| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kajal Khodamoradi, Hossein Amini-Khoei, Zahra Khosravizadeh, Seyed Reza Hosseini, Ahmad Reza Dehpour, Gholamreza Hassanzade. Oxidative stress, inflammatory reactions and apoptosis mediated the negative effect of chronic stress induced by maternal separation on the reproductive system in male mice. Reproductive biology. vol 19. issue 4. 2020-05-05. PMID:31711846. |
in addition, ms induced apoptosis as evidenced by increased bax, caspase-3 and caspase-8 as well as decreased bcl-2 expression. |
2020-05-05 |
2023-08-13 |
mouse |
| Xiang Shao, Suhua Zhang, Ying Tang, Weixin Kon. Micro RNA-30b (inhibitor) nanoparticles suppressed the lipopolysaccharide (LPS)-induced acute kidney injury. IET nanobiotechnology. vol 13. issue 9. 2020-05-05. PMID:31811760. |
in contrast, pag-mir (inhibitor) alleviated the apoptosis of hk-2 cells as indicated in the significantly reduced levels of bax and c-caspase-3 proteins. |
2020-05-05 |
2023-08-13 |
human |
| Fei Ren, Cheng Ji, Yujie Huang, Stanley Aniagu, Yan Jiang, Tao Che. AHR-mediated ROS production contributes to the cardiac developmental toxicity of PM2.5 in zebrafish embryos. The Science of the total environment. vol 719. 2020-05-05. PMID:31837856. |
incidentally, both ch and nac attenuated the eom-induced changes in the mrna expression of genes involved in cardiac development (nkx2.5, sox9b), oxidative stress (nrf2a, nrf2b, gstp1, gstp2, sod2, ho1, cat) and apoptosis (p53, bax). |
2020-05-05 |
2023-08-13 |
cat |
| Nathan J Klingensmith, Katherine T Fay, John D Lyons, Ching-Wen Chen, Shunsuke Otani, Zhe Liang, Deena B Chihade, Eileen M Burd, Mandy L Ford, Craig M Coopersmit. Chronic Alcohol Ingestion Worsens Survival and Alters Gut Epithelial Apoptosis and CD8+ T Cell Function After Pseudomonas Aeruginosa Pneumonia-Induced Sepsis. Shock (Augusta, Ga.). vol 51. issue 4. 2020-05-04. PMID:29664837. |
this was associated with a 5-fold increase in intestinal apoptosis in alcohol-fed septic animals, accompanied by an increase in the pro-apoptotic protein bax. |
2020-05-04 |
2023-08-13 |
mouse |
| Caixia Li, Zhongwei Zhang, Shukun Zhang, Wenqiang Yan, Chuanling Si, Mong-Hong Lee, Zhigang L. Inhibitory Effects of the Extracts of Juglans sigillata Green Husks on the Proliferation, Migration and Survival of KYSE150 and EC9706 Human Esophageal Cancer Cell Lines. Nutrition and cancer. vol 71. issue 1. 2020-05-01. PMID:30633592. |
flow cytometry revealed that these three constituents also induced cell apoptosis by increasing bax and cleaved caspase-3 but decreasing bcl-2 in kyse150 and ec9706 cells. |
2020-05-01 |
2023-08-13 |
human |
| Elham Ramazani, Masoud Fereidoni, Zahra Tayarani-Najara. Protective effects of vitamin K2 on 6-OHDA-induced apoptosis in PC12 cells through modulation bax and caspase-3 activation. Molecular biology reports. vol 46. issue 6. 2020-05-01. PMID:31392537. |
protective effects of vitamin k2 on 6-ohda-induced apoptosis in pc12 cells through modulation bax and caspase-3 activation. |
2020-05-01 |
2023-08-13 |
Not clear |
| Elham Ramazani, Masoud Fereidoni, Zahra Tayarani-Najara. Protective effects of vitamin K2 on 6-OHDA-induced apoptosis in PC12 cells through modulation bax and caspase-3 activation. Molecular biology reports. vol 46. issue 6. 2020-05-01. PMID:31392537. |
the protective effects of vitamin k2 against 6-ohda-induced apoptosis in pc12 cells were assessed using resazurin for viability, dcf-da for ros level, dtnb for glutathione level, flow cytometry for sub g1, and western blot analysis for detecting bax and pro-caspase-3 expression level. |
2020-05-01 |
2023-08-13 |
Not clear |
| Xiuli Wang, Yi Wang, Lulu Zhang, Da Zhang, Lu Bai, Wei Kong, Yaqian Huang, Chaoshu Tang, Junbao Du, Hongfang Ji. L-Cystathionine Protects against Homocysteine-Induced Mitochondria-Dependent Apoptosis of Vascular Endothelial Cells. Oxidative medicine and cellular longevity. vol 2019. 2020-05-01. PMID:31885769. |
