| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| E Gürsoy, K Ergin, H Başaloğlu, Y Koca, K Seyre. Expression and localisation of Bcl-2 and Bax proteins in developing rat ovary. Research in veterinary science. vol 84. issue 1. 2008-02-27. PMID:17570453. |
furthermore, increased levels of bax and decreased levels of bcl-2 in the fully developed corpus luteum suggest that bax plays a role in apoptosis of luteal cells in rat ovary. |
2008-02-27 |
2023-08-12 |
rat |
| Rakesh K Srivastava, Qinghe Chen, Imtiaz Siddiqui, Krishna Sarva, Sharmila Shanka. Linkage of curcumin-induced cell cycle arrest and apoptosis by cyclin-dependent kinase inhibitor p21(/WAF1/CIP1). Cell cycle (Georgetown, Tex.). vol 6. issue 23. 2008-02-27. PMID:18156803. |
we have recently shown that curcumin induces apoptosis in prostate cancer cells through bax translocation to mitochondria and caspase activation, and enhances the therapeutic potential of trail. |
2008-02-27 |
2023-08-12 |
human |
| Jamie I Fletcher, David C S Huan. Controlling the cell death mediators Bax and Bak: puzzles and conundrums. Cell cycle (Georgetown, Tex.). vol 7. issue 1. 2008-02-21. PMID:18196961. |
in spite of the available genetic, biochemical and structural data, precisely how the initiators of apoptosis, the bh3-only proteins, trigger bax and bak to cause organellar damage remains highly contentious. |
2008-02-21 |
2023-08-12 |
Not clear |
| Karuppaiyah Selvendiran, Anna Bratasz, Liyue Tong, Louis J Ignarro, Periannan Kuppusam. NCX-4016, a nitro-derivative of aspirin, inhibits EGFR and STAT3 signaling and modulates Bcl-2 proteins in cisplatin-resistant human ovarian cancer cells and xenografts. Cell cycle (Georgetown, Tex.). vol 7. issue 1. 2008-02-21. PMID:18196976. |
ncx-4016 modulated the bcl-2 family of proteins, and induced apoptosis by activating bax and cytochrome c release in a time-dependent manner. |
2008-02-21 |
2023-08-12 |
mouse |
| Shai J White, Laura M Kasman, Margaret M Kelly, Ping Lu, Laura Spruill, Paul J McDermott, Christina Voelkel-Johnso. Doxorubicin generates a proapoptotic phenotype by phosphorylation of elongation factor 2. Free radical biology & medicine. vol 43. issue 9. 2008-02-19. PMID:17893044. |
in addition, cells treated with hydrogen peroxide expressed less x-linked inhibitor of apoptosis protein (xiap) and survivin which, like cflip(s), are short-half-life proteins with an antiapoptotic function while expression levels of dr5, caspases-8, -9, -3, and bax are maintained. |
2008-02-19 |
2023-08-12 |
Not clear |
| Sridevi Yadavilli, Eduardo Martinez-Ceballos, Janana Snowden-Aikens, Angela Hurst, Tranole Joseph, Thomas Albrecht, Perpetua M Mugand. Diepoxybutane activates the mitochondrial apoptotic pathway and mediates apoptosis in human lymphoblasts through oxidative stress. Toxicology in vitro : an international journal published in association with BIBRA. vol 21. issue 8. 2008-02-15. PMID:17693053. |
bax and bak were found to be over-expressed and activated, and the mitochondrial trans-membrane potential was attenuated in cells undergoing deb-induced apoptosis. |
2008-02-15 |
2023-08-12 |
human |
| Lili Liu, Xiaoxuan Ning, Li Sun, Hongbo Zhang, Yongquan Shi, Changcun Guo, Shuang Han, Jie Liu, Shiren Sun, Zheyi Han, Kaichun Wu, Daiming Fa. Hypoxia-inducible factor-1 alpha contributes to hypoxia-induced chemoresistance in gastric cancer. Cancer science. vol 99. issue 1. 2008-02-15. PMID:17953712. |
we further demonstrated that hif-1 alpha overexpression showed a 1.85-fold increased expression of bcl-2 and a 2.16-fold decreased expression of bax, and also showed significantly induced expression of p-gp and mrp1, which indicated that hif-1 alpha may confer hypoxia-induced drug resistance via inhibition of drug-induced apoptosis and decreases in intracellular drug accumulation. |
