| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yi Wu, Chen Li, Zhiyuan Geng, Lihong Wang, Shufeng Wang, Dingxing Zhang, Dongxu Li, Fanyu Men. Anti-Colon Cancer Effects of Lysate from Potential Probiotic Yeast Strains Derived from Human Breast Milk. Probiotics and antimicrobial proteins. 2024-12-03. PMID:39627436. |
moreover, lysates from rhodotorula mucilaginosa and cryptococcus laurentii isolated from breast milk markedly inhibited the proliferation of colon cancer cell lines (ht-29 and sw620) and induced apoptosis by upregulating key apoptosis-related genes (caspase 3, caspase 9, and bax), as well as autophagy-related genes (beclin-1, lc3, and atg5). |
2024-12-03 |
2024-12-06 |
human |
| Yicong Chang, Xinru Jiang, Zhenghua Ji, Yingchao Gong, Xianan Fan, Beili Hao, Liang Yuan, Ishfaq Muhammad, Rui Li, Changwen Li, Fangping Li. Dihydromyricetin Suppresses Lipopolysaccharide-Induced Intestinal Injury Through Reducing Reactive Oxygen Species Generation and NOD-Like Receptor Pyrin Domain Containing 3 Inflammasome Activation. Journal of animal physiology and animal nutrition. 2024-12-02. PMID:39618421. |
dhm efficiently regulated ros production, thereby augmenting zo-1, occludin and claudin-1 expression to enhance barrier function; upregulating bcl-2 expression and downregulating bax and caspase-3 expression to regulate apoptosis and suppressing inflammation in iecs. |
2024-12-02 |
2024-12-06 |
chicken |
| Wesam Bassiouni, Zabed Mahmud, Thomas Simmen, John M Seubert, Richard Schul. MMP-2 inhibition attenuates ER stress-mediated cell death during myocardial ischemia-reperfusion injury by preserving IRE1α. Journal of molecular and cellular cardiology. 2024-12-02. PMID:39622369. |
ir also increased the levels of chop and mitochondrial bax and caspase-3 and -9 activities, indicating induction of apoptosis, all of which were attenuated by mmp-2 inhibitors, regardless of the reperfusion time. |
2024-12-02 |
2024-12-06 |
mouse |
| Yanping Wu, Zenghui Liang, Kun Li, Junli Fen. Knockdown of HOTAIR Alleviates High Glucose-Induced Apoptosis and Inflammation in Retinal Pigment Epithelial Cells. Applied biochemistry and biotechnology. 2024-11-28. PMID:39607470. |
knockdown of hotair improved viability, inhibited apoptosis, increased bcl-2 protein levels, and decreased bax and cleaved caspase 3 protein levels in hg-treated arpe-19 cells. |
2024-11-28 |
2024-11-30 |
human |
| Sai Xiao, Ke Peng, Rui Chen, Xinxin Liu, Benliang Zhou, Rijing He, Yujun Yan, Runtian Wan, Ye-Shi Yin, Shengsheng Lu, Xingwei Lian. Equol promotes the in vitro maturation of porcine oocytes by activating the NRF2/KEAP1 signaling pathway. Theriogenology. vol 233. 2024-11-28. PMID:39608307. |
equol also reduced dna damage and early apoptosis, with an associated upregulation of bcl2 and downregulation of bax expression. |
2024-11-28 |
2024-12-01 |
cat |
| Cuiying Liu, Jiayi Guo, Longfei Guan, Chenyang Li, Xiaoyan Hu, Xinchun Jin, Baohui Xu, Junfa Li, Heng Zha. Docosahexaenoic acid protects against ischemic stroke in diabetic mice by inhibiting inflammatory responses and apoptosis. Experimental neurology. 2024-11-28. PMID:39608560. |
western blotting assay revealed that pro-apoptotic protein bax was reduced whereas anti-apoptotic protein bcl-2 was increased, indicating the attenuation of apoptosis. |
2024-11-28 |
2024-12-01 |
mouse |
| Sandra Maria Barbalho, Karina Torres Pomini, Enzo Pereira de Lima, Jéssica da Silva Camarinha Oliveira, Beatriz Leme Boaro, Adriano Cressoni Araújo, Elen Landgraf Guiguer, Rose Eli Grassi Rici, Durvanei Augusto Maria, Jesselina Francisco Dos Santos Haber, Virgínia Maria Cavallari Strozze Catharin, Patrícia Cincotto Dos Santos Bueno, Eliana de Souza Bastos Mazuqueli Pereira, Ricardo de Alvares Goulart, Lucas Fornari Laurind. Fantastic Frogs and Where to Use Them: Unveiling the Hidden Cinobufagin's Promise in Combating Lung Cancer Development and Progression Through a Systematic Review of Preclinical Evidence. Cancers. vol 16. issue 22. 2024-11-27. PMID:39594713. |
