| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Chandramouli Ghosh, Neha Gupta, Abhik Mallick, Manas Kumar Santra, Sudipta Bas. Self-Assembled Glycosylated Chalcone-Boronic Acid Nanodrug Exhibits Anticancer Activity through Mitochondrial Impairment. ACS applied bio materials. vol 1. issue 2. 2022-01-12. PMID:35016390. |
in addition, it also induces apoptosis, primarily due to the inhibition of bcl-2/bcl-xl and the augmentation of bax to prompt mitochondrial damage and reactive oxygen species generation. |
2022-01-12 |
2023-08-13 |
Not clear |
| Zhen Wang, Xiaoyan Du, Daoyang Yu, Yang Yang, Gaoen Ma, Xueli Jia, Lulu Chen. Sufentanil alleviates cerebral ischemia-reperfusion injury by inhibiting inflammation and protecting the blood-brain barrier in rats. European journal of histochemistry : EJH. vol 66. issue 1. 2022-01-12. PMID:35016494. |
finally, we clarified the apoptosis of brain tissue through the tunel staining and the detection of caspase3, bcl2 and bax. |
2022-01-12 |
2023-08-13 |
rat |
| Zhen Wang, Xiaoyan Du, Daoyang Yu, Yang Yang, Gaoen Ma, Xueli Jia, Lulu Chen. Sufentanil alleviates cerebral ischemia-reperfusion injury by inhibiting inflammation and protecting the blood-brain barrier in rats. European journal of histochemistry : EJH. vol 66. issue 1. 2022-01-12. PMID:35016494. |
suf also inhibited caspase3 and bax rats and promoted bcl2 in mcao rats, thus inhibiting cell apoptosis. |
2022-01-12 |
2023-08-13 |
rat |
| H C Yang, Z K Xing, H Shao, X W Tan, E Q Wang, Y Liao, H J Chen, X W Wu, X L Chen, S J Zhan. The expression of cytokeratin and apoptosis-related molecules in echinococcosis related liver injury. Molecular and biochemical parasitology. 2022-01-12. PMID:35016896. |
cell counting kit-8 was used to detect cell proliferation, flow cytometry was used to detect hepatocyte apoptosis, and western blot was used to quantify cytokeratin and apoptosis-related proteins, such as caspase3, caspase9, bcl-2, and bax. |
2022-01-12 |
2023-08-13 |
mouse |
| H C Yang, Z K Xing, H Shao, X W Tan, E Q Wang, Y Liao, H J Chen, X W Wu, X L Chen, S J Zhan. The expression of cytokeratin and apoptosis-related molecules in echinococcosis related liver injury. Molecular and biochemical parasitology. 2022-01-12. PMID:35016896. |
echinococcus granulosus and echinococcus multilocularis in the co-culture model in vitro could promote the expression of ck, caspase3, caspase9, and bax protein, decrease the expression of bcl-2, promote hepatocyte apoptosis, and inhibit cell proliferation; in clinical samples, we found that compared with that in the normal tissues, the expression of cytokeratin, caspase3, caspase9, and bax in echinococcus tissues was high, but that in bcl-2 was low. |
2022-01-12 |
2023-08-13 |
mouse |
| Jianli Yu, Yang Guo, Yi Gu, Fei Li, Haipeng Song, Rui Nian, Xiying Fan, Wenshuai Li. Targeting and neutralizing human epididymis protein 4 by novel nanobodies to suppress ovarian cancer cells and attenuate cisplatin resistance. International journal of biological macromolecules. 2022-01-12. PMID:35016970. |
treatment with the anti-he4 nanobody 1g8 decreased bcl-2 expression and increased bax, cleaved parp, and p53 levels, resulting in apoptosis of ovcar3 cells. |
2022-01-12 |
2023-08-13 |
human |
| Dong Zhao, Yueting Ho. Long non-coding RNA nuclear-enriched abundant transcript 1 (LncRNA NEAT1) upregulates Cyclin T2 (CCNT2) in laryngeal papilloma through sponging miR-577/miR-1224-5p and blocking cell apoptosis. Bioengineered. vol 13. issue 1. 2022-01-11. PMID:35012431. |
