| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Marc Germain, Jocelyn Milburn, Vincent Duroni. MCL-1 inhibits BAX in the absence of MCL-1/BAX Interaction. The Journal of biological chemistry. vol 283. issue 10. 2008-05-30. PMID:18089567. |
the pro-apoptotic bcl-2 homologues bax and bak are activated following the induction of apoptosis and induce cytochrome c release from mitochondria. |
2008-05-30 |
2023-08-12 |
Not clear |
| Dayong Zhai, Chaofang Jin, Ziwei Huang, Arnold C Satterthwait, John C Ree. Differential regulation of Bax and Bak by anti-apoptotic Bcl-2 family proteins Bcl-B and Mcl-1. The Journal of biological chemistry. vol 283. issue 15. 2008-05-28. PMID:18178565. |
in this report, we compared the ability of the six human anti-apoptotic bcl-2 family members to suppress apoptosis induced by overexpression of bax or bak, correlating findings with protein interactions measured by three different methods: co-immunoprecipitation, glutathione s-transferase pulldown, and fluorescence polarization assays employing synthetic bh3 peptides from bax and bak. |
2008-05-28 |
2023-08-12 |
human |
| Dayong Zhai, Chaofang Jin, Ziwei Huang, Arnold C Satterthwait, John C Ree. Differential regulation of Bax and Bak by anti-apoptotic Bcl-2 family proteins Bcl-B and Mcl-1. The Journal of biological chemistry. vol 283. issue 15. 2008-05-28. PMID:18178565. |
in contrast, the other anti-apoptotic bcl-2 family proteins (bcl-2, bcl-x(l), bcl-w, and bfl-1) suppressed apoptosis induced by overexpression of either bax or bak, and they displayed an ability to bind both bax and bak by at least one of the three protein interaction methods. |
2008-05-28 |
2023-08-12 |
human |
| Yong-Lie Zhou, Wei-Xiao Hu, Ya-Ping Lü, Lian-Nü Qiu, Wen-Song Wang, Zhong-Yu Yang, Jian-Dong Liu, Guo-Wu Ra. [Effect of ZGDHu-1 on proliferation and apoptosis of A549 cells in vitro and antitumor activity in vivo]. Yao xue xue bao = Acta pharmaceutica Sinica. vol 42. issue 1. 2008-05-27. PMID:17520803. |
the mechanism may associate with its up-regulation of bax and p53 during the apoptosis process. |
2008-05-27 |
2023-08-12 |
mouse |
| Jerry E Chipuk, Douglas R Gree. How do BCL-2 proteins induce mitochondrial outer membrane permeabilization? Trends in cell biology. vol 18. issue 4. 2008-05-27. PMID:18314333. |
specifically, do the bh3-only proteins directly engage bax and/or bak activation or do these proteins solely promote apoptosis by neutralization of anti-apoptotic bcl-2 proteins? |
2008-05-27 |
2023-08-12 |
Not clear |
| Jie Shi, Han-Ming She. Critical role of Bid and Bax in indirubin-3'-monoxime-induced apoptosis in human cancer cells. Biochemical pharmacology. vol 75. issue 9. 2008-05-27. PMID:18377873. |
critical role of bid and bax in indirubin-3'-monoxime-induced apoptosis in human cancer cells. |
2008-05-27 |
2023-08-12 |
human |
| Jie Shi, Han-Ming She. Critical role of Bid and Bax in indirubin-3'-monoxime-induced apoptosis in human cancer cells. Biochemical pharmacology. vol 75. issue 9. 2008-05-27. PMID:18377873. |
in conclusion, our results indicate that i3m mainly elicites apoptosis through extrinsic pathway with type ii response mediated by the pro-apoptotic bcl-2 family members (bid and bax). |
2008-05-27 |
2023-08-12 |
human |
| Satoko Yui, Ryuhei Kanamoto, Tohru Saek. Deoxycholic acid can induce apoptosis in the human colon cancer cell line HCT116 in the absence of Bax. Nutrition and cancer. vol 60. issue 1. 2008-05-27. PMID:18444140. |
deoxycholic acid can induce apoptosis in the human colon cancer cell line hct116 in the absence of bax. |
