| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mingna Li, Weiwei Liang, Caiye Zhu, Shizhen Qi. Smad4 Mediates Bmf Involvement in Sheep Granulosa Cell Apoptosis. Gene. 2022-01-22. PMID:35063577. |
we found that the proliferation rate of sheep gcs was significantly increased after the knockdown of bmf, whereas overexpressing bmf increased the apoptosis rate of gcs, results also verified by the expression patterns of pcna, bcl-2, and bax genes. |
2022-01-22 |
2023-08-13 |
mouse |
| Qiling Tang, Hongce Chen, Zihao Mai, Han Sun, LingJun Xu, Guihao Wu, Zhuang Tu, Xuecheng Cheng, Xiaoping Wang, Tongsheng Che. Bim- and Bax-mediated mitochondrial pathway dominates abivertinib-induced apoptosis and ferroptosis. Free radical biology & medicine. 2022-01-22. PMID:35063650. |
moreover, knockout of bim or bax not only remarkably inhibited ac-induced apoptosis, but also markedly inhibited ac-triggered downregulation of slc711 and gpx4, accumulation of lipid ros, and damage to the plasma membrane. |
2022-01-22 |
2023-08-13 |
Not clear |
| Gi Dae Ki. Harmine Hydrochloride Triggers G2/M Cell Cycle Arrest and Apoptosis in HCT116 Cells through ERK and PI3K/AKT/mTOR Signaling Pathways. Preventive nutrition and food science. vol 26. issue 4. 2022-01-20. PMID:35047441. |
hmh mediated apoptosis by downregulating expression of apoptotic proteins (such as caspase-3, caspase-9, and parp) and the anti-apoptotic protein bcl-2 and by inducing expression of bax, a pro-apoptotic protein. |
2022-01-20 |
2023-08-13 |
human |
| Yadong Zhou, Fafu Dou, Huwei Song, Tao Li. Anti-ulcerative effects of wogonin on ulcerative colitis induced by dextran sulfate sodium via Nrf2/TLR4/NF-κB signaling pathway in BALB/c mice. Environmental toxicology. 2022-01-19. PMID:35044701. |
wogonin activates apoptosis via inhibiting bcl-2 and augmenting bax, caspase-3, and -9 expressions. |
2022-01-19 |
2023-08-13 |
mouse |
| Xin Xie, Hua Yang, Wenjun Yang, Tingshu Jian. Euphorbia angustifolia lactone B inhibits A549 proliferation and induces apoptosis. Pakistan journal of pharmaceutical sciences. vol 34. issue 6(Special). 2022-01-18. PMID:35039251. |
the content of cytochrome c (cyt c) protein and the expression quantity of bcl-2, bax, p-erk1/2, and p-akt proteins were detected by western blot and the apoptosis rates were detected by flow cytometry. |
2022-01-18 |
2023-08-13 |
Not clear |
| Ping-Ting Mao, Wei-Bao He, Xi Mai, Li-Hua Feng, Na Li, Yi-Jing Liao, Cai-Sheng Zhu, Jian Li, Ting Chen, Shu-Hao Liu, Qi-Ming Zhang, Ling H. Synthesis and biological evaluation of aminobenzamides containing purine moiety as class I histone deacetylases inhibitors. Bioorganic & medicinal chemistry. vol 56. 2022-01-18. PMID:35041998. |
further biological validation demonstrated that 9d prevented cell transition from g1 phase to s phase by reducing cyclin d1, cdk2 and lifting p21, induced early apoptosis by upregulating bax and downregulating bcl-2 in hct-116 cells. |
2022-01-18 |
2023-08-13 |
Not clear |
| Bingqiang Xu, Juedan Li, Xiaolong Chen, Mingqing Ko. Puerarin attenuates cisplatin-induced apoptosis of hair cells through the mitochondrial apoptotic pathway. Biochimica et biophysica acta. Molecular cell research. 2022-01-15. PMID:35032475. |
mechanistic studies revealed that puerarin attenuated mitochondrial apoptosis pathway by regulating apoptotic related proteins, such as bax and cleaved caspase-3, and attenuated ros accumulation after cisplatin damage. |
2022-01-15 |
2023-08-13 |
mouse |
