| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Shi-jie Wang, Xiong Guo, Jing-hong Chen, Feng-ling Ren, Rong Guo, Jin-jun Liu, Zeng-tie Zhan. [Mechanism of chondrocyte apoptosis in Kashin-Beck disease and primary osteoarthritis: a comparative study]. Nan fang yi ke da xue xue bao = Journal of Southern Medical University. vol 26. issue 7. 2008-04-24. PMID:16864079. |
to investigate chondrocyte apoptosis and the expressions of bcl-2, bax, fas and inos in the articular cartilage between kashin-beck disease (kbd) and primary osteoarthritis (oa) and explore the difference in pathogenesis between the two diseases. |
2008-04-24 |
2023-08-12 |
Not clear |
| Shinji Tsukahara, Rieko Hojo, Yoshiko Kuroda, Hidekazu Fujimak. Estrogen modulates Bcl-2 family protein expression in the sexually dimorphic nucleus of the preoptic area of postnatal rats. Neuroscience letters. vol 432. issue 1. 2008-04-24. PMID:18164816. |
we have reported that there are sex differences in the levels of bcl-2 (femalebax (female>male) in the central division of the medial preoptic nucleus (mpnc), a significant component of the sdn-poa, followed by a sex difference in induction of apoptosis via caspase-3 activation (female>male). |
2008-04-24 |
2023-08-12 |
rat |
| Hai-Bo Zhou, Jin-Ming Chen, Jian-Ting Cai, Qin Du, Chan-Ni W. Anticancer activity of genistein on implanted tumor of human SG7901 cells in nude mice. World journal of gastroenterology. vol 14. issue 4. 2008-04-24. PMID:18203299. |
to investigate genistein-induced apoptosis of implanted tumors of sg7901 cells in nude mice, and the relationship between this apoptosis and expression of bcl-2 and bax. |
2008-04-24 |
2023-08-12 |
mouse |
| Sangkon Oh, Liyanage P Perera, Masaki Terabe, Ling Ni, Thomas A Waldmann, Jay A Berzofsk. IL-15 as a mediator of CD4+ help for CD8+ T cell longevity and avoidance of TRAIL-mediated apoptosis. Proceedings of the National Academy of Sciences of the United States of America. vol 105. issue 13. 2008-04-23. PMID:18362335. |
in both priming and secondary responses, il-15 down-regulates proapoptotic bax, an intermediate in trail-mediated apoptosis, and increases anti-apoptotic bcl-x(l) in cd8+ t cells. |
2008-04-23 |
2023-08-12 |
Not clear |
| Avigail D Amsel, Moran Rathaus, Noam Kronman, Haim Y Cohe. Regulation of the proapoptotic factor Bax by Ku70-dependent deubiquitylation. Proceedings of the National Academy of Sciences of the United States of America. vol 105. issue 13. 2008-04-23. PMID:18362350. |
the dna end-joining protein ku70 is one of several proteins that inhibit apoptosis by sequestering the proapoptotic factor bax from the mitochondria. |
2008-04-23 |
2023-08-12 |
Not clear |
| Avigail D Amsel, Moran Rathaus, Noam Kronman, Haim Y Cohe. Regulation of the proapoptotic factor Bax by Ku70-dependent deubiquitylation. Proceedings of the National Academy of Sciences of the United States of America. vol 105. issue 13. 2008-04-23. PMID:18362350. |
upon induction of apoptosis in wild-type cells, a significant reduction in the levels of ubiquitylated bax was observed, whereas in ku70(-/-) cells, the ubiquitylated bax was robustly accumulated. |
2008-04-23 |
2023-08-12 |
Not clear |
| Avigail D Amsel, Moran Rathaus, Noam Kronman, Haim Y Cohe. Regulation of the proapoptotic factor Bax by Ku70-dependent deubiquitylation. Proceedings of the National Academy of Sciences of the United States of America. vol 105. issue 13. 2008-04-23. PMID:18362350. |
