| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yahong Cheng, Xin Zeng, Qianting Mai, Xinying Bai, Yuan Jiang, Jinjin Li, Shiqi Fan, Hong Din. Insulin injections inhibits PTZ-induced mitochondrial dysfunction, oxidative stress and neurological deficits via the SIRT1/PGC-1α/SIRT3 pathway. Biochimica et biophysica acta. Molecular basis of disease. vol 1867. issue 6. 2021-09-10. PMID:33727197. |
additionally, insulin pretreatment upregulated bcl-2, downregulated bax, and then played a neuroprotective role against hippocampal neuron apoptosis. |
2021-09-10 |
2023-08-13 |
mouse |
| Bijing Yang, Yingwei Liu, Yangwei Li, Shanshan Zhu, Yuanliang Li, Jiangnan Yi, Zhuanxu Ouyang, Bingxian Liu, Khalid Mehmood, Riaz Hussain, Jiaqiang Pan, Lianmei Hu, Zhaoxin Tang, Guanhua Wang, Ying Li, Hui Zhan. Exposure to the herbicide butachlor activates hepatic stress signals and disturbs lipid metabolism in mice. Chemosphere. vol 283. 2021-09-09. PMID:34146870. |
the results on the mechanisms of liver toxicity indicated that butachlor induced overexpression of apaf-1, bax, caspase-3, caspase-9, cyt-c, p53, beclin-1, atg-5, and lc3, whereas decreases the expression of bcl-2 and p62 suggesting abnormal processes of apoptosis and autophagy. |
2021-09-09 |
2023-08-13 |
mouse |
| Shenglan Wang, Yan Tan, Tingting Yang, Chen Liu, Rufang L. Pulmonary AngII promotes LPS-induced lung inflammation by regulating microRNA-143. Cytotechnology. 2021-09-09. PMID:34493899. |
pretreatment of angii and lps regulated the activity of ace2, increased the expression of proinflammatory cytokines and cell apoptosis and regulated the expression of bax, bcl-2 and cleaved caspase-3 in beas-2b cells, which could be reversed by transfecting mir-143-3p inhibitor. |
2021-09-09 |
2023-08-13 |
Not clear |
| Liang Li, Gao Li, Minbiao Chen, Renzhong Ca. Astragaloside IV enhances the sensibility of lung adenocarcinoma cells to bevacizumab by inhibiting autophagy. Drug development research. 2021-09-09. PMID:34499759. |
moreover, bv or ast-iv inhibited bcl-2 expression and increased the expressions of bax and cleaved caspase-3, and promoted apoptosis. |
2021-09-09 |
2023-08-13 |
Not clear |
| Jessica Dittmann, Tinka Haydn, Patrick Metzger, George A Ward, Melanie Boerries, Meike Vogler, Simone Fuld. Next-generation hypomethylating agent SGI-110 primes acute myeloid leukemia cells to IAP antagonist by activating extrinsic and intrinsic apoptosis pathways. Cell death and differentiation. vol 27. issue 6. 2021-09-08. PMID:31831875. |
unbiased transcriptome analysis revealed that sgi-110 alone or in combination with astx660 upregulated the expression of key regulators of both extrinsic and intrinsic apoptosis signaling pathways such as tnfrsf10b (dr5), fas, and bax. |
2021-09-08 |
2023-08-13 |
human |
| Jessica Dittmann, Tinka Haydn, Patrick Metzger, George A Ward, Melanie Boerries, Meike Vogler, Simone Fuld. Next-generation hypomethylating agent SGI-110 primes acute myeloid leukemia cells to IAP antagonist by activating extrinsic and intrinsic apoptosis pathways. Cell death and differentiation. vol 27. issue 6. 2021-09-08. PMID:31831875. |
consistently, sequential treatment with sgi-110 and astx660-triggered loss of mitochondrial membrane potential (mmp) and bax activation which contributes to cell death, as bax silencing significantly protected from sgi-110/astx660-mediated apoptosis. |
2021-09-08 |
2023-08-13 |
human |
| Hai-Ru Li, Chao Wang, Ping Sun, Dan-Dan Liu, Guo-Qing Du, Jia-Wei Tia. Melatonin attenuates doxorubicin-induced cardiotoxicity through preservation of YAP expression. Journal of cellular and molecular medicine. vol 24. issue 6. 2021-09-08. PMID:32068341. |
