| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Zhihong Lu, Xiujuan Zhu, Yuhong Ye, Haidong Fu, Jianhua Ma. PP2A protects podocytes against Adriamycin-induced injury and epithelial-to-mesenchymal transition via suppressing JIP4/p38-MAPK pathway. Cytotechnology. vol 73. issue 5. 2021-10-12. PMID:34629746. |
additionally, in adr-treated podocytes, pp2a suppression enhanced the effects of adr, yet silencing of jip4 reversed the effects of pp2a suppression on regulating p38-mapk pathway-, apoptosis- and emt-related factors expressions and apoptosis, with upregulations of b-cell lymphoma-2 (bcl-2) and e-cadherin and down-regulations of bcl-2 associated protein x (bax), cleaved (c)-casapse-3, n-cadherin, vimentin and snail. |
2021-10-12 |
2023-08-13 |
mouse |
| Yuxing Cai, Yi Hao, Hui Xu, Kai Chen, Baozhong Re. Gigantol inhibits cell proliferation and induces apoptosis by regulating DEK in non-small cell lung cancer. Experimental and therapeutic medicine. vol 22. issue 5. 2021-10-12. PMID:34630671. |
to conclude, the results of the present study suggested that gigantol inhibited cell proliferation and induced apoptosis by decreasing ki-67 and bcl-2 expression, increasing bax expression and activating the wnt/β-catenin signaling pathway by regulating dek. |
2021-10-12 |
2023-08-13 |
Not clear |
| Jonggul Lee, Donggu Lee, Yangjin Ki. Mathematical model of STAT signalling pathways in cancer development and optimal control approaches. Royal Society open science. vol 8. issue 9. 2021-10-12. PMID:34631119. |
in this study, we investigate how an intracellular signalling network (stat1, stat3, bcl-2 and bax) regulates important cellular states, either anti-apoptosis or apoptosis of cancer cells. |
2021-10-12 |
2023-08-13 |
Not clear |
| Jianqiang Bi, Quanle Liu, Yunchuan Sun, Xiuru Hu, Xinying He, Chengzhen X. CXCL14 inhibits the growth and promotes apoptosis of hepatocellular carcinoma cells via suppressing Akt/mTOR pathway. Journal of receptor and signal transduction research. vol 41. issue 6. 2021-10-11. PMID:33108937. |
overexpressed cxcl14 suppressed cell viability and growth, but promoted the apoptosis by upregulated bax and cleaved(c) caspase-3, donwregulated bcl-2 and the inhibition of akt and mtor phosphorylation. |
2021-10-11 |
2023-08-13 |
Not clear |
| Hui Lv, Jie Li, Yuqin Ch. miR-31 from adipose stem cell-derived extracellular vesicles promotes recovery of neurological function after ischemic stroke by inhibiting TRAF6 and IRF5. Experimental neurology. vol 342. 2021-10-11. PMID:33460643. |
similarly, in neuronal cell culture, mir-31 from adsc-derived evs reduced the expression of apoptosis-related factors cleaved caspase-3 and bax, increased the survival, and reduced apoptosis of neuronal cells after ogd. |
2021-10-11 |
2023-08-13 |
mouse |
| Rong Chen, Jennifer Tsai, Philip A Thompson, Yuling Chen, Ping Xiong, Chaomei Liu, Francis Burrows, Mariela Sivina, Jan A Burger, Michael J Keating, William G Wierda, William Plunket. The multi-kinase inhibitor TG02 induces apoptosis and blocks B-cell receptor signaling in chronic lymphocytic leukemia through dual mechanisms of action. Blood cancer journal. vol 11. issue 3. 2021-10-11. PMID:33714981. |
this mechanism of apoptosis was independent of cll prognostic factors or prior treatment history, but dependent on the expression of bax and bak. |
2021-10-11 |
2023-08-13 |
Not clear |
| Helen Y Wong, Queenie Hui, Zhenyue Hao, Garth L Warnock, Minna Woo, Dan S Luciani, Lucy Marzba. The role of mitochondrial apoptotic pathway in islet amyloid-induced β-cell death. Molecular and cellular endocrinology. vol 537. 2021-10-11. PMID:34400259. |
hiapp aggregation in ad-hiapp transduced ins-1 and human islet β-cells promoted cytochrome c release, caspase-9 activation and apoptosis, which were reduced by bax inhibitor. |
2021-10-11 |
2023-08-13 |
mouse |
| Pratyusha Mandal, Lynsey N Nagrani, Liliana Hernandez, Anita Louise McCormick, Christopher P Dillon, Heather S Koehler, Linda Roback, Emad S Alnemri, Douglas R Green, Edward S Mocarsk. Multiple Autonomous Cell Death Suppression Strategies Ensure Cytomegalovirus Fitness. Viruses. vol 13. issue 9. 2021-10-10. PMID:34578288. |