thus, ku70 regulates apoptosis by sequestering bax from the mitochondria and mediating bax deubiquitylation. |
2008-04-23 |
2023-08-12 |
Not clear |
| E D Bazhanova, V N Molodtsov, K I Pavlo. Aging-related changes in the expression of apoptosis-associated molecules in neurosecretory cells of the mouse hypothalamus. Neuroscience and behavioral physiology. vol 38. issue 1. 2008-04-22. PMID:18097759. |
age-related activation of apoptosis in the supraoptic (son) and paraventricular (pvn) nuclei was found to be mediated by different pathways and could result from changes in the ratio of synthesis of pro-(bax) and antiapoptotic (mcl-1, bcl-2) molecules. |
2008-04-22 |
2023-08-12 |
mouse |
| Tiziana Genovese, Emanuela Esposito, Emanuela Mazzon, Carmelo Muià, Rosanna Di Paola, Rosaria Meli, Placido Bramanti, Salvatore Cuzzocre. Evidence for the role of mitogen-activated protein kinase signaling pathways in the development of spinal cord injury. The Journal of pharmacology and experimental therapeutics. vol 325. issue 1. 2008-04-22. PMID:18180375. |
at 1 and 6 h after the sci significantly reduced 1) the degree of spinal cord inflammation and tissue injury (histological score), 2) neutrophil infiltration (myeloperoxidase activity), 3) nitrotyrosine formation, 4) proinflammatory cytokines expression, 5) nuclear factor-kappab activation, 6) phospho-erk1/2 expression, and 6) apoptosis (terminal deoxynucleotidyl transferase dutp nick-end labeling staining, fas ligand, bax, and bcl-2 expression). |
2008-04-22 |
2023-08-12 |
mouse |
| Xiang-Wei Yuan, Xiao-Feng Zhu, Sheng-Gen Liang, Quan Fan, Zhong-Xian Chen, Xiu-Fang Huang, Pu-Yi Sheng, Ai-Shan He, Zi-Bo Yang, Rong Deng, Gong-Kan Feng, Wei-Ming Lia. Interferonalpha enhances etoposide-induced apoptosis in human osteosarcoma U2OS cells by a p53-dependent pathway. Life sciences. vol 82. issue 7-8. 2008-04-22. PMID:18191951. |
the enhanced apoptosis was associated with the accumulation of transcriptionally active p53 accompanied with increased bax and mdm2, as well as decreased bcl-2. |
2008-04-22 |
2023-08-12 |
human |
| A T Palasz, P Beltrán Breña, Marcelo F Martinez, S S Perez-Garnelo, M A Ramirez, A Gutiérrez-Adán, J De la Fuent. Development, molecular composition and freeze tolerance of bovine embryos cultured in TCM-199 supplemented with hyaluronan. Zygote (Cambridge, England). vol 16. issue 1. 2008-04-22. PMID:18221580. |
in addition, ha presence in culture decreased the level of expression of apoptosis bax and oxidative stress sox genes (p<0.05). |
2008-04-22 |
2023-08-12 |
cattle |
| Hyeyoung Park, Ji Young Im, Jeonga Kim, Wahn Soo Choi, Hyung Sik Ki. Effects of apicidin, a histone deacetylase inhibitor, on the regulation of apoptosis in H-ras-transformed breast epithelial cells. International journal of molecular medicine. vol 21. issue 3. 2008-04-22. PMID:18288380. |
the up-regulation of p53 promoted bax expression leading to activation of caspases-9 and -6, and eventually to apoptosis in mcf10a-ras cells. |
2008-04-22 |
2023-08-12 |
human |
| E D Bazhanova, V N Molodtsov, I G Popovich, V N Anisimo. [Apoptosis regulation in hypothalamic neurosecretory cells of HER2/neu transgenic mice in ontogenesis]. Advances in gerontology = Uspekhi gerontologii. vol 20. issue 4. 2008-04-21. PMID:18383707. |
we detected the apoptosis protein expression (bax, c-raf) in comparison with apoptosis level and functional activity (vasopressin concentration) in neuroendocrine system. |
