| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kirsteen H Maclean, Frank C Dorsey, John L Cleveland, Michael B Kasta. Targeting lysosomal degradation induces p53-dependent cell death and prevents cancer in mouse models of lymphomagenesis. The Journal of clinical investigation. vol 118. issue 1. 2008-04-14. PMID:18097482. |
interestingly, chloroquine-induced cell death was not dependent on caspase-mediated apoptosis, as neither overexpression of the antiapoptotic protein bcl-2 nor deletion of the proapoptotic bax and bak affected chloroquine-induced mef death. |
2008-04-14 |
2023-08-12 |
mouse |
| Jagadish C Ghosh, Takehiko Dohi, Byoung Heon Kang, Dario C Altier. Hsp60 regulation of tumor cell apoptosis. The Journal of biological chemistry. vol 283. issue 8. 2008-04-10. PMID:18086682. |
this response involves disruption of an hsp60-p53 complex, which results in p53 stabilization, increased expression of pro-apoptotic bax, and bax-dependent apoptosis. |
2008-04-10 |
2023-08-12 |
human |
| Maria-Kyriaki A Kaseta, Lubna Khaldi, Ilias P Gomatos, George P Tzagarakis, Leonidas Alevizos, Emmanuel Leandros, Panayiotis J Papagelopoulos, Panayiotis N Soucaco. Prognostic value of bax, bcl-2, and p53 staining in primary osteosarcoma. Journal of surgical oncology. vol 97. issue 3. 2008-04-10. PMID:18161867. |
to investigate the immunohistochemical expression of three apoptosis-related genes (bax, bcl-2, and p53) and apoptosis (tunel) in patients with primary osteosarcoma, and examine potential correlations between gene expression and clinicopathological characteristics in these patients. |
2008-04-10 |
2023-08-12 |
Not clear |
| Aurora R Seminara, Peter P Ruvolo, Ferid Mura. LPS/IFNgamma-induced RAW 264.7 apoptosis is regulated by both nitric oxide-dependent and -independent pathways involving JNK and the Bcl-2 family. Cell cycle (Georgetown, Tex.). vol 6. issue 14. 2008-04-09. PMID:17622798. |
these results suggest a novel mechanism of lps/ifngamma-induced apoptosis in macrophages involving no-independent phosphorylation of bim and no-dependent dephosphorylation of bax. |
2008-04-09 |
2023-08-12 |
Not clear |
| Liang-yan Xue, Song-mao Chiu, Kashif Azizuddin, Sheeba Joseph, Nancy L Oleinic. Protection by Bcl-2 against apoptotic but not autophagic cell death after photodynamic therapy. Autophagy. vol 4. issue 1. 2008-04-09. PMID:18025862. |
here we investigated the occurrence of autophagy after pdt with the photosensitizer pc 4 in human cancer cells that are deficient in the pro-apoptotic factor bax (human prostate cancer du145) or the apoptosis mediator caspase-3 (human breast cancer mcf-7v) and in apoptosis-competent cells (mcf-7c3 stably overexpressing human pro-caspase-3 and chinese hamster ovary cho 5a100). |
2008-04-09 |
2023-08-12 |
human |
| Jyh-Rong Chao, Evan Parganas, Kelli Boyd, Cheol Yi Hong, Joseph T Opferman, James N Ihl. Hax1-mediated processing of HtrA2 by Parl allows survival of lymphocytes and neurons. Nature. vol 452. issue 7183. 2008-04-09. PMID:18288109. |
in mouse lymphocytes, the presence of processed htra2 prevents the accumulation of mitochondrial-outer-membrane-associated activated bax, an event that initiates apoptosis. |
2008-04-09 |
2023-08-12 |
mouse |
| Dharmalingam Subramaniam, Randal May, Sripathi M Sureban, Katherine B Lee, Robert George, Periannan Kuppusamy, Rama P Ramanujam, Kalman Hideg, Brian K Dieckgraefe, Courtney W Houchen, Shrikant Anan. Diphenyl difluoroketone: a curcumin derivative with potent in vivo anticancer activity. Cancer research. vol 68. issue 6. 2008-04-09. PMID:18339878. |
