| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| V S Nikiforov, E A Blinova, A I Kotikova, A V Akleye. Transcriptional activity of repair, apoptosis and cell cycle genes (TP53, MDM2, ATM, BAX, BCL-2, CDKN1A, OGG1, XPC, PADI4, MAPK8, NF-KB1, STAT3, GATA3) in chronically exposed persons with different intensity of apoptosis of peripheral blood lymphocytes. Vavilovskii zhurnal genetiki i selektsii. vol 26. issue 1. 2022-03-28. PMID:35342850. |
transcriptional activity of repair, apoptosis and cell cycle genes (tp53, mdm2, atm, bax, bcl-2, cdkn1a, ogg1, xpc, padi4, mapk8, nf-kb1, stat3, gata3) in chronically exposed persons with different intensity of apoptosis of peripheral blood lymphocytes. |
2022-03-28 |
2023-08-13 |
Not clear |
| V S Nikiforov, E A Blinova, A I Kotikova, A V Akleye. Transcriptional activity of repair, apoptosis and cell cycle genes (TP53, MDM2, ATM, BAX, BCL-2, CDKN1A, OGG1, XPC, PADI4, MAPK8, NF-KB1, STAT3, GATA3) in chronically exposed persons with different intensity of apoptosis of peripheral blood lymphocytes. Vavilovskii zhurnal genetiki i selektsii. vol 26. issue 1. 2022-03-28. PMID:35342850. |
transcriptional activity of genes involved in maintaining genetic homeostasis (genes for repair, cell cycle and apoptosis: tp53, mdm2, atm, bax, bcl-2, cdkn1a, ogg1, xpc, padi4, mapk8, nf-kb1, stat3, gata3) was studied in chronically exposed persons with an increased intensity of early and late stages of apoptosis and necrosis of peripheral blood lymphocytes. |
2022-03-28 |
2023-08-13 |
Not clear |
| A Tarko, A Štochmaľová, S Hrabovszká, A Vachanová, A H Harrath, W Aldahmash, R Grossman, A V Sirotki. Potential protective effect of puncturevine (Tribulus terrestris, L.) against xylene toxicity on bovine ovarian cell functions. Physiological research. 2022-03-28. PMID:35344671. |
markers of proliferation (accumulation of pcna), apoptosis (accumulation of bax) and the release of hormones (progesterone, testosterone and insulin-like growth factor i, igf-i) were analyzed by quantitative immunocytochemistry and ria, respectively. |
2022-03-28 |
2023-08-13 |
cattle |
| Yingwei Liu, Jiangnan Yi, Yuanliang Li, Riaz Hussain, Shanshan Zhu, Yangwei Li, Zhuanxu Ouyang, Khalid Mehmood, Lianmei Hu, Jiaqing Pan, Zhaoxin Tang, Ying Li, Hui Zhan. Residue of thiram in food, suppresses immune system stress signals and disturbs sphingolipid metabolism in chickens. Veterinary immunology and immunopathology. vol 247. 2022-03-28. PMID:35344810. |
the results on mechanisms (apoptosis and autophagy) of immunotoxicity showed significantly increased expression of bax, caspase3, cytc, atg5, beclin1 and p62 in spleen of treated mice. |
2022-03-28 |
2023-08-13 |
mouse |
| Yingwei Liu, Jiangnan Yi, Yuanliang Li, Riaz Hussain, Shanshan Zhu, Yangwei Li, Zhuanxu Ouyang, Khalid Mehmood, Lianmei Hu, Jiaqing Pan, Zhaoxin Tang, Ying Li, Hui Zhan. Residue of thiram in food, suppresses immune system stress signals and disturbs sphingolipid metabolism in chickens. Veterinary immunology and immunopathology. vol 247. 2022-03-28. PMID:35344810. |
the expressions of bax, p53 and m-tor were up-regulated in the thymus while the expressions of atg5 and beclin1 were down-regulated to mediate cell apoptosis and inhibit autophagy. |
2022-03-28 |
2023-08-13 |
mouse |
| Tansel Sapmaz, Kubra Sevgin, Sude Topkaraoglu, Muhammetnur Tekayev, Selman Aktas, Gulfidan Coskun, Sait Polat, Ekrem Sapmaz, Oktay Irkoruc. Comparison of melatonin, oxytetracycline, and N-acetylcysteine pre-treatments in autologous intraperitoneal ovarian transplantation in rats. Biochemical and biophysical research communications. vol 606. 2022-03-27. PMID:35339751. |
moreover, cellular apoptosis in tissues was evaluated with immunofluorescence staining of bcl-2 and bax. |
2022-03-27 |
2023-08-13 |
rat |
| Yu-Hai Xu, Yuan Luo, Jiang-Bei Cao, Yan-Hong Liu, Yu-Xiang Song, Xiao-Ying Zhang, Qiang Fu, Wei-Dong Mi, Hao L. lncRNA BDNF-AS Attenuates Propofol-Induced Apoptosis in HT22 Cells by Modulating the BDNF/TrkB Pathway. Molecular neurobiology. 2022-03-26. PMID:35338452. |
