| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hao-Chun Chang, Ran N Tao, Chong Teik Tan, Ya Jun Wu, Boon Huat Bay, Victor C Y. The BAX-binding protein MOAP1 associates with LC3 and promotes closure of the phagophore. Autophagy. vol 17. issue 11. 2021-12-11. PMID:33783314. |
apoptotic stimuli stabilize moap1 protein and facilitate its interaction with bax to promote apoptosis. |
2021-12-11 |
2023-08-13 |
Not clear |
| Shi-Ya Wang, Cao Zou, Xiao-Feng Liu, Yon-Jin Yan, Shun-Zhon Gu, Xun L. Vascular endothelial growth factor ameliorated palmitate-induced cardiomyocyte injury via JNK pathway. In vitro cellular & developmental biology. Animal. vol 57. issue 9. 2021-12-11. PMID:34791626. |
reduced apoptosis rate and expression of caspase 3, bax, and nf-κb p65 were observed in this process, while boosted bcl-2, p-jnk/jnk expression and activity of caspase 3 were checked. |
2021-12-11 |
2023-08-13 |
Not clear |
| Wang Lin, Honghui Guo, Liping Yang, Yu Kuang, Dapeng Li, Pinhong Yang, Li L. Alleviation of microcystin-LR-induced hepatic lipidosis and apoptosis in zebrafish by use of rice straw-derived biochar. Ecotoxicology and environmental safety. vol 229. 2021-12-11. PMID:34894426. |
the results indicated that sub-chronic mc-lr exposure induced hepatic lipidosis and apoptosis, including the formation of lipid droplets, significantly elevation of hepatic triglyceride (tg) level as well as significant upregulated expression of lipogenesis-related genes (foxo1a, elovl5, pparγ) and pro-apoptotic genes (bax, casp3). |
2021-12-11 |
2023-08-13 |
human |
| Ge Wu, Zhuang Tu, Fangfang Yang, Zihao Mai, Hongce Chen, Qiling Tang, Xianxin Ye, Kunhao Wang, Xiaoping Wang, Tongsheng Che. Evaluating the inhibitory priority of Bcl-xL to Bad, tBid and Bax by using live-cell imaging assay. Cytometry. Part A : the journal of the International Society for Analytical Cytology. vol 99. issue 11. 2021-12-10. PMID:33843148. |
fluorescence images of living cells co-expressing cfp-bcl-xl and yfp-bad or yfp-tbid or yfp-bax showed that bcl-xl markedly inhibited bad/tbid/bax-mediated apoptosis, revealing that bcl-xl inhibits the proapoptotic function of bad, tbid and bax. |
2021-12-10 |
2023-08-13 |
Not clear |
| Sisi Chen, Yunyan Du, Bin Xu, Qing Li, Le Yang, Zi Jiang, Zhaoxia Zeng, Leifeng Che. Vaccinia-related kinase 2 blunts sorafenib's efficacy against hepatocellular carcinoma by disturbing the apoptosis-autophagy balance. Oncogene. vol 40. issue 19. 2021-12-10. PMID:33875785. |
furthermore, vrk2-induced phosphorylation of bcl-2 promotes the interaction of bcl-2 with bax, thereby inhibiting apoptosis. |
2021-12-10 |
2023-08-13 |
Not clear |
| Wentong Li, Wenjuan Yu, Weichang Xu, Jianxian Xiong, Xuehong Zhong, Shuo Hu, Junjian Y. Death-Associated Protein Kinase 1 Regulates Oxidative Stress in Cardiac Ischemia Reperfusion Injury. Cells, tissues, organs. vol 210. issue 5-6. 2021-12-10. PMID:34348268. |
the apoptosis level (bax, bcl-2, cleaved caspase-3, and tunel staining) increased in the i/r group, and the dapk1 knockdown lentivirus could reverse the injury. |
2021-12-10 |
2023-08-13 |
cat |
| Rehab E Abdelrahman, Abdel Azeim A Khalaf, Mohamed A Elhady, Marwa A Ibrahim, Eman I Hassanen, Peter A Nosh. Quercetin ameliorates ochratoxin A-Induced immunotoxicity in broiler chickens by modulation of PI3K/AKT pathway. Chemico-biological interactions. vol 351. 2021-12-10. PMID:34717913. |
in addition, administration of ota resulted in apoptosis, which was evident by the increased expression level of pten, bax and caspase-3 genes and decreased expression level of pi3k, akt and bcl-2 genes. |