we found that in vitro doxorubicin treatment significantly decreased h9c2 cell viability and induced apoptosis as manifested by increased tunel-positive cells, down-regulation of anti-apoptotic protein bcl-2, as well as up-regulation of pro-apoptotic protein bax. |
2021-09-08 |
2023-08-13 |
Not clear |
| Yong Fa Zhang, Jian Ying Yang, Xiang Ping Meng, Na Nie, Mei Cui Tang, Xiao Li Yan. L-Arginine protects mouse Leydig cells against T-2 toxin-induced apoptosis Toxicology and industrial health. vol 36. issue 12. 2021-09-08. PMID:33215568. |
leydig cells were isolated and cultured with control, t-2 toxin (10 nm), l-arginine (0.25, 0.5, and 1.0 mm), and t-2 toxin (10 nm t-2 toxin) + l-arginine (0.25, 0.5, or 1.0 mm) for 24 h. cells and supernatants were harvested to examine proliferation of the cells, the apoptosis rate, activity of caspase-3 and mitochondria, and the gene expression levels of bcl-2, bax, parp, and caspase-3. |
2021-09-08 |
2023-08-13 |
mouse |
| Yong Fa Zhang, Jian Ying Yang, Xiang Ping Meng, Na Nie, Mei Cui Tang, Xiao Li Yan. L-Arginine protects mouse Leydig cells against T-2 toxin-induced apoptosis Toxicology and industrial health. vol 36. issue 12. 2021-09-08. PMID:33215568. |
bcl-2 gene expression levels was decreased, while the gene expression levels of bax and parp were increased, which could trigger mitochondria-mediated apoptosis, activate downstream caspase-3, and then increased caspase-3 at both activity and gene expression levels. |
2021-09-08 |
2023-08-13 |
mouse |
| Monika Kadela-Tomanek, Maria Jastrzębska, Krzysztof Marciniec, Elwira Chrobak, Ewa Bębenek, Małgorzata Latocha, Dariusz Kuśmierz, Stanisław Boryczk. Design, synthesis and biological activity of 1,4-quinone moiety attached to betulin derivatives as potent DT-diaphorase substrate. Bioorganic chemistry. vol 106. 2021-09-08. PMID:33272711. |
the transcriptional activity of the gene encoding a proliferation marker (h3 histone), cell cycle regulators (p53 and p21) and apoptosis pathway (bcl-2 and bax) for selected compounds were determined. |
2021-09-08 |
2023-08-13 |
human |
| Jung Joo Yoon, Chan Ok Son, Hye Yoom Kim, Byung Hyuk Han, Yun Jung Lee, Ho Sub Lee, Dae Gill Kan. Betulinic Acid Protects DOX-Triggered Cardiomyocyte Hypertrophy Response through the GATA-4/Calcineurin/NFAT Pathway. Molecules (Basel, Switzerland). vol 26. issue 1. 2021-09-08. PMID:33374365. |
in addition, ba treatment significantly reduced dox-induced cell apoptosis and protein expression levels of bax and cleaved caspase-3/-9, while the expression of bcl-2 was increased by ba. |
2021-09-08 |
2023-08-13 |
Not clear |
| Yuening Luo, Siqi Zhou, Haruna Haeiwa, Reiko Takeda, Kazuma Okazaki, Marie Sekita, Takuya Yamamoto, Mikio Yamano, Kazuichi Sakamot. Role of amber extract in protecting SHSY5Y cells against amyloid β1-42-induced neurotoxicity. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 141. 2021-09-08. PMID:34175817. |
we measured levels of ros, bcl-2, and bax mrna, and found that amber extract decreased aβ (1-42)-induced cell apoptosis via the reactive oxygen species (ros)-mediated mitochondrial pathway. |
2021-09-08 |
2023-08-13 |
Not clear |
| Xiaoping Liang, Yujie Liu, Ling Chen, Suyu Che. The natural compound puerarin alleviates inflammation and apoptosis in experimental cell and rat preeclampsia models. International immunopharmacology. vol 99. 2021-09-08. PMID:34311188. |