| Min Yao, Gan Li, Long-Yun Zhou, Zhong Zheng, Yue-Li Sun, Shu-Fen Liu, Yong-Jun Wang, Xue-Jun Cu. Shikonin inhibits neuronal apoptosis via regulating endoplasmic reticulum stress in the rat model of double-level chronic cervical cord compression. Cell biology and toxicology. 2022-01-14. PMID:35028790. |
the result showed that er stress-related upregulation of perk-eif2α-chop resulted in rat neuronal apoptosis after chronic cervical cord compression; then, shikonin promoted motor recovery and inhibited neuronal apoptosis by attenuating perk-eif2α-chop and prevented bax translocation from cytoplasm to mitochondrion induced by chop of neurons in rats with chronic compression. |
2022-01-14 |
2023-08-13 |
rat |
| Peng Zheng, Xue Qin, Rui Feng, Qi Li, Fushuo Huang, Yulong Li, Qian Zhao, He Huan. Alleviative effect of melatonin on the decrease of uterine receptivity caused by blood ammonia through ROS/NF-κB pathway in dairy cow. Ecotoxicology and environmental safety. vol 231. 2022-01-14. PMID:35030520. |
cell viability, apoptosis, oxidative stress and mitochondrial membrane potential were measured and the expression of apoptosis-related genes (p53, cyt-c, bax, bcl-2, caspase-8, caspase-9 and caspase-3), uterus receptivity related genes (vegf, lif and egf) and inflammatory factors (tlr-4, il-6 and nf-κb) were detected. |
2022-01-14 |
2023-08-13 |
cattle |
| Peng Zheng, Xue Qin, Rui Feng, Qi Li, Fushuo Huang, Yulong Li, Qian Zhao, He Huan. Alleviative effect of melatonin on the decrease of uterine receptivity caused by blood ammonia through ROS/NF-κB pathway in dairy cow. Ecotoxicology and environmental safety. vol 231. 2022-01-14. PMID:35030520. |
the results showed that ammonia significantly increased intracellular ros level, mrna and protein expression of bax, p53, cyt-c, caspase-9, caspase-8, caspase-3, tlr-4, nf-κb and il-6, promoted cell apoptosis, while decreased mitochondrial membrane potential, the mrna and protein expression of vegf and egf. |
2022-01-14 |
2023-08-13 |
cattle |
| Yang Yang, Yongjian Wu, Xiaojun Meng, Zhiying Wang, Muhammad Younis, Ye Liu, Peihui Wang, Xi Huan. SARS-CoV-2 membrane protein causes the mitochondrial apoptosis and pulmonary edema via targeting BOK. Cell death and differentiation. 2022-01-13. PMID:35022571. |
m protein induced bok to trigger apoptosis in the absence of bax and bak. |
2022-01-13 |
2023-08-13 |
mouse |
| Beibei Sha, Yaxin Sun, Shan Zhao, Miaomiao Li, Wenjing Huang, Zheng Li, Jianxiang Shi, Xuefei Han, Pei Li, Tao Hu, Ping Che. USP8 inhibitor-induced DNA damage activates cell cycle arrest, apoptosis, and autophagy in esophageal squamous cell carcinoma. Cell biology and toxicology. 2022-01-13. PMID:35022897. |
dub-in-1, an usp8 inhibitor, caused dna damage, led to g2/m phase block by p53-p21 axis, and triggered apoptosis by regulating the p53 target proteins including bax, noxa, and puma. |
2022-01-13 |
2023-08-13 |
Not clear |
| Beibei Sha, Yaxin Sun, Shan Zhao, Miaomiao Li, Wenjing Huang, Zheng Li, Jianxiang Shi, Xuefei Han, Pei Li, Tao Hu, Ping Che. USP8 inhibitor-induced DNA damage activates cell cycle arrest, apoptosis, and autophagy in esophageal squamous cell carcinoma. Cell biology and toxicology. 2022-01-13. PMID:35022897. |
dub-in-1 treatment led to g2/m cell cycle arrest by upregulating the protein level of p21 and triggered apoptosis by modulating the p53 target proteins including bax, noxa, and puma. |
2022-01-13 |
2023-08-13 |
Not clear |
