| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Nizar M Mhaidat, Rick F Thorne, Charles Edo de Bock, Xu Dong Zhang, Peter Herse. Melanoma cell sensitivity to Docetaxel-induced apoptosis is determined by class III beta-tubulin levels. FEBS letters. vol 582. issue 2. 2008-04-01. PMID:18086570. |
as proof of concept, abrogation of class iii by sirna reverted docetaxel-resistant cells to a sensitive phenotype, restoring the microtubular polymerisation response and promoting high levels of apoptosis through bax activation. |
2008-04-01 |
2023-08-12 |
Not clear |
| Babli Halder, Udayan Bhattacharya, Sibabrata Mukhopadhyay, Ashok K Gir. Molecular mechanism of black tea polyphenols induced apoptosis in human skin cancer cells: involvement of Bax translocation and mitochondria mediated death cascade. Carcinogenesis. vol 29. issue 1. 2008-03-31. PMID:17984116. |
molecular mechanism of black tea polyphenols induced apoptosis in human skin cancer cells: involvement of bax translocation and mitochondria mediated death cascade. |
2008-03-31 |
2023-08-12 |
human |
| Babli Halder, Udayan Bhattacharya, Sibabrata Mukhopadhyay, Ashok K Gir. Molecular mechanism of black tea polyphenols induced apoptosis in human skin cancer cells: involvement of Bax translocation and mitochondria mediated death cascade. Carcinogenesis. vol 29. issue 1. 2008-03-31. PMID:17984116. |
our intricate investigations on apoptosis also explained that tf and tr augmented bax:bcl2 ratio, up-regulated the expression of p53 as well as p21 and inhibited phosphorylation of the cell survival protein akt. |
2008-03-31 |
2023-08-12 |
human |
| Noömi Lombaert, Dominique Lison, Paul Van Hummelen, Micheline Kirsch-Volder. In vitro expression of hard metal dust (WC-Co)--responsive genes in human peripheral blood mononucleated cells. Toxicology and applied pharmacology. vol 227. issue 2. 2008-03-31. PMID:18078969. |
quantitative rt-pcr data for a selection of the most strongly modulated genes (hmox1, hspa1a, hspa1l, bnip3, bnip3l, adora2b, mt3, pla2g7, tnfaip6), and some additionally chosen apoptosis related genes (bcl2, bax, fas, fasl, tnfalpha), confirmed the microarray data after wc-co exposure and demonstrated limited differences between the co-containing compounds. |
2008-03-31 |
2023-08-12 |
human |
| T Genovese, E Mazzon, C Crisafulli, E Esposito, R Di Paola, C Muià, P Di Bella, R Meli, P Bramanti, S Cuzzocre. Combination of dexamethasone and etanercept reduces secondary damage in experimental spinal cord trauma. Neuroscience. vol 150. issue 1. 2008-03-28. PMID:17945432. |
treatment of the mice with etanercept (1.25 mg/kg) and dex (0.025 mg/kg) when administered as a combination therapy but not as a single treatment significantly reduced the degree of (1) spinal cord inflammation and tissue injury (histological score), (2) infiltration of neutrophils (mpo evaluation), (3) inducible nitric oxide synthase, nitrotyrosine, and cytokines expression (tumor necrosis factor-alpha and interleukin-1 beta), (4) and apoptosis (terminal deoxynucleotidyltransferase-mediated utp end labeling staining, fas-ligand expression and bax and bcl-2 expression). |
2008-03-28 |
2023-08-12 |
mouse |
| Jung-Mi Han, Byung-Joon Chang, Tian-Zhu Li, Nong-Hoon Choe, Fu-Shi Quan, Bong-Jun Jang, Ik-Hyun Cho, Hea-Nam Hong, Jong-Hwan Le. Protective effects of ascorbic acid against lead-induced apoptotic neurodegeneration in the developing rat hippocampus in vivo. Brain research. vol 1185. 2008-03-28. PMID:17959157. |
at the end of the treatment, neuronal damage, apoptosis and blood lead levels were determined and the levels of bax and bcl-2 were immunodetected in the hippocampus of 21-day-old male pups. |
2008-03-28 |
2023-08-12 |