abnormal placental inflammatory cytokines (tnf, il-6, ifn-γ, and il-4) and apoptosis markers (bcl-2, bax, caspase-3, caspase-8, and caspase-9) expressions in the lps-treated group were reversed after pue treatment. |
2021-09-08 |
2023-08-13 |
rat |
| Nagwa I Mohamed, Ghada M Suddek, Dalia H El-Kashe. Molsidomine alleviates acetic acid-induced colitis in rats by reducing oxidative stress, inflammation and apoptosis. International immunopharmacology. vol 99. 2021-09-08. PMID:34330056. |
furthermore, it suppressed apoptosis by reducing expression of caspase 3 and bax in colonic and hepatic tissues. |
2021-09-08 |
2023-08-13 |
rat |
| Xiaoqi Sun, Xiaotian Wang, Qianqian He, Muqing Zhang, Li Chu, Yang Zhao, Yongchao Wu, Jianping Zhang, Xue Han, Xi Chu, Zhonglin Wu, Shengjiang Gua. Investigation of the ameliorative effects of baicalin against arsenic trioxide-induced cardiac toxicity in mice. International immunopharmacology. vol 99. 2021-09-08. PMID:34333357. |
moreover, ba attenuated ato-induced apoptosis by promoting the expression of bcl-2 and suppressing the expression of bax and caspase-3. |
2021-09-08 |
2023-08-13 |
mouse |
| Hung Manh Phung, Sullim Lee, Ji Hye Hwang, Ki Sung Kan. Preventive Effect of Muscone against Cisplatin Nephrotoxicity in LLC-PK1 Cells. Biomolecules. vol 10. issue 10. 2021-09-07. PMID:33076219. |
furthermore, muscone mitigated cisplatin-induced apoptosis in llc-pk1 cells via both intrinsic and extrinsic pathways by inhibiting pro-apoptotic protein bax expression, and cleaved caspase-3, 7, and 8; and increase of anti-apoptotic protein bcl-2 level. |
2021-09-07 |
2023-08-13 |
Not clear |
| M Y Ansari, H C Ball, S J Wase, K Novak, T M Haqq. Lysosomal dysfunction in osteoarthritis and aged cartilage triggers apoptosis in chondrocytes through BAX mediated release of Cytochrome c. Osteoarthritis and cartilage. vol 29. issue 1. 2021-09-07. PMID:33161099. |
lysosomal dysfunction in osteoarthritis and aged cartilage triggers apoptosis in chondrocytes through bax mediated release of cytochrome c. lysosomes are the major catabolic organelle of the cell and regulate the macromolecular and organelle turnover and programmed cell death. |
2021-09-07 |
2023-08-13 |
Not clear |
| Yuhyun Chung, Yoonkyung Kim, Nuri Yun, Young J O. Dysregulated autophagy is linked to BAX oligomerization and subsequent cytochrome c release in 6-hydroxydopmaine-treated neuronal cells. Biochemical and biophysical research communications. vol 548. 2021-09-07. PMID:33631669. |
taken together, our results suggest that bax oligomerization comprises a critical step by which 6-ohda-induced dysregulated autophagy mediates neuronal apoptosis. |
2021-09-07 |
2023-08-13 |
Not clear |
| Xinghe Wang, Yang He, Jinlong Tian, Ishfaq Muhammad, Mingchun Liu, Changde Wu, Chang Xu, Xiaohuan Zhan. Ferulic acid prevents aflatoxin B1-induced liver injury in rats via inhibiting cytochrome P450 enzyme, activating Nrf2/GST pathway and regulating mitochondrial pathway. Ecotoxicology and environmental safety. vol 224. 2021-09-07. PMID:34416636. |
iv) afb1-induced hepatocyte apoptosis, the high expression of p53, bax, cyt-c, caspase-9, caspase-3, and the low expression of bcl-2 were all restored by fa. |
2021-09-07 |
2023-08-13 |
rat |
| Yiqi Wang, Lian Duan, Xing Zhang, Yang Jiao, Ying Liu, Lingling Dai, Hong Ya. Effect of long-term exposure to acrylamide on endoplasmic reticulum stress and autophagy in rat cerebellum. Ecotoxicology and environmental safety. vol 224. 2021-09-07. PMID:34450424. |
the enhanced apoptotic rates and the increased bax expression indicated the elevated level of apoptosis. |
2021-09-07 |
2023-08-13 |
human |