2008-04-21 |
2023-08-12 |
mouse |
| Elena Maksimova, Ting-An Yie, William N Ro. In vitro mechanisms of lovastatin on lung cancer cell lines as a potential chemopreventive agent. Lung. vol 186. issue 1. 2008-04-17. PMID:18034278. |
lovastatin induces apoptosis and necrosis in lung cancer cell lines by causing alterations in the cell cycle, reducing glutathione, and activating p53, bax protein, and caspases while increasing cytochrome c in apoptosis pathways. |
2008-04-17 |
2023-08-12 |
human |
| S Jajoo, D Mukherjea, G J Brewer, V Ramkuma. Pertussis toxin B-oligomer suppresses human immunodeficiency virus-1 Tat-induced neuronal apoptosis through feedback inhibition of phospholipase C-beta by protein kinase C. Neuroscience. vol 151. issue 2. 2008-04-15. PMID:18093742. |
functionally, ptx-b reduced tat-induced bax and caspase-3 proteins and reduced cell apoptosis. |
2008-04-15 |
2023-08-12 |
human |
| Samir G Agrawal, Feng-Ting Liu, Catherine Wiseman, Sima Shirali, Hongxiang Liu, Debra Lillington, Ming-Qing Du, Denise Syndercombe-Court, Adrian C Newland, John G Gribben, Li Ji. Increased proteasomal degradation of Bax is a common feature of poor prognosis chronic lymphocytic leukemia. Blood. vol 111. issue 5. 2008-04-15. PMID:18160666. |
bax is an essential proapoptotic protein and decreased levels in malignant cells lead to resistance to apoptosis. |
2008-04-15 |
2023-08-12 |
Not clear |
| Feng-Ting Liu, Samir G Agrawal, John G Gribben, Hongtao Ye, Ming-Qing Du, Adrian C Newland, Li Ji. Bortezomib blocks Bax degradation in malignant B cells during treatment with TRAIL. Blood. vol 111. issue 5. 2008-04-15. PMID:18160669. |
proapoptotic bcl-2 family member bax is a crucial protein in the induction of apoptosis, and its activation is required for this process. |
2008-04-15 |
2023-08-12 |
Not clear |
| Feng-Ting Liu, Samir G Agrawal, John G Gribben, Hongtao Ye, Ming-Qing Du, Adrian C Newland, Li Ji. Bortezomib blocks Bax degradation in malignant B cells during treatment with TRAIL. Blood. vol 111. issue 5. 2008-04-15. PMID:18160669. |
malignant b cells were relatively resistant to tumor necrosis factor-related apoptosis inducing ligand (trail)-induced apoptosis, and this correlated with low basal bax protein levels. |
2008-04-15 |
2023-08-12 |
Not clear |
| Feng-Ting Liu, Samir G Agrawal, John G Gribben, Hongtao Ye, Ming-Qing Du, Adrian C Newland, Li Ji. Bortezomib blocks Bax degradation in malignant B cells during treatment with TRAIL. Blood. vol 111. issue 5. 2008-04-15. PMID:18160669. |
accumulation and stabilization of bax protein by bortezomib-sensitized malignant b cells to trail-induced apoptosis. |
2008-04-15 |
2023-08-12 |
Not clear |
| Barbara Marengo, Chiara De Ciucis, Daniela Verzola, Vito Pistoia, Lizzia Raffaghello, Stefania Patriarca, Emanuela Balbis, Nicola Traverso, Damiano Cottalasso, Maria A Pronzato, Umberto M Marinari, Cinzia Domenicott. Mechanisms of BSO (L-buthionine-S,R-sulfoximine)-induced cytotoxic effects in neuroblastoma. Free radical biology & medicine. vol 44. issue 3. 2008-04-14. PMID:17991446. |
these results describe a novel pathway of apoptosis dependent on ros formation and pkc-delta activation and independent of p53, bcl-2, and bax levels; the selective redox modulation of pkc-delta might be suggested as a potential strategy for sensitizing mycn-amplified cells to therapeutic approaches. |
2008-04-14 |
2023-08-12 |
Not clear |