2008-02-15 |
2023-08-12 |
human |
| b' V Pavlovi\\xc4\\x87, S Ceki\\xc4\\x87, G Koci\\xc4\\x87, D Sokolovi\\xc4\\x87, V Zivkovi\\xc4\\x8. Effect of monosodium glutamate on apoptosis and Bcl-2/Bax protein level in rat thymocyte culture. Physiological research. vol 56. issue 5. 2008-02-14. PMID:17184147.' |
in this study, we evaluated the in vitro effect of different msg concentrations on rat thymocyte apoptosis and expression of two apoptosis-related proteins, bcl-2 and bax. |
2008-02-14 |
2023-08-12 |
rat |
| b' V Pavlovi\\xc4\\x87, S Ceki\\xc4\\x87, G Koci\\xc4\\x87, D Sokolovi\\xc4\\x87, V Zivkovi\\xc4\\x8. Effect of monosodium glutamate on apoptosis and Bcl-2/Bax protein level in rat thymocyte culture. Physiological research. vol 56. issue 5. 2008-02-14. PMID:17184147.' |
the temporal profile of bcl-2 and bax expression after msg treatment suggests that downregulation of bcl-2 protein and the resulting change of bcl-2/bax protein ratio may be an important event in thymocyte apoptosis triggered by msg. |
2008-02-14 |
2023-08-12 |
rat |
| Jürgen Eberle, Lothar F Fecker, Amir M Hossini, Bahtier M Kurbanov, Henry Fechne. Apoptosis pathways and oncolytic adenoviral vectors: promising targets and tools to overcome therapy resistance of malignant melanoma. Experimental dermatology. vol 17. issue 1. 2008-02-14. PMID:18095940. |
genes and strategies suitable for efficient induction of apoptosis in melanoma cells were identified, which are based on proapoptotic bcl-2 proteins (bcl-x(s), bcl-x(ak), bik/nbk and bax) as well as on tumor necrosis factor (tnf)-related death ligands (cd95l/fas ligand and tnf-related apoptosis-inducing ligand, trail). |
2008-02-14 |
2023-08-12 |
Not clear |
| Thomas Zuliani, Hélène Obriot, Martine Tual, Nadège Lachman-Weber, Marc Dumas, Pierre Formstecher, Renata Polakowska, Marie-Hélène Ratinau. Variable Bax antigenicity is linked to keratinocyte position within epidermal strata and UV-induced apoptosis. Experimental dermatology. vol 17. issue 2. 2008-02-14. PMID:18177350. |
variable bax antigenicity is linked to keratinocyte position within epidermal strata and uv-induced apoptosis. |
2008-02-14 |
2023-08-12 |
human |
| Thomas Zuliani, Hélène Obriot, Martine Tual, Nadège Lachman-Weber, Marc Dumas, Pierre Formstecher, Renata Polakowska, Marie-Hélène Ratinau. Variable Bax antigenicity is linked to keratinocyte position within epidermal strata and UV-induced apoptosis. Experimental dermatology. vol 17. issue 2. 2008-02-14. PMID:18177350. |
among them, bax plays a key role in apoptosis induction by mediating the release of apoptogenic factors from mitochondria to the cytosol. |
2008-02-14 |
2023-08-12 |
human |
| Thomas Zuliani, Hélène Obriot, Martine Tual, Nadège Lachman-Weber, Marc Dumas, Pierre Formstecher, Renata Polakowska, Marie-Hélène Ratinau. Variable Bax antigenicity is linked to keratinocyte position within epidermal strata and UV-induced apoptosis. Experimental dermatology. vol 17. issue 2. 2008-02-14. PMID:18177350. |
bax expression was evaluated with three different, western blot pretested, anti-bax antibodies (ab) and correlated with markers of keratinocyte differentiation and apoptosis using anti-beta(1) integrin and anti-active caspase-3 abs respectively. |
2008-02-14 |
2023-08-12 |
human |
| Thomas Zuliani, Hélène Obriot, Martine Tual, Nadège Lachman-Weber, Marc Dumas, Pierre Formstecher, Renata Polakowska, Marie-Hélène Ratinau. Variable Bax antigenicity is linked to keratinocyte position within epidermal strata and UV-induced apoptosis. Experimental dermatology. vol 17. issue 2. 2008-02-14. PMID:18177350. |
