| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Surajit Karmakar, Naren L Banik, Sunil J Patel, Swapan K Ra. Garlic compounds induced calpain and intrinsic caspase cascade for apoptosis in human malignant neuroblastoma SH-SY5Y cells. Apoptosis : an international journal on programmed cell death. vol 12. issue 4. 2008-01-14. PMID:17219050. |
apoptosis was associated with an increase in [ca(2+)](i), increase in bax:bcl-2 ratio, mitochondrial release of cytochrome c, increase in cytosolic smac/diablo, and down regulation of inhibitor-of-apoptosis proteins and nuclear factor kappa b (nfkappab). |
2008-01-14 |
2023-08-12 |
human |
| Lisenn Lalier, Pierre-François Cartron, Philippe Juin, Svetlana Nedelkina, Stephen Manon, Burkhart Bechinger, François M Vallett. Bax activation and mitochondrial insertion during apoptosis. Apoptosis : an international journal on programmed cell death. vol 12. issue 5. 2008-01-14. PMID:17453158. |
bax activation and mitochondrial insertion during apoptosis. |
2008-01-14 |
2023-08-12 |
Not clear |
| Lisenn Lalier, Pierre-François Cartron, Philippe Juin, Svetlana Nedelkina, Stephen Manon, Burkhart Bechinger, François M Vallett. Bax activation and mitochondrial insertion during apoptosis. Apoptosis : an international journal on programmed cell death. vol 12. issue 5. 2008-01-14. PMID:17453158. |
considering the critical role of bax in cancer cells apoptosis, we focus in this review on the molecular events of bax activation through its interaction with the other proteins from the bcl-2 family. |
2008-01-14 |
2023-08-12 |
Not clear |
| Astrid Janssen, Susanne Schiffmann, Kerstin Birod, Thorsten J Maier, Ivonne Wobst, Gerd Geisslinger, Sabine Grösc. p53 is important for the anti-proliferative effect of ibuprofen in colon carcinoma cells. Biochemical and biophysical research communications. vol 365. issue 4. 2008-01-10. PMID:18036557. |
furthermore, results indicate that induction of apoptosis in hct-116 p53(wt) cells after ibuprofen treatment is in part dependent on a signalling pathway including the neutrophin receptor p75(ntr), p53 and bax. |
2008-01-10 |
2023-08-12 |
mouse |
| Philip M Beart, Maria L R Lim, Baohong Chen, Shanti Diwakarla, Linda D Mercer, Nam Sang Cheung, Phillip Nagle. Hierarchical recruitment by AMPA but not staurosporine of pro-apoptotic mitochondrial signaling in cultured cortical neurons: evidence for caspase-dependent/independent cross-talk. Journal of neurochemistry. vol 103. issue 6. 2008-01-08. PMID:17887970. |
ampa-mediated apoptosis involved induction of bax, loss of mitochondrial transmembrane potential (deltapsi(m)), early release of cytochrome c (cyt c), and more delayed release of second mitochondrial activator of caspases (smac), omi, and apoptosis-inducing factor (aif) with early calpain and minor late activation of caspase 3. |
2008-01-08 |
2023-08-12 |
Not clear |
| Liang-yan Xue, Song-mao Chiu, Kashif Azizuddin, Sheeba Joseph, Nancy L Oleinic. The death of human cancer cells following photodynamic therapy: apoptosis competence is necessary for Bcl-2 protection but not for induction of autophagy. Photochemistry and photobiology. vol 83. issue 5. 2008-01-07. PMID:17880494. |
here we investigated the occurrence of autophagy after pdt with the photosensitizer pc 4 in human cancer cells that are deficient in the pro-apoptotic factor bax (human prostate cancer du145 cells) or the apoptosis mediator caspase-3 (human breast cancer mcf-7v cells) and in apoptosis-competent cells (mcf-7c3 cells that stably overexpress human pro-caspase-3 and chinese hamster ovary cho 5a100 cells). |
2008-01-07 |
2023-08-12 |
human |
