| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hanlong He, Huiren Su, Xinjian Chen, Xiaohong Chen, Shaoze Yan. Interference with GPR4 inactivates NLRP3 inflammasome signaling by inhibiting LPAR1 expression to ameliorate oxygen-glucose deprivation/reoxygenation-induced inflammation and apoptosis of cardiomyocytes. Prostaglandins & other lipid mediators. 2024-06-27. PMID:38936540. |
ogd/r induced inflammation and apoptosis were markedly inhibited by gpr4 silencing, as evidenced by the decreased tnf-α, il-6 and il-8 levels as well as the elevated bcl-2 expression and reduced bax and cleaved caspase3 expression. |
2024-06-27 |
2024-06-30 |
Not clear |
| Erhao Wang, Yuxia Wu, Yan Wang, Jiao Li, Xiuzhen Liang, Zhongtao Wang, Xiaofei Liu, Faming Feng, JianCang Mao, Yingqi Zhu, Le L. Natural product nanozymes of herbal extract galangin in managing hepatocellular carcinoma. Frontiers in chemistry. vol 12. 2024-06-25. PMID:38915904. |
upon uptake by hepg-2 cells, galazyme efficiently converts excess hydrogen peroxide (h2o2) into highly reactive •oh radicals and upregulates mapk expression, leading to the activation of bax and caspase 3, thereby promoting irreversible tumor cell apoptosis. |
2024-06-25 |
2024-06-27 |
Not clear |
| Ya Chen, Congcong Zhu, Zongguang Tai, Tianyan Lian, Quangang Zhu, Zhongjian Che. Cordycepin Ameliorates Psoriasis-Like Skin Lesion by Regulating p53/MDM2 Feedback Loop. Molecular biotechnology. 2024-06-24. PMID:38914920. |
regulating the expression of apoptotic proteins bax, bcl-2, and p53 promote apoptosis. |
2024-06-24 |
2024-06-27 |
mouse |
| Yaqiong Zhang, Aizhen Yang, Zhenzhen Zhao, Fengwu Chen, Xiaofeng Yan, Yue Han, Depei Wu, Yi W. Protein disulfide isomerase is essential for spermatogenesis in mice. JCI insight. vol 9. issue 12. 2024-06-24. PMID:38912589. |
stra8-cre/pdifl/fl spermatocytes had significantly upregulated er stress-related proteins (grp78 and xbp1) and apoptosis-related proteins (cleaved caspase-3 and bax), together with cell apoptosis. |
2024-06-24 |
2024-06-26 |
mouse |
| Tengfei Xu, Shan Jiang, Tongtong Liu, Shiqiang Han, Yueqiang Wan. ADAM10 Alleviates Hypoxia/Reoxygenation-Induced Cardiomyocyte Injury by Activating the Notch Signaling Pathway. Cell biochemistry and biophysics. 2024-06-24. PMID:38913282. |
meanwhile, overexpression of adam10 inhibited apoptosis in h9c2 cells exposed to h/r by regulating the expression of apoptosis-related proteins, such as bax, bcl-2 and cleaved-caspase-3. |
2024-06-24 |
2024-06-26 |
Not clear |
| Dongjie Chen, Yongpeng Wang, Shanshan Xiao, Guiguang Cheng, Yaping Liu, Tianrui Zhao, Jianxin Cao, Yan We. Investigation on the mechanism of androsta-4,6,8,14-tetraene-3,11,16-trione against acute lymphoblastic leukemia. The Journal of steroid biochemistry and molecular biology. 2024-06-23. PMID:38909867. |
western blotting results showed that att reduced the relative protein level of p-pi3k and p-akt, thereby increasing the relative level of pro-apoptosis protein bax and reducing the relative level of anti-apoptosis protein bcl-2, the apoptosis downstream protein pro-caspase3, and cell proliferation-related proteins (p-gsk3b and cyclind1). |
2024-06-23 |
2024-06-26 |
Not clear |
| Hui Jiang, Qiqi Fu, Jiali Yang, Haokuan Qin, Angze Li, Shangfeng Liu, Muqing Li. Blue light irradiation suppresses oral squamous cell carcinoma through induction of endoplasmic reticulum stress and mitochondrial dysfunction. Journal of photochemistry and photobiology. B, Biology. vol 257. 2024-06-22. PMID:38908147. |
moreover, we observed that 420 nm blue light triggered endoplasmic reticulum (er) stress and mitochondrial dysfunction in oscc cells, leading to activation of the chop signal pathway and alterations in the levels of bcl-2 and bax proteins, ultimately promoting cell apoptosis. |
