| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Zhongyang Ding, Ying Li, Zhangfeng Tang, Xiaoyi Song, Fa Jing, Haotian Wu, Bei L. Role of gambogenic acid in regulating PI3K/Akt/NF-kβ signaling pathways in rat model of acute hepatotoxicity. Bioscience, biotechnology, and biochemistry. vol 85. issue 3. 2021-07-27. PMID:33624779. |
the levels of mda, gsh, sod, cat, gpx, gst, alp, ast, alt, proinflammatory cytokines (tnf-α, il-1β, il-6), apoptosis markers (caspase-3 and -9, bax, bcl-2), 4-hydroxynonenal (4-hne), and prostaglandin e2 (pge2) were evaluated. |
2021-07-27 |
2023-08-13 |
rat |
| Le Fang, Hong Wang, Jie Zhang, Xiaolei Fan. Punicalagin induces ROS-mediated apoptotic cell death through inhibiting STAT3 translocation in lung cancer A549 cells. Journal of biochemical and molecular toxicology. vol 35. issue 6. 2021-07-27. PMID:33720461. |
here, the punicalagin inhibited stat-3 translocation and thereby induces apoptosis by inhibiting expression bcl-2 and enhanced expression of bax, cytochrome-c, caspase-9, and caspase-3 in a549 cells. |
2021-07-27 |
2023-08-13 |
Not clear |
| Qing-Zhi He, Bi-Qi Zhu, Xiao-Na Xu, Huai-Cai Zen. Role of the BDNF/TrkB/CREB signaling pathway in the cytotoxicity of bisphenol S in SK-N-SH cells. Journal of biochemical and molecular toxicology. vol 35. issue 6. 2021-07-27. PMID:33749030. |
the cells were treated with various concentrations of bps, and cell viability, apoptosis rate, mitochondrial membrane potential (mmp), and the bdnf, cleaved-caspase-3, b-cell lymphoma 2 (bcl-2), bcl-2-associated x protein (bax), trkb, creb, and phospho-creb (p-creb) levels were determined. |
2021-07-27 |
2023-08-13 |
Not clear |
| Qing-Zhi He, Bi-Qi Zhu, Xiao-Na Xu, Huai-Cai Zen. Role of the BDNF/TrkB/CREB signaling pathway in the cytotoxicity of bisphenol S in SK-N-SH cells. Journal of biochemical and molecular toxicology. vol 35. issue 6. 2021-07-27. PMID:33749030. |
their apoptosis rate was increased, as were the levels of the proapoptotic proteins bax and cleaved-caspase-3, but mmp was decreased. |
2021-07-27 |
2023-08-13 |
Not clear |
| Abdolamir Ghadaksaz, Abbas Ali Imani Fooladi, Hamideh Mahmoodzadeh Hosseini, Taher Nejad Satari, Mohsen Ami. ARA-linker-TGFαL3: a novel chimera protein to target breast cancer cells. Medical oncology (Northwood, London, England). vol 38. issue 8. 2021-07-27. PMID:34273028. |
moreover, rt-pcr was conducted to study the expression of apoptosis (bax, bcl2, and casp3), angiogenesis (vegfr2), and metastasis (mmp2 and mmp9) genes. |
2021-07-27 |
2023-08-13 |
Not clear |
| Liang Yan, Yi Liu, Xue-Feng Ma, Dan Hou, Yu-Hui Zhang, Yong Sun, Shan-Shan Shi, Tim Forouzanfar, Hai-Yan Lin, Jun Fan, Gang W. Triclabendazole Induces Pyroptosis by Activating Caspase-3 to Cleave GSDME in Breast Cancer Cells. Frontiers in pharmacology. vol 12. 2021-07-27. PMID:34305590. |
triclabendazole activates apoptosis by regulating the apoptoic protein levels including bax, bcl-2, and enhanced cleavage of caspase-8/9/3/7 and parp. |
2021-07-27 |
2023-08-13 |
Not clear |
| Yi Liu, Jian Cao, Yan-Song Pu, Yu Ma, Min Wu, Jian-Hua Wan. RP11-874J12.4, a novel lncRNA, confers chemoresistance in human gastric cancer cells by sponging miR-3972 and upregulating SSR2 expression. American journal of translational research. vol 13. issue 6. 2021-07-27. PMID:34306333. |
ssr2 downregulation further sensitized gastric cancer cells with rp11-874j12.4 knockdown to chemotherapeutic drugs via enhanced apoptosis, which was evidenced by significantly upregulated expressions of cleaved caspase-3, cleaved caspase-9, and bax and downregulated expression of bcl-2. |
2021-07-27 |
2023-08-13 |
mouse |