2008-05-27 |
2023-08-12 |
human |
| Satoko Yui, Ryuhei Kanamoto, Tohru Saek. Deoxycholic acid can induce apoptosis in the human colon cancer cell line HCT116 in the absence of Bax. Nutrition and cancer. vol 60. issue 1. 2008-05-27. PMID:18444140. |
in the human colon cancer cells hct116, deoxycholic acid (dca) induces apoptosis via the mitochondrial pathway by triggering the release of mitochondrial factors such as cytochrome c. to elucidate if bax, a proapoptotic member of the bcl-2 family known to trigger cytochrome c release in response to various types of apoptotic stimuli, is involved in dca-induced apoptosis in hct116 cells, we analyzed dca-induced apoptosis in bax-knockout (bax(-/-)) hct116 cells. |
2008-05-27 |
2023-08-12 |
human |
| Satoko Yui, Ryuhei Kanamoto, Tohru Saek. Deoxycholic acid can induce apoptosis in the human colon cancer cell line HCT116 in the absence of Bax. Nutrition and cancer. vol 60. issue 1. 2008-05-27. PMID:18444140. |
bax(-/-) cells were protected from apoptosis by treating them with ursodeoxycholic acid for 12 h prior to dca treatment. |
2008-05-27 |
2023-08-12 |
human |
| Satoko Yui, Ryuhei Kanamoto, Tohru Saek. Deoxycholic acid can induce apoptosis in the human colon cancer cell line HCT116 in the absence of Bax. Nutrition and cancer. vol 60. issue 1. 2008-05-27. PMID:18444140. |
these results are consistent with our previous observations that were obtained by using wild-type hct116 cells and suggest that bax is not indispensable for dca-induced apoptosis in hct116 cells. |
2008-05-27 |
2023-08-12 |
human |
| Salvatore Cuzzocrea, Tiziana Genovese, Emanuela Mazzon, Emanuela Esposito, Rosanna Di Paola, Carmelo Muià, Concetta Crisafulli, Angelo Peli, Placido Bramanti, Irshad H Chaudr. Effect of 17beta-estradiol on signal transduction pathways and secondary damage in experimental spinal cord trauma. Shock (Augusta, Ga.). vol 29. issue 3. 2008-05-23. PMID:17704735. |
to gain a better insight into the mechanism of action of the anti-inflammatory effects of e2, the following end points of the inflammatory process were evaluated: (1) spinal cord inflammation and tissue injury (histological score); (2) neutrophil infiltration (myeloperoxidase activity); (3) expression of inos, nitrotyrosine, and cox-2; (4) apoptosis (terminal deoxynucleotidyltransferase-mediated utp end labeling staining and bax and bcl-2 expression); and (5) tissue tnf-alpha, il-6, il-1beta, and monocyte chemoattractant protein 1 levels. |
2008-05-23 |
2023-08-12 |
Not clear |
| Fernanda Parborell, Dalhia Abramovich, Marta Teson. Intrabursal administration of the antiangiopoietin 1 antibody produces a delay in rat follicular development associated with an increase in ovarian apoptosis mediated by changes in the expression of BCL2 related genes. Biology of reproduction. vol 78. issue 3. 2008-05-22. PMID:17989359. |
in particular, we examined the effect of local administration of anti-angpt1 antibody on follicular development, apoptosis, and expression of bcl2 protein family members (bax, bcl2, and bcl2l1), tnfrsf6, and faslg in ovarian follicles from prepubertal ecg-treated rats. |
2008-05-22 |
2023-08-12 |
rat |
| Arabinda Das, Naren L Banik, Swapan K Ra. Retinoids induced astrocytic differentiation with down regulation of telomerase activity and enhanced sensitivity to taxol for apoptosis in human glioblastoma T98G and U87MG cells. Journal of neuro-oncology. vol 87. issue 1. 2008-05-21. PMID:17987264. |
