| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sharmila Shankar, Imtiaz Siddiqui, Rakesh K Srivastav. Molecular mechanisms of resveratrol (3,4,5-trihydroxy-trans-stilbene) and its interaction with TNF-related apoptosis inducing ligand (TRAIL) in androgen-insensitive prostate cancer cells. Molecular and cellular biochemistry. vol 304. issue 1-2. 2008-02-05. PMID:17636462. |
treatment of prostate cancer cells with resveratrol resulted in generation of reactive oxygen species (ros), translocation of bax to mitochondria and subsequent drop in mitochondrial membrane potential, release of mitochondrial proteins (cytochrome c, smac/diablo, and aif) to cytosol, activation of effector caspase-3 and caspase-9, and induction of apoptosis. |
2008-02-05 |
2023-08-12 |
Not clear |
| Sharmila Shankar, Imtiaz Siddiqui, Rakesh K Srivastav. Molecular mechanisms of resveratrol (3,4,5-trihydroxy-trans-stilbene) and its interaction with TNF-related apoptosis inducing ligand (TRAIL) in androgen-insensitive prostate cancer cells. Molecular and cellular biochemistry. vol 304. issue 1-2. 2008-02-05. PMID:17636462. |
bax was a major proapoptotic gene mediating the effects of resveratrol as bax sirna inhibited resveratrol-induced apoptosis. |
2008-02-05 |
2023-08-12 |
Not clear |
| Jaber Lyahyai, Rosa Bolea, Carmen Serrano, Enric Vidal, Martí Pumarola, Juan J Badiola, Pilar Zaragoza, Inmaculada Martín-Burrie. Differential expression and protein distribution of Bax in natural scrapie. Brain research. vol 1180. 2008-02-05. PMID:17949698. |
bax is a pro-apoptotic member of the bcl-2 family that plays an important role in neuronal apoptosis. |
2008-02-05 |
2023-08-12 |
Not clear |
| Jaber Lyahyai, Rosa Bolea, Carmen Serrano, Enric Vidal, Martí Pumarola, Juan J Badiola, Pilar Zaragoza, Inmaculada Martín-Burrie. Differential expression and protein distribution of Bax in natural scrapie. Brain research. vol 1180. 2008-02-05. PMID:17949698. |
we conclude that apoptosis either occurs in an extremely low number of neurons or neuroprotective mechanisms arrest the mitochondrial pathway after bax induction. |
2008-02-05 |
2023-08-12 |
Not clear |
| Y Lao, D C Chan. Study of the functional role of Bcl-2 family proteins in regulating Ca(2+) signals in apoptotic cells. Biochemical Society transactions. vol 35. issue Pt 5. 2008-02-05. PMID:17956272. |
on the basis of our findings, we suggest that bax may interact with ip(3)rs to facilitate the release of ca(2+) from the er during apoptosis. |
2008-02-05 |
2023-08-12 |
Not clear |
| Hubert Arokium, Hakim Ouerfelli, Gisèle Velours, Nadine Camougrand, François M Vallette, Stéphen Mano. Substitutions of potentially phosphorylatable serine residues of Bax reveal how they may regulate its interaction with mitochondria. The Journal of biological chemistry. vol 282. issue 48. 2008-02-04. PMID:17911107. |
during apoptosis, the pro-apoptotic protein bax relocalizes from the cytosol to the mitochondrial outer membrane. |
2008-02-04 |
2023-08-12 |
Not clear |
| Hubert Arokium, Hakim Ouerfelli, Gisèle Velours, Nadine Camougrand, François M Vallette, Stéphen Mano. Substitutions of potentially phosphorylatable serine residues of Bax reveal how they may regulate its interaction with mitochondria. The Journal of biological chemistry. vol 282. issue 48. 2008-02-04. PMID:17911107. |
we conclude that sequential phosphorylation of these serine residues might participate in the triggering of the different conformational changes associated with bax activation during apoptosis. |
2008-02-04 |
2023-08-12 |
Not clear |
