| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Diogo Sequeira, Pedro V Baptista, Ruben Valente, M Fátima M Piedade, M Helena Garcia, Tânia S Morais, Alexandra R Fernande. Cu(I) complexes as new antiproliferative agents against sensitive and doxorubicin resistant colorectal cancer cells: synthesis, characterization, and mechanisms of action. Dalton transactions (Cambridge, England : 2003). vol 50. issue 5. 2021-10-04. PMID:33470993. |
this oxidative mechanism corroborates the induction of reactive oxygen species (ros), that triggers hct116 cell death via apoptosis, as proved by the increased expression of bax protein relative to bcl-2 protein and the depolarization of mitochondrial membrane potential, and via autophagy. |
2021-10-04 |
2023-08-13 |
Not clear |
| Song Guo, Qihang Su, Junxiang Wen, Kai Zhu, Jun Tan, Qiang Fu, Guixin Su. S100A9 induces nucleus pulposus cell degeneration through activation of the NF-κB signaling pathway. Journal of cellular and molecular medicine. vol 25. issue 10. 2021-10-04. PMID:33734570. |
immunofluorescence staining and western blotting revealed that s100a9 induced np cell apoptosis in vitro by up-regulating the expression of pro-apoptotic markers, including cleaved caspase-3, cytochrome c and bax. |
2021-10-04 |
2023-08-13 |
Not clear |
| Li He, Liang Dong, Sujing Zhang, Yongqian Zhang, Zheng Zheng, Ying Guo, Liping Guo, Changwen B. Study of the radiosensitization of docetaxel in human esophageal squamous carcinoma ECA109 cell line. Pakistan journal of pharmaceutical sciences. vol 34. issue 3(Special). 2021-10-04. PMID:34602402. |
p21, bax, bcl-2 and other related proteins can regulate cell cycle phase distribution and induce cell apoptosis, thereby increasing the radiosensitivity effect of docetaxel in eca109 cell line. |
2021-10-04 |
2023-08-13 |
human |
| Mingliang Xu, Jianguo Feng, Mingxi Tang, Qingxi Guo, Jian Zhan, Fuzu Zhu, Hong Lei, Qingmei Kan. Blocking retrograde axonal transport of autophagosomes contributes to sevoflurane-induced neuron apoptosis in APP/PS1 mice. Acta neurologica Belgica. vol 121. issue 5. 2021-10-02. PMID:32385796. |
morris water maze experiment was used to test the learning and memory abilities of mice, flow cytometry was conducted to detect apoptosis and mitochondrial membrane potential of brain cells in mice, transmission electron microscopy was used to observe the number of autophagosomes at the axon in mice, and western blot was carried out to detect the expression of bax, bcl-2, lc3ii, p62, kif3b and dic proteins of brain cells in mice. |
2021-10-02 |
2023-08-13 |
mouse |
| Nrateng Tsotetsi, Daniel G Amoako, Anou M Somboro, Hezekiel M Khumalo, Rene B Kha. Molecular mechanisms underlying the renoprotective effects of 1,4,7-triazacyclononane: a βeta-lactamase inhibitor. Cytotechnology. vol 72. issue 5. 2021-10-02. PMID:32920746. |
likewise, decreased apoptosis was supported by the decreased phosphatidylserine, caspases, bax, cleaved parp, iap and nf-kb. |
2021-10-02 |
2023-08-13 |
human |
| Yanlin Jin, Yi Zhang, Xiaoming Lu. circRNA_PTPRA functions as a sponge of miR-582-3p to regulate hepatocellular carcinoma cell proliferation, migration, invasion and apoptosis. Experimental and therapeutic medicine. vol 22. issue 5. 2021-10-02. PMID:34594413. |
in addition, transfection of hcc cells with the mir-582-3p mimic promoted apoptosis by downregulating bcl-2 expression and upregulating bax expression in huh-7 cells. |
2021-10-02 |
2023-08-13 |
human |
| Yanlin Jin, Yi Zhang, Xiaoming Lu. circRNA_PTPRA functions as a sponge of miR-582-3p to regulate hepatocellular carcinoma cell proliferation, migration, invasion and apoptosis. Experimental and therapeutic medicine. vol 22. issue 5. 2021-10-02. PMID:34594413. |
