| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yue Lv, Zhonghao Liu, Leihong Deng, Shunyao Xia, Qingchun Mu, Bang Xiao, Youcheng Xiu, Zan Li. Hesperetin promotes bladder cancer cells death via the PI3K/AKT pathway by network pharmacology and molecular docking. Scientific reports. vol 14. issue 1. 2024-01-10. PMID:38200039. |
the increased expression of bax and cleaved caspase-3 indicated that he could promote blca cell apoptosis. |
2024-01-10 |
2024-01-13 |
Not clear |
| Yamu Li, Sulin Wu, Yiqing Zhao, Trang Dinh, Dongxu Jiang, J Eva Selfridge, George Myers, Yuxiang Wang, Xuan Zhao, Suzanne L Tomchuck, George Dubyak, Richard T Lee, Bassam Estfan, Marc Shapiro, Suneel D Kamath, Amr Mohamed, Stanley C-C Huang, Alex Y Huang, Ronald A Conlon, Smitha S Krishnamurthi, Jennifer R Eads, Joseph E Willis, Alok A Khorana, David L Bajor, Zhenghe Wan. Neutrophil extracellular traps induced by chemotherapy inhibit tumor growth in vivo. The Journal of clinical investigation. 2024-01-09. PMID:38194275. |
the internalized ctsg cleaves 14-3-3 proteins, releases bax, and triggers apoptosis in crc cells. |
2024-01-09 |
2024-01-10 |
mouse |
| Qionghua Hu, Lingqin Qiu, Li Ge, Yi We. Sevoflurane postconditioning alleviates hypoxic-ischemic brain damage in rats by inhibiting the endoplasmic reticulum stress PERK/ATF4/CHOP pathway. Tissue & cell. vol 86. 2024-01-09. PMID:38194851. |
additionally, nissl staining assessed hippocampal ca1 area neuronal density, tunel staining evaluated hippocampal ca1 area neuronal apoptosis, and western blot determined hippocampal ca1 area protein levels, including bax, bcl-2, p-perk/perk, p-eif2/eif2, atf4, chop, grp78, bax, and bcl-2 protein levels. |
2024-01-09 |
2024-01-13 |
rat |
| Qionghua Hu, Lingqin Qiu, Li Ge, Yi We. Sevoflurane postconditioning alleviates hypoxic-ischemic brain damage in rats by inhibiting the endoplasmic reticulum stress PERK/ATF4/CHOP pathway. Tissue & cell. vol 86. 2024-01-09. PMID:38194851. |
following spc treatment, hibd rats exhibited improved spatial learning and memory abilities, reduced neuronal apoptosis, increased neuronal density in the hippocampal ca1 area, elevated bcl-2 protein level, decreased bax protein levels, and decreased levels of endoplasmic reticulum stress pathway related proteins (p-perk/perk, p-eif2/eif2, atf4, chop and grp78). |
2024-01-09 |
2024-01-13 |
rat |
| Yuan Dai, Shuangshuang Shi, Hongda Liu, Hong Zhou, Wenqiu Ding, Chenyang Liu, Linling Jin, Weiping Xie, Hui Kong, Qun Zhan. Protein tyrosine phosphatase PTPRO represses lung adenocarcinoma progression by inducing mitochondria-dependent apoptosis and restraining tumor metastasis. Cell death & disease. vol 15. issue 1. 2024-01-05. PMID:38182570. |
furthermore, ptpro overexpression was found to suppress the progression of luad both in vitro and in vivo by inducing cell death via mitochondria-dependent apoptosis, downregulating protein expression of molecules (bcl-2, bax, caspase 3, cleaved-caspase 3/9, cleaved-parp and bid) essential in cell survival. |
2024-01-05 |
2024-01-08 |
Not clear |
| Yu Hu, QingHan Li, ZhengLi Qian, BeiXiao, KeYan Luo, NanJian Lu. Joint Analysis of Genome-wide DNA Methylation and Transcription Sequencing Identifies the Role of BAX Gene in Heat Stress-Induced-Sertoli Cells Apoptosis. Reproductive sciences (Thousand Oaks, Calif.). 2024-01-05. PMID:38180610. |
joint analysis of genome-wide dna methylation and transcription sequencing identifies the role of bax gene in heat stress-induced-sertoli cells apoptosis. |
2024-01-05 |
2024-01-07 |
Not clear |
| Yu Hu, QingHan Li, ZhengLi Qian, BeiXiao, KeYan Luo, NanJian Lu. Joint Analysis of Genome-wide DNA Methylation and Transcription Sequencing Identifies the Role of BAX Gene in Heat Stress-Induced-Sertoli Cells Apoptosis. Reproductive sciences (Thousand Oaks, Calif.). 2024-01-05. PMID:38180610. |
the joint analysis showed that several gene expressions in rna-seq and wgbs overlapped and the shortlisted genes bax, hsph1, hsf1b, and bag were strongly correlated with stress response and apoptosis. |