2021-12-10 |
2023-08-13 |
cat |
| Yi Liu, Jing Guo, June Zhang, Yunyun Deng, Guanghua Xiong, Jianpin Fu, Lili Wei, Huiqiang L. Chlorogenic acid alleviates thioacetamide-induced toxicity and promotes liver development in zebrafish (Danio rerio) through the Wnt signaling pathway. Aquatic toxicology (Amsterdam, Netherlands). vol 242. 2021-12-10. PMID:34856462. |
the results of western blotting analysis showed that cga inhibited cell apoptosis by increasing the levels of bcl2 apoptosis regulator and decreasing the levels of bcl2 associated x (bax), apoptosis regulator and tumor protein p53. |
2021-12-10 |
2023-08-13 |
cat |
| Dan Su, Chunye L. Hydroxysafflor yellow A inhibits the proliferation, migration, and invasion of colorectal cancer cells through the PPARγ/PTEN/Akt signaling pathway. Bioengineered. vol 12. issue 2. 2021-12-10. PMID:34889713. |
western blotting assay was utilized to observe the expression of proteins involved in cell apoptosis, migration, and peroxisome proliferator-activated receptor γ (pparγ)/pten/akt signaling, including pcna, bax, bcl-2, cleaved-caspase3, e-cadherin, n-cadherin, vimentin, pparγ, and phosphorylated (p)-akt. |
2021-12-10 |
2023-08-13 |
human |
| Decai Chi, Dong Wang, Minghui Zhang, Hui Ma, Fuhui Chen, Yajiao Su. CLEC12B suppresses lung cancer progression by inducing SHP-1 expression and inactivating the PI3K/AKT signaling pathway. Experimental cell research. vol 409. issue 2. 2021-12-09. PMID:34780782. |
over-expression of clec12b promoted lung cancer cell apoptosis, accompanied by decreased bcl-2 and increased bax, cleaved caspase-3 and cleaved caspase-9. |
2021-12-09 |
2023-08-13 |
Not clear |
| Hyun-Young Lee, Seon-Hee O. Arsenite-induced cytotoxicity is regulated by p38-SQSTM1/p62 and JNK-BNIP3L/Nix signaling in lung cancer cells. Biochemical and biophysical research communications. vol 587. 2021-12-09. PMID:34861471. |
arsenite exposure resulted in dose-dependent growth inhibition, which was associated with apoptosis, as demonstrated by depolarized mitochondrial membrane potential and cleavage of caspase-8, caspase-3, parp-1, and bax. |
2021-12-09 |
2023-08-13 |
Not clear |
| Hyun-Young Lee, Seon-Hee O. Arsenite-induced cytotoxicity is regulated by p38-SQSTM1/p62 and JNK-BNIP3L/Nix signaling in lung cancer cells. Biochemical and biophysical research communications. vol 587. 2021-12-09. PMID:34861471. |
in contrast, nix knockdown did not affect the p62 and lc3-ii levels but reduced caspase-8, caspase-3, and bax cleavage, indicating that nix accumulation resulted from its reduced autophagic degradation and promoted apoptosis. |
2021-12-09 |
2023-08-13 |
Not clear |
| Dania A Nava-Tapia, Lorena Cayetano-Salazar, Leonardo D Herrera-Zúñiga, Jorge Bello-Martínez, Miguel A Mendoza-Catalán, Napoleón Navarro-Tit. Brazilin: biological activities and therapeutic potential in chronic degenerative diseases and cancer. Pharmacological research. 2021-12-09. PMID:34883212. |
furthermore, it inhibits cell proliferation and induces apoptosis through increased expression of bcl-2, bcl-xl, p21, p27, activation of caspase-3 and -7, and the cleavage of parp and inhibiting the expression of bax. |
2021-12-09 |
2023-08-13 |
Not clear |
| Wei Han, Desong Kong, Qin Lu, Wei Zhang, Zhimin Fa. Aloperine inhibits colorectal cancer cell proliferation and metastasis progress via regulating miR-296-5p/STAT3 axis. Tissue & cell. vol 74. 2021-12-09. PMID:34883316. |
up-regulation of mir-296-5p and alo treatment both suppressed stat3 expression, inhibited crc cell proliferation, migration, invasion as well as the expressions of bcl-2 and n-cadherin, but promoted apoptosis and expressions of bax and e-cadherin, which were all reversed by overexpressed stat3. |
