| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hui-Xing Zhang, You Kang, Ning Li, Hai-Feng Wang, Yong-Rui Bao, Yan-Wu Li, Xue-Zheng Li, Zhe Jiang, Gang Che. Triterpenoids from Liquidambar Fructus induced cell apoptosis via a PI3K-AKT related signal pathway in SMMC7721 cancer cells. Phytochemistry. vol 171. 2020-03-16. PMID:31911265. |
mechanism studies suggested that these three compounds could regulate the mitochondrial pathway by up-regulating the expressions of pro-apoptotic factors (bad and bax) and activating caspase-3 and caspase-9 to induce apoptosis. |
2020-03-16 |
2023-08-13 |
Not clear |
| Sadat Dokanehiifard, Bahram M Soltani, Parisa Ghiasi, Hossein Baharvand, Mohammad Reza Ganjali, Saman Hosseinkhan. hsa-miR-766-5p as a new regulator of mitochondrial apoptosis pathway for discriminating of cell death from cardiac differentiation. Gene. vol 736. 2020-03-16. PMID:32032743. |
by using bioinformatics tools hsa-mir-766-5p was predicted to target the bax, bak and bok genes involved in mitochondrial apoptosis pathway. |
2020-03-16 |
2023-08-13 |
human |
| Bo Wang, Shuangshuang Ha. Modified Exosomes Reduce Apoptosis and Ameliorate Neural Deficits Induced by Traumatic Brain Injury. ASAIO journal (American Society for Artificial Internal Organs : 1992). vol 65. issue 3. 2020-03-09. PMID:29762232. |
the current study sought to investigate the effect of modified exosome-containing plasmids expressing b-cell lymphoma-2 (bcl-2) and bcl-2-associated x-protein (bax) short hairpin rna (shrna) on apoptosis and neural functions after tbi. |
2020-03-09 |
2023-08-13 |
mouse |
| Yue Hei, Rong Chen, Xingang Mao, Jiancai Wang, Qianfa Long, Weiping Li. Neuregulin1 attenuates cognitive deficits and hippocampal CA1 neuronal apoptosis partly via ErbB4 receptor in a rat model of chronic cerebral hypoperfusion. Behavioural brain research. vol 365. 2020-03-09. PMID:30826297. |
the results showed that nrg1 significantly improved the performances in mwm (spatial learning and memory) and rawm (spatial working and reference memory), attenuated hippocampal ca1 neuronal loss and apoptosis, upregulated the expression of perbb4/erbb4 and the anti-apoptotic protein bcl-2, and downregulated the expression of pro-apoptotic proteins of cleaved (cl)-caspase3 and bax. |
2020-03-09 |
2023-08-13 |
rat |
| Jing Jin, Hongxue Sun, Dan Liu, Haining Wang, Qingqing Liu, Hongping Chen, Di Zhong, Guozhong L. LRG1 Promotes Apoptosis and Autophagy through the TGFβ-smad1/5 Signaling Pathway to Exacerbate Ischemia/Reperfusion Injury. Neuroscience. vol 413. 2020-03-09. PMID:31220542. |
meanwhile, lrg1 significantly enhanced apoptosis and autophagy during tmcao, as detected by caspase3, bax, bcl-2, lc3ii/lc3i, beclin1, p62, and a tunel assay. |
2020-03-09 |
2023-08-13 |
mouse |
| Samah R Khalil, Sabry M Abdel-Motal, Mohamed Abd-Elsalam, Noura E Abd El-Hameed, Ashraf Awa. Restoring strategy of ethanolic extract of Moringa oleifera leaves against Tilmicosin-induced cardiac injury in rats: Targeting cell apoptosis-mediated pathways. Gene. vol 730. 2020-03-09. PMID:31812513. |
the co-administration of mo ethanolic extract with til considerably modulates the expression of apoptosis pathway-encoding genes (bcl-2, caspase-3, bax, p53, apoptosis-inducing factor, and apaf-1), particularly in the high-dose group. |
