bax by a novel chrysin ruthenium complex for effective chemotherapeutic efficacy against breast cancer. Journal of cellular physiology. vol 234. issue 4. 2020-03-18. PMID:30246261. |
potentiating apoptosis and modulation of p53, bcl2, and bax by a novel chrysin ruthenium complex for effective chemotherapeutic efficacy against breast cancer. |
2020-03-18 |
2023-08-13 |
human |
| Xin-Yong Wang, Xian-Zhao Zhang, Feng Li, Qing-Rong J. MiR-128-3p accelerates cardiovascular calcification and insulin resistance through ISL1-dependent Wnt pathway in type 2 diabetes mellitus rats. Journal of cellular physiology. vol 234. issue 4. 2020-03-18. PMID:30341898. |
furthermore, upregulation of mir-128-3p and isl1 gene silencing promoted the expression of wnt-1, β-catenin, gsk-3β, and bax and the phosphorylation of β-catenin and gsk-3β, inhibited c-fos, pdx-1, and bcl-2 expression, and enhanced cell apoptosis. |
2020-03-18 |
2023-08-13 |
rat |
| Zhenlong Kang, Na Qiao, Gaoyang Liu, Hanming Chen, Zhaoxin Tang, Ying L. Copper-induced apoptosis and autophagy through oxidative stress-mediated mitochondrial dysfunction in male germ cells. Toxicology in vitro : an international journal published in association with BIBRA. vol 61. 2020-03-18. PMID:31491480. |
copper also down-regulated bcl2 and up-regulated bax, casp8 and casp3 linking the effects of copper to increased apoptosis. |
2020-03-18 |
2023-08-13 |
cat |
| . Retraction: Bak Compensated for Bax in p53-null Cells to Release Cytochrome c for the Initiation of Mitochondrial Signaling during Withanolide D-Induced Apoptosis. PloS one. vol 15. issue 2. 2020-03-18. PMID:32012207. |
retraction: bak compensated for bax in p53-null cells to release cytochrome c for the initiation of mitochondrial signaling during withanolide d-induced apoptosis. |
2020-03-18 |
2023-08-13 |
Not clear |
| Enze Li, Yi Sun, Guixiang Lv, Yongning Li, Zhiguo Zhang, Zheng Hu, Wenwu Ca. Sinoporphyrin sodium based sonodynamic therapy induces anti-tumor effects in hepatocellular carcinoma and activates p53/caspase 3 axis. The international journal of biochemistry & cell biology. vol 113. 2020-03-17. PMID:30660690. |
the increased ros production up-regulated the expression of p53 and bax, and down-regulated bcl-2 expression, which led to the activation of caspase-3, ultimately initiated cell apoptosis. |
2020-03-17 |
2023-08-13 |
mouse |
| Yong-Shu Dong, Shu-Li Xing, Hong-Yan Zhou, Wei Zhang, Wei Sun, Jun-Ming Fa. [Effects of fast-twisting long-retaining acupuncture therapy on apoptosis and expression of related proteins in vestibular nucleus in rats with vertigo induced by posterior circulation ischemia]. Zhongguo zhen jiu = Chinese acupuncture & moxibustion. vol 40. issue 2. 2020-03-17. PMID:32100505. |
to observe the effects of fast-twisting long-retaining (ftlr) acupuncture therapy on apoptosis of vestibular nucleus and expression of caspase-3, bcl-2 and bax in rats with vertigo induced by posterior circulation ischemia. |
2020-03-17 |
2023-08-13 |
rat |
| Hong-Cheng Fang, Bao-Quan Wu, Yun-Ling Hao, Ying Luo, Hong-Lei Zhao, Wen-Ying Zhang, Zhi-Ling Zhang, Jin-Jie Liang, Wei Liu, Xie-Hui Che. KRT1 gene silencing ameliorates myocardial ischemia-reperfusion injury via the activation of the Notch signaling pathway in mouse models. Journal of cellular physiology. vol 234. issue 4. 2020-03-16. PMID:30191968. |
mice with miri had a higher positive rate of krt1 protein expression, apoptosis of myocardial cells, ck and ldh expression, myocardial infarction area, increased expression of mda, no, sdh, il-1, il-6, tnf-α, crp, krt1, bax protein, ck, and ldh, and decreased expression of sod, nicd, hes1, and bcl-2. |
2020-03-16 |
2023-08-13 |
mouse |
| Hong-Cheng Fang, Bao-Quan Wu, Yun-Ling Hao, Ying Luo, Hong-Lei Zhao, Wen-Ying Zhang, Zhi-Ling Zhang, Jin-Jie Liang, Wei Liu, Xie-Hui Che. KRT1 gene silencing ameliorates myocardial ischemia-reperfusion injury via the activation of the Notch signaling pathway in mouse models. Journal of cellular physiology. vol 234. issue 4. 2020-03-16. PMID:30191968. |
the downregulation of krt1 led to decreased expression of krt1 and bax protein, increased expression of nicd, hes1, and bcl-2, decreased cell apoptosis, and improved cell proliferation. |
2020-03-16 |
2023-08-13 |
mouse |
| Hong-Cheng Fang, Bao-Quan Wu, Yun-Ling Hao, Ying Luo, Hong-Lei Zhao, Wen-Ying Zhang, Zhi-Ling Zhang, Jin-Jie Liang, Wei Liu, Xie-Hui Che. KRT1 gene silencing ameliorates myocardial ischemia-reperfusion injury via the activation of the Notch signaling pathway in mouse models. Journal of cellular physiology. vol 234. issue 4. 2020-03-16. PMID:30191968. |
the inhibition of the notch signaling pathway leads to reduced expression of bax, increased expression of nicd, hes1, and bcl 2, and also decreased cell apoptosis and increased cell proliferation. |
2020-03-16 |
2023-08-13 |
mouse |
| Cheng-Liang Yang, Xiao-Li Zheng, Ke Ye, Ya-Nan Sun, Yu-Fei Lu, Hong Ge, Hui Li. Effects of microRNA-217 on proliferation, apoptosis, and autophagy of hepatocytes in rat models of CCL4-induced liver injury by targeting NAT2. Journal of cellular physiology. vol 234. issue 4. 2020-03-16. PMID:30417525. |
compared with the blank and nc groups, in the mir-217 mimic and sirna-nat2 groups, bax, lc3-ii, and becline-1 expressions and the ratio of caspase-3/cleaved caspase-3, and hepatocyte apoptosis and autophagy increased, while nat2, bcl-2, and p35 expressions and hepatocyte proliferation decreased; opposite results were observed in the mir-217 inhibitor group. |
2020-03-16 |
2023-08-13 |
rat |
| Toshiaki Tanaka, Yasukazu Hozumi, Alberto M Martelli, Mitsuyoshi Iino, Kaoru Got. Nucleosome assembly proteins NAP1L1 and NAP1L4 modulate p53 acetylation to regulate cell fate. Biochimica et biophysica acta. Molecular cell research. vol 1866. issue 12. 2020-03-16. PMID:31634504. |
by contrast, nap1l4 knockdown decreases lys382 acetylation with attenuated bax levels, thereby suppressing apoptosis. |
2020-03-16 |
2023-08-13 |
Not clear |