| Atefeh Babaei, Sajjad Moradi, Zohreh Hoseinkhani, Davood Rezazadeh, Sadat Dokaneheifard, Reza Asadpour, Gaurav Sharma, Kamran Mansour. Expression of Hypoxia-Inducible Factor1-α in Varicocele Disease: a Comprehensive Systematic Review. Reproductive sciences (Thousand Oaks, Calif.). 2021-07-27. PMID:34313997. |
expression of hif-1α regulates the expression of many genes, including vegf, p53, glut, bax, and caspase-3, that could be involved in many of the varicocele pathophysiological effects such as dna fragmentation and apoptosis of sperm cells. |
2021-07-27 |
2023-08-13 |
human |
| Bo Wang, Haijia Xu, Jing Kong, Deshan Liu, Wei-Dong Qin, Wenwu Ba. Krüppel-like factor 15 reduces ischemia-induced apoptosis involving regulation of p38/MAPK signaling. Human gene therapy. 2021-07-27. PMID:34314239. |
meanwhile, klf15 overexpression dramatically reduced the myocardial apoptosis, regulated apoptosis-related genes such as bcl2 and bax, diminished the activities of caspase-9/3 and inactivated p38/mapk signaling in the border zone. |
2021-07-27 |
2023-08-13 |
mouse |
| Bo Lin, Youguang Gao, Zhiwang Li, Zhiming Zhang, Xianzhong Lin, Jinpeng Ga. Cannabidiol alleviates hemorrhagic shock-induced neural apoptosis in rats by inducing autophagy through activation of the PI3K/AKT pathway. Fundamental & clinical pharmacology. vol 34. issue 6. 2021-07-26. PMID:32215966. |
cbd treatment attenuated the neural apoptosis induced by hs, as reflected by restoring mitochondrial dysfunction, downregulation of bax, neuro-apoptosis ratio and nf-κb signaling activation, and upregulation of bcl2 in the cerebral cortex. |
2021-07-26 |
2023-08-13 |
rat |
| Danixa Martínez, Catalina Moncada-Kopp, Kurt Paschke, Jorge M Navarro, Luis Vargas-Chacof. Warming and freshening activate the transcription of genes involved in the cellular stress response in Harpagifer antarcticus. Fish physiology and biochemistry. vol 47. issue 2. 2021-07-26. PMID:33523350. |
we used qpcr analysis to evaluate the transcription of genes involved in the thermal shock response (hsp70, hsc70, hsp90, and grp78), ubiquitination (e2, e3, ubiquitin, and chip), 26s proteasome complex (psma2, psmb7, and psmc1), and apoptosis (smac/diablo and bax) in the liver and gill. |
2021-07-26 |
2023-08-13 |
Not clear |
| Shan Zhou, Liang Xia, Yuanyuan Chen, Weiying Guo, Jinxing H. miR-3188 Regulates proliferation and apoptosis of granulosa cells by targeting KCNA5 in the polycystic ovary syndrome. Acta biochimica Polonica. vol 68. issue 1. 2021-07-26. PMID:33533580. |
moreover, cell apoptosis was suppressed by mir-3188 in kgn, indicated by enhanced bcl-2, and reduced bax and cleaved caspase-3 levels, whereas knockdown of mir-3188 resulted in opposite effects. |
2021-07-26 |
2023-08-13 |
Not clear |
| Panpan Liu, Jinghan Li, Miaomiao Liu, Muqing Zhang, Yucong Xue, Yuanyuan Zhang, Xue Han, Xuan Jing, Li Ch. Hesperetin modulates the Sirt1/Nrf2 signaling pathway in counteracting myocardial ischemia through suppression of oxidative stress, inflammation, and apoptosis. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 139. 2021-07-26. PMID:33839495. |
furthermore, l-hsp and h-hsp also reversed the iso-induced apoptosis and the changes in the sirt1/nrf2 signaling pathway, as evident from the levels of proteins bax, bcl-2, caspase-3, sirt1, nrf2, nqo-1, and ho-1. |
2021-07-26 |
2023-08-13 |
mouse |
| Liu Liu, Ping Zhang, Zhaosi Zhang, Yidan Liang, Hong Chen, Zhaohui He, Xiaochuan Sun, Zongduo Guo, Yongbing Den. 5-Lipoxygenase inhibition reduces inflammation and neuronal apoptosis via AKT signaling after subarachnoid hemorrhage in rats. Aging. vol 13. issue 8. 2021-07-26. PMID:33878031. |
