| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Song Wu, Xiaoqian Li, Junqi Yang, Liu Yan. PCDH8 participates in the growth process of colorectal cancer cells by regulating the AKT/GSK3β/β-catenin signaling pathway. Tissue & cell. vol 78. 2022-07-30. PMID:35907345. |
moreover, overexpressed pcdh8 could induce apoptosis, significantly down-regulate expressions of b-cell lymphoma-2 (bcl-2), n-cadherin and vimentin but up-regulate those of bcl-2 associated x (bax), cleaved caspase-3 and e-cadherin, whereas the negative regulations on the apoptosis and the expressions of apoptosis- and emt-related proteins were observed in colorectal cancer cells following the silence of pcdh8. |
2022-07-30 |
2023-08-14 |
human |
| Kanchana Suksri, Namoiy Semprasert, Thawornchai Limjindaporn, Pa-Thai Yenchitsomanus, Sirirat Kooptiwoot, Suwattanee Kooptiwu. Cytoprotective effect of genistein against dexamethasone-induced pancreatic β-cell apoptosis. Scientific reports. vol 12. issue 1. 2022-07-28. PMID:35902739. |
combination treatment with dexamethasone and genistein protected against pancreatic β-cell apoptosis, and reduced the effects of dexamethasone on the expressions of trail, dr5, dcr1, superoxide production, bax, bcl-2, nf-κb, caspase-8, and caspase-3. |
2022-07-28 |
2023-08-14 |
mouse |
| Jiaqi Zhu, Bernd Gillissen, Dieu Linh Dang Tran, Stefanie May, Claas Ulrich, Eggert Stockfleth, Jürgen Eberl. Inhibition of Cell Proliferation and Cell Viability by Sinecatechins in Cutaneous SCC Cells Is Related to an Imbalance of ROS and Loss of Mitochondrial Membrane Potential. Antioxidants (Basel, Switzerland). vol 11. issue 7. 2022-07-27. PMID:35883905. |
loss of mmp and induced cell death were, however, largely independent of caspases and of the proapoptotic bcl-2 proteins bax and bak, suggesting that sinecatechins induce also non-apoptotic, alternative cell death pathways, in addition to apoptosis. |
2022-07-27 |
2023-08-14 |
Not clear |
| Janani Ramesh, Rejani Chalikkaran Thilakan, Raja Mohan Gopalakrishnan, Singaravel Vijayapoopathi, Arianna Dorschel, Bhuvarahamurthy Venugopa. Ginsenoside Rg5 Sensitizes Paclitaxel-Resistant Human Cervical-Adeno-Carcinoma Cells to Paclitaxel-And Enhances the Anticancer Effect of Paclitaxel. Genes. vol 13. issue 7. 2022-07-27. PMID:35885925. |
we found increased mrna expression of bak, bax, bid, and puma genes, whereas the mrna expression of bcl2, bcl-xl, c-iap-1, and mcl-1 were low; grg5 combination triggered the efficacy of paclitaxel, which led to increased expression of bax with an enhanced caspase-9/-3 activation, and apoptosis. |
2022-07-27 |
2023-08-14 |
human |
| Yu-Chin Nieh, Yu-Ting Chou, Yu-Ting Chou, Chao-Yung Wang, Shi-Xian Lin, Shih-Ci Ciou, Chiou-Hwa Yuh, Horng-Dar Wan. Suppression of Ribose-5-Phosphate Isomerase a Induces ROS to Activate Autophagy, Apoptosis, and Cellular Senescence in Lung Cancer. International journal of molecular sciences. vol 23. issue 14. 2022-07-27. PMID:35887232. |
in addition, decreased rpia expression induced apoptosis by increasing levels of bax, cleaved parp and caspase-3 and apoptotic cells. |
2022-07-27 |
2023-08-14 |
human |
| Ruijing Liu, Boping Liu, Lingmin Tian, Xinwei Jiang, Xusheng Li, Dongbao Cai, Jianxia Sun, Weibin Bai, Yulong Ji. Exposure to Bisphenol A Caused Hepatoxicity and Intestinal Flora Disorder in Rats. International journal of molecular sciences. vol 23. issue 14. 2022-07-27. PMID:35887390. |