| Yael Avramovich-Tirosh, Lydia Reznichenko, Tamar Mit, Hailin Zheng, Mati Fridkin, Orly Weinreb, Silvia Mandel, Moussa B H Youdi. Neurorescue activity, APP regulation and amyloid-beta peptide reduction by novel multi-functional brain permeable iron- chelating- antioxidants, M-30 and green tea polyphenol, EGCG. Current Alzheimer research. vol 4. issue 4. 2008-02-01. PMID:17908043. |
m-30 and egcg decreased apoptosis of human sh-sy5y neuroblastoma cells in a neurorescue, serum deprivation model, via multiple protection mechanisms including: reduction of the pro-apoptotic proteins, bad and bax, reduction of apoptosis-associated ser139 phosphorylated h2a.x and inhibition of the cleavage and activation of caspase-3. |
2008-02-01 |
2023-08-12 |
human |
| Bárbara Macedo, Ana Rita Batista, José Barbas do Amaral, Maria João Saraiv. Biomarkers in the assessment of therapies for familial amyloidotic polyneuropathy. Molecular medicine (Cambridge, Mass.). vol 13. issue 11-12. 2008-02-01. PMID:17932549. |
death-receptor fas, caspase-8, and bax were also found to be increased, indicative of the involvement of death receptors in the observed apoptosis process. |
2008-02-01 |
2023-08-12 |
mouse |
| Wen-Xing Ding, Hong-Min Ni, Xiao-Ming Yi. Absence of Bax switched MG132-induced apoptosis to non-apoptotic cell death that could be suppressed by transcriptional or translational inhibition. Apoptosis : an international journal on programmed cell death. vol 12. issue 12. 2008-01-30. PMID:17912641. |
absence of bax switched mg132-induced apoptosis to non-apoptotic cell death that could be suppressed by transcriptional or translational inhibition. |
2008-01-30 |
2023-08-12 |
Not clear |
| Lan Zhang, Da Xing, Lei Liu, Xuejuan Gao, Miaojuan Che. TNFalpha induces apoptosis through JNK/Bax-dependent pathway in differentiated, but not naïve PC12 cells. Cell cycle (Georgetown, Tex.). vol 6. issue 12. 2008-01-24. PMID:17568197. |
our results showed that during tnfalpha-induced apoptosis, bax translocation to mitochondria and cytochrome c (cyt c) release from mitochondria were observed in differentiated pc12 cells, but not in naïve pc12 cells. |
2008-01-24 |
2023-08-12 |
Not clear |
| Lan Zhang, Da Xing, Lei Liu, Xuejuan Gao, Miaojuan Che. TNFalpha induces apoptosis through JNK/Bax-dependent pathway in differentiated, but not naïve PC12 cells. Cell cycle (Georgetown, Tex.). vol 6. issue 12. 2008-01-24. PMID:17568197. |
while in differentiated pc12 cells, the process of apoptosis could only be inhibited effectively by z-ietd-fmk and sp600125 cotreatment, and sp600125 inhibited the bax translocation to mitochondria implying that jnk mediated activation of bax. |
2008-01-24 |
2023-08-12 |
Not clear |
| Suparna Mazumder, Dragos Plesca, Alexandru Almasa. A jekyll and hyde role of cyclin E in the genotoxic stress response: switching from cell cycle control to apoptosis regulation. Cell cycle (Georgetown, Tex.). vol 6. issue 12. 2008-01-24. PMID:17581275. |
by interacting with ku70, p18-cyclin e liberates bax, which participates in the amplification of apoptosis by sustaining a positive feedback loop targeting mitochondria. |
2008-01-24 |
2023-08-12 |
Not clear |
| Jizhong Cheng, Jiqiang Zhang, Aksam Merched, Liping Zhang, Ping Zhang, Luan Truong, Aladin M Boriek, Jie D. Mechanical stretch inhibits oxidized low density lipoprotein-induced apoptosis in vascular smooth muscle cells by up-regulating integrin alphavbeta3 and stablization of PINCH-1. The Journal of biological chemistry. vol 282. issue 47. 2008-01-23. PMID:17878168. |
disruption of the cytoskeleton abolished the protective effect of stretch or alphavbeta3 overexpression on ox-ldl-induced activation of bax and apoptosis. |