we found that 5-lox expression was significantly increased in the cytoplasm of cortical neurons after sah and was accompanied by upregulated expression of the inflammatory factors ltb4, tnf-α, il-1β and il-6; upregulation of the pro-apoptotic factor bax; downregulation of the anti-apoptotic factor bcl-2; and an increased apoptosis rate. |
2021-07-26 |
2023-08-13 |
rat |
| Chunsun Jiang, Gang Liu, Lu Cai, Jessy Deshane, Veena Antony, Victor J Thannickal, Rui-Ming Li. Divergent Regulation of Alveolar Type 2 Cell and Fibroblast Apoptosis by Plasminogen Activator Inhibitor 1 in Lung Fibrosis. The American journal of pathology. vol 191. issue 7. 2021-07-26. PMID:33887217. |
deletion of pai-1 in adult mice led to a reduction in p53, p21, and bax protein expression, as well as apoptosis sensitivity in atii cells, and their increase in the lung fibroblasts, as indicated by in vivo studies. |
2021-07-26 |
2023-08-13 |
mouse |
| Haopeng Xu, Yi Xia, Juan Qin, Jie Xu, Chongyan Li, Yan Wan. Effects of low intensity pulsed ultrasound on expression of B-cell lymphoma-2 and BCL2-Associated X in premature ovarian failure mice induced by 4-vinylcyclohexene diepoxide. Reproductive biology and endocrinology : RB&E. vol 19. issue 1. 2021-07-24. PMID:34284777. |
this study was performed to determine the effects of lipus on granulosa cells (gcs) apoptosis and protein expression of b-cell lymphoma-2 (bcl-2) and bcl2-associated x (bax) in 4-vinylcyclohexene diepoxide (vcd)-induced pof mice and investigate the mechanisms of lipus on ovarian function and reserve capacity. |
2021-07-24 |
2023-08-13 |
mouse |
| Peng Zhang, Xue Zhang, Jing Zhang, Yanqiu Song, Ting Liu, Zhican Zeng, Xiaofeng Fu, Han Fu, Hong Zhang, Qin Qin, Naikuan Fu, Zhigang Gu. Novel Nanoliposomes Alleviate Contrast-Induced Nephropathy by Mediating Apoptosis Response in New Zealand Rabbits. Frontiers in molecular biosciences. vol 8. 2021-07-24. PMID:34295921. |
oxidative stress markers, such as superoxide dismutase (sod) and malondialdehyde (mda), and apoptosis markers, such as bcl2-associated x (bax) and b-cell lymphoma-2 (bcl-2), were measured by enzyme-linked immunosorbent assay (elisa). |
2021-07-24 |
2023-08-13 |
Not clear |
| Mojtaba Moradi, Nader Goodarzi, Azita Faramarzi, Hadi Cheraghi, Amir Hossein Hashemian, Cyrus Jalil. Melatonin protects rats testes against bleomycin, etoposide, and cisplatin-induced toxicity via mitigating nitro-oxidative stress and apoptosis. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 138. 2021-07-22. PMID:33752059. |
more importantly, melatonin therapy suppressed bep-evoked apoptosis by modulating bcl-2, bax, caspase-3, p53, and tnf-α expression in testes. |
2021-07-22 |
2023-08-13 |
rat |
| Xu Li, Jingjing Mu, Yang Lin, Jin Zhao, Xianjun Men. Combination of cyanidin-3-O-glucoside and cisplatin induces oxidative stress and apoptosis in HeLa cells by reducing activity of endogenous antioxidants, increasing bax/bcl-2 mRNA expression ratio, and downregulating Nrf2 expression. Journal of food biochemistry. vol 45. issue 7. 2021-07-22. PMID:34080212. |
in addition, c3g-ddp protected hela cells from oxidative stress-induced apoptosis by increasing bcl-2 levels and decreasing bax levels. |
2021-07-22 |
2023-08-13 |
cat |
| Xiao-Heng Xu, Si-Jin Zhang, Qi-Bo Hu, Xing-Yu Song, Wei Pa. Effects of microRNA-494 on proliferation, migration, invasion, and apoptosis of medulloblastoma cells by mediating c-myc through the p38 MAPK signaling pathway. Journal of cellular biochemistry. 2021-07-21. PMID:30304554. |
in response to mir-494 mimic, mb cells were found to have increased bax and pten expressions, as well as cell number in g1 phase and cell apoptosis and decreased c-myc, p38 mapk, bcl-2, mtdh, il-6, and survivin expression and cell number count in the s phase, cell proliferation, migration, and invasion. |
2021-07-21 |
2023-08-13 |
Not clear |