furthermore, reduced hcc cell proliferation, migration and invasion, increased levels of cell apoptosis, upregulated bax expression and downregulated cyclin d1, mmp-9 and bcl-2 expression were all observed after knocking down circrna_ptpra. |
2021-10-02 |
2023-08-13 |
human |
| S Oka, X Li, F Zhang, C Taguchi, N Tewari, I-S Kim, L Zhong, K Arikawa, Y Liu, U K Bhawa. Oral toxicity to high level sodium fluoride causes impairment of autophagy. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society. vol 71. issue 5. 2021-10-01. PMID:33571967. |
hcem-2 cells exposed to 5 mm naf had decreased levels of autophagy, as shown by reduced expression levels of atg5, beclin-1 and lc3-ii, elicited apoptosis, which in turn induced oxidative stress and inflammation, as manifested by elevated levels of bax, cleaved caspase-3, sod1 and phospho nf-κb. |
2021-10-01 |
2023-08-13 |
mouse |
| Zhuohong Li, Juncai Tian, Lei Du, Ying Gao, Yao Wang, Fengming You, Li Wan. Anlotinib exerts anti-cancer efficiency on lung cancer stem cells in vitro and in vivo through reducing NF-κB activity. Journal of cellular and molecular medicine. vol 25. issue 12. 2021-10-01. PMID:33955683. |
in addition, anlotinib induced apoptosis of these cells along with down-regulated expression level of bcl-2 whereas up-regulated bax and cleaved caspase-3 expression. |
2021-10-01 |
2023-08-13 |
mouse |
| Jun-Min Liu, Min Li, Wei Luo, Hong-Bo Su. Curcumin attenuates Adriamycin-resistance of acute myeloid leukemia by inhibiting the lncRNA HOTAIR/miR-20a-5p/WT1 axis. Laboratory investigation; a journal of technical methods and pathology. vol 101. issue 10. 2021-10-01. PMID:34282279. |
overexpression of hotair reversed the regulatory effect of curcumin on apoptosis and migration and restored the effect of curcumin on inducing the expression of cleaved caspase3, bax, and p27. |
2021-10-01 |
2023-08-13 |
human |
| Min Yu, Xiaoyan Hu, Jingyu Yan, Ying Wang, Fei Lu, Junlei Chan. RIOK2 Inhibitor NSC139021 Exerts Anti-Tumor Effects on Glioblastoma via Inducing Skp2-Mediated Cell Cycle Arrest and Apoptosis. Biomedicines. vol 9. issue 9. 2021-10-01. PMID:34572430. |
in addition, nsc139021 also increased the apoptosis of glioblastoma cells by activating the p53 signaling pathway and increasing the levels of bax and cleaved caspase 3. |
2021-10-01 |
2023-08-13 |
mouse |
| Woo-Ju Song, Jang-Hyuk Yun, Myeong-Seon Jeong, Kil-Nam Kim, Taekyun Shin, Hyoung-Chun Kim, Myung-Bok Wi. Inhibitors of Lipoxygenase and Cyclooxygenase-2 Attenuate Trimethyltin-Induced Neurotoxicity through Regulating Oxidative Stress and Pro-Inflammatory Cytokines in Human Neuroblastoma SH-SY5Y Cells. Brain sciences. vol 11. issue 9. 2021-10-01. PMID:34573138. |
apoptosis induced by tmt was identified by altered expression of cleaved caspase-3, bax, bcl-2, and bcl-xl through western blot analysis. |
2021-10-01 |
2023-08-13 |
human |
| Saima Ali, Muhammad Rashid Khan, Riffat Batool, Sayed Afzal Shah, Javed Iqbal, Banzeer Ahsan Abbasi, Tabassum Yaseen, Nida Zahra, Adil Aldhahrani, Fayez Althobait. Characterization and phytochemical constituents of Periploca hydaspidis Falc crude extract and its anticancer activities. Saudi journal of biological sciences. vol 28. issue 10. 2021-10-01. PMID:34588860. |
phm induced apoptosis via downregulation of anti-apoptotic (survivin, b-cell lymphoma extra-large; bcl-xl, x-linked inhibitor of apoptosis protein; xiap, myelocytomatosis; c-myc), metastatic (matrix metallopeptidases 9/2; mmp9/2), and cell-cycle regulatory (cyclin d1 and e) proteins, whereas upregulation of pro-apoptotic proteins (bcl-2 homologous antagonist/killer; bak, bcl-2-associate x protein; bax, cleaved caspases; 3,7,8,9, and parp) and activation of mapk (jun amino-terminal kinase; jnk and p38) pathway. |
2021-10-01 |
2023-08-13 |
Not clear |