2024-01-05 |
2024-01-07 |
Not clear |
| Yu Hu, QingHan Li, ZhengLi Qian, BeiXiao, KeYan Luo, NanJian Lu. Joint Analysis of Genome-wide DNA Methylation and Transcription Sequencing Identifies the Role of BAX Gene in Heat Stress-Induced-Sertoli Cells Apoptosis. Reproductive sciences (Thousand Oaks, Calif.). 2024-01-05. PMID:38180610. |
methylation-specific pcr (msp) and flow cytometry (fcm) analyzes showed that reduced promoter methylation and enhanced gene expression of bax with a consequence of apoptosis. |
2024-01-05 |
2024-01-07 |
Not clear |
| Mahitab G Haggagy, Lamiaa A Ahmed, Marwa Sharaky, Mahmoud M Elhefnawi, Mervat M Omra. SIRT1 as a potential key regulator for mediating apoptosis in oropharyngeal cancer using cyclophosphamide and all-trans retinoic acid. Scientific reports. vol 14. issue 1. 2024-01-03. PMID:38167952. |
apoptosis was induced through elevating mrna expressions of bax and par-4 and suppressing that of bcl-xl and bcl-2, parallel with increased caspases 3 and 9 and decreased vegf, endothelin-1 and ctgf levels. |
2024-01-03 |
2024-01-06 |
Not clear |
| Suryaa Manoharan, Kunjkumar Prajapati, Ekambaram Peruma. Natural bioactive compounds and FOXO3a in cancer therapeutics: An update. Fitoterapia. 2024-01-03. PMID:38168566. |
foxo3a promotes its anticancer effects by upregulating the levels of its downstream targets, including bim, fasl, and bax, leading to apoptosis. |
2024-01-03 |
2024-01-06 |
Not clear |
| Wei Liu, Linzhang Zhang, Xia Wei, Yongbin Xu, Qinqin Fang, Shenglan Qi, Jiamei Chen, Changhong Wang, Shunchun Wang, Luping Qin, Ping Liu, Jianjun W. Structural characterization of an inulin neoseries-type fructan from Ophiopogonis Radix and the therapeutic effect on liver fibrosis in vivo. Carbohydrate polymers. vol 327. 2024-01-03. PMID:38171656. |
pharmacological studies revealed that ojp-w2 exerted a marked hepatoprotective effect against liver fibrosis, the mechanism of action was involved in regulating collagen deposition (α-sma, col1a1 and liver hyp contents) and tgf-β/smads signaling pathway, alleviating liver inflammation (il-1β, il-6, ccl5 and f4/80) and mapk signaling pathway, and inhibiting hepatic apoptosis (bax, bcl-2, atf4 and caspase 3). |
2024-01-03 |
2024-01-06 |
Not clear |
| Qianling Ye, Hanjing Wang, Yue Chen, Yihao Zheng, Yuqiong Du, Chongyang Ma, Qiuyun Zhan. PANoptosis-like death in acute-on-chronic liver failure injury. Scientific reports. vol 14. issue 1. 2024-01-03. PMID:38172209. |
we screened out bax from the intersection of pyroptosis, apoptosis, necroptosis, and degs. |
2024-01-03 |
2024-01-06 |
rat |
| Lin Li, Liuyan Xin, Xiang Yang, Zhengrong Zo. Oncogenic lncRNA FAM215A promotes the malignant cell phenotypes of acute myeloid leukemia (AML) cell lines. Journal of molecular histology. 2024-01-02. PMID:38165572. |
fam215a knockdown inhibited aml cell viability, elicited g0/g1-phase arrest of cell cycle, enhanced cell apoptosis, increased proapoptotic bax and cleaved-caspase3 levels, and decreased antiapoptotic bcl2. |
2024-01-02 |
2024-01-10 |
Not clear |
| Xiaopeng Peng, Haoyao Yuan, Guangtian Chen, Yuliang Guo, Qiuer Liang, Qiming Chen, Weidong Ca. Investigation on the effect of ulinastatin on the apoptosis of vascular smooth muscle cells in rats with aortic dissection based on the Sirt1/FoxO3a pathway. Cellular and molecular biology (Noisy-le-Grand, France). vol 69. issue 13. 2023-12-30. PMID:38158682. |
findings suggested that the aortic wall of ad rats was thickened, and the dissection false cavity appeared; vsmc mostly presented different shapes such as triangles and stars, the immunofluorescence staining results showed that α-sma was arranged in the cytoplasm in the form of myofilaments, showing green fluorescence, and the nucleus showed blue fluorescence, and the rate of positive cells was more than 95%; various doses of ulinastatin had a certain inhibitory effect on the proliferation of vsmc, and 5000 u/ml ulinastatin had a higher proliferation inhibition rate; compared with the blank group, the vsmc apoptosis rate, caspase-3, bax