| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M Saunders, M B Eldeen, L Del Valle, K Reiss, F Peruzzi, G Mameli, B B Gelman, K Khalili, S Amini, B E Saway. p73 modulates HIV-1 Tat transcriptional and apoptotic activities in human astrocytes. Apoptosis : an international journal on programmed cell death. vol 10. issue 6. 2008-03-25. PMID:16235026. |
we demonstrated that p73 interferes with tat-mediated apoptosis by preventing the up-regulation of bax and down-regulation of bcl-2 proteins in astrocytes. |
2008-03-25 |
2023-08-12 |
human |
| Hui Xiao, Malika Rawal, Eun-Ryeong Hahm, Shivendra V Sing. Benzo[a]pyrene-7,8-diol-9,10-epoxide causes caspase-mediated apoptosis in H460 human lung cancer cell line. Cell cycle (Georgetown, Tex.). vol 6. issue 22. 2008-03-25. PMID:17986867. |
the sv40 immortalized mouse embryonic fibroblasts (mefs) derived from bak and bax double knockout mice, but not bid knockout mice, were significantly more resistant to bpde-induced apoptosis compared with the mefs derived from wild-type mice. |
2008-03-25 |
2023-08-12 |
mouse |
| B Espina, M Liang, R G G Russell, P A Hulle. Regulation of bim in glucocorticoid-mediated osteoblast apoptosis. Journal of cellular physiology. vol 215. issue 2. 2008-03-25. PMID:18064628. |
gene silencing experiments show that short interference rna (sirna) specific for bim or the downstream effector bax both reduced apoptosis induced by dex in osteoblastic cells. |
2008-03-25 |
2023-08-12 |
human |
| E Vairaktaris, G Kalokerinos, L Goutzanis, C Yapijakis, S Derka, S Vassiliou, S Spyridonidou, A Vylliotis, E Nkenke, A Lazaris, E Patsouri. Diabetes enhances cell proliferation but not Bax/Bcl-2-mediated apoptosis during oral oncogenesis. International journal of oral and maxillofacial surgery. vol 37. issue 1. 2008-03-18. PMID:17825529. |
markers of cell proliferation (ki-67 antigen) and apoptosis (bax, bcl-2) were studied in an experimental model of chemically induced carcinogenesis in normal and diabetic (type i) sprague-dawley rats. |
2008-03-18 |
2023-08-12 |
rat |
| M L Topuridze, V A Kipiani, N S Pavliashvili, N V Kipiani, T G Petriashvil. [Molecular mechanisms of apoptosis]. Georgian medical news. issue 150. 2008-03-13. PMID:17984562. |
the special attention is paid to mitochondrial factors of apoptosis, ca(2+)-ions, and proteins (bcl-2, bax, p-53). |
2008-03-13 |
2023-08-12 |
human |
| Laurent Brault, Denyse Bagre. Activity of novel Cdc25 inhibitors and preliminary evaluation of their potentiation of chemotherapeutic drugs in human breast cancer cells. Life sciences. vol 82. issue 5-6. 2008-03-13. PMID:18191419. |
moreover, apoptosis was triggered within 48-h treatment, without oxidative burst and modulation of the bax to bcl-2 ratio. |
2008-03-13 |
2023-08-12 |
human |
| Chia-Wen Lo, Hui-Pei Huang, Hui-Mei Lin, Cheng-Ting Chien, Chau-Jong Wan. Effect of Hibiscus anthocyanins-rich extract induces apoptosis of proliferating smooth muscle cell via activation of P38 MAPK and p53 pathway. Molecular nutrition & food research. vol 51. issue 12. 2008-03-11. PMID:18030661. |
has induces apoptosis via (i) activating p38 map kinase that subsequently phosphorylates target protein c-jun and transduces the signal to further activate the apoptotic protein cascades that contain fas-mediated signaling (fas/caspase-8 signaling module) and (ii) activating p53 and inducing bax expression. |
2008-03-11 |
2023-08-12 |
Not clear |