in addition, bpa weakened the mitochondrial function of hepatocytes and promoted cell apoptosis in the liver by up-regulating the protein levels of bax, cleaved-caspase3, and cleaved-parp1 while down-regulating the bcl-2 in the liver. |
2022-07-27 |
2023-08-14 |
rat |
| Yun-Ha Lee, Hyeyoon Kim, Sorim Nam, Jae-Ryang Chu, Jung-Hwan Kim, Jong-Seok Lim, Sung-Eun Kim, Mi-Kyung Sun. Protective Effects of High-Fat Diet against Murine Colitis in Association with Leptin Signaling and Gut Microbiome. Life (Basel, Switzerland). vol 12. issue 7. 2022-07-27. PMID:35888062. |
the hfd+dss mice showed significantly increased serum leptin concentrations, colonic leptin receptor expression, enhanced anti-apoptotic akt expression, and reduced pro-apoptotic mapk and bax expression compared with the nd+dss mice, suggesting the involvement of the leptin-mediated pathway in intestinal epithelial cell apoptosis. |
2022-07-27 |
2023-08-14 |
mouse |
| Chengyong Guo, Shuo Liu, Tao Zhang, Jipeng Yang, Zhaohui Liang, Shengkui L. Knockdown of PHLDA2 promotes apoptosis and autophagy of glioma cells through the AKT/mTOR pathway. Journal of neurogenetics. 2022-07-27. PMID:35894264. |
cell apoptosis of glioma cells was promoted by silencing of phlda2 with increased bax and decreased bcl-2. |
2022-07-27 |
2023-08-14 |
Not clear |
| Mohammad Rumman, Shivani Pandey, Babita Singh, Mrinal Gupta, Abbas Ali Mahd. Genistein suppresses microglial activation and inhibits apoptosis in different brain regions of hypoxia-exposed mice model of amnesia. Metabolic brain disease. 2022-07-27. PMID:35895244. |
apoptosis was assessed by evaluating bax, bad, and bcl-2 mrna levels, and caspase-3 activity. |
2022-07-27 |
2023-08-14 |
mouse |
| Dong-Dong Zhao, Jing-Jing Wang, Jun-Juan Fan, Yu Fu, Yi-di Ma, Chen Li, Gao-Feng Wu, Mei Liu, Shu-Mei Lin, Jian-Min H. Taurine Prevents LPS-Induced Liver Injury in Weaned Piglets. Advances in experimental medicine and biology. vol 1370. 2022-07-26. PMID:35882821. |
tunel was used to detect apoptosis, while qpcr was employed to detect ho-1, nrf-2, bcl2, bax, caspase-3, and nf- κb p65 transcriptomic expression levels. |
2022-07-26 |
2023-08-14 |
cat |
| Mustafa Ileriturk, Ozge Kandemir, Fatih Mehmet Kandemi. Evaluation of protective effects of quercetin against cypermethrin-induced lung toxicity in rats via oxidative stress, inflammation, apoptosis, autophagy, and endoplasmic reticulum stress pathway. Environmental toxicology. 2022-07-25. PMID:35876585. |
cyp adminisitration caused of apoptosis in the lung by up-regulating caspase-3 and bax levels and down-regulating bcl-2. |
2022-07-25 |
2023-08-14 |
rat |
| Luis Alberto Caro-Gómez, Jorge L Rosas-Trigueros, Edgar Mixcoha, Absalom Zamorano-Carrillo, Jesús Martínez-Martínez, Claudia Guadalupe Benítez-Cardoz. Anti-apoptotic Bcl-2 protein in apo and holo conformation anchored to the membrane: comparative molecular dynamics simulations. Journal of biomolecular structure & dynamics. 2022-07-23. PMID:35869651. |
the interaction between the anti-apoptotic bcl-2 protein and its antagonist bax is essential to the regulation of the mitochondrial pathway of apoptosis. |
2022-07-23 |