here, we expanded the understanding of three cell autonomous suppression mechanisms on which murine cytomegalovirus relies: (i) m38.5-encoded viral mitochondrial inhibitor of apoptosis (vmia), a bax suppressor that functions in concert with m41.1-encoded viral inhibitor of bak oligomerization (vibo), (ii) m36-encoded viral inhibitor of caspase-8 activation (vica), and (iii) m45-encoded viral inhibitor of rip/rhim activation (vira). |
2021-10-10 |
2023-08-13 |
Not clear |
| Massumeh Sanaei, Fraidoon Kavoos. Effect of Valproic Acid on the Class I Histone Deacetylase 1, 2 and 3, Tumor Suppressor Genes p21WAF1/CIP1 and p53, and Intrinsic Mitochondrial Apoptotic Pathway, Pro- (Bax, Bak, and Bim) and anti- (Bcl-2, Bcl-xL, and Mcl-1) Apoptotic Genes Expression, Cell Viability, and Apoptosis Induction in Hepatocellular Carcinoma HepG2 Cell Line. Asian Pacific journal of cancer prevention : APJCP. vol 22. issue S1. 2021-10-08. PMID:33576217. |
effect of valproic acid on the class i histone deacetylase 1, 2 and 3, tumor suppressor genes p21waf1/cip1 and p53, and intrinsic mitochondrial apoptotic pathway, pro- (bax, bak, and bim) and anti- (bcl-2, bcl-xl, and mcl-1) apoptotic genes expression, cell viability, and apoptosis induction in hepatocellular carcinoma hepg2 cell line. |
2021-10-08 |
2023-08-13 |
Not clear |
| Massumeh Sanaei, Fraidoon Kavoos. Effect of Valproic Acid on the Class I Histone Deacetylase 1, 2 and 3, Tumor Suppressor Genes p21WAF1/CIP1 and p53, and Intrinsic Mitochondrial Apoptotic Pathway, Pro- (Bax, Bak, and Bim) and anti- (Bcl-2, Bcl-xL, and Mcl-1) Apoptotic Genes Expression, Cell Viability, and Apoptosis Induction in Hepatocellular Carcinoma HepG2 Cell Line. Asian Pacific journal of cancer prevention : APJCP. vol 22. issue S1. 2021-10-08. PMID:33576217. |
the present study was designed to investigate the effect of vpa on the class i histone deacetylase (hdac) 1, 2 and 3, tsgs p21and p53, and intrinsic mitochondrial pathway, pro- (bax, bak, and bim) and anti- (bcl-2, bcl-xl, and mcl-1) apoptotic genes, viability, and apoptosis in hcc hepg2 cell line. |
2021-10-08 |
2023-08-13 |
Not clear |
| Linhao Xu, Yanli Bi, Yizhou Xu, Yihao Wu, Xiaoxue Du, Yixuan Mou, Jian Che. Suppression of CHOP Reduces Neuronal Apoptosis and Rescues Cognitive Impairment Induced by Intermittent Hypoxia by Inhibiting Bax and Bak Activation. Neural plasticity. vol 2021. 2021-10-08. PMID:34471408. |
suppression of chop reduces neuronal apoptosis and rescues cognitive impairment induced by intermittent hypoxia by inhibiting bax and bak activation. |
2021-10-08 |
2023-08-13 |
mouse |
| Wenjing Fei, Wei Jiao, Xiaoyan Feng, Xufeng Chen, Yuhai Wan. Intermittent hypoxia mimicking obstructive sleep apnea aggravates early brain injury following ICH via neuroinflammation and apoptosis. Molecular medicine reports. vol 24. issue 5. 2021-10-08. PMID:34558649. |
the results showed that osa induction decreased survival rate, neurological score and neuron survival and upregulated the protein expression levels of caspase‑3, bax, cytokines il‑1β, il‑6 and tnf‑α and nf‑κb, which indicated that osa‑mediated induction of apoptosis and neuroinflammation aggravated neuronal death following ich. |
2021-10-08 |
2023-08-13 |
mouse |
| Mao Zheng, Nanzhen Kuang, Xiaoping Zeng, Jieying Wang, Yu Zou, Yingyuan F. Daphnetin induces apoptosis in fibroblast-like synoviocytes from collagen-induced arthritic rats mainly via the mitochondrial pathway. Cytokine. vol 133. 2021-10-07. PMID:32505094. |
our results showed that dap markedly decreased cell viability and induced the apoptosis of cia-fls along with typical morphological and ultrastructural changes; moreover, dap increased fasl, cytochrome c (cyt-c), bax, caspase-3, caspase-8, and caspase-9 mrna expression and bax, caspase-3, caspase-8, and caspase-9 protein expression. |
2021-10-07 |
2023-08-13 |
rat |
