| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Palin Jiwaganont, Kotchapol Jaturanratsamee, Siriwan Thaisakun, Sittiruk Roytrakul, Soontaree Petchde. Analysis of serum proteomic in cats with polycystic kidney disease-1 gene mutation. Heliyon. vol 10. issue 15. 2024-08-22. PMID:39170222. |
the apoptosis regulator bcl-2 (bcl2) was overexpressed in the chronic kidney disease (ckd) group, while apoptotic peptidase activating factor 1 (apaf1) and bcl2-associated x apoptosis regulator (bax) were only expressed in the pkd group. |
2024-08-22 |
2024-08-24 |
Not clear |
| Jiannan Wang, Na Jia, Kaiyi Zhu, Kun Xu, Mingjing Yan, Ming Lan, Junmeng Liu, Bing Liu, Tao Shen, Qing H. Shock Wave Therapy Alleviates Hypoxia/Reoxygenation-Induced Cardiomyocyte Injury by Inhibiting Both Apoptosis and Ferroptosis. Analytical cellular pathology (Amsterdam). vol 2024. 2024-08-22. PMID:39170930. |
meanwhile, we found that swt could increase the expression of gpx4, xct, and bcl-2, while decreasing the expression of bax and cleaved caspase-3, and inhibiting cardiomyocyte apoptosis and ferroptosis. |
2024-08-22 |
2024-08-24 |
rat |
| Guangdong Ren, Ran Liu, Huiqiang Mai, Gang Yin, Fulai Ding, Chunmei Wang, Shuxin Chen, Xianqi La. GAB1 attenuates lipopolysaccharide‑mediated endothelial dysfunction via regulation of SOCS3. Experimental and therapeutic medicine. vol 28. issue 4. 2024-08-22. PMID:39171145. |
however, gab1 overexpression significantly mitigated lps-induced cell viability decrease and apoptosis in huvecs, accompanied by upregulation of bcl2 expression, and downregulation of bax and cleaved caspase-3 expression. |
2024-08-22 |
2024-08-24 |
Not clear |
| Xin Liu, Liu Ye, Ying Ding, Wei Gong, Hongwu Qian, Kai Jin, Yingjie Niu, Qisheng Zuo, Jiuzhou Song, Wei Han, Guohong Chen, Bichun L. Role of PI3K/AKT signaling pathway involved in self-renewing and maintaining biological properties of chicken primordial germ cells. Poultry science. vol 103. issue 11. 2024-08-22. PMID:39173217. |
we further demonstrated that inhibition of pi3k/akt regulates the cell cycle and promotes apoptosis in pgcs by activating the expression of bax and inhibiting that of bcl-2. |
2024-08-22 |
2024-08-25 |
chicken |
| Deqi Kong, Heeryun Cho, Soowon Hwang, Ahyoung Lee, Uk Lee, Yun-Bae Kim, Dong Ho Geum, Byung-Soo Kim, Young Mi Jung, Ho Yeon Kim, Geum Joon Cho, Kihoon Ahn, Min-Jeong Oh, Hai-Joong Kim, Hee Young Cho, Joong Shin Park, SoonCheol Hon. The Role of Prolactin in Amniotic Membrane Regeneration: Therapeutic Potential for Premature Rupture of Membranes. Endocrinology. vol 165. issue 9. 2024-08-19. PMID:39082703. |
prl (500 ng/ml) significantly improved the viability of haescs and inhibited cell apoptosis, related to the upregulation of ccn2 expression and downregulation of bax, caspase 3, and caspase 8. |
2024-08-19 |
2024-08-21 |
human |
| Xi Chen, Yan Song, Yaoyao Tian, Xiushuai Dong, Yuying Chang, Wei Wan. miR-149-3p Enhances Drug Sensitivity of AML Cells by Inhibiting Warburg Effect Through PI3K/AKT Pathway. Cell biochemistry and biophysics. 2024-08-17. PMID:39154128. |
down-regulation of mir-149-3p significantly promoted proliferation and invasion of aml cells while inhibiting apoptosis by up-regulating the expression of bcl-2 and down-regulating the expression of bax. |
2024-08-17 |
2024-08-20 |
Not clear |
| Prem Kumar Govindappa, Rahul V G, Govindaraj Ellur, Amir A Gaber, John Elfa. 4-aminopyridine attenuates inflammation and apoptosis and increases angiogenesis to promote skin regeneration following a burn injury. Research square. 2024-08-16. PMID:39149501. |
4-ap attenuated apoptosis, with decreases in apoptotic markers bax, caspase-9, and caspase-3 and increases in anti-apoptotic markers bcl2 and bcl-xl. |