2023-08-14 |
Not clear |
| Hongbing Cheng, Liangji Chen, Zhenyu Fang, Qian Wan, Zhuo Du, Nanshan Ma, Genxin Guo, Wenjing L. The effect of miR-138 on the proliferation and apoptosis of breast cancer cells through the NF-κB/VEGF signaling pathway. Cellular and molecular biology (Noisy-le-Grand, France). vol 68. issue 2. 2022-07-23. PMID:35869716. |
observe the cell proliferation and apoptosis ability of each group, and the changes in tumor necrosis factor-α (tnf-α), interleukin 1β, 6, 18 (il-1β, il-6, il-18) levels, and compare the bax of each group, nf-κb, vegf protein expression level. |
2022-07-23 |
2023-08-14 |
Not clear |
| Cai Zhang, Sudan Meng, Qi Shao, Xueying Wang, Chenxu Li, Wenbin Chen, Yuanxiao Li, Shucheng Huang, Yanbo M. Protective effects of monoammonium glycyrrhizinate on fatty deposit degeneration induced in primary calf hepatocytes by sodium oleate administration in vitro. Research in veterinary science. vol 150. 2022-07-22. PMID:35868152. |
to evaluate the effect of mag on fat-induced degradation of primary hepatocytes, we evaluated lipid deposition, cell viability, apoptosis rate, alanine aminotransferase (alt) and aspartate aminotransferase (ast) activity in the culture supernatant, and expression of oxidant and antioxidant enzymes (ldh, mda, gsh, and cat), as well as the expression of lipid metabolism-related genes (pparα, srebp-1c, chrebp, cpt1, cpt2, and mtp) and apoptosis-related genes (cyt-c, caspase 9, caspase 8, caspase 3, bax, and bcl-2). |
2022-07-22 |
2023-08-14 |
cat |
| Zimin Li, Junzheng Zheng, Jian Xu, Quan Ni. Knockdown of Circ_0000798 Impedes Cell Growth and Motility of Renal Cell Carcinoma Cells Through Functioning as miRNA Sponge for miR-589-5p. Biochemical genetics. 2022-07-20. PMID:35857217. |
proliferation markers ki67 and bcl-2 were depressed by inhibiting circ_0000798, accompanied with promoted levels of apoptosis proteins bax and cleaved caspase-3. |
2022-07-20 |
2023-08-14 |
Not clear |
| Changcun Bai, Yongshuai Yao, Zhihui Wang, Xiaoquan Huang, Tingting Wei, Lingyue Zou, Na Liu, Ting Zhang, Meng Tan. CdTe quantum dots trigger oxidative stress and endoplasmic reticulum stress-induced apoptosis and autophagy in rat schwann cell line RSC96. Journal of applied toxicology : JAT. 2022-07-20. PMID:35857417. |
the results showed that cdte qds induced apoptosis in rsc96 cells in a concentration-dependent manner, promoted the accumulation of intracellular ros, decreased the mitochondrial membrane potential, caused the release of cytochrome c, and also increased the expression of bax, caspase-3 and cytochrome c proteins and decreased the expression of bcl-2 protein. |
2022-07-20 |
2023-08-14 |
rat |
| Xin Yang, Heling Zhang, Tong Qu, Yi Wang, Yongxian Zhong, Yuchen Yan, Xuefei Ji, Tiayan Chi, Peng Liu, Libo Zo. Tolfenamic acid inhibits ROS-generating oxidase Nox1-regulated p53 activity in intrastriatal injection of malonic acid rats. The journal of physiological sciences : JPS. vol 72. issue 1. 2022-07-19. PMID:35850611. |
tolfenamic acid reduced mouse double minute 2 (mdm2), phosphatase and tensin homologue (pten), p53-upregulated modulator of apoptosis (puma) and bcl2-associated x (bax) at the mrna level to inhibit apoptosis and downregulated sestrin 2 (sesn2) and hypoxia inducible factor 1, alpha subunit (hif-1α) mrna levels to exert antioxidative stress effects. |
