| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Dongyan Yang, Lei Zhang, Zhisheng Zhang, Sulei Hu, Yanbo Fu, Jari A Laukkanen, Gang L. Silencing of C3G increases cardiomyocyte survival inhibition and apoptosis via regulation of p-ERK1/2 and Bax. Clinical and experimental pharmacology & physiology. vol 46. issue 3. 2020-04-20. PMID:30152875. |
however, it is still unclear if silencing of c3g may increase cell survival inhibition and apoptosis in cardiomyocytes, and whether c3g silence induced injuries are reduced by the overexpression of c3g through regulation of p-erk1/2 and pro-apoptotic molecule bax. |
2020-04-20 |
2023-08-13 |
Not clear |
| Dongyan Yang, Lei Zhang, Zhisheng Zhang, Sulei Hu, Yanbo Fu, Jari A Laukkanen, Gang L. Silencing of C3G increases cardiomyocyte survival inhibition and apoptosis via regulation of p-ERK1/2 and Bax. Clinical and experimental pharmacology & physiology. vol 46. issue 3. 2020-04-20. PMID:30152875. |
in conclusion, our results provide new experimental evidence that silencing of c3g can increase cell survival inhibition and apoptosis in cardiomyocytes via regulation of p-erk1/2 and bax. |
2020-04-20 |
2023-08-13 |
Not clear |
| Thu Ha Pham, Lohann Derian, Christine Kervarrec, Pierre-Yves Kernanec, Bernard Jégou, Fatima Smagulova, Aurore Gely-Perno. Perinatal Exposure to Glyphosate and a Glyphosate-Based Herbicide Affect Spermatogenesis in Mice. Toxicological sciences : an official journal of the Society of Toxicology. vol 169. issue 1. 2020-04-20. PMID:30785197. |
moreover, the undifferentiated spermatogonia numbers were decreased by 60% in 5 mg/kg/day glyphosate group, which could be due to the alterations in the expression of genes involved in germ cell differentiation such as sall4 and nano3 and apoptosis as bax and bcl2. |
2020-04-20 |
2023-08-13 |
mouse |
| Yao Hu, Yu Tao, Jing H. Cannabinoid receptor 2 deletion deteriorates myocardial infarction through the down-regulation of AMPK-mTOR-p70S6K signaling-mediated autophagy. Bioscience reports. vol 39. issue 4. 2020-04-20. PMID:30923227. |
cleaved caspase-3 and bax were detected for analyzing apoptosis. |
2020-04-20 |
2023-08-13 |
mouse |
| Adhiraj Dasgupta, Dhritiman Dey, Dipanjan Ghosh, Tapan Kumar Lai, Nattamai Bhuvanesh, Sandip Dolui, Ravichandiran Velayutham, Krishnendu Achary. Astrakurkurone, a sesquiterpenoid from wild edible mushroom, targets liver cancer cells by modulating Bcl-2 family proteins. IUBMB life. vol 71. issue 7. 2020-04-16. PMID:30977280. |
further investigations indicated that astrakurkurone acts by inducing apoptosis in the cells, disrupting mitochondrial membrane potential and inducing the expression of bcl-2 family proteins, for example, bax, and the downstream effector caspases 3 and 9. |
2020-04-16 |
2023-08-13 |
Not clear |
| Yue Sun, Yanhui Han, Mingyue Song, Noppawat Charoensinphon, Jinkai Zheng, Peiju Qiu, Xian Wu, Hang Xia. Inhibitory effects of nobiletin and its major metabolites on lung tumorigenesis. Food & function. vol 10. issue 11. 2020-04-16. PMID:31664275. |
flow cytometry and western blotting analysis revealed that m2 and m3 caused significant cell cycle arrest and cellular apoptosis and profoundly modulated multiple proteins associated with cell proliferation and cell death, including p21, cyclin b1, cdk1, cyclin d1, cdk6, cdk4, bax, cleaved caspase-1, and cleaved parp. |
2020-04-16 |
2023-08-13 |
mouse |
| David Álvarez-Cilleros, María Elvira López-Oliva, María Ángeles Martín, Sonia Ramo. Cocoa ameliorates renal injury in Zucker diabetic fatty rats by preventing oxidative stress, apoptosis and inactivation of autophagy. Food & function. vol 10. issue 12. 2020-04-16. PMID:31773121. |
