| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Junqing Qian, Jinqiu Zhang, Yan Chen, Chengen Dai, Jing Fan, Hui Gu. Hypoglycemic activity and mechanisms of myricetin. Natural product research. 2022-04-04. PMID:35369824. |
moreover, myricetin protected pancreatic tissue from hfd fed stz induced apoptosis through regulation of bcl-2 associated x (bax) gene and b-cell lymphoma-2 (bcl-2) gene. |
2022-04-04 |
2023-08-13 |
rat |
| Qingfei Xiao, Ying Zhao, Lei Ma, Rongli Pia. Orientin reverses acetaminophen-induced acute liver failure by inhibiting oxidative stress and mitochondrial dysfunction. Journal of pharmacological sciences. vol 149. issue 1. 2022-04-04. PMID:35369900. |
moreover, ori regulated apap-induced hepatocyte apoptosis and mitochondrial dysfunction by inhibiting cytochrome c mitochondrial translocation and c-jun n-terminal kinase phosphorylation, promoting bcl-2 expression and reducing bax and caspase-3 cleavage. |
2022-04-04 |
2023-08-13 |
mouse |
| Zhili Rao, Xiangyu Li, Xia Zhang, Jiuseng Zeng, Baojun Wang, Ruocong Yang, Nan Zen. Fengreqing Oral Liquid Exerts Anti-Inflammatory Effects by Promoting Apoptosis and Inhibiting PI3K/AKT and NF-κB Signaling Pathways. Frontiers in pharmacology. vol 13. 2022-04-04. PMID:35370749. |
in addition, the results showed that fol induced apoptosis in lps-induced raw264.7 cells at the level of 80%-90%, and significantly increased the protein expression levels of the pro-apoptotic bax and cleaved-caspase-3. |
2022-04-04 |
2023-08-13 |
mouse |
| Hong Wu, Lidong Xu, Xun H. KDM5A regulates the growth and gefitinib drug resistance against human lung adenocarcinoma cells. 3 Biotech. vol 12. issue 4. 2022-04-04. PMID:35371900. |
the induction of apoptosis in sk-lu-1 lung adenocarcinoma cells was concomitant with upregulation of bax and downregulation of bcl-2 expression. |
2022-04-04 |
2023-08-13 |
human |
| Qian Wang, Yue-Yue Wan, Na Li, Pengpai Zhang, Kai Guo, Bo Li. The Mechanism Underlying the Regulation of LncRNA-ASLNC18810 Involved in the Abnormal Function of Vascular Endothelial Cell in Atherosclerosis: Its Function as a microRNA (miRNA) Sponge for miR-559. Journal of cardiovascular translational research. 2022-04-04. PMID:35377130. |
when aslnc18810 is low or missing, hif-1α indirectly negatively regulates the bax in post-transcription through hif-1α/mir-559/bax pathway which makes ecs acquire apoptosis resistance and form arecs. |
2022-04-04 |
2023-08-13 |
Not clear |
| ZhiFu Li, DongDong Meng, YongYi Liu, FangGang Bi, Ke Tian, JianZhong Xu, JianGuang Sun, ChenXi Gu, Yu L. Circular RNA VMA21 ameliorates IL-1β-engendered chondrocyte injury through the miR-495-3p/FBWX7 signaling axis. Clinical immunology (Orlando, Fla.). 2022-04-04. PMID:35378300. |
forced expression of circvma21 heightened cell viability and attenuated cell apoptosis, accompanied by upregulation of bcl-2, and downregulation of bax and c-caspase-3 in c28/i2 cells in response to il-1β exposure. |
2022-04-04 |
2023-08-13 |
human |
| Gan Rao, Gaolong Zhong, Ting Hu, Shaofeng Wu, Jiajia Tan, Xiaoyong Zhang, Riming Huang, Zhaoxin Tang, Lianmei H. Arsenic Trioxide Triggers Mitochondrial Dysfunction, Oxidative Stress, and Apoptosis via Nrf 2/Caspase 3 Signaling Pathway in Heart of Ducks. Biological trace element research. 2022-04-03. PMID:35366752. |
at the same time, ato induced apoptosis which not only upregulated the expression levels of mrna and proteins (caspase 3, cyt-c, p53, bax) but also decreased the mrna and protein expression level of bcl-2. |
2022-04-03 |
2023-08-13 |
human |