| Andreas Jenner, Aida Peña-Blanco, Raquel Salvador-Gallego, Begoña Ugarte-Uribe, Cristiana Zollo, Tariq Ganief, Jan Bierlmeier, Marcus Mund, Jason E Lee, Jonas Ries, Dirk Schwarzer, Boris Macek, Ana J Garcia-Sae. DRP1 interacts directly with BAX to induce its activation and apoptosis. The EMBO journal. 2022-01-13. PMID:35023587. |
drp1 interacts directly with bax to induce its activation and apoptosis. |
2022-01-13 |
2023-08-13 |
Not clear |
| Andreas Jenner, Aida Peña-Blanco, Raquel Salvador-Gallego, Begoña Ugarte-Uribe, Cristiana Zollo, Tariq Ganief, Jan Bierlmeier, Marcus Mund, Jason E Lee, Jonas Ries, Dirk Schwarzer, Boris Macek, Ana J Garcia-Sae. DRP1 interacts directly with BAX to induce its activation and apoptosis. The EMBO journal. 2022-01-13. PMID:35023587. |
the apoptotic executioner protein bax and the dynamin-like protein drp1 co-localize at mitochondria during apoptosis to mediate mitochondrial permeabilization and fragmentation. |
2022-01-13 |
2023-08-13 |
Not clear |
| Andreas Jenner, Aida Peña-Blanco, Raquel Salvador-Gallego, Begoña Ugarte-Uribe, Cristiana Zollo, Tariq Ganief, Jan Bierlmeier, Marcus Mund, Jason E Lee, Jonas Ries, Dirk Schwarzer, Boris Macek, Ana J Garcia-Sae. DRP1 interacts directly with BAX to induce its activation and apoptosis. The EMBO journal. 2022-01-13. PMID:35023587. |
here, we show that bax and drp1 physically interact, and that this interaction is enhanced during apoptosis. |
2022-01-13 |
2023-08-13 |
Not clear |
| Andreas Jenner, Aida Peña-Blanco, Raquel Salvador-Gallego, Begoña Ugarte-Uribe, Cristiana Zollo, Tariq Ganief, Jan Bierlmeier, Marcus Mund, Jason E Lee, Jonas Ries, Dirk Schwarzer, Boris Macek, Ana J Garcia-Sae. DRP1 interacts directly with BAX to induce its activation and apoptosis. The EMBO journal. 2022-01-13. PMID:35023587. |
forced dimerization of bax and drp1 triggers their activation and translocation to mitochondria, where they induce mitochondrial remodeling and permeabilization to cause apoptosis even in the absence of apoptotic triggers. |
2022-01-13 |
2023-08-13 |
Not clear |
| Andreas Jenner, Aida Peña-Blanco, Raquel Salvador-Gallego, Begoña Ugarte-Uribe, Cristiana Zollo, Tariq Ganief, Jan Bierlmeier, Marcus Mund, Jason E Lee, Jonas Ries, Dirk Schwarzer, Boris Macek, Ana J Garcia-Sae. DRP1 interacts directly with BAX to induce its activation and apoptosis. The EMBO journal. 2022-01-13. PMID:35023587. |
based on this, we propose that drp1 can promote apoptosis by acting as noncanonical direct activator of bax through physical contacts with its n-terminal region. |
2022-01-13 |
2023-08-13 |
Not clear |
| Yige Yu, Xiu Xin, Feifei Ma, Xiaoheng Li, Yiyan Wang, Qiqi Zhu, Haiqiong Chen, Huitao Li, Ren-Shan G. Bisphenol AF blocks Leydig cell regeneration from stem cells in male rats. Environmental pollution (Barking, Essex : 1987). 2022-01-13. PMID:35026324. |
it induced apoptosis and autophagy by increasing the levels of bax, lc3b, and beclin1 and lowering the levels of bcl2 and p62 at 100 and 200 mg/kg. |
2022-01-13 |
2023-08-13 |
rat |
| Hui Wang, Yanbing Liu, Ziyu Guo, Kexin Wu, Yunhao Zhang, Yanan Tian, Baoyu Zhao, Hao L. Aconitine induces cell apoptosis via mitochondria and death receptor signaling pathways in hippocampus cell line. Research in veterinary science. vol 143. 2022-01-13. PMID:35026629. |
aconitine treatment induced apoptosis in ht22 cells and we found aconitine induced apoptosis by upregulating the expression of bax, cyto c, apaf-1, caspase9, fas, fas-l, fadd, caspase8, caspase3 with concomitant decreasing of bcl-2 and bid expression. |
2022-01-13 |
2023-08-13 |
Not clear |