rat |
| Xiaohong Liang, Juan Du, Yugang Liu, Min Cui, Chunhong Ma, Lihui Han, Zhonghua Qu, Zhiyong Zhang, Zhaohui Sun, Lining Zhang, Youhai H Chen, Wensheng Su. The hepatitis B virus protein MHBs(t) sensitizes hepatoma cells to TRAIL-induced apoptosis through ERK2. Apoptosis : an international journal on programmed cell death. vol 12. issue 10. 2008-03-27. PMID:17701086. |
our previous studies showed that hbx, a protein encoded by the hbv genome, enhanced trail-induced apoptosis through upregulating bax. |
2008-03-27 |
2023-08-12 |
Not clear |
| Dong Yeok Shin, Gi Young Kim, Nam Deuk Kim, Jee Hyung Jung, Se-Kwon Kim, Ho Sung Kang, Yung Hyun Cho. Induction of apoptosis by pectenotoxin-2 is mediated with the induction of DR4/DR5, Egr-1 and NAG-1, activation of caspases and modulation of the Bcl-2 family in p53-deficient Hep3B hepatocellular carcinoma cells. Oncology reports. vol 19. issue 2. 2008-03-27. PMID:18202802. |
the apoptosis induced by ptx-2 in hep3b cells was associated with the down-regulation of anti-apoptotic bcl-2 members (bcl-2 and bcl-xl) and iap family proteins, the up-regulation of pro-apoptotic bax protein and tumor necrosis factor-related apoptosis-inducing ligand (trail)-receptor 1/receptor 2 (dr4/dr5) and mitochondrial dysfunction. |
2008-03-27 |
2023-08-12 |
Not clear |
| C Bascones-Ilundain, M A González-Moles, J Campo-Trapero, J A Gil-Montoya, G C Esparza-Gómez, J Cano-Sánchez, A Bascones-Martíne. No differences in caspase-3 and Bax expression in atrophic-erosive vs. reticular oral lichen planus. Journal of the European Academy of Dermatology and Venereology : JEADV. vol 22. issue 2. 2008-03-27. PMID:18211414. |
caspase-3 (cpp32) and bax expression levels in oral lichen planus (olp) lesions are considered reliable markers of apoptosis. |
2008-03-27 |
2023-08-12 |
Not clear |
| Maria Gomez-Lazaro, Maria F Galindo, Caoimhín G Concannon, Miguel F Segura, Francisco J Fernandez-Gomez, Nuria Llecha, Joan X Comella, Jochen H M Prehn, Joaquin Jorda. 6-Hydroxydopamine activates the mitochondrial apoptosis pathway through p38 MAPK-mediated, p53-independent activation of Bax and PUMA. Journal of neurochemistry. vol 104. issue 6. 2008-03-26. PMID:17996028. |
6-hydroxydopamine activates the mitochondrial apoptosis pathway through p38 mapk-mediated, p53-independent activation of bax and puma. |
2008-03-26 |
2023-08-12 |
mouse |
| Maria Gomez-Lazaro, Maria F Galindo, Caoimhín G Concannon, Miguel F Segura, Francisco J Fernandez-Gomez, Nuria Llecha, Joan X Comella, Jochen H M Prehn, Joaquin Jorda. 6-Hydroxydopamine activates the mitochondrial apoptosis pathway through p38 MAPK-mediated, p53-independent activation of Bax and PUMA. Journal of neurochemistry. vol 104. issue 6. 2008-03-26. PMID:17996028. |
experiments in mouse embryonic fibroblasts deficient in bax or puma demonstrated a role for both proteins in 6-ohda-induced apoptosis. |
2008-03-26 |
2023-08-12 |
mouse |
| Maria Gomez-Lazaro, Maria F Galindo, Caoimhín G Concannon, Miguel F Segura, Francisco J Fernandez-Gomez, Nuria Llecha, Joan X Comella, Jochen H M Prehn, Joaquin Jorda. 6-Hydroxydopamine activates the mitochondrial apoptosis pathway through p38 MAPK-mediated, p53-independent activation of Bax and PUMA. Journal of neurochemistry. vol 104. issue 6. 2008-03-26. PMID:17996028. |
these data demonstrate a critical involvement of p38 mapk, puma, and bax in 6-ohda-induced apoptosis. |
2008-03-26 |
2023-08-12 |
mouse |
| Mei Shi, Shi-Gan Yan, Shu-Tao Xie, Hong-Na Wan. Tip30-induced apoptosis requires translocation of Bax and involves mitochondrial release of cytochrome c and Smac/DIABLO in hepatocellular carcinoma cells. Biochimica et biophysica acta. vol 1783. issue 2. 2008-03-26. PMID:17997990. |