| Tao Sun, Di Wang, Baoying Wang, Xianghua Liu, Ningning Li, Ke Sh. Melatonin attenuates cisplatin-induced acute kidney injury in mice: Involvement of PPARα and fatty acid oxidation. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2022-04-03. PMID:35367536. |
melatonin not only partially modulated fao via pparα signaling, but also decreased cisplatin-induced apoptosis by inhibiting the caspase-3, -9 and bax pathways. |
2022-04-03 |
2023-08-13 |
mouse |
| Hong-Shuang Liu, Man-Yu Zhou, Xi Zhang, Ya-Lan Li, Jing-Wei Kong, Xin Gao, Dong-Yu Ge, Jia-Jing Liu, Pei-Guang Ma, Gui-Ying Peng, Yan Lia. Sagittaria sagittifolia polysaccharide protects against six-heavy-metal-induced hepatic injury associated with the activation of Nrf2 pathway to regulate oxidative stress and apoptosis. Journal of inorganic biochemistry. vol 232. 2022-04-03. PMID:35367820. |
besides, ssp can attenuates apoptosis through reducing the protein expression of bcl-2-associated x protein (bax) and caspase-3, and increasing b-cell lymphoma gene 2 (bcl-2) and b-cell lymphoma-extra large (bcl-xl). |
2022-04-03 |
2023-08-13 |
mouse |
| Sajedeh Daei, Roghayeh Abbasalipourkabir, Maryam Khajvand-Abedini, Nasrin Ziamajid. The Alleviative Efficacy of Vitamins A, C, and E Against Zinc Oxide Nanoparticles-Induced Hepatic Damage by Reducing Apoptosis in Rats. Biological trace element research. 2022-04-02. PMID:35364806. |
to investigate apoptosis, the mrna and protein expression of bcl-2-associated x (bax) and b-cell lymphoma protein 2 (bcl-2) were examined by qrt-pcr and western blot techniques. |
2022-04-02 |
2023-08-13 |
human |
| Vishal Kumar Gupta, Ajay Kuma. Targeting lysophosphatidic acid receptor with Ki16425 impedes T cell lymphoma progression through apoptosis induction, glycolysis inhibition, and activation of antitumor immune response. Apoptosis : an international journal on programmed cell death. 2022-04-02. PMID:35366141. |
the administration of ki16425 triggered apoptosis by down-regulating the expression of bcl2 and up-regulating p53, bax, cleaved caspase-3, and cyt c expression. |
2022-04-02 |
2023-08-13 |
Not clear |
| Joana P Guedes, Vitória Baptista, Cátia Santos-Pereira, Maria João Sousa, Stéphen Manon, Susana R Chaves, Manuela Côrte-Rea. Acetic acid triggers cytochrome c release in yeast heterologously expressing human Bax. Apoptosis : an international journal on programmed cell death. 2022-04-01. PMID:35362903. |
proteins of the bcl-2 protein family, including pro-apoptotic bax and anti-apoptotic bcl-xl, are critical for mitochondrial-mediated apoptosis regulation. |
2022-04-01 |
2023-08-13 |
human |
| Joana P Guedes, Vitória Baptista, Cátia Santos-Pereira, Maria João Sousa, Stéphen Manon, Susana R Chaves, Manuela Côrte-Rea. Acetic acid triggers cytochrome c release in yeast heterologously expressing human Bax. Apoptosis : an international journal on programmed cell death. 2022-04-01. PMID:35362903. |
given the central role of bax in apoptosis, studies aiming to understand its regulation are of paramount importance towards its exploitation as a therapeutic target. |
2022-04-01 |
2023-08-13 |
human |
| Sahand Mazloum-Ravasan, Maryam Mohammadi, Elaheh Madadi Hiagh, Alireza Ebrahimi, Joo-Hyun Hong, Hamed Hamishehkar, Ki Hyun Ki. Nano-liposomal zein hydrolysate for improved apoptotic activity and therapeutic index in lung cancer treatment. Drug delivery. vol 29. issue 1. 2022-04-01. PMID:35363101. |
they induced apoptosis via cell cycle arrest at the g0 phase, as well as significant increases in pro-apoptotic genes, such as bax, caspase-3, -8, -9, and p53, accompanied with significant decreases in the anti-apoptotic marker bcl-2. |