| Jianfei Jiang, Zhentai Huang, Qing Zhao, Weihong Feng, Natalia A Belikova, Valerian E Kaga. Interplay between bax, reactive oxygen species production, and cardiolipin oxidation during apoptosis. Biochemical and biophysical research communications. vol 368. issue 1. 2008-03-10. PMID:18211809. |
interplay between bax, reactive oxygen species production, and cardiolipin oxidation during apoptosis. |
2008-03-10 |
2023-08-12 |
mouse |
| Xiaohua Li, Liu Hong, Yunping Zhao, Haifeng Jin, Rui Fan, Rui Du, Lin Xia, Guanhong Luo, Daiming Fa. A new apoptosis inhibitor, CIAPIN1 (cytokine-induced apoptosis inhibitor 1), mediates multidrug resistance in leukemia cells by regulating MDR-1, Bcl-2, and Bax. Biochemistry and cell biology = Biochimie et biologie cellulaire. vol 85. issue 6. 2008-03-07. PMID:18059532. |
a new apoptosis inhibitor, ciapin1 (cytokine-induced apoptosis inhibitor 1), mediates multidrug resistance in leukemia cells by regulating mdr-1, bcl-2, and bax. |
2008-03-07 |
2023-08-12 |
Not clear |
| N A D'iakova, V A Matveeva, L M Kashkina, E N Uvarova, G I Deĭchma. [Bcl-2 family proteins and mechanisms of the acceleration and inhibition of tumor progression in vivo]. Vestnik Rossiiskoi akademii meditsinskikh nauk. issue 11. 2008-03-06. PMID:18084829. |
the results of the study demonstrated the following 1) immediate in vivo activation of endogenous proapoptotic bax protein in disseminated tumor cells, not protected by bcl-2 against apoptosis, and its correlation with accelerated tumor progression; 2) complete suppression of in vivo bax activation in tumor cells protected by bcl-expression, and inhibited tumor progression; 3) alternative character of bcl-2 and bax expression under the conditions of accelerated and inhibited tumor progression. |
2008-03-06 |
2023-08-12 |
Not clear |
| G Calviello, S Serini, E Piccion. n-3 polyunsaturated fatty acids and the prevention of colorectal cancer: molecular mechanisms involved. Current medicinal chemistry. vol 14. issue 29. 2008-03-06. PMID:18220742. |
several molecular mechanisms have been hypothesized to explain their anti-neoplastic action and, in particular, the modulating effect on the expression of several proteins involved in the regulation of cell cycle and apoptosis, such as bcl-2, bax, c-myc seem to play a central role. |
2008-03-06 |
2023-08-12 |
Not clear |
| Andrea J Dowling, Nicholas R Waterfield, Michelle C Hares, Gaëlle Le Goff, Charles H Streuli, Richard H ffrench-Constan. The Mcf1 toxin induces apoptosis via the mitochondrial pathway and apoptosis is attenuated by mutation of the BH3-like domain. Cellular microbiology. vol 9. issue 10. 2008-03-04. PMID:17848168. |
mcf1 also alters mitochondrial membrane potential and triggers the release of cytochrome c. cells overexpressing bcl-x(l), an anti-apoptotic bcl-2 family member, are resistant to mcf1-mediated apoptosis, as are cells deficient in bax. |
2008-03-04 |
2023-08-12 |
Not clear |
| Ki Deok Shin, Young Ju Yoon, Yeong-Rim Kang, Kwang-Hee Son, Hwan Mook Kim, Byoung-Mog Kwon, Dong Cho Ha. KRIBB3, a novel microtubule inhibitor, induces mitotic arrest and apoptosis in human cancer cells. Biochemical pharmacology. vol 75. issue 2. 2008-03-04. PMID:17915194. |
the temporal pattern of bax activation by kribb3 was similar to parp cleavage, suggesting that bax is a mediator of kribb3-dependent apoptosis. |
2008-03-04 |
2023-08-12 |
mouse |