tip30-induced apoptosis requires translocation of bax and involves mitochondrial release of cytochrome c and smac/diablo in hepatocellular carcinoma cells. |
2008-03-26 |
2023-08-12 |
Not clear |
| Mei Shi, Shi-Gan Yan, Shu-Tao Xie, Hong-Na Wan. Tip30-induced apoptosis requires translocation of Bax and involves mitochondrial release of cytochrome c and Smac/DIABLO in hepatocellular carcinoma cells. Biochimica et biophysica acta. vol 1783. issue 2. 2008-03-26. PMID:17997990. |
translocation of bax was essential for tip30-induced apoptosis, whereas overexpression of the anti-apoptotic protein bcl-xl delayed both second mitochondria-derived activator of caspases (smac/diablo) release and onset of apoptosis. |
2008-03-26 |
2023-08-12 |
Not clear |
| Nuzhat I Pathan, Peter Chu, Kandasamy Hariharan, Carolyn Cheney, Arturo Molina, John Byr. Mediation of apoptosis by and antitumor activity of lumiliximab in chronic lymphocytic leukemia cells and CD23+ lymphoma cell lines. Blood. vol 111. issue 3. 2008-03-26. PMID:18032710. |
lumiliximab-induced apoptosis was accompanied by the down-regulation of antiapoptotic proteins bcl-2, bcl-x(l), and xiap, activation of bax, and release of cytochrome c from the mitochondria. |
2008-03-26 |
2023-08-12 |
mouse |
| S-M Chiu, L-Y Xue, K Azizuddin, N L Oleinic. Photodynamic therapy-induced death of HCT 116 cells: Apoptosis with or without Bax expression. Apoptosis : an international journal on programmed cell death. vol 10. issue 6. 2008-03-25. PMID:16215676. |
photodynamic therapy-induced death of hct 116 cells: apoptosis with or without bax expression. |
2008-03-25 |
2023-08-12 |
human |
| S-M Chiu, L-Y Xue, K Azizuddin, N L Oleinic. Photodynamic therapy-induced death of HCT 116 cells: Apoptosis with or without Bax expression. Apoptosis : an international journal on programmed cell death. vol 10. issue 6. 2008-03-25. PMID:16215676. |
to evaluate the importance of bax in apoptosis after pdt, we compared the pdt responses of bax-proficient (bax(+/-)) and bax knock-out (baxko) hct116 human colon cancer cells. |
2008-03-25 |
2023-08-12 |
human |
| S-M Chiu, L-Y Xue, K Azizuddin, N L Oleinic. Photodynamic therapy-induced death of HCT 116 cells: Apoptosis with or without Bax expression. Apoptosis : an international journal on programmed cell death. vol 10. issue 6. 2008-03-25. PMID:16215676. |
in spite of differences in the efficiency and mode of apoptosis induced by pdt in the bax(+/-) and baxko cells, they were found to be equally sensitive to killing by pdt, as determined by loss of clonogenicity. |
2008-03-25 |
2023-08-12 |
human |
| Z M Liu, G G Chen, A C Vlantis, N-C Liang, Y-F Deng, C A van Hassel. Cell death induced by ent-11alpha-hydroxy-15-oxo-kaur-16-en-19-oic-acid in anaplastic thyroid carcinoma cells is via a mitochondrial-mediated pathway. Apoptosis : an international journal on programmed cell death. vol 10. issue 6. 2008-03-25. PMID:16215682. |
in the process of the induction of apoptotic cell death, bax translocated into mitochondria, a reduction in delta psi(m) was observed and a release of cytochrome c and apoptosis inducing factor (aif) from mitochondria into the cytosol occurred, indicating that cell death induced by 5f was through a mitochondrial-mediated pathway. |
2008-03-25 |
2023-08-12 |
Not clear |
| N Takada, H Yamaguchi, K Shida, D Terajima, Y Satou, A Kasuya, N Satoh, M Satake, H-G Wan. The cell death machinery controlled by Bax and Bcl-XL is evolutionarily conserved in Ciona intestinalis. Apoptosis : an international journal on programmed cell death. vol 10. issue 6. 2008-03-25. PMID:16215691. |
bax and bcl-xl are key regulators of apoptosis in mammals. |
2008-03-25 |
2023-08-12 |
human |