moreover, in zdf rats cocoa-rich diet contributed to alleviation of the renal cortical injury through autophagy activation (p62 upregulation, and downregulation of beclin-1 and lc3), and inhibition of apoptosis (bcl-xl stimulation and suppression of bax and caspases-9 and -3). |
2020-04-16 |
2023-08-13 |
rat |
| Wei Wang, Yang Wang, Mingxing Liu, Yifan Zhang, Tao Yang, Dongsheng Li, Yinpeng Huang, Qing Li, Guang Bai, Linlin Sh. Betulinic acid induces apoptosis and suppresses metastasis in hepatocellular carcinoma cell lines in vitro and in vivo. Journal of cellular and molecular medicine. vol 23. issue 1. 2020-04-15. PMID:30417527. |
moreover, western blot analysis showed that ba-induced apoptosis associated with increasing of pro-apoptotic protein bax and cleaved caspase-3 and decreasing of anti-apoptotic protein bcl-2. |
2020-04-15 |
2023-08-13 |
mouse |
| Qingquan Wen, Kai Luo, Haiyan Huang, Weiguo Liao, Hong Yan. Xanthoxyletin Inhibits Proliferation of Human Oral Squamous Carcinoma Cells and Induces Apoptosis, Autophagy, and Cell Cycle Arrest by Modulation of the MEK/ERK Signaling Pathway. Medical science monitor : international medical journal of experimental and clinical research. vol 25. 2020-04-15. PMID:31654522. |
apoptosis and autophagy induced by xanthoxyletin were also associated with changes in expression of the apoptosis-associated proteins, bax and bcl-2, and the autophagy-associated proteins, lc3i, lc3ii, beclin 1, p62, and vsp34. |
2020-04-15 |
2023-08-13 |
mouse |
| Chengjie Lv, Qi Ji. Maresin-1 Inhibits Oxidative Stress and Inflammation and Promotes Apoptosis in a Mouse Model of Caerulein-Induced Acute Pancreatitis. Medical science monitor : international medical journal of experimental and clinical research. vol 25. 2020-04-15. PMID:31671079. |
in the mar1-treated ap mice, inflammation of the pancreas and the expression of inflammatory cytokines, pancreatic acinar cell apoptosis, bcl-2 expression, and expression of tlr4, myd88, and p-nf-kappab p65 were reduced, but bax, cleaved caspase-3, and cleaved caspase-9 expression increased. |
2020-04-15 |
2023-08-13 |
mouse |
| Juan Cao, Xiang-Sheng Li. Circular RNA 0060428 sponges miR-375 to promote osteosarcoma cell proliferation by upregulating the expression of RPBJ. Gene. vol 740. 2020-04-15. PMID:32130980. |
western blot analyses indicated that circ-0060428 regulated the expression of apoptosis related proteins (bax, bcl-2, and cleaved-caspase-3) by upregulating rpbj expression in osteosarcoma cells. |
2020-04-15 |
2023-08-13 |
Not clear |
| Yahong Liu, Hui Chen, Li Zhang, Tao Zhang, Xuan Re. Correction to: The Association Between Thyroid Injury and Apoptosis, and Alterations of Bax, Bcl-2, and Caspase-3 mRNA/Protein Expression Induced by Nickel Sulfate in Wistar Rats. Biological trace element research. vol 195. issue 1. 2020-04-14. PMID:31884558. |
correction to: the association between thyroid injury and apoptosis, and alterations of bax, bcl-2, and caspase-3 mrna/protein expression induced by nickel sulfate in wistar rats. |
2020-04-14 |
2023-08-13 |
rat |
| Min Pang, Yu Shan, Fei-Fei Wang, Shu-Xian Yang, Li-Yong Li, Li Ca. [Protective effect of water extracts of Orychophragmus violaceus seeds on TAA-induced acute liver injury in mice]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 45. issue 6. 2020-04-14. PMID:32281354. |
in conclusion, o. violaceus seeds extract exhibited potent protective effect on liver injury induced by taa in mice, and its mechanism may be related to down-regulating levels of keap-1, up-regulating the expressions of nrf2, inhibiting the expressions of p-p38, p-erk and nf-κb p65 signaling pathway, and inhibiting hepatocyte apoptosis by down-regulating the expressions of p-jnk and bax and up-regulating the expressions of bcl-2. |
2020-04-14 |
2023-08-13 |
mouse |
| Mei-Fang Xia. [Effect of polyphyllin D on proliferation and apoptosis of human pancreatic cancer cells]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 45. issue 6. 2020-04-14. PMID:32281356. |