bdnf-as downregulation mediated by sirna mitigated apoptosis, upregulated the expression of bcl-2, and downregulated the expression of bax and caspase-3, 7, and 9. |
2022-03-26 |
2023-08-13 |
Not clear |
| Yu-Hai Xu, Yuan Luo, Jiang-Bei Cao, Yan-Hong Liu, Yu-Xiang Song, Xiao-Ying Zhang, Qiang Fu, Wei-Dong Mi, Hao L. lncRNA BDNF-AS Attenuates Propofol-Induced Apoptosis in HT22 Cells by Modulating the BDNF/TrkB Pathway. Molecular neurobiology. 2022-03-26. PMID:35338452. |
ana-12 downregulated the expression of bcl-2, upregulated the expression of bax and caspase-3, 7, and 9, and increased apoptosis. |
2022-03-26 |
2023-08-13 |
Not clear |
| Valéria Bumiller-Bini Hoch, Larissa Schneider, Anna Elisabeth Pumpe, Emelie Lüders, Jennifer Elisabeth Hundt, Angelica Beate Winter Bold. Marked to Die-Cell Death Mechanisms for Keratinocyte Acantholysis in Pemphigus Diseases. Life (Basel, Switzerland). vol 12. issue 3. 2022-03-25. PMID:35330080. |
among the molecules, most investigated were pleiotropic molecules such as tnf and casp3, followed by fasl and casp8, and then by fas, bax, bcl2, and tp53, all involved in more than one pathway but interpreted to function only within apoptosis. |
2022-03-25 |
2023-08-13 |
mouse |
| Diane Moujalled, Adam G Southon, Eiman Saleh, Kerstin Brinkmann, Francine Ke, Melinda Iliopoulos, Ryan S Cross, Misty R Jenkins, Duong Nhu, Zilu Wang, Melissa X Shi, Ruth M Kluck, Guillaume Lessene, Stephanie Grabow, Ashley I Bush, Andreas Strasse. BH3 mimetic drugs cooperate with Temozolomide, JQ1 and inducers of ferroptosis in killing glioblastoma multiforme cells. Cell death and differentiation. 2022-03-25. PMID:35332309. |
the combined loss of bax and bak, the essential executioners of intrinsic apoptosis, rendered u251 and snb-19 cells refractory to any of the drug combinations tested, demonstrating that apoptosis is responsible for their killing. |
2022-03-25 |
2023-08-13 |
mouse |
| Naveenkumar Chandrashekar, Raghunandhakumar Subramanian, Devaki Thiruvengada. Baicalein inhibits cell proliferation and enhances apoptosis in human A549 cells and benzo(a)pyrene-induced pulmonary carcinogenesis in mice. Journal of biochemical and molecular toxicology. 2022-03-25. PMID:35332611. |
be induces caspase-dependent apoptosis by increasing the levels of cytosolic cytochrome c accompanied by upregulating the outflow of p53, bax, and caspase-3 with a concomitant abatement in the outflow of bcl-2 in both in vitro and in vivo. |
2022-03-25 |
2023-08-13 |
mouse |
| Xun Fang, Bereket Molla Tanga, Seonggyu Bang, Gyeonghwan Seong, Islam M Saadeldin, Ahmad Yar Qamar, Joohyun Shim, Kimyung Choi, Sanghoon Lee, Jongki Ch. Vitamin C enhances porcine cloned embryo development and improves the derivation of embryonic stem-like cells. Reproductive biology. vol 22. issue 2. 2022-03-25. PMID:35334451. |
vitamin c decreased the gene expression of apoptosis (bax) and increased the expression of genes associated with nuclear reprogramming (nanog, pou5f1, sox2, c-myc, klf4, and tead4), antioxidation (sod1), anti-apoptotic (bcl2), and trophectoderm (cdx2). |
2022-03-25 |
2023-08-13 |
Not clear |
| Duo He, Bo Wu, Juan Du, Ling Li, Jumei Zha. Synergistic inhibition of the growth of MDA-MB-231 cells in triple-negative breast cancer by salinomycin combined with 17-AAG and its mechanism. Oncology letters. vol 23. issue 4. 2022-03-23. PMID:35317027. |
it was found that sal combined with 17-aag synergistically inhibited the cell growth and induced the apoptosis in a concentration-dependent manner, with the expression of caspase 3 and bcl-2 were decreased while the expression of bax was increased. |
2022-03-23 |
2023-08-13 |
Not clear |
