| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ting Zhang, Changhua Zhou, Mengfan Lv, Jia Yu, Sha Cheng, Xudong Cui, Xinwei Wan, Mashaal Ahmad, Bixue Xu, Juan Qin, Xueling Meng, Heng Lu. Trifluoromethyl quinoline derivative targets inhibiting HDAC1 for promoting the acetylation of histone in cervical cancer cells. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 2024-01-20. PMID:38244809. |
fkl117 inhibited the proliferation of cervical cancer cells in a dose and time-dependent manner, induced apoptosis in hela cells, arrested the cell cycle in the g2/m phase, and regulated the expression of the apoptotic and cell cycle-related proteins bcl-2, bax, cyclin b1, and cdc2. |
2024-01-20 |
2024-01-23 |
Not clear |
| Jun Qian, Tao Liang, Yu Xu, Zhi-Peng Liu, Lin-Lin Jing, Hong-Bo Lu. Effect of the novel free radical scavenger 4'-hydroxyl-2-substituted phenylnitronyl nitroxide on oxidative stress, mitochondrial dysfunction and apoptosis induced by cerebral ischemia-reperfusion in rats. Neuroscience. 2024-01-19. PMID:38242279. |
additionally, hpn effectively preserved the morphology and function of mitochondria, reduced the protein and gene expression of caspase-3 and bax, increased the protein and gene expression of bcl-2, mitigated neuronal apoptosis, improved neurological deficits, and decreased the volume of cerebral infarction. |
2024-01-19 |
2024-01-22 |
human |
| Chandramohan Kiruthiga, Devasahayam Jaya Balan, Nagaiah Hari Prasath, Muthushanmugam Manikandakrishnan, Sakthivel Jafni, Narayanasamy Marimuthu Prabhu, Shunmugiah Karutha Pandian, Kasi Pandima Dev. Synergistic induction of apoptosis in lung cancer cells through co-delivery of PLGA phytol/α-bisabolol nanoparticles. Naunyn-Schmiedeberg's archives of pharmacology. 2024-01-19. PMID:38240783. |
apoptosis was confirmed through annexin v-fitc/pi staining and western blot analysis, which also revealed changes in bax and bcl-2 protein expression. |
2024-01-19 |
2024-01-21 |
zebrafish |
| Xin Zhao, Fang Yin, Yilin Huang, Luoqin Fu, Yingyu Ma, Luyi Ye, Weijiao Fan, Wenxue Gao, Yu Cai, Xiaozhou Mo. Oral administration of grape-derived nanovesicles for protection against LPS/D-GalN-induced acute liver failure. International journal of pharmaceutics. 2024-01-18. PMID:38237707. |
treatment with gdnvs significantly prevented the massive apoptosis of hepatocytes caused by lps/d-galn and down-regulated the activation and expression of the mitochondrial apoptosis-related proteins p53, caspase 9, caspase 8, caspase 3 and bax. |
2024-01-18 |
2024-01-21 |
mouse |
| Mojtaba Moradi, Mohammad Arshia Hashemian, Azita Faramarzi, Nader Goodarzi, Amir Hossein Hashemian, Hadi Cheraghi, Cyrus Jalil. Therapeutic effect of sodium alginate on bleomycin, etoposide and cisplatin (BEP)-induced reproductive toxicity by inhibiting nitro-oxidative stress, inflammation and apoptosis. Scientific reports. vol 14. issue 1. 2024-01-18. PMID:38238398. |
further, modifications to the expression of bcl2, bax, caspase3, p53, and tnf-α suggested that naal alleviated bep-induced apoptosis and inflammation. |
2024-01-18 |
2024-01-21 |
rat |
| Jie Cao, Jun Mei, Jing Xi. Combined effects of hypoxia and ammonia-N exposure on the immune response, oxidative stress, tissue injury and apoptosis of hybrid grouper (Epinephelus fuscoguttatus♀×E. lanceolatus♂). Environmental science and pollution research international. vol 31. issue 1. 2024-01-17. PMID:38032527. |
additionally, antioxidant genes (sod, cat, gsh-px, hsp70, and hsp90), apoptosis genes (p53, bax, caspase 3, caspase 8, and caspase 9), and inflammatory genes (tnf-α, il-1β, il-6, and il-8) were upregulated by hypoxia and ammonia-n exposure. |
2024-01-17 |
2024-01-19 |
cat |
| Matthew W McHenry, Peiwen Shi, Christina M Camara, Daniel T Cohen, T Justin Rettenmaier, Utsarga Adhikary, Micah A Gygi, Ka Yang, Steven P Gygi, Thomas E Wales, John R Engen, James A Wells, Loren D Walensk. Covalent inhibition of pro-apoptotic BAX. Nature chemical biology. 2024-01-17. PMID:38233584. |