2024-06-22 |
2024-06-25 |
Not clear |
| Yanlei Zheng, Ronghua Hu, Jinrong Hu, Lina Feng, Shi L. Protective effects of butorphanol in oleic acid-endotoxin "two-hit" induced rat lung injury by suppression of inflammation and apoptosis. Scientific reports. vol 14. issue 1. 2024-06-20. PMID:38902260. |
in addition, butorphanol decreased bax and cleaved caspase-3, increased an antiapoptotic protein (bcl-2), and inhibited the "two-hit" cell apoptosis ratio. |
2024-06-20 |
2024-06-23 |
rat |
| Ji-Hee Kim, Kyu-Hee Hwang, Seong-Heon Kim, Hi-Ju Kim, Jung-Min Kim, Mi-Young Lee, Seung-Kuy Cha, Jinhee Le. Particulate Matter-Induced Neurotoxicity: Unveiling the Role of NOX4-Mediated ROS Production and Mitochondrial Dysfunction in Neuronal Apoptosis. International journal of molecular sciences. vol 25. issue 11. 2024-06-19. PMID:38892302. |
this increase in mitochondrial ros triggers the opening of the mitochondrial permeability transition pore (mptp), leading to apoptosis through key mediators, including caspase3, bax, and bcl2. |
2024-06-19 |
2024-06-21 |
human |
| Yinwen Hong, Xueliang Sun, Lijuan L. Loureirin B inhibits Cervical Cancer Development by Blocking PI3K/AKT Signaling Pathway: Network Pharmacology Analysis and Experimental Validation. Applied biochemistry and biotechnology. 2024-06-18. PMID:38888697. |
compared to the cell apoptosis rate of 2.63% in control group, lb increased it to 6.59% via upregulating bax and suppressing bcl-2 expressions. |
2024-06-18 |
2024-06-21 |
Not clear |
| Yanju Bi, Haidong Wei, Tingting Yu, Xiaojing Li, Shiwen X. New insights into resveratrol attenuates hepatotoxicity in emamectin benzoate-exposed grass carp (Ctenopharyngodon idella) via NO system/NF-κB signaling pathway. Pesticide biochemistry and physiology. vol 202. 2024-06-15. PMID:38879332. |
in addition, compared with the con group, the results of flow cytometry and dansylcadaverine (mdc) staining showed a significant increase in apoptosis and autophagy in the emb-exposed group (p < 0.05) with the activation of the b-cell lymphoma-2 (bcl-2)/bcl-2 associated x (bax)/cysteine-aspartic acid protease 3 (caspase-3)/cysteine-aspartic acid protease 9 (caspase-9) pathway and microtubule-associated protein light chain 3 (lc3)/sequestosome 1 (p62)/beclin1 pathway. |
2024-06-15 |
2024-06-18 |
Not clear |
| Aurélien Haustrate, Clément Cordier, George Shapovalov, Adriana Mihalache, Emilie Desruelles, Benjamin Soret, Nadège Charlène Essonghé, Corentin Spriet, Maya Yassine, Alexandre Barras, Johanna Marines, Lindsay B Alcaraz, Sabine Szunerits, Gautier Robin, Pierre Gosset, Natalia Prevarskaya, V'yacheslav Lehen'ky. Trpv6 channel targeting using monoclonal antibody induces prostate cancer cell apoptosis and tumor regression. Cell death & disease. vol 15. issue 6. 2024-06-15. PMID:38879621. |
mab82 decreased pca survival rate in vitro by 71% at 12 µg/ml via inducing cell death through the apoptosis cascade via activation of the protease calpain, following bax activation, mitochondria enlargement, and loss of cristae, cyt c release, pro-caspase 9 cleavage with the subsequent activation of caspases 3/7. |
2024-06-15 |
2024-06-18 |
mouse |
| Kazim Husain, Domenico Coppola, Chung S Yang, Mokenge P Malaf. Effect of vitamin E δ-tocotrienol and aspirin on Wnt signaling in human colon cancer stem cells and in adenoma development in APCmin/+ mice. Carcinogenesis. 2024-06-15. PMID:38877828. |
in addition, dt3 and/or aspirin-induced apoptosis was associated with cleaved parp, elevated levels of cytosolic cytochrome c and bax, and depletion of anti-apoptotic protein bcl-2 in ccscs. |
2024-06-15 |
2024-06-17 |
mouse |
| Peng Niu, Fei Huang, Jie Wang, Jia-Jia Suo, Jie-Ru Wang, Di Fang, Chun-Mei Han, Qing-Hua Ga. Effects of melatonin on sperm quality, enzyme activity, antioxidant gene expression and fertility of cryopreserved bovine semen. Theriogenology. vol 226. 2024-06-14. PMID:38875920. |
