| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Alexander V Sirotkin, Zuzana Fabová, Barbora Loncová, Kristína Popovičová, Miroslav Bauer, Maroua Jalouli, Abdel Halim Harrat. The microRNA miR-152 can mitigate and prevent the toxic effect of benzene on porcine ovarian cells. Toxicology in vitro : an international journal published in association with BIBRA. vol 99. 2024-06-08. PMID:38815736. |
the expression of mir-152; viability; proliferation (cell proliferation and expression of mrnas and accumulation of pcna and cyclin b1); apoptosis (expression of mrnas and accumulation of bax and caspase 3; and the proportion of cells with fragmented dna); and release of progesterone, estradiol and igf-i were analyzed via rt-qpcr; the trypan blue exclusion test; quantitative immunocytochemistry; brdu; xtt; tunel assays; and elisa. |
2024-06-08 |
2024-06-11 |
Not clear |
| Alexander V Sirotkin, Zuzana Fabová, Barbora Loncová, Maria Bauerová, Abdel Halim Harrat. The adipokines progranulin and omentin can directly regulate feline ovarian granulosa cell functions. Research in veterinary science. vol 175. 2024-06-06. PMID:38843689. |
for this purpose, we investigated the effects of the addition of progranulin and omentin (0, 0.1, 1, or 10 ng/ml) on the proliferation (accumulation of pcna and cyclin b1), apoptosis (accumulation of bax and caspase 3) and progesterone release of cultured feline ovarian granulosa cells by quantitative immunocytochemistry and enzyme-linked immunosorbent assays (elisas). |
2024-06-06 |
2024-06-10 |
Not clear |
| Peng Sun, Kang Huo, Fude Liu, Yawen Cheng, Chen Chen, Jianfeng Han, Jia Y. Regulation and molecular mechanism of adiponectin on the proliferation, apoptosis, autophagy, and chemosensitivity of LN18 Glioma cell line. Cellular and molecular biology (Noisy-le-Grand, France). vol 70. issue 6. 2024-06-05. PMID:38836664. |
moreover, adiponectin inhibits the proliferation rate of the pten wild-type glioma cell line ln18, enhances the expression of cleaved caspase3 and bax, and significantly elevates the apoptosis rate, as evidenced by annexinv/pi flow cytometry. |
2024-06-05 |
2024-06-07 |
Not clear |
| Jianping Chen, Xuehua Chen, Anqi Tang, Zhuo Wang, Kit-Leong Cheong, Xiaofei Liu, Saiyi Zhon. Chondroitin sulfate-functionalized selenium nanoparticle-induced S-phase cell cycle arrest and apoptosis in HeLa Cells. Journal of food science. 2024-06-05. PMID:38837700. |
moreover, secs increased the level of bax and decreased the expression of bcl-2, resulting in the release of cytochrome c from mitochondria and activating caspase-3/8/9 for caspase-dependent apoptosis. |
2024-06-05 |
2024-06-08 |
Not clear |
| Monika Pebam, Sajmina Khatun, Mohammad Sadik Ali, Aditya Srivastava, Aravind Kumar Renga. Self-assembled IR dye/mitoxantrone loaded Porphysomes nanosystem for enhanced combinatorial chemo-photothermal cancer therapy. Colloids and surfaces. B, Biointerfaces. vol 241. 2024-06-05. PMID:38838443. |
the activation of p53-dependent apoptosis pathways was vividly expressed, evidenced by the upregulation of bax and increased pattern of caspase-3 cleavage. |
2024-06-05 |
2024-06-08 |
Not clear |
| Mengxia Shen, Jiafeng Fu, Yunna Zhang, Yanfen Chang, Xiaohong Li, Haipeng Cheng, Yujia Qiu, Min Shao, Yang Han, Yan Zhou, Ziqiang Lu. A novel senolytic drug for pulmonary fibrosis: BTSA1 targets apoptosis of senescent myofibroblasts by activating BAX. Aging cell. 2024-06-04. PMID:38831635. |
a novel senolytic drug for pulmonary fibrosis: btsa1 targets apoptosis of senescent myofibroblasts by activating bax. |
2024-06-04 |
2024-06-06 |
Not clear |