2008-01-23 |
2023-08-12 |
mouse |
| Joana D Amaral, Rui E Castro, Susana Solá, Clifford J Steer, Cecília M P Rodrigue. p53 is a key molecular target of ursodeoxycholic acid in regulating apoptosis. The Journal of biological chemistry. vol 282. issue 47. 2008-01-23. PMID:17881359. |
in this study we demonstrated that udca reduces p53 transcriptional activity, thereby preventing its ability to induce bax expression, mitochondrial translocation, cytochrome c release, and apoptosis in primary rat hepatocytes. |
2008-01-23 |
2023-08-12 |
rat |
| Z-X Xu, J Liang, V Haridas, A Gaikwad, F P Connolly, G B Mills, J U Gutterma. A plant triterpenoid, avicin D, induces autophagy by activation of AMP-activated protein kinase. Cell death and differentiation. vol 14. issue 11. 2008-01-22. PMID:17690712. |
here, we show that tumor cells treated with benzyloxycarbonylvalyl-alanyl-aspartic acid (o-methyl)-fluoro-methylketone, an apoptosis inhibitor, and bax(-/-)bak(-/-) apoptosis-resistant cells can still undergo cell death in response to avicin d treatment. |
2008-01-22 |
2023-08-12 |
Not clear |
| D Y H Hallaert, R Spijker, M Jak, I A M Derks, N L Alves, F M Wensveen, J P de Boer, D de Jong, S R Green, M H J van Oers, E Elderin. Crosstalk among Bcl-2 family members in B-CLL: seliciclib acts via the Mcl-1/Noxa axis and gradual exhaustion of Bcl-2 protection. Cell death and differentiation. vol 14. issue 11. 2008-01-22. PMID:17703234. |
this suggests that after mcl-1 degradation, the remaining apoptosis neutralizing capacity of bcl-2 is gradually overwhelmed, until bax forms large multimeric pores in the mitochondria. |
2008-01-22 |
2023-08-12 |
Not clear |
| Emanuela Mazzon, Salvatore Cuzzocre. Role of TNF-alpha in lung tight junction alteration in mouse model of acute lung inflammation. Respiratory research. vol 8. 2008-01-18. PMID:17971210. |
pharmacological and genetic tnf-alpha inhibition significantly reduced the degree of (1) tnf-alpha production in pleural exudates and in the lung tissues, (2) the inflammatory cell infiltration in the pleural cavity as well as in the lung tissues (evaluated by mpo activity), (3) the alteration of zo-1, claudin-2, claudin-4, claudin-5 and beta-catenin (immunohistochemistry) and (4) apoptosis (tunel staining, bax, bcl-2 expression). |
2008-01-18 |
2023-08-12 |
mouse |
| Mai Nguyen, Richard C Marcellus, Anne Roulston, Mark Watson, Lucile Serfass, S R Murthy Madiraju, Daniel Goulet, Jean Viallet, Laurent Bélec, Xavier Billot, Stephane Acoca, Enrico Purisima, Adrian Wiegmans, Leonie Cluse, Ricky W Johnstone, Pierre Beauparlant, Gordon C Shor. Small molecule obatoclax (GX15-070) antagonizes MCL-1 and overcomes MCL-1-mediated resistance to apoptosis. Proceedings of the National Academy of Sciences of the United States of America. vol 104. issue 49. 2008-01-18. PMID:18040043. |
small molecule obatoclax (gx15-070), which is predicted to occupy a hydrophobic pocket within the bh3 binding groove of bcl-2, antagonizes these members and induces apoptosis, dependent on bax and bak. |
2008-01-18 |
2023-08-12 |
Not clear |
| Heekyoung Chung, Young-mi Jung, Dong-Hui Shin, Jeong-Yeon Lee, Mi-Yun Oh, Hyun-Jun Kim, Ki Seok Jang, Su Jin Jeon, Kun Ho Son, Gu Kon. Anticancer effects of wogonin in both estrogen receptor-positive and -negative human breast cancer cell lines in vitro and in nude mice xenografts. International journal of cancer. vol 122. issue 4. 2008-01-17. PMID:17957784. |
apoptosis was enhanced and accompanied by upregulation of parp and caspase 3 cleavages as well as proapoptotic bax protein. |
2008-01-17 |
2023-08-12 |
mouse |