meanwhile, the mrna expression of antioxidant genes sod2, cat and gpx increased in the 0.3 mg/ml mlt treatment group, and the mrna expression of apoptosis genes caspase-3 and bax were significantly reduced. |
2024-06-14 |
2024-06-17 |
cat |
| Ana Dias-Carvalho, Mariana Ferreira, Ana Reis-Mendes, Rita Ferreira, Maria de Lourdes Bastos, Eduarda Fernandes, Susana Isabel Sá, João Paulo Capela, Félix Carvalho, Vera Marisa Cost. Doxorubicin-induced neurotoxicity differently affects the hippocampal formation subregions in adult mice. Heliyon. vol 10. issue 11. 2024-06-13. PMID:38868005. |
concerning the apoptosis pathway, whereas bax increased in the dox9 group, it decreased in the dox18 group. |
2024-06-13 |
2024-06-15 |
mouse |
| Warumporn Yingsunthonwattana, Pakkakul Sangsuriya, Premruethai Supungul, Anchalee Tassanakajo. Litopenaeus vannamei heat shock protein 90 (LvHSP90) interacts with white spot syndrome virus protein, WSSV322, to modulate hemocyte apoptosis during viral infection. Fish & shellfish immunology. 2024-06-13. PMID:38871140. |
moreover, the co-silencing of lvhsp90 and wssv322 triggered apoptosis by the mitochondrial pathway, resulting in the upregulation of pro-apoptotic protein expression (bax) and the downregulation of anti-apoptotic protein expression (bcl, akt). |
2024-06-13 |
2024-06-16 |
Not clear |
| Jie Xu, Shouzhu Xu, Jiayin Luo, Shihao Zhang, Dongdong Wu, Qifan Yang, Rourou Fang, Chuandao Shi, Qiling Liu, Jing Zha. Epigallocatechin-3-gallate alleviates ethanol-induced endothelia cells injury partly through alteration of NF-κB translocation and activation of the Nrf2 signaling pathway. Biological & pharmaceutical bulletin. 2024-06-12. PMID:38866477. |
the findings revealed that a concentration of 20.0 mm of ethanol reduced cell viability and bcl-2 expression, while increasing cell apoptosis, intracellular ros levels, mitochondrial depolarization, and the expression of bax and cleaved-caspase-3 in endothelial cells. |
2024-06-12 |
2024-06-15 |
Not clear |
| Zhao-Da Duan, Li-Yang Zheng, Qiu-Ye Jia, Hao-Lun Chen, Dong-Yao Xu, Yu-Jia Yang, Zhi Qi, Li Yang, Chun-Yun W. Effect of scutellarin on BV-2 microglial-mediated apoptosis in PC12 cells via JAK2/STAT3 signalling pathway. Scientific reports. vol 14. issue 1. 2024-06-11. PMID:38862696. |
we observed that pc12 cells apoptosis in cm was significantly increased, the expression and fluorescence intensity of the pro-apoptotic protein bax and apoptosis-related protein cleaved caspase-3 were increased, and expression of the anti-apoptotic protein b-cell lymphoma-2 (bcl-2) was decreased. |
2024-06-11 |
2024-06-14 |
Not clear |
| Zhao-Da Duan, Li-Yang Zheng, Qiu-Ye Jia, Hao-Lun Chen, Dong-Yao Xu, Yu-Jia Yang, Zhi Qi, Li Yang, Chun-Yun W. Effect of scutellarin on BV-2 microglial-mediated apoptosis in PC12 cells via JAK2/STAT3 signalling pathway. Scientific reports. vol 14. issue 1. 2024-06-11. PMID:38862696. |
after treatment with scutellarin, pc12 cells apoptosis as well as cleaved caspase-3 and bax protein expression and fluorescence intensity decreased. |
2024-06-11 |
2024-06-14 |
Not clear |
| Ashrakt H Abdelhamid, Eman M Mantawy, Riham S Said, Ebtehal El-Demerdas. Neuroprotective effects of saxagliptin against radiation-induced cognitive impairment: Insights on Akt/CREB/SIRT1/BDNF signaling pathway. Toxicology and applied pharmacology. 2024-06-10. PMID:38857790. |
moreover, saxa abrogated radiation-induced hippocampal neuronal apoptosis through downregulating proapoptotic bcl-2 associated x-protein (bax) and upregulating antiapoptotic b-cell lymphoma 2 (bcl-2) expressions and eventually diminishing expression of cleaved caspase 3. |
2024-06-10 |
2024-06-14 |
rat |