| Mei-Xiang Qin, Sheng-Yong Su, Xi Zhang, Hui-Qian Cai, Xin-Ying Lin, Yuan-Yuan Lin, Tian Wan. [Effect of mild moxibustion on pain and expression of LC3 and Bax in spinal cord in cervical spondylotic radiculopathy rats]. Zhen ci yan jiu = Acupuncture research. vol 47. issue 3. 2022-03-23. PMID:35319842. |
to observe the effect of mild moxibustion (moxi) at "dazhui" (gv14) on neuropathic pain, expression of autophagy and apoptosis factor lc3 and bax proteins and mrnas in the spinal cord tissue in rats with cervical spondylotic radiculopathy (csr), so as to explore its underlying mechanism underlying relief of csr-induced pain. |
2022-03-23 |
2023-08-13 |
rat |
| b' Mustafa Onur Y\\xc4\\xb1ld\\xc4\\xb1z, Hamit \\xc3\\x87elik, Cuneyt Caglayan, Ayd\\xc4\\xb1n Gen\\xc3\\xa7, Tuba Do\\xc4\\x9fan, Emine Sat\\xc4\\xb1c\\xc4\\xb. Neuroprotective effects of carvacrol against cadmium-induced neurotoxicity in rats: role of oxidative stress, inflammation and apoptosis. Metabolic brain disease. 2022-03-22. PMID:35316447.' |
additionally, carvacrol alleviated the in levels of inflammation and apoptosis related proteins involving p38 mitogen-activated protein kinase (p38 mapk), cyclooxygenase-2 (cox-2), nuclear factor kappa b (nf-κb), b-cell lymphoma-3 (bcl-3), tumor necrosis factor-α (tnf-α), interleukin-1β (il-1β), myeloperoxidase (mpo), prostaglandin e2 (pge2), neuronal nitric oxide synthase (nnos), inducible nitric oxide synthase (inos), cysteine aspartate specific protease-3 (caspase-3) and bcl-2 associated x protein (bax) in the cd-induced neurotoxicity. |
2022-03-22 |
2023-08-13 |
rat |
| Hongyu Zhou, Yang Zhang, Yuan Tian, Yushi Sun, Yajuan Chen, Yanli Zhang, Qin Zhu, Junfang Pan, Chen Qin. 9-Nitro-20(S)-carbonate-camptothecin (NCP4), a novel prodrug of 9-nitrocamptothecin (9-NC), exhibits potent chemotherapeutic efficacy and improved safety against hepatocarcinoma. European journal of pharmacology. 2022-03-20. PMID:35305999. |
mechanistically, ncp4 induced cell apoptosis by increasing the expressions of caspase-3 and bax in tumor tissues. |
2022-03-20 |
2023-08-13 |
mouse |
| Yan Zhang, Xiangyu Zhang, V Wee Yong, Mengzhou Xu. Vildagliptin improves neurological function by inhibiting apoptosis and ferroptosis following intracerebral hemorrhage in mice. Neuroscience letters. 2022-03-19. PMID:35304193. |
moreover, vilda attenuated brain cell apoptosis as determined by tunel staining, raised bcl-2 protein level, and simultaneously suppressed bax as validated by western blots. |
2022-03-19 |
2023-08-13 |
mouse |
| Xiangmin He, Kai Kang, Dan Pan, Yue Sun, Bing Chan. FTY720 attenuates APAP‑induced liver injury via the JAK2/STAT3 signaling pathway. International journal of molecular medicine. vol 49. issue 5. 2022-03-18. PMID:35302173. |
fty720 activated jak2/stat3 signaling and regulated the expression of bax, bcl‑2 and p65 to inhibit apoptosis and inflammation. |
2022-03-18 |
2023-08-13 |
mouse |
| Sen Zhu, Xuan Li, Fen Wu, Xinhui Cao, Kexin Gou, Chunming Wang, Changjun Li. Blue light induces skin apoptosis and degeneration through activation of the endoplasmic reticulum stress-autophagy apoptosis axis: Protective role of hydrogen sulfide. Journal of photochemistry and photobiology. B, Biology. vol 229. 2022-03-16. PMID:35292420. |
interestingly, we have found that blue light (435 nm ~ 445 nm, 8000 lx, 6-24 h)-induced oxidative stress triggers the er stress-chop (c/ebp homologous protein) signal and affects the protein levels of b-cell lymphoma-2 (bcl-2) and bcl2-associated x (bax), thereby promoting apoptosis. |
2022-03-16 |
2023-08-13 |
Not clear |
| Hangcheng Guo, Yanyi Xiao, Ziwei Yuan, Xuejia Yang, Jiawei Chen, Chaoyue Chen, Mengsi Wang, Lili Xie, Qinbo Chen, Yu Tong, Qiyu Zhang, Yongheng Ba. Inhibition of STAT3 Cell death discovery. vol 8. issue 1. 2022-03-15. PMID:35288541. |
in addition, stattic-induced mitochondrial-dependent apoptosis by elevating cleaved caspase-3, and bax, cytochrome c levels, while reducing expression of bcl-2, which may be regulated by reduced survivin expression. |
2022-03-15 |
2023-08-13 |
Not clear |