the apoptosis was detected by annexin v-fitc/pi staining, and western blot was used to detect the protein expressions of cytochrome c(cyto c), bax, bcl-2, cleaved caspase-3 and cleaved caspase-9. |
2020-04-14 |
2023-08-13 |
human |
| Mei-Fang Xia. [Effect of polyphyllin D on proliferation and apoptosis of human pancreatic cancer cells]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 45. issue 6. 2020-04-14. PMID:32281356. |
flow cytometry results showed that polyphyllin d could block the cells in s and g_2/m phase in a concentration manner, the mmp of the cells was significantly reduced, and the apoptosis rate increased with the concentration of polyphyllin d. western blot results showed that polyphyllin d could concentration-dependently up-regulate the protein expression levels of bax, cyto c, cleaved caspase-3 and cleaved caspase-9, and down-regulate the protein expression level of bcl-2. |
2020-04-14 |
2023-08-13 |
human |
| Jian-Hui Xie, Zheng-Quan Lai, Xing-Han Zheng, Yan-Fang Xian, Qian Li, Siu-Po Ip, You-Liang Xie, Jian-Nan Chen, Zi-Ren Su, Zhi-Xiu Lin, Xiao-Bo Yan. Apoptosis induced by bruceine D in human non‑small‑cell lung cancer cells involves mitochondrial ROS‑mediated death signaling. International journal of molecular medicine. vol 44. issue 6. 2020-04-13. PMID:31638181. |
western blotting demonstrated that treatment with bruceine d significantly suppressed the expression of the anti‑apoptotic proteins bcl‑2, bcl‑xl and x‑linked inhibitor of apoptosis, enhanced the expression levels of apoptotic proteins bax and bak, and inhibited the expression of pro‑caspase‑3 and pro‑caspase‑8. |
2020-04-13 |
2023-08-13 |
human |
| Wei Wang, Luyang Zhang, Wei Gao, Dongyong Zhang, Zilong Zhao, Yijun Ba. miR‑489 promotes apoptosis and inhibits invasiveness of glioma cells by targeting PAK5/RAF1 signaling pathways. Oncology reports. vol 42. issue 6. 2020-04-13. PMID:31638257. |
the results demonstrated that mir‑489 decreased the activity of raf1, reduced bcl‑2 and promoted bax expression, resulting in increased cell apoptosis. |
2020-04-13 |
2023-08-13 |
Not clear |
| Xianpeng Shi, Man Zhu, Zhengyan Gong, Tianfeng Yang, Runze Yu, Jingjing Wang, Yanmin Zhan. Homoharringtonine suppresses LoVo cell growth by inhibiting EphB4 and the PI3K/AKT and MAPK/EKR1/2 signaling pathways. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 136. 2020-04-13. PMID:31726078. |
hht inhibited ephb4 downstream pathways such as pi3k/akt and mapk/ekr1/2, resulting in the regulation of cell cycle-related molecules (cyclina2 and cdc2), and the molecules in the bcl-2 mitochondrial apoptosis pathway including bcl-2, mcl-1, bax, bad, caspase-3, caspase-7, and caspase-9. |
2020-04-13 |
2023-08-13 |
Not clear |
| Lijun Chen, Xiaoyue Wu, Falak Zeb, Yunxiang Huang, Jing An, Pan Jiang, Aochang Chen, Chuyue Xu, Qing Fen. Acrolein-induced apoptosis of smooth muscle cells through NEAT1-Bmal1/Clock pathway and a protection from asparagus extract. Environmental pollution (Barking, Essex : 1987). vol 258. 2020-04-13. PMID:31864078. |
acrolein exposure reduced survival rate of vsmcs, and raised apoptosis percentage through upregulating the expression of bax, cytochrome c and cleaved caspase-3 and downregulating bcl-2. |
2020-04-13 |
2023-08-13 |
Not clear |
| Lijun Chen, Xiaoyue Wu, Falak Zeb, Yunxiang Huang, Jing An, Pan Jiang, Aochang Chen, Chuyue Xu, Qing Fen. Acrolein-induced apoptosis of smooth muscle cells through NEAT1-Bmal1/Clock pathway and a protection from asparagus extract. Environmental pollution (Barking, Essex : 1987). vol 258. 2020-04-13. PMID:31864078. |
knockdown of neat1, bmal1 or clock promoted vsmcs apoptosis by regulating bax, bcl-2, cytochrome c and caspase-3 levels. |
2020-04-13 |
2023-08-13 |
Not clear |