| Zuli Wang, Xiaowen Chen, Na Liu, Ying Shi, Yating Liu, Lianlian Ouyang, Samantha Tam, Desheng Xiao, Shuang Liu, Feiqiu Wen, Yongguang Ta. A Nuclear Long Non-Coding RNA LINC00618 Accelerates Ferroptosis in a Manner Dependent upon Apoptosis. Molecular therapy : the journal of the American Society of Gene Therapy. vol 29. issue 1. 2021-09-30. PMID:33002417. |
furthermore, linc00618 promotes apoptosis by increasing the levels of bcl2-associated x (bax) and cleavage of caspase-3. |
2021-09-30 |
2023-08-13 |
human |
| Ying Chen, Jiabing Shen, Chengxiao Ma, Maosheng Cao, Jianan Yan, Jingjing Liang, Kaifu Ke, Maohong Cao, Gu Xiaos. Skin-derived precursor Schwann cells protect SH-SY5Y cells against 6-OHDA-induced neurotoxicity by PI3K/AKT/Bcl-2 pathway. Brain research bulletin. vol 161. 2021-09-29. PMID:32360763. |
our results showed that the treatment with skp-scs prevented sh-sy5y cells from 6-ohda-induced apoptosis, accompanied by modulation of apoptosis-related proteins (bcl-2 and bax) and the decreased expression of active caspase-3. |
2021-09-29 |
2023-08-13 |
rat |
| Yan Huang, Yuanyuan Lin, Xiangxiang Song, Depei W. LINC00857 contributes to proliferation and lymphomagenesis by regulating miR-370-3p/CBX3 axis in diffuse large B-cell lymphoma. Carcinogenesis. vol 42. issue 5. 2021-09-29. PMID:33657224. |
linc00857 overexpression also suppressed dlbcl cell apoptosis as evidenced by elevated bcl-2 protein level, reduced bax and cleaved caspase-3 protein levels. |
2021-09-29 |
2023-08-13 |
human |
| Reham M Abd-Elsalam, Shymaa A El Badawy, Hanan A Ogaly, Faten M Ibrahim, Ola M Farag, Kawkab A Ahme. Eruca sativa seed extract modulates oxidative stress and apoptosis and up-regulates the expression of Bcl-2 and Bax genes in acrylamide-induced testicular dysfunction in rats. Environmental science and pollution research international. vol 28. issue 38. 2021-09-29. PMID:34024031. |
eruca sativa seed extract modulates oxidative stress and apoptosis and up-regulates the expression of bcl-2 and bax genes in acrylamide-induced testicular dysfunction in rats. |
2021-09-29 |
2023-08-13 |
rat |
| Jiankun Cui, Bo Zhang, Min Gao, Baohai Liu, Cong Dai, Yumei Dong, FanJi Men. The Protective Effect of Tetrahydroxystilbene Glucoside on High Glucose-Induced Injury in Human Umbilical Vein Endothelial Cells through the PI3K/Akt/eNOS Pathway and Regulation of Bcl-2/Bax. Journal of vascular research. vol 58. issue 5. 2021-09-29. PMID:34218226. |
in addition, we found that tsg not only increased the expression of bcl-2, while decreasing bax expression, but also activated phosphorylation of akt and endothelial nitric oxide synthase (enos) with subsequent nitric oxide production and ultimately reduced high glucose-induced apoptosis. |
2021-09-29 |
2023-08-13 |
human |
| Xueying Pei, Mingxu Chu, Peng Tang, Hongyan Zhang, Xinyu Zhang, Xiang Zheng, Jie Li, Jie Mei, Tao Wang, Shaowu Yi. Effects of acute hypoxia and reoxygenation on oxygen sensors, respiratory metabolism, oxidative stress, and apoptosis in hybrid yellow catfish "Huangyou-1". Fish physiology and biochemistry. vol 47. issue 5. 2021-09-29. PMID:34313912. |
the expressions of genes related to apoptosis (apaf-1, bax, caspase 3, caspase 9, and p53) were higher than those in control during hypoxic exposure, while the expressions of bcl-2 and cyt c were decreased. |
2021-09-29 |
2023-08-13 |
cat |
| Hongsong Li, Rong Li, Lijun Wang, Dingying Liao, Wenyi Zhang, Jianming Wan. Proanthocyanidins attenuate the high glucose-induced damage of retinal pigment epithelial cells by attenuating oxidative stress and inhibiting activation of the NLRP3 inflammasome. Journal of biochemical and molecular toxicology. vol 35. issue 9. 2021-09-29. PMID:34338401. |
moreover, pacs attenuated the high glucose-induced apoptosis, and the increased expression levels of caspase-3 and bax. |
2021-09-29 |
2023-08-13 |
Not clear |