2021-12-09 |
2023-08-13 |
Not clear |
| Suzan M Hazzaa, Asmaa Gaber Abdou, Essam O Ibraheim, Esraa A Salem, Mohamad H A Hassan, Hesham A D Abdel-Raze. Effect of L-carnitine and atorvastatin on a rat model of ischemia-reperfusion injury of spinal cord. Journal of immunoassay & immunochemistry. vol 42. issue 6. 2021-12-08. PMID:33900902. |
astrogliosis was detected by gfap, and increased apoptosis was demonstrated by increasing bax and decreasing bcl-2. |
2021-12-08 |
2023-08-13 |
rat |
| Jarrod J Sandow, Iris Kl Tan, Alan S Huang, Shashank Masaldan, Jonathan P Bernardini, Ahmad Z Wardak, Richard W Birkinshaw, Robert L Ninnis, Ziyan Liu, Destiny Dalseno, Daisy Lio, Giuseppi Infusini, Peter E Czabotar, Andrew I Webb, Grant Dewso. Dynamic reconfiguration of pro-apoptotic BAK on membranes. The EMBO journal. vol 40. issue 20. 2021-12-08. PMID:34523147. |
bak and bax, the effectors of intrinsic apoptosis, each undergo major reconfiguration to an activated conformer that self-associates to damage mitochondria and cause cell death. |
2021-12-08 |
2023-08-13 |
Not clear |
| Sicon Mitra, Uttpal Anand, Rupa Sanyal, Niraj Kumar Jha, Tapan Behl, Avinash Mundhra, Arabinda Ghosh, Radha, Manoj Kumar, Jarosław Proćków, Abhijit De. Neoechinulins: Molecular, cellular, and functional attributes as promising therapeutics against cancer and other human diseases. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 145. 2021-12-08. PMID:34741824. |
alongside, it also inhibits cervical cancer cells by caspase-dependent apoptosis and via upregulation of apoptosis inducing genes like bax, it suppresses lps-induced inflammation in raw264.7 macrophages and acts as an antidepressant. |
2021-12-08 |
2023-08-13 |
human |
| Yong Huang, Ping He, Juan Din. Protein disulfide isomerase family 6 promotes the imatinib-resistance of renal cell carcinoma by regulation of Wnt3a-Frizzled1 axis. Bioengineered. vol 12. issue 2. 2021-12-08. PMID:34781823. |
secondly, cell proliferation of imatinib-resistant renal cell carcinoma cells was suppressed by pdia6 silencing, and the apoptosis was promoted with reduced bcl-2, enhanced bax and cleaved caspase-3. |
2021-12-08 |
2023-08-13 |
Not clear |
| Liyuan Yang, Chunfu Du, Hui Chen, Zhengwen Dia. Downregulation of Williams syndrome transcription factor (WSTF) suppresses glioblastoma cell growth and invasion by inhibiting PI3K/AKT signal pathway. European journal of histochemistry : EJH. vol 65. issue 4. 2021-12-08. PMID:34784707. |
additionally, gbm cell apoptosis was reduced by over-expression of wstf accompanied by decrease in bax and cleaved caspase-3, while promoted by silencing of wstf with increase in bax and cleaved caspase-3. |
2021-12-08 |
2023-08-13 |
Not clear |
| Heron F V Torquato, Manoel Trindade Rodrigues Junior, Cauê Santos Lima, Roberto Theodoro de Araujo Júnior, Fernanda Talhati, Dhebora Albuquerque Dias, Giselle Zenker Justo, Alice Teixeira Ferreira, Ronaldo Aloise Pilli, Edgar J Paredes-Gamer. A canthin-6-one derivative induces cell death by apoptosis/necroptosis-like with DNA damage in acute myeloid cells. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 145. 2021-12-08. PMID:34808555. |
our results identify reactive oxygen species production, mitochondrial depolarization, annexin v-fitc/7-aad double staining, caspase cleave and upregulation of mitochondria-dependent apoptosis proteins (bax, bim, bik, puma and phosphorylation of p53) for both cell lineages. |
2021-12-08 |
2023-08-13 |
Not clear |