2020-03-09 |
2023-08-13 |
rat |
| Parvaneh Mehrbod, Sudharsana R Ande, Javad Alizadeh, Shahrzad Rahimizadeh, Aryana Shariati, Hadis Malek, Mohammad Hashemi, Kathleen K M Glover, Affan A Sher, Kevin M Coombs, Saeid Ghavam. The roles of apoptosis, autophagy and unfolded protein response in arbovirus, influenza virus, and HIV infections. Virulence. vol 10. issue 1. 2020-03-05. PMID:30966844. |
abbreviation: aids: acquired immunodeficiency syndrome; atf6: activating transcription factor 6; atg6: autophagy-specific gene 6; bag3: bcl associated athanogene 3; bak: bcl-2-anatagonist/killer1; bax; bcl-2: associated x protein; bcl-2: b cell lymphoma 2x; bip: chaperon immunoglobulin heavy chain binding protein; card: caspase recruitment domain; cart: combination antiretroviral therapy; ccr5: c-c chemokine receptor type 5; cd4: cluster of differentiation 4; chop: c/ebp homologous protein; cxcr4: c-x-c chemokine receptor type 4; cyto c: cytochrome c; dcs: dendritic cells; edem1: er-degradation enhancing-a-mannosidase-like protein 1; env: envelope; er: endoplasmic reticulum; fasr: fas receptor;g2: gap 2; g2/m: gap2/mitosis; gfap: glial fibrillary acidic protein; gp120: glycoprotein120; gp41: glycoprotein41; hand: hiv associated neurodegenerative disease; hek: human embryonic kidney; hela: human cervical epithelial carcinoma; hiv: human immunodeficiency virus; ips-1: ifn-β promoter stimulator 1; ire-1: inositol requiring enzyme 1; irgm: immunity related gtpase family m protein; lamp2a: lysosome associated membrane protein 2a; lc3: microtubule associated light chain 3; mda5: melanoma differentiation associated gene 5; mef: mouse embryonic fibroblast; mmp: mitochondrial membrane permeabilization; nef: negative regulatory factor; oasis: old astrocyte specifically induced substrate; pamp: pathogen-associated molecular pattern; perk: pancreatic endoplasmic reticulum kinase; prr: pattern recognition receptor; puma: p53 upregulated modulator of apoptosis; rig-i: retinoic acid-inducible gene-i; tat: transactivator protein of hiv; tlr: toll-like receptor; ulk1: unc51 like autophagy activating kinase 1; upr: unfolded protein response; vpr: viral protein regulatory; xbp1: x-box binding protein 1. |
2020-03-05 |
2023-08-13 |
mouse |
| Yuanzhou He, Xiaoyu Fang, Jing Shi, Xiaochen Li, Min Xie, Xiansheng Li. Apigenin attenuates pulmonary hypertension by inducing mitochondria-dependent apoptosis of PASMCs via inhibiting the hypoxia inducible factor 1α-KV1.5 channel pathway. Chemico-biological interactions. vol 317. 2020-03-04. PMID:31930969. |
to explore the underlying mechanisms, the mitochondrial membrane potential (Δψm) and the mitochondria-dependent apoptosis factors cytochrome c, bax, bcl-2, cleaved caspase 3, and cleaved caspase 9 were analysed. |
2020-03-04 |
2023-08-13 |
rat |
| Fang-Fang Yu, Xia-Lu Lin, Xi Wang, Zhi-Guang Ping, Xiong Gu. Comparison of Apoptosis and Autophagy in Human Chondrocytes Induced by the T-2 and HT-2 Toxins. Toxins. vol 11. issue 5. 2020-03-03. PMID:31072003. |
the expression levels of apoptosis and autophagy related proteins, bax, caspase-9, caspase-3, and beclin1 in chondrocytes induced by the t-2 toxin were significantly higher when compared with those levels induced by the ht-2 toxin. |