| Mengxia Shen, Jiafeng Fu, Yunna Zhang, Yanfen Chang, Xiaohong Li, Haipeng Cheng, Yujia Qiu, Min Shao, Yang Han, Yan Zhou, Ziqiang Lu. A novel senolytic drug for pulmonary fibrosis: BTSA1 targets apoptosis of senescent myofibroblasts by activating BAX. Aging cell. 2024-06-04. PMID:38831635. |
in this study, we demonstrated that senescent myofibroblasts are resistant to apoptosis by upregulating the proapoptotic protein bax and antiapoptotic protein bcl-2 and bcl-xl, leading to bax inactivation. |
2024-06-04 |
2024-06-06 |
Not clear |
| Mengxia Shen, Jiafeng Fu, Yunna Zhang, Yanfen Chang, Xiaohong Li, Haipeng Cheng, Yujia Qiu, Min Shao, Yang Han, Yan Zhou, Ziqiang Lu. A novel senolytic drug for pulmonary fibrosis: BTSA1 targets apoptosis of senescent myofibroblasts by activating BAX. Aging cell. 2024-06-04. PMID:38831635. |
moreover, the bax activator btsa1 selectively promoted the apoptosis of senescent myofibroblasts, as btsa1-activated bax converted minority momp to complete momp while not injuring other cells with low levels of bax. |
2024-06-04 |
2024-06-06 |
Not clear |
| Peng Qian, Gangxiang Yuan, Chao Yang, Qi Zhang, Lin Chen, Ningjia H. Kuwanon C inhibits proliferation and induction of apoptosis via the intrinsic pathway in MDA-MB231 and T47D breast cancer cells. Steroids. vol 208. 2024-06-03. PMID:38823755. |
flow cytometry confirmed that kuwanon c induced cell apoptosis and upregulated the expression levels of pro-apoptotic proteins (bax and c-caspase3). |
2024-06-03 |
2024-06-06 |
human |
| Shashank Dadsena, Rodrigo Cuevas Arenas, Gonçalo Vieira, Susanne Brodesser, Manuel N Melo, Ana J García-Sáe. Lipid unsaturation promotes BAX and BAK pore activity during apoptosis. Nature communications. vol 15. issue 1. 2024-06-03. PMID:38830851. |
lipid unsaturation promotes bax and bak pore activity during apoptosis. |
2024-06-03 |
2024-06-06 |
Not clear |
| Shashank Dadsena, Rodrigo Cuevas Arenas, Gonçalo Vieira, Susanne Brodesser, Manuel N Melo, Ana J García-Sáe. Lipid unsaturation promotes BAX and BAK pore activity during apoptosis. Nature communications. vol 15. issue 1. 2024-06-03. PMID:38830851. |
bax and bak are proapoptotic members of the bcl2 family that directly mediate mitochondrial outer membrane permeabilition (momp), a central step in apoptosis execution. |
2024-06-03 |
2024-06-06 |
Not clear |
| Shashank Dadsena, Rodrigo Cuevas Arenas, Gonçalo Vieira, Susanne Brodesser, Manuel N Melo, Ana J García-Sáe. Lipid unsaturation promotes BAX and BAK pore activity during apoptosis. Nature communications. vol 15. issue 1. 2024-06-03. PMID:38830851. |
altogether, our work provides an insight on how local lipid environment affects bax and bak function during apoptosis. |
2024-06-03 |
2024-06-06 |
Not clear |
| Zhenwei Zhang, Linghui Hou, Dan Liu, Shenglin Luan, Min Huang, Linxiang Zha. Directly targeting BAX for drug discovery: Therapeutic opportunities and challenges. Acta pharmaceutica Sinica. B. vol 14. issue 6. 2024-06-03. PMID:38828138. |
furthermore, it highlights the structural and mechanistic insights into small-molecule modulators targeting diverse binding surfaces or conformations of bax, offering a promising avenue for developing next-generation apoptosis modulators to treat a wide range of diseases associated with dysregulated cell death by directly targeting bax. |
2024-06-03 |
2024-06-05 |
Not clear |
| Sheng-Yan He, Wen Liu, Chu-Man Huang, Hui-Mei Huang, Qi-Long Cao, Yun-Xiao Li, Yong-Nan Xu, Nam-Hyung Kim, Ying-Hua L. Enhancing antioxidant levels and mitochondrial function in porcine oocyte maturation and embryonic development through notoginsenoside R1 supplementation. Reproduction in domestic animals = Zuchthygiene. vol 59. issue 6. 2024-06-03. PMID:38828566. |