specifically, cb was found to decrease cell viability and increase apoptosis in lung cancer cells by modulating key molecular pathways, including bcl-2, bax, cleaved caspases, caveolin-1, flot2, akt, stat3, and foxo1. |
2024-11-27 |
2024-11-29 |
human |
| Ilter Ilhan, Halil Asci, Ibrahim Aydın Candan, Mehtap Savran, Orhan Berk Imeci, Mehmet Abdulkadir Sevu. Cannabidiol mitigates methotrexate-induced hepatic injury via SIRT-1/p53 signaling and mitochondrial pathways: reduces oxidative stress and inflammation. Drug and chemical toxicology. 2024-11-27. PMID:39603835. |
it activates antioxidant defenses via sirt-1 upregulation, suppresses inflammation by reducing tnf-α, and prevents apoptosis by modulating p53, bcl-2, and bax gene expressions. |
2024-11-27 |
2024-11-30 |
rat |
| Zhe Bai, Hui Li, Baoping Jia. Potential Therapeutic Effect of Sinigrin on Diethylnitrosamine-Induced Liver Cancer in Mice: Exploring the Involvement of Nrf-2/HO-1, PI3K-Akt-mTOR Signaling Pathways, and Apoptosis. ACS omega. vol 9. issue 46. 2024-11-25. PMID:39583716. |
sinigrin also activated the intrinsic mitochondrial apoptosis pathway mediated by p53, downregulated antiapoptotic proteins (bcl-2), up-regulated pro-apoptosis regulatory proteins like bax and caspase-3. |
2024-11-25 |
2024-11-27 |
mouse |
| Lu Li, Wan Li, Yufeng Liu, Bing Han, Yanbo Yu, Hongjin Li. MEHP induced mitochondrial damage by promoting ROS production in CIK cells, leading to apoptosis, autophagy, cell cycle arrest. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 2024-11-25. PMID:39586385. |
in addition, mehp treatment not only can increase the level of cyt-c, atg12, atg13, atg14, beclin1, ulk1, lc3-ii, caspase3, caspase9, and bax, but also can decrease the level of bcl2, p62, cyclinb, cyclind, and cycline in a concentration-dependent manner, which resulted in apoptosis, autophagy and cell cycle arrest. |
2024-11-25 |
2024-11-28 |
Not clear |
| Yifei Liu, Siyu Lin, Jianzhong Wang, Jianli Jiang, Aihua Shu, Mi Zho. TGF-β1 inhibits apoptosis of cardiomyocytes H9c2 by regulating autophagy and ERK pathway. General physiology and biophysics. vol 43. issue 6. 2024-11-25. PMID:39584297. |
upon overexpression of tgf-β1, the viability of ogd/r-induced h9c2 cells was enhanced, while apoptosis was suppressed by downregulating bax and upregulating bcl-2. |
2024-11-25 |
2024-11-27 |
Not clear |
| Yifei Liu, Siyu Lin, Jianzhong Wang, Jianli Jiang, Aihua Shu, Mi Zho. TGF-β1 inhibits apoptosis of cardiomyocytes H9c2 by regulating autophagy and ERK pathway. General physiology and biophysics. vol 43. issue 6. 2024-11-25. PMID:39584297. |
importantly, treatments with 3-methyladenine (3-ma), an autophagy inhibitor, and u0126, an extracellular signal-related kinases 1 and 2 (erk1/2) inhibitor, significantly inhibited cell viability, increased intracellular reactive oxygen species levels, promoted cell apoptosis (by upregulating bax and downregulating bcl-2), and inhibited cell autophagy (by downregulating beclin-1 and lc3ii/lc3i) in ogd/r-induced h9c2 cells with tgf-β1 overexpression. |
2024-11-25 |
2024-11-27 |
Not clear |
| Canqiang Lu, Yun Feng, Zhenhua Tang, Ruru Jia, Fan Xia, Tingzi Yu, Heng Wang, Hongfang Mo, Deshun Shi, Fenghua L. Supplementation with L-kynurenine during in vitro maturation improves bovine oocytes developmental competence through its antioxidative action. Theriogenology. vol 233. 2024-11-23. PMID:39579654. |