2020-03-03 |
2023-08-13 |
human |
| Pardes Habib, Ann-Sophie Stamm, Thomas Zeyen, Rozina Noristani, Alexander Slowik, Cordian Beyer, Thomas Wilhelm, Michael Huber, Daniel Komnig, Jörg B Schulz, Arno Reic. EPO regulates neuroprotective Transmembrane BAX Inhibitor-1 Motif-containing (TMBIM) family members GRINA and FAIM2 after cerebral ischemia-reperfusion injury. Experimental neurology. vol 320. 2020-03-03. PMID:31211943. |
transmembrane bax inhibitor-1 motif-containing (tmbim) family members exert inhibitory activities in apoptosis and necroptosis. |
2020-03-03 |
2023-08-13 |
Not clear |
| Xu Luo, Bo Lin, Youguang Gao, Xianghui Lei, Xiang Wang, Yunfeng Li, Tao L. Genipin attenuates mitochondrial-dependent apoptosis, endoplasmic reticulum stress, and inflammation via the PI3K/AKT pathway in acute lung injury. International immunopharmacology. vol 76. 2020-03-03. PMID:31466050. |
in addition, genipin pretreatment attenuated lps-mediated mitochondrial apoptosis, as indicated by improved mitochondrial dysfunction, downregulation of bax (bcl2 associated x, apoptosis regulator), upregulation of bcl2 (bcl2 apoptosis regulator), inhibited the release of cytochrome c, activation of caspase-3, and cell apoptosis. |
2020-03-03 |
2023-08-13 |
Not clear |
| Chengguo Su, Yuzhou Chen, Yunfei Chen, Yin Zhou, Lianbo Li, Qunwen Lu, Huahui Liu, Xiaochao Luo, Jun Zh. Effect of electroacupuncture at the ST36 and GB39 acupoints on apoptosis by regulating the p53 signaling pathway in adjuvant arthritis rats. Molecular medicine reports. vol 20. issue 5. 2020-03-03. PMID:31545441. |
in addition, the expression levels of the apoptosis‑associated proteins, bax, phorbol‑12‑myristate‑13‑acetate‑induced protein 1 (noxa) and p53 upregulated modulator of apoptosis (puma), were determined by western blot analysis. |
2020-03-03 |
2023-08-13 |
mouse |
| Shan-Wei Shi, Bo Li, Yang Dong, Yang Ge, Xing Qu, Li-Guang Lu, Yi-Hang Yuan, Long-Jiang Li, Yi L. In Vitro and Clinical Studies of Gene Therapy with Recombinant Human Adenovirus-p53 Injection for Malignant Melanoma. Human gene therapy. Clinical development. vol 30. issue 1. 2020-02-27. PMID:30618300. |
the invasive ability, apoptosis, cycle changes of the cells, and the expression of the p53, p21, and bax genes and proteins were significantly changed in the experimental group. |
2020-02-27 |
2023-08-13 |
mouse |
| Bin Sun, Changxian Dong, Hongzhao Lei, Yubin Gong, Miaomiao Li, Yuanfang Zhang, Hongyu Zhang, Longlong Su. Propranolol inhibits proliferation and induces apoptosis of hemangioma-derived endothelial cells via Akt pathway by down-regulating Ang-2 expression. Chemico-biological interactions. vol 316. 2020-02-27. PMID:31838054. |
cell apoptosis was measured by flow cytometry analysis and western blot of bax and bcl-2 levels. |
2020-02-27 |
2023-08-13 |
human |
| Qing Li, Hui-Ran Wu, Shu-Juan Fan, De-Xiang Liu, Hong Jiang, Qian Zhang, Fang Pa. The effects of sub-anesthetic ketamine plus ethanol on behaviors and apoptosis in the prefrontal cortex and hippocampus of adolescent rats. Pharmacology, biochemistry, and behavior. vol 184. 2020-02-26. PMID:31348944. |
apoptosis in prefrontal cortex (pfc) and hippocampus (hip) were determined by the tdt-mediated dutp nick-end labeling (tunel) and protein and mrna levels of caspase-3, bax and bcl-2. |