furthermore, the cancer cells showed increased levels of activated caspase-3 and increased bax to bcl-2 and bax to bcl-xl ratios, suggesting that the cells were undergoing apoptosis. |
2008-04-09 |
2023-08-12 |
mouse |
| Hae Jong Kim, Ji Eun Oh, Sang Woo Kim, Young Jin Chun, Mie Young Ki. Ceramide induces p38 MAPK-dependent apoptosis and Bax translocation via inhibition of Akt in HL-60 cells. Cancer letters. vol 260. issue 1-2. 2008-04-08. PMID:18054155. |
ceramide induces p38 mapk-dependent apoptosis and bax translocation via inhibition of akt in hl-60 cells. |
2008-04-08 |
2023-08-12 |
Not clear |
| Hae Jong Kim, Ji Eun Oh, Sang Woo Kim, Young Jin Chun, Mie Young Ki. Ceramide induces p38 MAPK-dependent apoptosis and Bax translocation via inhibition of Akt in HL-60 cells. Cancer letters. vol 260. issue 1-2. 2008-04-08. PMID:18054155. |
ceramide induces apoptosis through caspase activation, cytochrome c release, and bax translocation in hl-60 cells. |
2008-04-08 |
2023-08-12 |
Not clear |
| Hae Jong Kim, Ji Eun Oh, Sang Woo Kim, Young Jin Chun, Mie Young Ki. Ceramide induces p38 MAPK-dependent apoptosis and Bax translocation via inhibition of Akt in HL-60 cells. Cancer letters. vol 260. issue 1-2. 2008-04-08. PMID:18054155. |
however, the upstream signal transduction pathways that induce bax translocation during ceramide-mediated apoptosis have not been well defined yet. |
2008-04-08 |
2023-08-12 |
Not clear |
| Hae Jong Kim, Ji Eun Oh, Sang Woo Kim, Young Jin Chun, Mie Young Ki. Ceramide induces p38 MAPK-dependent apoptosis and Bax translocation via inhibition of Akt in HL-60 cells. Cancer letters. vol 260. issue 1-2. 2008-04-08. PMID:18054155. |
in this study, the activation of p38 mitogen-activated protein kinase (mapk) was found to be critical for the induction of apoptosis and subcellular redistribution of bax. |
2008-04-08 |
2023-08-12 |
Not clear |
| Hae Jong Kim, Ji Eun Oh, Sang Woo Kim, Young Jin Chun, Mie Young Ki. Ceramide induces p38 MAPK-dependent apoptosis and Bax translocation via inhibition of Akt in HL-60 cells. Cancer letters. vol 260. issue 1-2. 2008-04-08. PMID:18054155. |
overexpression of akt also led to suppression of bax translocation to mitochondria during ceramide-induced apoptosis in hl-60 cells. |
2008-04-08 |
2023-08-12 |
Not clear |
| A V Sirotkin, R Grossman. Effects of ghrelin and its analogues on chicken ovarian granulosa cells. Domestic animal endocrinology. vol 34. issue 2. 2008-04-03. PMID:17207955. |
indices of cell apoptosis (expression of the apoptotic peptide bax and the anti-apoptotic peptide bcl-2), proliferation (expression of proliferation-associated peptide pcna), and expression of protein kinases (pka and mapk) within ovarian granulosa cells were analysed by immunocytochemistry. |
2008-04-03 |
2023-08-12 |
chicken |
| G Strauss, M-A Westhoff, P Fischer-Posovszky, S Fulda, M Schanbacher, S M Eckhoff, K Stahnke, N Vahsen, G Kroemer, K-M Debati. 4-hydroperoxy-cyclophosphamide mediates caspase-independent T-cell apoptosis involving oxidative stress-induced nuclear relocation of mitochondrial apoptogenic factors AIF and EndoG. Cell death and differentiation. vol 15. issue 2. 2008-04-03. PMID:18034189. |