however, btsa1, a bax agonist, or bax overexpression successfully abolished the inhibitory effect of l-cystathionine on hcy-induced mptp opening, caspase-9 and caspase-3 activation, and huvec apoptosis. |
2020-05-01 |
2023-08-13 |
human |
| Shilpa Kuttikrishnan, Kodappully S Siveen, Kirti S Prabhu, Abdul Quaiyoom Khan, Sabah Akhtar, Jericha M Mateo, Maysaloun Merhi, Ruba Taha, Halima El Omri, Fatima Mraiche, Said Dermime, Shahab Uddi. Sanguinarine suppresses growth and induces apoptosis in childhood acute lymphoblastic leukemia. Leukemia & lymphoma. vol 60. issue 3. 2020-04-30. PMID:30187808. |
sang-mediated apoptosis was found to be associated with the increased expression of proapoptotic bax with concomitant decrease of bcl-2 expression leading to depolarization of mitochondria membrane resulting in loss of mitochondrial membrane potential (mmp). |
2020-04-30 |
2023-08-13 |
Not clear |
| Fengwu Li, Zhiying Yang, Christopher Stone, Jamie Y Ding, Lauren Previch, Jiamei Shen, Yu Ji, Xiaokun Geng, Yuchuan Din. Phenothiazines Enhance the Hypothermic Preservation of Liver Grafts: A Pilot in Vitro Study. Cell transplantation. vol 28. issue 3. 2020-04-30. PMID:30666889. |
c+p augmentation induced significant reductions in alt and ast activities; the ast/alt ratio; as well as in cellular swelling, vacuolar degeneration, apoptosis, and bax expression. |
2020-04-30 |
2023-08-13 |
rat |
| Farhin Ara, Adrija Tripathy, Debidas Ghos. Possible Antidiabetic and Antioxidative Activity of Hydro-Methanolic Extract of Musa balbisiana (Colla) Flower in Streptozotocin-Induced Diabetic Male Albino Wistar Strain Rat: A Genomic Approach. Assay and drug development technologies. vol 17. issue 2. 2020-04-28. PMID:30869526. |
for focusing the status of apoptosis in hepatic tissue, an important organ for carbohydrate metabolism, bax and bcl-2 gene expression were included, which are the novelty of this study. |
2020-04-28 |
2023-08-13 |
rat |
| Qianru Chi, Yilin Luan, Yiming Zhang, Xueyuan Hu, Shu L. The regulatory effects of miR-138-5p on selenium deficiency-induced chondrocyte apoptosis are mediated by targeting SelM. Metallomics : integrated biometal science. vol 11. issue 4. 2020-04-28. PMID:30869711. |
the expression of mir-138-5p was increased in response to se deficiency, and the overexpression of mir-138-5p increased caspase-3, caspase-9, bax and bak levels, while the bcl-2 level was decreased, suggesting that mir-138-5p induced apoptosis via the mitochondrial pathway in vivo and in vitro. |
2020-04-28 |
2023-08-13 |
chicken |
| Huijie Chen, Rui Feng, Ishfaq Muhammad, Ghulam Abbas, Yue Zhang, Yudong Ren, Xiaodan Huang, Ruili Zhang, Lei Diao, Xiurong Wang, Guangxing L. Protective effects of hypericin against infectious bronchitis virus induced apoptosis and reactive oxygen species in chicken embryo kidney cells. Poultry science. vol 98. issue 12. 2020-04-28. PMID:31399732. |
furthermore, hy inhibited ibv-induced apoptosis in cek cells, and significantly reduced the mrna expression levels of fas, fasl, jnk, bax, caspase 3, and caspase 8, and significantly increased bcl-2 mrna expression level in cek cells. |
2020-04-28 |
2023-08-13 |
chicken |
| Cesar A López, Mark F Swift, Xiao-Ping Xu, Dorit Hanein, Niels Volkmann, S Gnanakara. Biophysical Characterization of a Nanodisc with and without BAX: An Integrative Study Using Molecular Dynamics Simulations and Cryo-EM. Structure (London, England : 1993). vol 27. issue 6. 2020-04-27. PMID:30982634. |
b cell lymphoma-2-associated x protein (bax) plays a pivotal role in triggering cell apoptosis by permeabilizing the mitochondrial outer membrane. |
2020-04-27 |
2023-08-13 |