bcl-2-associated x protein (bax) is a promising therapeutic target for activating or restraining apoptosis in diseases of pathologic cell survival or cell death, respectively. |
2024-01-17 |
2024-01-20 |
Not clear |
| Matthew W McHenry, Peiwen Shi, Christina M Camara, Daniel T Cohen, T Justin Rettenmaier, Utsarga Adhikary, Micah A Gygi, Ka Yang, Steven P Gygi, Thomas E Wales, John R Engen, James A Wells, Loren D Walensk. Covalent inhibition of pro-apoptotic BAX. Nature chemical biology. 2024-01-17. PMID:38233584. |
these data inform a pharmacologic strategy for suppressing apoptosis in diseases of unwanted cell death by covalent targeting of bax c126. |
2024-01-17 |
2024-01-20 |
Not clear |
| Samira Barangi, Soghra Mehri, Zahra Moosavi, Fatemeh Yarmohammadi, A Wallace Hayes, Gholamreza Karim. Melatonin attenuates liver injury in arsenic-treated rats: The potential role of the Nrf2/HO-1, apoptosis, and miR-34a/Sirt1/autophagy pathways. Journal of biochemical and molecular toxicology. vol 38. issue 1. 2024-01-17. PMID:38229313. |
the liver tissue was removed and then histological alterations, oxidative stress markers, antioxidant capacity, the levels of nrf2 and ho-1, apoptosis (bcl-2, survivin, mcl1, bax, and caspase-3), and autophagy (sirt1, beclin-1, and lc3 ii/i ratio) proteins, as well as the expression level of mir-34a, were evaluated on this tissue. |
2024-01-17 |
2024-01-19 |
rat |
| Nuray Üremiş, Meral Aslan, Elif Taşlidere, Elif Güre. Dexpanthenol exhibits antiapoptotic and anti-inflammatory effects against nicotine-induced liver damage by modulating Bax/Bcl-xL, Caspase-3/9, and Akt/NF-κB pathways. Journal of biochemical and molecular toxicology. vol 38. issue 1. 2024-01-17. PMID:38229321. |
conversely, dex effectively attenuated nicotine-induced liver injury by modulating apoptosis through nf-κb, caspase-3, caspase-9, bax inhibition, and bcl-xl activation. |
2024-01-17 |
2024-01-19 |
rat |
| Qiuzhi Gao, Chao Huang, Ting Liu, Fumeng Yang, Zhihong Chen, Li Sun, Yuanyuan Zhao, Mei Wang, Liqi Luo, Chenglin Zhou, Wei Zh. Gastric cancer mesenchymal stem cells promote tumor glycolysis and chemoresistance by regulating B7H3 in gastric cancer cells. Journal of cellular biochemistry. 2024-01-16. PMID:38226525. |
acquired oxa and ptx resistance was characterized by increased cell viability for oxa and ptx, the formation of cell colonies, and decreased levels of cell apoptosis, which were accompanied by reduced levels of cleaved caspase-3 and bax expression, and increased levels of bcl-2, hk2, mdr1, and b7h3 expression. |
2024-01-16 |
2024-01-18 |
Not clear |
| Zi-Tan Peng, Rong Hu, Jing-Yu F. Sulforaphane suppresses cell proliferation and induces apoptosis in glioma via the ACTL6A/PGK1 axis. Toxicology mechanisms and methods. 2024-01-15. PMID:38221767. |
cell viability, proliferation, and apoptosis were assessed using standard assays, and levels of mrnas encoding actl6a, pgk1, cyclin d1, myc, bax or bcl-2 were measured using quantitative real-time polymerase chain reaction (qrt-pcr). |
2024-01-15 |
2024-01-17 |
Not clear |
| Jinuk Seo, Doyoung Kwon, Sou Hyun Kim, Mi Ran Byun, Yun-Hee Lee, Young-Suk Jun. Role of autophagy in betaine-promoted hepatoprotection against non-alcoholic fatty liver disease in mice. Current research in food science. vol 8. 2024-01-15. PMID:38222825. |
in addition, it reduced the cdahfd-induced er stress (bip, atf6, and chop) and apoptosis (bax, cleaved caspase-3, and cleaved parp); however, it induced autophagy (lc3ii/i and p62) which was downregulated by cdahfd. |
2024-01-15 |
2024-01-17 |
mouse |
| Xinyu Ying, Xinyi Ma, Ziru Yang, Bo Zho. Th9 Cytokines Inhibit Proliferation, Promote Apoptosis, and Immune Escape in Thyroid Carcinoma Cells. Applied biochemistry and biotechnology. 2024-01-15. PMID:38224392. |