2020-02-26 |
2023-08-13 |
rat |
| Wenjian Shi, Jing Dong, Yumei Liang, Kanghan Liu, Youming Pen. NR4A1 silencing protects against renal ischemia-reperfusion injury through activation of the β-catenin signaling pathway in old mice. Experimental and molecular pathology. vol 111. 2020-02-26. PMID:31465766. |
levels of the apoptosis markers b-cell lymphoma-2 (bcl-2), bcl-2 associated protein x (bax), and cleaved caspase-3 were determined. |
2020-02-26 |
2023-08-13 |
mouse |
| Wenjian Shi, Jing Dong, Yumei Liang, Kanghan Liu, Youming Pen. NR4A1 silencing protects against renal ischemia-reperfusion injury through activation of the β-catenin signaling pathway in old mice. Experimental and molecular pathology. vol 111. 2020-02-26. PMID:31465766. |
si-nr4a1 treatment resulted in reduced scr and bun levels and a decrease of cell apoptosis, indicated by lower expression of bax and cleaved caspase-3, while in contrast increased levels of bcl-2 were detected. |
2020-02-26 |
2023-08-13 |
mouse |
| Wenhan Wang, Hairui Yang, Jing Deng, Lina Zhu, Yan Yang, Zhendong Liu, Jing-Song Zhang, Chuanhong Tang, Zhong Zhang, Haining Zhuang, Henan Zhang, Wei Ji. Increased Inhibition Effect of Antrodin C from the Stout Camphor Medicinal Mushroom, Taiwanofungus camphoratus (Agaricomycetes), on A549 through Crosstalk between Apoptosis and Autophagy. International journal of medicinal mushrooms. vol 21. issue 6. 2020-02-26. PMID:31679231. |
flow cytometry revealed that antrodin c increased the percentages of cells in the g0/g1 phase at concentrations of 50 and 80 μg/ml and the apoptosis was related to upregulation of caspase-3, bax, p53 expression, downregulation of bcl-2, rapr expression, and the release of reactive oxygen species in the a549 cells. |
2020-02-26 |
2023-08-13 |
Not clear |
| Jianfeng Mu, Xiaodong Wang, Lihua Dong, Pengda Su. Curcumin derivative L6H4 inhibits proliferation and invasion of gastric cancer cell line BGC-823. Journal of cellular biochemistry. vol 120. issue 1. 2020-02-25. PMID:30242876. |
curcumin l6h4 can significantly inhibit the proliferation and induce the apoptosis of bgc-823 cells, thus enhancing the expression levels of p53, p21, bax, and bcl-2 noticeably in vivo and in vitro. |
2020-02-25 |
2023-08-13 |
mouse |
| Dandan Song, Hongsheng Liang, Bo Qu, Yijing Li, Jingjing Liu, Yanan Zhang, Lu Li, Li Hu, Xiangtong Zhang, Aili Ga. Ivermectin inhibits the growth of glioma cells by inducing cell cycle arrest and apoptosis in vitro and in vivo. Journal of cellular biochemistry. vol 120. issue 1. 2020-02-25. PMID:30596403. |
meanwhile, the results also revealed that ivm induced apoptosis by increasing caspase-3 and caspase-9 activity, upregulating the expressions of p53 and bax, downregulating bcl-2, activating cleaved caspase-3 and cleaved caspase-9, and blocking cell cycle in g0/g1 phase by downregulating levels of cdk2, cdk4, cdk6, cyclin d1, and cyclin e. these findings suggest that ivm has an inhibition effect on the proliferation of glioma cells by triggering cell cycle arrest and inducing cell apoptosis in vitro and in vivo, and probably represents promising agent for treating glioma. |
2020-02-25 |
2023-08-13 |
Not clear |