Not clear |
| Mohd Faraz Zafeer, Fakiha Firdaus, Ehraz Anis, M Mobarak Hossai. Prolong treatment with Trans-ferulic acid mitigates bioenergetics loss and restores mitochondrial dynamics in streptozotocin-induced sporadic dementia of Alzheimer's type. Neurotoxicology. vol 73. 2020-04-27. PMID:31029786. |
furthermore, fa treatment has shown mitigation in intracerebral-ventricular streptozocin (icv-stz) induced bioenergetics loss and dynamic changes by regulating peroxisome proliferator-activated receptor gamma coactivator 1-alpha (pgc-1alpha) protein levels in nucleus and hence, mitigating exacerbation of drp-1 dependent mitochondrial fission and apoptosis by alleviating loss of mitochondrial membrane potential (ΔΨm), downregulating cytochrome-c release into the cytosol by limiting mitochondrial permeability transition pore (mptp) opening concomitant increase in caspase3 activation, bax expression and dna fragmentation along with downregulating glial fibrillary acidic protein (gfap) expression. |
2020-04-27 |
2023-08-13 |
Not clear |
| D S Kutilin, T G Airapetova, P A Anistratov, S P Pyltsin, I A Leiman, N S Karnaukhov, O I Ki. Copy Number Variation in Tumor Cells and Extracellular DNA in Patients with Lung Adenocarcinoma. Bulletin of experimental biology and medicine. vol 167. issue 6. 2020-04-27. PMID:31655998. |
changed copy numbers were detected for genes responsible for apoptosis regulation (bax, p53, and casp3), proliferation (sox2), dna reparation (xrcc1), oxidative phosphorylation (hv2), egfr signaling pathway (grb2, sos1, mapk1, stat1, and braf), and for mir3678 gene in lung tumor cells and extracellular dna. |
2020-04-27 |
2023-08-13 |
Not clear |
| Jun Zhou, Liang Xia, Yu Zhan. Naringin inhibits thyroid cancer cell proliferation and induces cell apoptosis through repressing PI3K/AKT pathway. Pathology, research and practice. vol 215. issue 12. 2020-04-27. PMID:31727500. |
moreover, cell proliferation and apoptosis related genes (cyclin d1, c-myc, survivin, caspase3, bcl-2, and bax) were measured by western blot assay and quantitative reverse transcription-polymerase chain reaction (qrt-pcr) respectively. |
2020-04-27 |
2023-08-13 |
Not clear |
| Junmei Wang, Yongcheng Jin, Shunlu Wu, Hao Yu, Yun Zhao, Hengtong Fang, Jinglin Shen, Changhai Zhou, Yurong Fu, Ruihua Li, Rui Wang, Junxiong Wang, Kexin Zheng, Qingsong Fan, Bojiong Chen, Jing Zhan. Deoxynivalenol induces oxidative stress, inflammatory response and apoptosis in bovine mammary epithelial cells. Journal of animal physiology and animal nutrition. vol 103. issue 6. 2020-04-23. PMID:31423645. |
in addition, the apoptosis rate measured using annexin v-fitc significantly increased (p < .05) with increase in the mrna expression level of bax (p < .01) and increase in the bax/bcl-2 ratio (p < .01) in cells incubated for 24 hr. |
2020-04-23 |
2023-08-13 |
cattle |
| Yunqing Zhang, Li Wang, Jie Xu, Xiaomei Kong, Lin Zo. Up-regulated miR-106b inhibits ox-LDL-induced endothelial cell apoptosis in atherosclerosis. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas. vol 53. issue 3. 2020-04-21. PMID:32130290. |
compared with the control group, the proportion and number of haecs apoptosis and bax, caspase-3, and caspase-9 expression in ox-ldl and mir-106b mimics+pten+ox-ldl groups were significantly increased (all p<0.05). |
2020-04-21 |
2023-08-13 |
human |
| Dongyan Yang, Lei Zhang, Zhisheng Zhang, Sulei Hu, Yanbo Fu, Jari A Laukkanen, Gang L. Silencing of C3G increases cardiomyocyte survival inhibition and apoptosis via regulation of p-ERK1/2 and Bax. Clinical and experimental pharmacology & physiology. vol 46. issue 3. 2020-04-20. PMID:30152875. |
silencing of c3g increases cardiomyocyte survival inhibition and apoptosis via regulation of p-erk1/2 and bax. |
2020-04-20 |
2023-08-13 |
Not clear |