2024-08-16 |
2024-08-18 |
Not clear |
| Mohammad Hossein Derakhshan Nazari, Ronak Heidarian, Mina Masoudnia, Rana Askari Dastjerdi, Parnian Ghaedi Talkhounche, Sara Taleahma. Targeting GLI1 and BAX by nanonoscapine could impede prostate adenocarcinoma progression. Scientific reports. vol 14. issue 1. 2024-08-16. PMID:39152150. |
we monitored the effects of nanonoscapine on the androgen-sensitive human prostate adenocarcinoma cell line, lncap, investigating its impact on gli1 and bax genes' expressions, crucial regulators of cell cycle and apoptosis. |
2024-08-16 |
2024-08-20 |
human |
| Qian Ma, Liwei Cai, Yu Zhou, Changyi Zhan. HuMSC-EVs Protect Endothelial Cells Against Hypoxia/Reoxygenation Injury by Inhibiting the Pannexin 1/p38-MAPK Pathway. Transplantation proceedings. 2024-08-15. PMID:39147615. |
mechanistically, humsc-evs were found to inhibit the p38 mitogen-activated protein kinase (mapk)-dependent apoptosis pathway, as evidenced by increased bcl2 expression and reductions in p38 mapk phosphorylation, bax expression, and cleaved-caspase 3 expression. |
2024-08-15 |
2024-08-18 |
human |
| Yuanyuan Li, Yongkang Wang, Zonghan Jiang, Chenglin Yang, You Wu, Aoao Wu, Qike Zhang, Xiaofang Liu, Bo Xiao, Yiya Feng, Jing Wu, Zengenni Liang, Zhihang Yua. Apoptosis mediated by crosstalk between mitochondria and endoplasmic reticulum: A possible cause of citrinin disruption of the intestinal barrier. Ecotoxicology and environmental safety. vol 284. 2024-08-14. PMID:39142118. |
meanwhile, the results showed that ctn exposure could induce excessive apoptosis in intestinal cells by altering the expression of proteins such as chop and grp78 in the endoplasmic reticulum and bax and cyt c in mitochondria. |
2024-08-14 |
2024-08-17 |
mouse |
| Yanqin Song, Jian Ruan, Shuxian Liu, Haizhou Y. Bisdemethoxycurcumin Augments Docetaxel Efficacy for Treatment of Prostate Cancer. Biological & pharmaceutical bulletin. vol 47. issue 8. 2024-08-14. PMID:39143009. |
we found that a combination treatment of bdmc (10 µm) with dtx (10 nm) was more effective in the inhibition of pc3 and lncap cell growth and induction of apoptosis as well as g2/m arrest, which is accompanied with the significant inhibition of bcl-2, cyclin b1, cdk1 expression and significant increase of bax, cleaved caspase-9, cleaved caspase-3 and cleaved parp, than those by treatment of bdmc or dtx alone. |
2024-08-14 |
2024-08-17 |
Not clear |
| Faruk Altinbasak, Murat Serkant Unal, Semih Tan, Gul Yildiri. The effects of testicular stromal stem cells on surgically injured testicular tissue in rats. Anatomia, histologia, embryologia. vol 53. issue 5. 2024-08-13. PMID:39137161. |
high expressions of bax, bcl-2 and caspase-3 in the dg group revealed prominent features of apoptosis. |
2024-08-13 |
2024-08-16 |
rat |
| Saad Shaaban, Mohamed M Hammouda, Hanan A Althikrallah, Jawaher Y Al Nawah, Hussein Ba-Ghazal, Marwa Sharaky, Hamada S Abulkhair, Ahmed A Al-Karmalaw. Organoselenium-based Azomethines as Apoptosis Inducers in Colorectal Carcinoma via P53, BAX, Caspase-3, Caspase-6, and Caspase-9 Modulations. Current medicinal chemistry. 2024-08-13. PMID:39136522. |
organoselenium-based azomethines as apoptosis inducers in colorectal carcinoma via p53, bax, caspase-3, caspase-6, and caspase-9 modulations. |
2024-08-13 |
2024-08-16 |
Not clear |
| Hussam A Althagaf. Neuroprotective role of chlorogenic acid against hippocampal neuroinflammation, oxidative stress, and apoptosis following acute seizures induced by pentylenetetrazole. Metabolic brain disease. 2024-08-12. PMID:39133453. |