2022-04-01 |
2023-08-13 |
human |
| Qiming Gong, Yan Jiang, Xiuhong Pan, Yanwu Yo. [CX3CL1/fractalkine inhibits lipopolysaccharide-induced apoptosis of mouse RAW264.7 macrophages by activating Wnt/β-catenin signal pathway]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 38. issue 2. 2022-03-31. PMID:35356878. |
results compared with control group, the apoptosis rate and the protein levels of fkn, wnt4, β-catenin, c-caspase-3, c-caspase-9, bax and cytc increased significantly in lps group. |
2022-03-31 |
2023-08-13 |
mouse |
| Hai Duc Nguyen, Min-Sun Ki. Exposure to a mixture of heavy metals induces cognitive impairment: genes and microRNAs involved. Toxicology. 2022-03-29. PMID:35346790. |
the mixed heavy metals altered the genes bax, casp3, bcl2, tnf, and il-1b, indicating the significance of apoptosis and pro-inflammatory cytokines in the pathogenesis of cognitive impairment and the possibility of targeting these genes in future neuroprotective therapy. |
2022-03-29 |
2023-08-13 |
Not clear |
| Takahiro Yamazaki, Lorenzo Galluzz. BAX and BAK dynamics control mitochondrial DNA release during apoptosis. Cell death and differentiation. 2022-03-29. PMID:35347233. |
bax and bak dynamics control mitochondrial dna release during apoptosis. |
2022-03-29 |
2023-08-13 |
Not clear |
| Nancy P Gómez-Crisóstomo, Selva Rivas-Arancibia, Erika Rodríguez-Martínez, Erick N De la Cruz-Hernández, Corazón de María Márquez Álvarez, Pablo Alexis Estrada Caraveo, Noemí Gelista Herrera, Marlen Valdés-Fuentes, Eduardo Martínez-Abundi. Chronic exposition to ozone induces cardiac antioxidant response and overexpression of either mitochondrial fision protein DRP1 and hipertrophyc-related proteins. Journal of bioenergetics and biomembranes. 2022-03-29. PMID:35347511. |
oxidative stress was evaluated by tbars and protein nitrosylation in addition to superoxide dismutase 1 (sod1) and catalase levels; the apoptosis related-proteins caspase 3, caspase 9, bax, bcl-2, and the mitochondrial dynamic-associated proteins fis1, drp1, opa1, and mfn1 were quantified by western blot among the cardiac hypertrophy indicator alpha-actin (cardiac actin). |
2022-03-29 |
2023-08-13 |
rat |
| Yi Zheng, Xueyin Li, Fan Zhang, Bo Zhao, Wanting Du, Da Sun, Guangping L. Protective effect of nicorandil against myocardial ischemia/reperfusion injury mediated via IL33/ST2 signaling pathway. Molecular and cellular biochemistry. 2022-03-29. PMID:35347547. |
in this in vitro study, hypoxia/reoxygenation (h/r) processing of h9c2 cells significantly suppressed the expressions of il33 and st2, reduced cell viability, increased production of reactive oxygen species, downregulated protein expression of bcl-2, upregulated protein expressions of bax, cleaved caspase3, and cleaved parp, increased intracellular calcium overload, and induced cell apoptosis. |
2022-03-29 |
2023-08-13 |
Not clear |
| Fei Song, Yi-Jie Mao, Yu Hu, Shan-Shan Zhao, Ruiying Wang, Wei-Yin Wu, Gui-Rong Li, Yan Wang, Gang L. Acacetin attenuates diabetes-induced cardiomyopathy by inhibiting oxidative stress and energy metabolism via PPAR-α/AMPK pathway. European journal of pharmacology. 2022-03-28. PMID:35341782. |
significantly improved the cardiac function and reduced myocardial injury, and reversed the increase of serum mda, ang Ⅱ, and il-6 levels and myocardial bax and il-6, and the decrease of serum sod, indicating that acacetin plays a cardioprotective effect by inhibiting oxidative stress, inflammation, and apoptosis. |
2022-03-28 |
2023-08-13 |
rat |