further analysis revealed that this treatment effectively down-regulated expression levels of genes to cumulus cell apoptosis (bax and caspase3), up-regulated expression levels of genes to cumulus cell expansion (has2, ptx3, and ptgs2) and oocyte antioxidant (gpx4 and cat). |
2024-11-23 |
2024-11-26 |
cat |
| Le Zhang, Prashanthi Ramesh, Lidia Atencia Taboada, Rebecca Roessler, Dick W Zijlmans, Michiel Vermeulen, Daisy I Picavet-Havik, Nicole N van der Wel, Frédéric M Vaz, Jan Paul Medem. UGT8 mediated sulfatide synthesis modulates BAX localization and dictates apoptosis sensitivity of colorectal cancer. Cell death and differentiation. 2024-11-23. PMID:39580596. |
ugt8 mediated sulfatide synthesis modulates bax localization and dictates apoptosis sensitivity of colorectal cancer. |
2024-11-23 |
2024-11-26 |
Not clear |
| Le Zhang, Prashanthi Ramesh, Lidia Atencia Taboada, Rebecca Roessler, Dick W Zijlmans, Michiel Vermeulen, Daisy I Picavet-Havik, Nicole N van der Wel, Frédéric M Vaz, Jan Paul Medem. UGT8 mediated sulfatide synthesis modulates BAX localization and dictates apoptosis sensitivity of colorectal cancer. Cell death and differentiation. 2024-11-23. PMID:39580596. |
in conclusion, our data indicates that ugt8 mediated synthesis of sulfatides controls mitochondrial homeostasis and bax localization, dictating apoptosis sensitivity of colorectal cancer cells. |
2024-11-23 |
2024-11-26 |
Not clear |
| Ming Du, Xinyu Li, Bayinnamula, Na Wang, Yuanyi Liu, Lei Zhang, Yiping Zhao, Manglai Dugarjavii. Optimization of vitrification methods for equine oocytes. Tissue & cell. vol 91. 2024-11-22. PMID:39577324. |
apoptosis gene analysis revealed that bax, bid, bok, and tp53 expression was substantially higher in oocytes from the ed20 (20 s) + edfs40 + 120 s group than in oocytes from the ed10 (39 s) + edfs30 + 80 s and control groups (p<0.01). |
2024-11-22 |
2024-11-25 |
Not clear |
| Jung-Woo Lim, Jun-Hee Lee, Jalil Ghassemi Nejad, Hong-Gu Le. Effects of L-leucine and sodium acetate on milk protein synthesis under heat stress conditions in bovine mammary epithelial cells in vitro. Journal of thermal biology. vol 126. 2024-11-21. PMID:39571500. |
when 1.8 mm of leu was added under hs at 41 °c, it suppressed apoptosis by reducing the gene expression of hsp70 and controlling the gene expression of apoptosis-related genes such as bax and bcl-2. |
2024-11-21 |
2024-11-24 |
cattle |
| Xiaorong Guo, Xinhao Fan, Chundi Xie, Ayoola Ebenezer Afe, Yalan Yang, Rong Zho. Suppressing IGF2R mitigates hypoxia-induced apoptosis by reducing the expression of pro-apoptotic factor BAX. International journal of biological macromolecules. 2024-11-18. PMID:39557264. |
suppressing igf2r mitigates hypoxia-induced apoptosis by reducing the expression of pro-apoptotic factor bax. |
2024-11-18 |
2024-11-22 |
Not clear |
| Xiaorong Guo, Xinhao Fan, Chundi Xie, Ayoola Ebenezer Afe, Yalan Yang, Rong Zho. Suppressing IGF2R mitigates hypoxia-induced apoptosis by reducing the expression of pro-apoptotic factor BAX. International journal of biological macromolecules. 2024-11-18. PMID:39557264. |
meanwhile, the expression of the pro-apoptotic gene bax is reduced, the hypoxia-induced apoptosis is rescued, and cell survival is significantly improved. |
2024-11-18 |
2024-11-22 |
Not clear |
| Gyu-Hyun Lee, Song-Hee Lee, Xiao-Han Li, Qin-Yue Lu, Cheng-Lin Zhan, Ji-Dam Kim, Jae-Min Sim, Hyeon-Ji Song, Ming-Hong Sun, Xiang-Shun Cu. ERK5 is essential for early porcine embryonic development by maintaining Endoplasmic Reticulum homeostasis. Gene. 2024-11-18. PMID:39557370. |
in addition, erk5 inhibition increased the expression of bax, a pro-apoptotic gene, resulting in apoptosis. |
2024-11-18 |
2024-11-22 |
Not clear |