remarkably, cga counteracted hippocampal apoptosis by lessening the levels of pro-apoptotic biomarkers [bcl-2-associated x protein (bax) and caspase-3] and increasing the anti-apoptogenic marker level of b-cell lymphoma 2 (bcl-2). |
2024-08-12 |
2024-08-14 |
mouse |
| Jabeen Farheen, M Zubair Iqbal, Asim Mushtaq, Yike Hou, Xiangdong Kon. Hippophae Rhamnoides-derived Phytomedicine Nano-System Modulates Bax/Fas Pathways to Reduce Proliferation in Triple-Negative Breast Cancer. Advanced healthcare materials. 2024-08-12. PMID:39132863. |
mechanistically, in vivo sbp-met proteome expression profiling reveals upregulation of proapoptotic bax protein and activation of fas signaling pathways convince downstream daxx and fadd proteins, which further triggers caspase-3 that prompts apoptosis in human tnbc cells by cleaving parp-1 protein. |
2024-08-12 |
2024-08-14 |
human |
| Vasiliki G Sapanidou, Byron Asimakopoulos, Theodoros Lialiaris, Sophia N Lavrentiadou, Konstantinos Feidantsis, Georgios Kourousekos, Maria P Tsantarlioto. The Role of Erythropoietin in Bovine Sperm Physiology. Animals : an open access journal from MDPI. vol 14. issue 15. 2024-08-10. PMID:39123702. |
moreover, epo inhibited apoptosis, as it reduced both bcl2-associated x apoptosis regulator (bax)/b-cell lymphoma 2 (bcl-2) ratio and cleaved cysteine-aspartic proteases (caspases) substrate levels in a dose-dependent manner. |
2024-08-10 |
2024-08-13 |
cattle |
| Sukhmandeep Kaur, Patricia Mendonca, Karam F A Solima. The Anticancer Effects and Therapeutic Potential of Kaempferol in Triple-Negative Breast Cancer. Nutrients. vol 16. issue 15. 2024-08-10. PMID:39125273. |
kaempferol showed anti-breast cancer effects by inducing dna damage and increasing caspase 3, caspase 9, and pamt expression, modifying ros production by nrf2 modulation, inducing apoptosis by increasing cleaved parp and bax and downregulating bcl-2 expression, inducing cell cycle arrest at the g2/m phase; inhibiting immune evasion by modulating the jak-stat3 pathway; and inhibiting the angiogenic and metastatic potential of tumors by downregulating mmp-3 and mmp-9 levels. |
2024-08-10 |
2024-08-13 |
human |
| Jiayu Liu, Qiunan Zhou, Kai Meng, Xiaojuan Yang, Bin Ma, Chunxia Su, Xiangguo Dua. Aspirin Inhibits Colorectal Cancer via the TIGIT-BCL2-BAX pathway in T Cells. International journal of medical sciences. vol 21. issue 10. 2024-08-08. PMID:39113892. |
further, aspirin could inhibit jurkat cell proliferation and induce apoptosis via downregulation of tigit expression and the anti-apoptosis b cell lymphoma 2 (bcl2) protein and upregulation of bcl2-associated x protein (bax) expression. |
2024-08-08 |
2024-08-10 |
mouse |
| Sally M Khadrawy, Naif G Altoom, Abdullah G Alotaibi, Sarah I Othma. Hepatoprotective potential of taxifolin in type 2 diabetic rats: modulation of oxidative stress and Bcl2/Bax/Caspase-3 signaling pathway. Molecular biology reports. vol 51. issue 1. 2024-08-08. PMID:39115553. |
apoptosis is also an essential event in dm pathophysiology, -with b-cell lymphoma 2 (bcl-2) and bcl-2 associated x (bax) determining apoptotic susceptibility. |
2024-08-08 |
2024-08-10 |
rat |
| Junyi Liu, Yongying Tang, Jiang Li, Hong Zhang, Xu Zha, Quan Chen, Jinghua Li, Xueying Zha. TRB3 Promotes Cataract Progression through Endoplasmic Reticulum Stress-mediated Mitochondrial Dysfunction and Cell Apoptosis. Cell biochemistry and biophysics. 2024-08-08. PMID:39115645. |
this effect includes increasing the mitochondrial membrane potential in lec cells, lowering reactive oxygen species (ros) levels, increasing atp production, suppressing the expression of the apoptosis-related proteins bax and c-caspase-3, increasing bcl-2 expression, and decreasing apoptosis. |
2024-08-08 |
2024-08-10 |
rat |