2022-07-19 |
2023-08-14 |
mouse |
| Mei-Zhu Wu, Yun Xiang, Cui-Yu Bao, Tao Li. [Protective effect of salidroside on high fat-induced apoptosis in H9c2 cardiomyocytes through AMPK/mTOR/p70S6K pathway]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 47. issue 14. 2022-07-19. PMID:35850842. |
the study explored the effect of salidroside(sal) on high fat-induced apoptosis in h9 c2 cardiomyocytes based on ampk/mtor/p70 s6 k pathway.h9 c2 cardiomyocytes were cultured in vitro and the lipotoxicity model of h9 c2 cardiomyocytes was constructed by 0.2 mmol·l~(-1) palmitic acid(pa) treatment for 24 hours.the cells were divided into control group, pa group, and sal group(20 μmol·l~(-1)).cell proliferation was detected with cell proliferation kit i(mtt) assay after sal and pa treatment.dihydroethidium(dhe) probe, annexin v-fitc/pi kit, and jc-1 probe were used to estimate reactive oxygen species(ros) level, cell apoptosis, and mitochondrial membrane potential(mmp) change, respectively.the expression levels of p-ampk/ampk, p-mtor/mtor, p-p70 s6 k/p70 s6 k and apoptosis-related proteins bax, bcl-2, and cleaved caspase-3 were investigated with western blot.the mrna levels of ampk, mtor and p70 s6 k were determined by quantitative reverse transcription-polymerase chain reaction(qrt-pcr).results:: showed that compared with control group, pa group had decreased cell proliferation ability, mmp, bcl-2 protein expression and ampk protein and mrna expression, while increased ros level, bax and cleaved caspase-3 protein expression, and mtor and p70 s6 k mrna and protein expression, and the difference was statistically significant(p<0.05, p<0.01).compared with pa group, sal improved cell proliferation ability, mmp level, bcl-2 protein expression, and ampk mrna and protein expression, while down-regulated ros level, cell apoptosis, bax and cleaved caspase-3 protein expression, and mtor and p70 s6 k mrna and protein expression, and the difference was statistically significant(p<0.05, p<0.01).in conclusion, sal exerted protective effects on high fat-induced lipotoxicity of h9 c2 cardiomyocytes, alleviated the oxidative stress injury and reduced cell apoptosis via regulating ampk/mtor/p70 s6 k signaling pathway. |
2022-07-19 |
2023-08-14 |
Not clear |
| Shadi Kahalian, Maryam Koopaie, Neda Hakimiha, Sajad Kolahdoo. Assessment of the methylene blue mediated photodynamic therapy on Folia medica. vol 64. issue 2. 2022-07-19. PMID:35851773. |
assessment of the methylene blue mediated photodynamic therapy on this study aimed to assess the effect of photodynamic therapy (pdt) on apoptosis of head and neck squamous cell carcinoma (hnscc) cells by flow cytometry and evaluating bax and bcl2 genes expression. |
2022-07-19 |
2023-08-14 |
Not clear |
| TianYu Liu, Zhaodong Juan, Bin Xia, GuanHua Ren, Zhen Xi, JunWen Hao, ZhongDong Su. HSP70 protects H9C2 cells from hypoxia and reoxygenation injury through STIM1/IP3R. Cell stress & chaperones. 2022-07-16. PMID:35841499. |
similarly, direct silencing of stim1 by sirna significantly increased cell viability and expression of anti-apoptotic protein bcl-2 and decreased apoptosis rate and expression of pro-apoptotic protein bax. |
2022-07-16 |
2023-08-14 |
rat |