our data highlight the differentiation- and apoptosis-associated changes in the pattern of bax subcellular and cellular distribution as uncovered by different anti-bax abs and suggest that bax undergoes successive activation that progresses in parallel with keratinocyte differentiation and apoptosis. |
2008-02-14 |
2023-08-12 |
human |
| Eleftherios Vairaktaris, Sofia Spyridonidou, Lambros Goutzanis, Antonis Vylliotis, Andreas Lazaris, Ismini Donta, Despina Perrea, Christos Yapijakis, Efstratios Patsouri. Diabetes and oral oncogenesis. Anticancer research. vol 27. issue 6B. 2008-02-12. PMID:18225590. |
the expression of egfr, erbb2, erbb3, fgfr-2, fgfr-3, c-myc, n-ras, ets-1, h-ras, c-fos and c-jun, the tumor suppressor genes p53 and p16, apoptosis markers bax and bcl-2, and the cell proliferation marker ki-67 in the sequential stages of rat oral oncogenesis was investigated. |
2008-02-12 |
2023-08-12 |
rat |
| Byeong Mo Kim, Hai Won Chun. Hypoxia/reoxygenation induces apoptosis through a ROS-mediated caspase-8/Bid/Bax pathway in human lymphocytes. Biochemical and biophysical research communications. vol 363. issue 3. 2008-02-11. PMID:17904098. |
time-sequence analysis of the induction of apoptosis by h/r revealed that h/r triggers apoptosis through a mitochondrial pathway involving caspase-8, bid cleavage, and bax activation. |
2008-02-11 |
2023-08-12 |
human |
| Byeong Mo Kim, Hai Won Chun. Hypoxia/reoxygenation induces apoptosis through a ROS-mediated caspase-8/Bid/Bax pathway in human lymphocytes. Biochemical and biophysical research communications. vol 363. issue 3. 2008-02-11. PMID:17904098. |
furthermore, suppression of caspase-8 activity with z-ietd-fmk prevented bid cleavage and bax activation during apoptosis. |
2008-02-11 |
2023-08-12 |
human |
| Melissa R Dent, Samarjit Das, Naranjan S Dhall. Alterations in both death and survival signals for apoptosis in heart failure due to volume overload. Journal of molecular and cellular cardiology. vol 43. issue 6. 2008-02-07. PMID:17931652. |
these data suggest that there is a downregulation in the akt-dependent survival signal involving anti-apoptotic protein, bcl-2, whereas the signals for the pro-apoptotic protein, bax, are upregulated and these alterations may play a role in cardiomyocyte apoptosis in heart failure due to volume overload. |
2008-02-07 |
2023-08-12 |
rat |
| Aina He, Jian-an Wang, Chun Gui, Yun Jiang, Yong Sun, Tielong Che. Changes of mitochondrial pathway in hypoxia/reoxygenation induced cardiomyocytes apoptosis. Folia histochemica et cytobiologica. vol 45. issue 4. 2008-02-07. PMID:18165181. |
our data showed apoptosis of cardiomyocytes was significantly increased during h/r, accompanied by translocation of bax to mitochondria, release of cytochrome c and aif to cytosol. |
2008-02-07 |
2023-08-12 |
rat |
| Marc S Mendonca, Helen Chin-Sinex, Jaime Gomez-Millan, Nicholas Datzman, Michael Hardacre, Kathleen Comerford, Harikrishna Nakshatri, Monica Nye, Laura Benjamin, Sachin Mehta, Fatima Patino, Christopher Sweene. Parthenolide sensitizes cells to X-ray-induced cell killing through inhibition of NF-kappaB and split-dose repair. Radiation research. vol 168. issue 6. 2008-02-06. PMID:18088190. |
treatment with 5 microm parthenolide for 48 to 72 h inhibited constitutive nf-kappab binding and cell growth, reduced plating efficiency, and induced apoptosis through stabilization of p53 (tp53), induction of the pro-apoptosis protein bax, and phosphorylation of bid. |
2008-02-06 |
2023-08-12 |
human |