| Huiling Liang, Andrew H Coles, Zhiqing Zhu, Jennifer Zayas, Roland Jurecic, Joonsoo Kang, Stephen N Jone. Noncanonical Wnt signaling promotes apoptosis in thymocyte development. The Journal of experimental medicine. vol 204. issue 13. 2008-01-07. PMID:18070933. |
loss of wnt5a down-regulates bax expression, promotes bcl-2 expression, and inhibits apoptosis of cd4(+)cd8(+) thymocytes, whereas exogenous wnt5a increases apoptosis of fetal thymocytes in culture. |
2008-01-07 |
2023-08-12 |
mouse |
| Laxmi Yeruva, Keon J Pierre, Abiodun Elegbede, Robert C Wang, Stephen W Carpe. Perillyl alcohol and perillic acid induced cell cycle arrest and apoptosis in non small cell lung cancer cells. Cancer letters. vol 257. issue 2. 2008-01-03. PMID:17888568. |
both poh and pa elicited dose-dependent cytotoxicity, induced cell cycle arrest and apoptosis with increasing expression of bax, p21 and caspase-3 activity in both the cell lines. |
2008-01-03 |
2023-08-12 |
human |
| Surajit Karmakar, Naren L Banik, Swapan K Ra. Curcumin suppressed anti-apoptotic signals and activated cysteine proteases for apoptosis in human malignant glioblastoma U87MG cells. Neurochemical research. vol 32. issue 12. 2008-01-02. PMID:17562168. |
wright staining and apoptag assay, respectively, showed the morphological and biochemical features of apoptosis in u87mg cells treated with 25 microm and 50 microm of ccm for 24 h. western blotting showed activation of caspase-8, cleavage of bid to tbid, increase in bax:bcl-2 ratio, and release of cytochrome c from mitochondria followed by activation of caspase-9 and caspase-3 for apoptosis. |
2008-01-02 |
2023-08-12 |
human |
| Ran Zhang, Naren L Banik, Swapan K Ra. Combination of all-trans retinoic acid and interferon-gamma suppressed PI3K/Akt survival pathway in glioblastoma T98G cells whereas NF-kappaB survival signaling in glioblastoma U87MG cells for induction of apoptosis. Neurochemical research. vol 32. issue 12. 2008-01-02. PMID:17616812. |
combination of atra and ifn-gamma showed more efficacy than ifn-gamma alone in causing apoptosis that occurred due to increases in bax:bcl-2 ratio, mitochondrial release of cytochrome c, and caspase-3 activity. |
2008-01-02 |
2023-08-12 |
human |
| Surajit Karmakar, Naren L Banik, Swapan K Ra. Molecular mechanism of inositol hexaphosphate-mediated apoptosis in human malignant glioblastoma T98G cells. Neurochemical research. vol 32. issue 12. 2008-01-02. PMID:17616815. |
western blotting indicated changes in expression of bax and bcl-2 proteins resulting in an increase in bax:bcl-2 ratio and upregulation of cytosolic levels of cytochrome c and smac/diablo, suggesting involvement of mitochondria-dependent caspase cascade in apoptosis. |
2008-01-02 |
2023-08-12 |
human |
| S Gupta, T Young, L Yel, H Su, S Gollapud. Differential sensitivity of naïve and subsets of memory CD4+ and CD8+ T cells to hydrogen peroxide-induced apoptosis. Genes and immunity. vol 8. issue 7. 2008-01-02. PMID:17690685. |
apoptosis in naïve and central memory cd4+ and cd8+ is associated with the release of cytochrome c and activation of caspase-9 and caspase-3, upregulation of bax and voltage-dependent anion channel (vdac) expression, and decreased intracellular glutathione (gsh). |
2008-01-02 |
2023-08-12 |
human |
| S Gupta, T Young, L Yel, H Su, S Gollapud. Differential sensitivity of naïve and subsets of memory CD4+ and CD8+ T cells to hydrogen peroxide-induced apoptosis. Genes and immunity. vol 8. issue 7. 2008-01-02. PMID:17690685. |
these data demonstrate that h2o2 induces apoptosis preferentially in human naïve and central memory cd4+ and cd8+ t cells via the mitochondrial pathway by regulating intracellular gsh and the expression of bax and vdac. |
2008-01-02 |
2023-08-12 |
human |