notably, ccnt2 knockdown blocked lnc-neat1-induced lp cell proliferation, and rescued cell apoptosis, which was specifically indicated by restoration of bax, cleaved caspase 3 and cleaved caspase 9. |
2022-01-11 |
2023-08-13 |
Not clear |
| Mahsa Toolabi, Fatemeh Safari, Adileh Ayati, Parnian Fathi, Setareh Moghimi, Somayeh Salarinejad, Roham Foroumadi, Shima H M E Ketabforoosh, Alireza Foroumad. Synthesis of novel 2-acetamide-5-phenylthio-1,3,4-thiadiazole-containing phenyl urea derivatives as potential VEGFR-2 inhibitors. Archiv der Pharmazie. 2022-01-11. PMID:35014090. |
further assessment by western blot analysis assay confirmed the induction of apoptosis by compound 9e, with upregulation of bax and downregulation of bcl-2 proteins in a431 cancer cells. |
2022-01-11 |
2023-08-13 |
human |
| Jianlin Chen, Zijiong Dong, Yang Lei, Yanjian Yang, Zheng Guo, Jianmin Y. β-glucan mitigation on toxicological effects in monocytes/macrophages of Nile tilapia (Oreochromis niloticus) following copper exposure. Fish & shellfish immunology. 2022-01-09. PMID:34998984. |
copper induced mo/mФ underwent apoptosis through mitochondrial signaling pathway by mitochondrial membrane potential (ΔΨm) detection and bax, bcl-2, cyt-c, apaf-1, caspase 9, caspase 3 genes validation. |
2022-01-09 |
2023-08-13 |
Not clear |
| Nadeeya Mad-Adam, Thidarath Rattanaburee, Tanotnon Tanawattanasuntorn, Potchanapond Graidis. Effects of trans-(±)-kusunokinin on chemosensitive and chemoresistant ovarian cancer cells. Oncology letters. vol 23. issue 2. 2022-01-07. PMID:34992691. |
moreover, western blot analysis was performed to determine the proteins level of topoisomerase ii, cyclin d1, cdk1, bax and p53-upregulated modulator of apoptosis (puma). |
2022-01-07 |
2023-08-13 |
Not clear |
| Xiao-Jing Liu, Yu-Qi Wang, Shao-Qian Shang, Shiwen Xu, Mengyao Gu. TMT induces apoptosis and necroptosis in mouse kidneys through oxidative stress-induced activation of the NLRP3 inflammasome. Ecotoxicology and environmental safety. vol 230. 2022-01-07. PMID:34995909. |
the expression of apoptosis (bcl-2, bax, caspase-3, caspase-9) and necroptosis (ripk1, ripk33, mlkl, caspase-8) increased.in addition, hek293t human embryonic kidney cells were treated with trimethyltin chloride, and the results were similar to the tissue. |
2022-01-07 |
2023-08-13 |
mouse |
| Luxi Lin, Pengfei Fu, Nuoman Chen, Ningyu Gao, Qinqin Cao, Ke Yue, Tingting Xu, Chaodong Zhang, Cai Zhang, Fang Liu, Xuebing Wang, Shucheng Huan. Total flavonoids of Rhizoma Drynariae protect hepatocytes against aflatoxin B1-induced oxidative stress and apoptosis in broiler chickens. Ecotoxicology and environmental safety. vol 230. 2022-01-07. PMID:34995912. |
at the same time, tfrd treatment inhibited afb1-induced apoptosis and significantly changed mrna expression of apoptosis-related genes, including pi3k, akt, bax, and bcl-2 (p < 0.05). |
2022-01-07 |
2023-08-13 |
cat |
| Xiangjun Shi, Yanzhe Wei, Xingchen Yao, Boran Du, Xiaoguang Wu, Xiangyu Kong, Xinru D. In vivo antitumor efficacy of 17-AAG loaded PMMA in a human multiple myeloma xenograft mouse model. Clinical and experimental medicine. 2022-01-06. PMID:34989932. |
in addition, 17-aag-loaded pmma promotes mm apoptosis by downregulating bax and active caspase-3. |
2022-01-06 |
2023-08-13 |
mouse |