protein, sirt1/foxo3a pathway related protein expression in the ulinastatin group were significantly increased, and the bcl-2 protein expression was significantly decreased (p<0.05), the vsmc apoptosis rate, caspase-3, bax protein, sirt1/foxo3a pathway related protein expression in the sirt1 inhibitor group were significantly decreased, and the bcl-2 protein expression was significantly increased (p<0.05); compared with the ulinastatin group, the vsmc apoptosis rate, caspase-3, bax protein, sirt1/foxo3a pathway related protein expression in the ulinastatin + sirt1 inhibitor group were significantly decreased, and the bcl-2 protein expression was significantly increased (p<0.05). |
2023-12-30 |
2024-01-05 |
rat |
| M E Ladera Gómez, M V Nieto Farias, M Rodríguez, A Váter, M C Ceriani, G L Dolcin. Altered apoptosis and proliferation in milk cells and PBMc from BLV-infected bovines with different proviral loads: Possible role of the BCL-2 family proteins, TNF-alpha, and receptors. Veterinary immunology and immunopathology. vol 268. 2023-12-28. PMID:38154260. |
our data suggest that the increased mrna expression of bax corresponds to the late lactation state of bovine evaluated and the exacerbated increase of mrna expression of bcl-2 may be one of the mechanisms for the negative apoptosis regulation in the mammary gland induced by blv infection. |
2023-12-28 |
2023-12-31 |
human |
| Changkun Hu, Zebin Liao, Liangliang Zhang, Zengchun Ma, Chengrong Xiao, Shuai Shao, Yue Ga. Alleviation of Splenic Injury by CB001 after Low-Dose Irradiation Mediated by NLRP3/Caspase-1-BAX/Caspase-3 Axis. Radiation research. 2023-12-28. PMID:38154483. |
furthermore, the crosstalk between apoptosis signaling and nlrp3 inflammasome signaling in mediating the radio-protective activity of cb001 was clarified, in which the pro-apoptotic protein bax but not the anti-apoptotic protein bcl2 was found to be downstream of nlrp3. |
2023-12-28 |
2023-12-31 |
Not clear |
| Boxin Zhao, Yunhui Zang, Lin Gui, Yingyu Xiang, Zhiyong Zhang, Xueyuan Sun, Jingyao Fan, Lijuan Huan. The effect of miR-223-3p on endothelial cells in coronary artery disease. In vitro cellular & developmental biology. Animal. 2023-12-28. PMID:38155264. |
more importantly, in the tnf-α-induced endothelial cell apoptosis model, transfection with the mir-223-3p inhibitor reversed the effects of tnf-α on bcl-2, bax expression. |
2023-12-28 |
2023-12-31 |
Not clear |
| Elif Ertürk, Oğuzhan Akgün, Yaren Yildiz, Pınar Alper Kalkan, Oksana V Salomatina, Nariman F Salakhutdinov, Engin Ulukaya, Ferda Ar. Soloxolone methyl induces apoptosis and oxidative/ER stress in breast cancer cells and target cancer stem cell population. Turkish journal of biology = Turk biyoloji dergisi. vol 47. issue 4. 2023-12-28. PMID:38152618. |
the mode of cell death was apoptosis, evidenced by phosphatidylserine exposure, caspase activation, and bax overexpression. |
2023-12-28 |
2023-12-30 |
human |
| Guoyang Liu, Yong Lv, Yanting Wang, Zhenzhen Xu, Lu Chen, Shiqiang Chen, Wanli Xie, Yiqi Feng, Jie Liu, Yunxiao Bai, Yuyao He, Xia Li, Qingping W. Remote ischemic preconditioning reduces mitochondrial apoptosis mediated by calpain 1 activation in myocardial ischemia-reperfusion injury through calcium channel subunit Cacna2d3. Free radical biology & medicine. 2023-12-27. PMID:38151212. |
this ultimately leads to a decrease in calpain 1 cleavage of bax, consequently inhibiting increased mitochondrial permeability-mediated apoptosis. |
2023-12-27 |
2023-12-30 |
human |
| Ting Yang, Sijuan Tian, Juan Zhao, Meili Pei, Minyi Zhao, Xiaofeng Yan. LncRNA ABHD11-AS1 activates EGFR signaling to promote cervical cancer progression by preventing FUS-mediated degradation of ABHD11 mRNA. Cell cycle (Georgetown, Tex.). 2023-12-26. PMID:38146687. |
knockdown of abhd11-as1 and egfr significantly inhibited the proliferation, migration, and invasion and promoted apoptosis of siha and hela cells by up-regulating p21 and bax and down-regulating cyclin d1, bcl2, mmp9, and vimentin. |
2023-12-26 |
2023-12-28 |
Not clear |