furthermore, ngr1 supplementation resulted in decreased apoptosis, reduced caspase 3 (cas3) and bcl2-associated x (bax) mrna levels and decreased glucose-regulated protein 78 kd (grp78) immunofluorescence in porcine oocytes undergoing in vitro maturation. |
2024-06-03 |
2024-06-05 |
cat |
| Xian Ding, Xiang Gao, Aolin Ren, Jingjing Xu, Xuliang Jiang, Xiao Liang, Kangjie Xie, Yan Zhou, Chunxiao Hu, Dongxiao Huan. Sevoflurane enhances autophagy via Rac1 to attenuate lung ischaemia‒reperfusion injury. Chemico-biological interactions. vol 397. 2024-05-31. PMID:38815668. |
activation of inflammation (elevated il-1β, il-6, and tnf-α) and apoptosis (elevated cleaved caspase3/caspase3 and bax, degraded expression of bcl2) and inhibition of autophagy (elevated p62, degraded expression of beclin1 and lc3-ii/lc3i) in the model group were ameliorated by sevoflurane. |
2024-05-31 |
2024-06-02 |
rat |
| Rania H Abu-Baih, Dalia H Abu-Baih, Sara Mohamed Naguib Abdel-Hafez, Moustafa Fath. Activation of SIRT1/Nrf2/HO-1 and Beclin-1/AMPK/mTOR autophagy pathways by eprosartan ameliorates testicular dysfunction induced by testicular torsion in rats. Scientific reports. vol 14. issue 1. 2024-05-31. PMID:38822026. |
in terms of apoptosis, eprosartan effectively countered apoptotic processes by decreasing cleaved caspase-3 content, suppressing bax and stimulating bcl-2 gene expression. |
2024-05-31 |
2024-06-02 |
rat |
| Jian Zhong, Yongzhi Hua, Shuting Zou, Bo Wan. Juglone triggers apoptosis of non-small cell lung cancer through the reactive oxygen species -mediated PI3K/Akt pathway. PloS one. vol 19. issue 5. 2024-05-30. PMID:38814975. |
additionally, juglone arrested the cell cycle, induced apoptosis, increased the cleavage of caspase 3 and the protein expression of bax and cyt c, and decreased the protein expression of bcl-2 and caspase-3. |
2024-05-30 |
2024-06-02 |
mouse |
| Jun-Yu He, Jia-Xin Yang, Shi-Ying Qin, Jing-Qi Zheng, Yi-Ran Guo, Tian-Xing M. [Exploration of mechanism of total triterpenoids from fruits of Chaenomeles speciosa against senescent GES-1 cells induced by D-galactose based on Gln/GLS1/α-KG metabolic axis and mitochondrial apoptosis signaling pathway]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 49. issue 8. 2024-05-30. PMID:38812238. |
cyto c concentration in the cytoplasm, the mrna expressions of bax, bad, apoptosis protease activating factor 1(apaf-1), and protein expressions of cleaved-caspase-9, cleaved-caspase-3, cleaved-parp-1 were increased(p<0.01). |
2024-05-30 |
2024-06-08 |
Not clear |
| Jiangxia Cheng, Zhuo Wang, Hui Yu, Ye Chen, Zhengchao Wang, Liangcheng Zhang, Xiaohong Pen. The duration-dependent and sex-specific effects of neonatal sevoflurane exposure on cognitive function in rats. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas. vol 57. 2024-05-29. PMID:38808889. |
we found that neonatal exposure to sevoflurane promoted apoptosis in the hippocampus, and bax and caspase-3 were increased in a dose-dependent manner. |
2024-05-29 |
2024-06-02 |
rat |
| Jia He, Jia Zuo, Xiaochen Fan, Zhe L. Electro-acupuncture modulated miR-214 expression to prevent chondrocyte apoptosis and reduce pain by targeting BAX and TRPV4 in osteoarthritis rats. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas. vol 57. 2024-05-29. PMID:38808885. |
electro-acupuncture modulated mir-214 expression to prevent chondrocyte apoptosis and reduce pain by targeting bax and trpv4 in osteoarthritis rats. |
2024-05-29 |
2024-06-02 |
rat |