the apoptosis rate, proportions of th9 and activated cd8+ t cells, killing rate of human peripheral blood lymphocytes, the expression of bax and caspase-3 proteins in tpc-1 cells, the expression of tpc-1 and human peripheral blood lymphocytes il-9r and il-21r proteins were all higher (p<0.05) in il-9+il-21 group compared with the il-9 group and the il-21 group. |
2024-01-15 |
2024-01-17 |
human |
| Hua Yu, Zhao-Xia Zou, Wei Wei, Ying L. Conjugated Linoleic Acid Reduces Lipid Accumulation via Down-regulation Expression of Lipogenic Genes and Up-regulation of Apoptotic Genes in Grass Carp (Ctenopharyngodon idella) Adipocyte In Vitro. Marine biotechnology (New York, N.Y.). 2024-01-15. PMID:38224425. |
in addition, cla induced adipocyte apoptosis through downregulated anti-apoptotic gene b-cell cll/lymphoma 2 (bcl-2) mrna level and up-regulated pro-apoptotic genes tumor necrosis factor-α (tnf-α), bcl-2-associated x protein (bax), caspase-3, and caspase-9 mrna level in a dose-dependent manner. |
2024-01-15 |
2024-01-17 |
Not clear |
| Lei Ma, Ke Huang, Haibo Zhang, Eungyung Kim, Hyeonjin Kim, Zhibin Liu, Chae Yeon Kim, Kanghyun Park, Muhammad Atif Raza, Kirim Kim, Junkoo Yi, Yonghun Sung, Zae Young Ryoo, Yong-Gun Kim, Myoung Ok Ki. Imatinib inhibits oral squamous cell carcinoma by suppressing the PI3K/AKT/mTOR signaling pathway. Journal of Cancer. vol 15. issue 3. 2024-01-12. PMID:38213733. |
furthermore, imatinib suppressed migration and colony formation while promoting oscc cell apoptosis by enhancing p53, bax, and parp expression levels and reducing bcl-2 expression. |
2024-01-12 |
2024-01-14 |
Not clear |
| Qianwei Zhao, Mengdan Yu, Jinxia Li, Yaoyu Guo, Zexuan Wang, Kefei Hu, Fang Xu, Yixian Liu, Lili Li, Didi Wan, Ying Zhao, Jian Shang, Jintao Zhan. GLUD1 inhibits hepatocellular carcinoma progression via ROS-mediated p38/JNK MAPK pathway activation and mitochondrial apoptosis. Discover. Oncology. vol 15. issue 1. 2024-01-12. PMID:38216781. |
excessive ros lead to mitochondrial apoptosis that was characterized by increased expression levels of p53, cytochrome c, bax, caspase 3 and decreased expression level of bcl-2. |
2024-01-12 |
2024-01-15 |
Not clear |
| Peng Hui, Xianrui Zheng, Jiao Dong, Fan Lu, Chao Xu, Huan Qu, Xiaoyang Zhu, Yoshinobu Uemoto, Xiaoyang Lv, Zongjun Yin, Wei Sun, Wenbin Bao, Haifei Wan. Metabolomics and Transcriptomics Analyses of Curcumin Alleviation of Ochratoxin A-Induced Hepatotoxicity. International journal of molecular sciences. vol 25. issue 1. 2024-01-11. PMID:38203339. |
further mechanistical analyses revealed that pa can downregulate the expression level of proapoptotic protein bax, enhance the expression level of apoptosis inhibitory protein bcl2, and decrease the level of phosphorylated extracellular signal-regulated kinase 1/2 (perk1/2). |
2024-01-11 |
2024-01-13 |
mouse |
| Yuliya S Kolesova, Yulia Y Stroylova, Ekaterina E Maleeva, Anastasia M Moysenovich, Denis V Pozdyshev, Vladimir I Muronetz, Yaroslav A Andree. Modulation of TRPV1 and TRPA1 Channels Function by Sea Anemones' Peptides Enhances the Viability of SH-SY5Y Cell Model of Parkinson's Disease. International journal of molecular sciences. vol 25. issue 1. 2024-01-11. PMID:38203538. |
a mutant alpha-synuclein a53t significantly increased the expression of the pro-apoptotic protein bax and made cells more susceptible to apoptosis. |
2024-01-11 |
2024-01-13 |
Not clear |
| Xinpeng Wang, Linguo Xie, Chunyu Li. CCR2 antagonist attenuates calcium oxalate-induced kidney oxidative stress and inflammation by regulating macrophage activation. Experimental animals. 2024-01-10. PMID:38199255. |
ccr2 antagonist had inhibitory effects on gox-induced inflammatory cytokine expression (il1b, il6 and mcp1), and inhibited apoptosis by increasing bcl-2 expression and decreasing bax and cleaved-caspase 3 expression. |
2024-01-10 |
2024-01-13 |
mouse |