the antioxidant n-acetyl-l-cysteine substantially inhibited conformational changes of bax, loss of mitochondrial membrane potential, nuclear relocation of mitochondrial factors, and apoptosis induction in 4-ooh-cy-treated t cells. |
2008-04-03 |
2023-08-12 |
Not clear |
| R Cianfrocca, M Muscolini, V Marzano, A Annibaldi, B Marinari, M Levrero, A Costanzo, L Tuost. RelA/NF-kappaB recruitment on the bax gene promoter antagonizes p73-dependent apoptosis in costimulated T cells. Cell death and differentiation. vol 15. issue 2. 2008-04-03. PMID:18034190. |
rela/nf-kappab recruitment on the bax gene promoter antagonizes p73-dependent apoptosis in costimulated t cells. |
2008-04-03 |
2023-08-12 |
Not clear |
| R Cianfrocca, M Muscolini, V Marzano, A Annibaldi, B Marinari, M Levrero, A Costanzo, L Tuost. RelA/NF-kappaB recruitment on the bax gene promoter antagonizes p73-dependent apoptosis in costimulated T cells. Cell death and differentiation. vol 15. issue 2. 2008-04-03. PMID:18034190. |
here, we show that cd28 activation protects memory t cells from irradiation-induced apoptosis by both upregulating bcl-xl and inhibiting bax gene expression. |
2008-04-03 |
2023-08-12 |
Not clear |
| Jimmy A Rotolo, Jerzy G Maj, Regina Feldman, Decheng Ren, Adriana Haimovitz-Friedman, Carlos Cordon-Cardo, Emily H-Y Cheng, Richard Kolesnick, Zvi Fuk. Bax and Bak do not exhibit functional redundancy in mediating radiation-induced endothelial apoptosis in the intestinal mucosa. International journal of radiation oncology, biology, physics. vol 70. issue 3. 2008-04-03. PMID:18191336. |
bax and bak do not exhibit functional redundancy in mediating radiation-induced endothelial apoptosis in the intestinal mucosa. |
2008-04-03 |
2023-08-12 |
Not clear |
| Jimmy A Rotolo, Jerzy G Maj, Regina Feldman, Decheng Ren, Adriana Haimovitz-Friedman, Carlos Cordon-Cardo, Emily H-Y Cheng, Richard Kolesnick, Zvi Fuk. Bax and Bak do not exhibit functional redundancy in mediating radiation-induced endothelial apoptosis in the intestinal mucosa. International journal of radiation oncology, biology, physics. vol 70. issue 3. 2008-04-03. PMID:18191336. |
to address in vivo the issue of whether bax and bak are functionally redundant in signaling apoptosis, capable of substituting for each other. |
2008-04-03 |
2023-08-12 |
Not clear |
| Fu Li, Ling He, Zhan-Qian Song, Jin-Cheng Yao, Xiao-Ping Rao, Hai-Tao L. Cytotoxic effects and pro-apoptotic mechanism of TBIDOM, a novel dehydroabietylamine derivative, on human hepatocellular carcinoma SMMC-7721 cells. The Journal of pharmacy and pharmacology. vol 60. issue 2. 2008-04-03. PMID:18237468. |
hoechst 33342 staining and flow cytometry analysis showed an increase of apoptosis rate and decrease of mitochondrial membrane potential after smmc-7721 cells were exposed to tbidom for 24 h. pretreatment of smmc-7721 cells with tbidom significantly induced a decrease of bcl-2 protein expression and an increase of caspase-3 activity and bax protein expression. |
2008-04-03 |
2023-08-12 |
human |
| Verena Labi, Miriam Erlacher, Stephan Kiessling, Claudia Manzl, Anna Frenzel, Lorraine O'Reilly, Andreas Strasser, Andreas Villunge. Loss of the BH3-only protein Bmf impairs B cell homeostasis and accelerates gamma irradiation-induced thymic lymphoma development. The Journal of experimental medicine. vol 205. issue 3. 2008-04-03. PMID:18299399. |
bax and bak then elicit the downstream events in apoptosis signaling. |
2008-04-03 |
2023-08-12 |
mouse |