| Mingchu Fang, Junhui Yuan, Shishuang Jiang, Yingying Hu, Shulin Pan, Jianghu Zhu, Xiaoqin Fu, Huai Jiang, Jian Lin, Peijun Li, Zhenlang Li. Dl-3-n-butylphthalide attenuates hypoxic-ischemic brain injury through inhibiting endoplasmic reticulum stress-induced cell apoptosis and alleviating blood-brain barrier disruption in newborn rats. Brain research. vol 1747. 2021-10-07. PMID:32763236. |
we further demonstrated an inhibitory effect of nbp on endoplasmic reticulum (er) stress-induced apoptosis, evidenced by reduction in er stress-related protein expressions (grp78, xbp-1, pdi and chop), decrease in tunel-positive cells, down-regulation in pro-apoptosis protein (bax and cleaved caspase-3), up-regulation in anti-apoptosis protein (bcl-2). |
2021-10-07 |
2023-08-13 |
human |
| Xiao Wei, Yijin Wu, Hao Tang, Bin Wang, Yong Wang, Wei Sun, James Asenso, Feng Xiao, Chun Wan. CP-25 ameliorates methotrexate induced nephrotoxicity via improving renal apoptosis and methotrexate excretion. Journal of pharmacological sciences. vol 146. issue 1. 2021-10-06. PMID:33858651. |
cp-25 prevented mtx induced apoptosis of renal tubular cells, and the effect was further confirmed by its regulatory effects on abnormal expression of bax, cleaved-caspase-3, cleaved-caspase-8, cyt-c, bcl-2. |
2021-10-06 |
2023-08-13 |
rat |
| Jianhua Qu, Yu Han, Ziyan Zhao, Yuan Wu, Ying Lu, Gang Chen, Junkang Jiang, Lianglin Qiu, Aihua Gu, Xinru Wan. Perfluorooctane sulfonate interferes with non-genomic estrogen receptor signaling pathway, inhibits ERK1/2 activation and induces apoptosis in mouse spermatocyte-derived cells. Toxicology. vol 460. 2021-10-05. PMID:34303733. |
gc-2 cells were treated with pfos (0, 50, 100 and 150 μm) for 24 h or 48 h. results demonstrated that pfos dose-dependently inhibited cell viability, induced g0/g1 cell cycle arrest and triggered apoptosis, which might be partly explained by the decrease in cyclin d1, pcna and bcl-2 protein expression; increase in bax protein expression; and activation of caspase-9, -3. |
2021-10-05 |
2023-08-13 |
mouse |
| Li Cao, Jie Zhao, Li Ma, Jiawen Chen, Jingru Xu, Sajid Ur Rahman, Shibin Feng, Yu Li, Jinjie Wu, Xichun Wan. Lycopene attenuates zearalenone-induced oxidative damage of piglet sertoli cells through the nuclear factor erythroid-2 related factor 2 signaling pathway. Ecotoxicology and environmental safety. vol 225. 2021-10-05. PMID:34482067. |
zea downregulated the relative mrna and protein expression of bcl-2 in piglet scs, promoted cell apoptosis, and upregulated the relative mrna and protein expression of lc3, beclin-1, and bax. |
2021-10-05 |
2023-08-13 |
Not clear |
| Li Cao, Jie Zhao, Li Ma, Jiawen Chen, Jingru Xu, Sajid Ur Rahman, Shibin Feng, Yu Li, Jinjie Wu, Xichun Wan. Lycopene attenuates zearalenone-induced oxidative damage of piglet sertoli cells through the nuclear factor erythroid-2 related factor 2 signaling pathway. Ecotoxicology and environmental safety. vol 225. 2021-10-05. PMID:34482067. |
moreover, after pretreatment with lyc, the mrna expression of bcl-2 was upregulated, the apoptosis rate was decreased, the relative mrna and protein expressions of lc3, beclin-1 and bax were downregulated, and autophagy was alleviated. |
2021-10-05 |
2023-08-13 |
Not clear |
| Shenli Zhang, Kunlin Ou, Jie Huang, Lu Fang, Chonggang Wan. In utero exposure to mixed PAHs causes heart mass reduction in adult male mice. Ecotoxicology and environmental safety. vol 225. 2021-10-05. PMID:34555720. |
the downregulated phosphatidylinositol 3-kinase and akt led to increased expression of caspase3, caspase9, bax and reduced expression of bcl-2, which was responsible for the increased cell apoptosis. |
2021-10-05 |
2023-08-13 |
mouse |
| Deqiang Li, Junlong Zhang, Lijun Yin, Zhen Jin, Xuejun Chen, Xiangxue Men. Etomidate inhibits cell proliferation and induces apoptosis in A549 non-small cell lung cancer cells via downregulating WWP2. Experimental and therapeutic medicine. vol 22. issue 5. 2021-10-05. PMID:34603522. |
eto also promoted cell apoptosis and decreased the expression of the anti-apoptotic protein bcl-2, whilst increasing that of pro-apoptotic proteins bax and cleaved caspase 3 in a dose-dependent manner. |
2021-10-05 |
2023-08-13 |
Not clear |