| J Wen, Y Duan, Y Zou, Z Nie, H Feng, F Lugnani, J G Baus. Cryoablation induces necrosis and apoptosis in lung adenocarcinoma in mice. Technology in cancer research & treatment. vol 6. issue 6. 2008-03-04. PMID:17994794. |
cryoablation appears to induce apoptosis in the peripheral freeze zone through the intrinsic mitochondrial caspase pathway based on bax upregulation. |
2008-03-04 |
2023-08-12 |
mouse |
| Antonio Basile, Daniela Biziato, Gajanan V Sherbet, Paola Comi, Francesco Cajon. Hyperthermia inhibits cell proliferation and induces apoptosis: relative signaling status of P53, S100A4, and Notch in heat sensitive and resistant cell lines. Journal of cellular biochemistry. vol 103. issue 1. 2008-02-29. PMID:17497677. |
hepg2 and hut cells differed in respect of anchorage to growth surface, degree of proliferation and apoptosis and expression of p53, bax, bcl-2, notch, and s100a4 genes. |
2008-02-29 |
2023-08-12 |
Not clear |
| Antonio Basile, Daniela Biziato, Gajanan V Sherbet, Paola Comi, Francesco Cajon. Hyperthermia inhibits cell proliferation and induces apoptosis: relative signaling status of P53, S100A4, and Notch in heat sensitive and resistant cell lines. Journal of cellular biochemistry. vol 103. issue 1. 2008-02-29. PMID:17497677. |
the induction of apoptosis and the inhibition of cell proliferation occurred independently of p53, and independently also of involvement of the apoptosis family genes bax and bcl-2. |
2008-02-29 |
2023-08-12 |
Not clear |
| Tiziana Genovese, Emanuela Mazzon, Concetta Crisafulli, Rosanna Di Paola, Carmelo Muià, Emanuela Esposito, Placido Bramanti, Salvatore Cuzzocre. TNF-alpha blockage in a mouse model of SCI: evidence for improved outcome. Shock (Augusta, Ga.). vol 29. issue 1. 2008-02-29. PMID:17621255. |
pharmacological and genetic tnf-alpha inhibition significantly reduced the degree of (1) spinal cord inflammation and tissue injury (histological score), (2) neutrophil infiltration (evaluated by myeloperoxidase activity), (3) cytokine expression (tnf-alpha), (4) and apoptosis (terminal deoxynucleotidyltransferase-mediated uridine triphosphate end labeling staining, bax, bcl-2, and fas-l expression). |
2008-02-29 |
2023-08-12 |
mouse |
| Mayank Singh, Himani Sharma, Neeta Sing. Hydrogen peroxide induces apoptosis in HeLa cells through mitochondrial pathway. Mitochondrion. vol 7. issue 6. 2008-02-29. PMID:17855174. |
we demonstrate here, that in hela cells, apoptosis is triggered by h(2)o(2) via the mitochondrial pathway involving upregulation of p73, and its downstream target bax. |
2008-02-29 |
2023-08-12 |
human |
| Zhijian Tao, Yunlong Zhou, Jinjian Lu, Wenhu Duan, Yuxin Qin, Xinxia He, Liping Lin, Jian Din. Caspase-8 preferentially senses the apoptosis-inducing action of NG-18, a Gambogic acid derivative, in human leukemia HL-60 cells. Cancer biology & therapy. vol 6. issue 5. 2008-02-28. PMID:17426447. |
ng-18-induced tumor cell apoptosis was associated with up-regulation of pro-apoptotic bcl-2 family member bax, and downregulation of anti-apoptotic protein bcl-2. |
2008-02-28 |
2023-08-12 |
human |
| E Gürsoy, K Ergin, H Başaloğlu, Y Koca, K Seyre. Expression and localisation of Bcl-2 and Bax proteins in developing rat ovary. Research in veterinary science. vol 84. issue 1. 2008-02-27. PMID:17570453. |
in conclusion, there was an apparent relation between the expression of the apoptosis regulating protein bcl-2 and bax and follicular development. |
2008-02-27 |
2023-08-12 |
rat |