| Arabinda Das, Naren L Banik, Swapan K Ra. Differentiation decreased telomerase activity in rat glioblastoma C6 cells and increased sensitivity to IFN-gamma and taxol for apoptosis. Neurochemical research. vol 32. issue 12. 2008-01-02. PMID:17694433. |
sensitivity of differentiated cells to ifn-gamma or txl was greatly increased for apoptosis with increases in calcineurin expression, bax:bcl-2 ratio, mitochondrial release of cytochrome c, and expression and activity of calpain and caspases. |
2008-01-02 |
2023-08-12 |
rat |
| Kristin L Campbell, Anne McTiernan, Shuying S Li, Bess E Sorensen, Yutaka Yasui, Johanna W Lampe, Irena B King, Cornelia M Ulrich, Rebecca E Rudolph, Melinda L Irwin, Christina Surawicz, Kamran Ayub, John D Potter, Paul D Lamp. Effect of a 12-month exercise intervention on the apoptotic regulating proteins Bax and Bcl-2 in colon crypts: a randomized controlled trial. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. vol 16. issue 9. 2007-12-31. PMID:17855695. |
the objective of this study is to examine the effects of a 12-month aerobic exercise program on expression of proteins that promote (bax) or inhibit (bcl-2) apoptosis in colon crypts. |
2007-12-31 |
2023-08-12 |
Not clear |
| Qun Li, Jun Re. Influence of cardiac-specific overexpression of insulin-like growth factor 1 on lifespan and aging-associated changes in cardiac intracellular Ca2+ homeostasis, protein damage and apoptotic protein expression. Aging cell. vol 6. issue 6. 2007-12-31. PMID:17973971. |
pro- and anti-apoptotic proteins including bax, p53, pp53, bcl2, omi/htra2, apoptosis repressor with caspase recruitment domain (arc) and x-linked inhibitor of apoptosis protein (xiap) were assessed by western blot. |
2007-12-31 |
2023-08-12 |
mouse |
| Yan Guo, Hui-jun Yin, Da-zhuo Sh. [Effect of xinnao shutong capsule on cardiac muscle cell apoptosis and protein expressions of Bcl-2 and Bax in hyperlipidemia rats after myocardial infarction]. Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine. vol 26. issue 6. 2007-12-28. PMID:16841674. |
[effect of xinnao shutong capsule on cardiac muscle cell apoptosis and protein expressions of bcl-2 and bax in hyperlipidemia rats after myocardial infarction]. |
2007-12-28 |
2023-08-12 |
rat |
| Yan Guo, Hui-jun Yin, Da-zhuo Sh. [Effect of xinnao shutong capsule on cardiac muscle cell apoptosis and protein expressions of Bcl-2 and Bax in hyperlipidemia rats after myocardial infarction]. Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine. vol 26. issue 6. 2007-12-28. PMID:16841674. |
to investigate the effect of xinnao shutong capsule, whose main ingredients gross saponins from tribulus terrestris l (gstt) on cardiac muscle cell (cmc) apoptosis and expressions of bcl-2 compound rat model of and bax in murine model of hyperlipemia after myocardial infarction (mi). |
2007-12-28 |
2023-08-12 |
rat |
| Ge Yang, Shui-miao Lin, Wei-kang Zha. [Effect of TX0201 on expression of the apoptosis signal transduction molecule caspase-3 and apoptosis associated genes bcl-2 and bax mRNA in brain tissue of rat analogue model of Alzheimer's disease]. Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine. vol 26. issue 2. 2007-12-27. PMID:16548358. |
[effect of tx0201 on expression of the apoptosis signal transduction molecule caspase-3 and apoptosis associated genes bcl-2 and bax mrna in brain tissue of rat analogue model of alzheimer's disease]. |
2007-12-27 |
2023-08-12 |
rat |
| Jerry M Adams, Suzanne Cor. Bcl-2-regulated apoptosis: mechanism and therapeutic potential. Current opinion in immunology. vol 19. issue 5. 2007-12-27. PMID:17629468. |
the bh3-only proteins sense and relay stress signals, but commitment to apoptosis requires bax or bak. |
2007-12-27 |
2023-08-12 |
Not clear |