| Meng Wang, Fan Zhan, Hui Cheng, Qinglin L. Gambogenic Acid Inhibits Basal Autophagy of Drug-Resistant Hepatoma Cells and Improves Its Sensitivity to Adriamycin. Biological & pharmaceutical bulletin. vol 45. issue 1. 2022-01-04. PMID:34980780. |
cell viability test represented that gna could improve the sensitivity of hepatoma drug-resistant cell line bel-7402/adm to adriamycin (adm), and further study by 4',6-diamidino-2-phenylindole (dapi) staining and flow cytometry found that gna could improve the effect of adm on promoting apoptosis in bel-7402/adm cells, and the activation of apoptosis-related protein was significantly increased, and the ratio of bax to bcl-2 was significantly increased. |
2022-01-04 |
2023-08-13 |
Not clear |
| Wagner J Fávaro, Eduardo A R Socca, Petra K Böckelmann, Ianny B Reis, Patrick V Garcia, Nelson Durá. Impact of intravesical instillation of a novel biological response modifier (P-MAPA) on progress of non-muscle invasive bladder cancer treatment in a rat model. Medical oncology (Northwood, London, England). vol 39. issue 2. 2022-01-04. PMID:34982270. |
in addition, rats treated with p-mapa intravesical immunotherapy showed the highest bax protein levels and the lowest proliferation/apoptotic ratio in relation to bcg-treated rats, pointing out a preponderance of apoptosis. |
2022-01-04 |
2023-08-13 |
rat |
| Nicholas A Smith, Ahmad Z Wardak, Angus D Cowan, Peter M Colman, Peter E Czabotar, Brian J Smit. Bak Core Dimer Focusses Triacylglycerides in the Membrane. Biophysical journal. 2022-01-02. PMID:34973947. |
apoptosis, the intrinsic programmed cell death process, is mediated by bcl-2 family members bak and bax. |
2022-01-02 |
2023-08-13 |
Not clear |
| Deepa Geethakumari, Anoop Bhaskaran Sathyabhama, Krishnapriya Raji Sathyan, Dhaneesha Mohandas, Jisha V Somasekharan, Sajeevan Thavarool Puthiyedath. Folate Functionalized Chitosan Nanoparticles as Targeted Delivery Systems for improved anticancer efficiency of Cytarabine in MCF-7 human breast cancer cell lines. International journal of biological macromolecules. 2022-01-02. PMID:34973988. |
the relative fold of expression of genes involved in apoptosis such as bax, cyt c and cas 9 were upregulated. |
2022-01-02 |
2023-08-13 |
human |
| T Barczi, P Brody, M Klein, I Varga, L Bies Pivackova, P Krenek, P Janega, P Baba. Proapoptotic and antiapoptotic stimuli alternation in myocardial infarction experimental model. Bratislavske lekarske listy. vol 123. issue 1. 2021-12-30. PMID:34967654. |
keywords: myocardial infarction, isoprenaline, apoptosis, necrosis, bcl-2, bax. |
2021-12-30 |
2023-08-13 |
rat |
| Xiaoliang Bai, Yong Lian, Changqing Hu, Shuai Yang, Bo Pei, Mingyan Yao, Xiaojuan Zhu, Lin Shang, Zhihong L. Cyanidin-3-glucoside protects against high glucose-induced injury in human nucleus pulposus cells by regulating the Nrf2/HO-1 signaling. Journal of applied toxicology : JAT. 2021-12-29. PMID:34964128. |
hg-induced cell apoptosis of hnpcs was attenuated by c3g with decreased apoptotic rate and relative levels of cl-caspase-3/caspase-3, bax, and bim. |
2021-12-29 |
2023-08-13 |
human |
| Zheng Bao, Li Bao, Na Han, Yueyun Hou, Fumin Fen. rTMS alleviates AD-induced cognitive impairment by inhibitng apoptosis in SAMP8 mouse. Aging. vol 13. issue undefined. 2021-12-29. PMID:34965216. |
in addition, rtms reduced apoptosis of neurons caused by ad and the expression of pro-apoptotic proteins (caspase-3 and bax) and increased the expression of an antiapoptotic protein (bcl-2). |
2021-12-29 |
2023-08-13 |
mouse |