the events of apoptosis included increase in expression of bax, down regulation of bcl-2 and baculoviral inhibitor-of-apoptosis protein (iap) repeat containing (birc) proteins, mitochondrial release of cytochrome c and smac into the cytosol, increase in intracellular free [ca(2+)], and activation of calpain, caspase-9, and caspase-3. |
2008-05-21 |
2023-08-12 |
human |
| Sung Hwa Bae, Hun-Mo Ryoo, Min Kyoung Kim, Kyung Hee Lee, Jeong-Im Sin, Myung Soo Hyu. Effects of the proteasome inhibitor bortezomib alone and in combination with chemotherapeutic agents in gastric cancer cell lines. Oncology reports. vol 19. issue 4. 2008-05-21. PMID:18357392. |
further combination studies with other chemotherapeutic drugs, in particular docetaxel showing more tumor cell growth inhibition and apoptosis suggest that combining bortezomib with docetaxel might be more effective for displaying tumor cell growth inhibitory effects in gastric cancer cells through regulation of bcl-2, bax and p27 proteins in vitro. |
2008-05-21 |
2023-08-12 |
human |
| Wenjing Luo, Jinyi Liu, Jingxia Li, Dongyun Zhang, Mingchao Liu, James K Addo, Shivaputra Patil, Lin Zhang, Jian Yu, John K Buolamwini, Jingyuan Chen, Chuanshu Huan. Anti-cancer effects of JKA97 are associated with its induction of cell apoptosis via a Bax-dependent and p53-independent pathway. The Journal of biological chemistry. vol 283. issue 13. 2008-05-20. PMID:18218619. |
further studies showed that jka97-induced apoptosis was dramatically impaired in bax knock-out (bax(-/-)) hct116 cells, whereas the knock-out of p53 or puma did not show any inhibitory effects. |
2008-05-20 |
2023-08-12 |
mouse |
| Wenjing Luo, Jinyi Liu, Jingxia Li, Dongyun Zhang, Mingchao Liu, James K Addo, Shivaputra Patil, Lin Zhang, Jian Yu, John K Buolamwini, Jingyuan Chen, Chuanshu Huan. Anti-cancer effects of JKA97 are associated with its induction of cell apoptosis via a Bax-dependent and p53-independent pathway. The Journal of biological chemistry. vol 283. issue 13. 2008-05-20. PMID:18218619. |
in addition, our results showed an induction of bax translocation and cytochrome c release from the mitochondria to the cytosol in hct116 cells, demonstrating that the compound induces apoptosis through a bax-initiated mitochondria-dependent pathway. |
2008-05-20 |
2023-08-12 |
mouse |
| Kah Fei Wan, Shing-Leng Chan, Sunil Kumar Sukumaran, Mei-Chin Lee, Victor C Y. Chelerythrine induces apoptosis through a Bax/Bak-independent mitochondrial mechanism. The Journal of biological chemistry. vol 283. issue 13. 2008-05-20. PMID:18230621. |
although murine embryonic fibroblasts (mefs) with bax or bak deleted displayed no defect in apoptosis signaling, mefs with bax and bak double knock-out (dko) showed dramatic resistance to diverse apoptotic stimuli, suggesting that bax and bak are redundant but essential regulators for apoptosis signaling. |
2008-05-20 |
2023-08-12 |
Not clear |
| Ajay Kumar, Fayaz Malik, Shashi Bhushan, Vijay K Sethi, Ashok K Shahi, Jagdeep Kaur, Subhash C Taneja, Ghulam N Qazi, Jaswant Sing. An essential oil and its major constituent isointermedeol induce apoptosis by increased expression of mitochondrial cytochrome c and apical death receptors in human leukaemia HL-60 cells. Chemico-biological interactions. vol 171. issue 3. 2008-05-19. PMID:18070620. |
further, bax translocation, and decrease in nuclear nf-kappab expression predict multi-target effects of the essential oil and iso while both appeared to follow similar signaling apoptosis pathways. |
2008-05-19 |
2023-08-12 |
human |
| Mark F Jacquin, Joop J A Arends, Chuanxi Xiang, Lee A Shapiro, Charles E Ribak, Zhou-Feng Che. In DRG11 knock-out mice, trigeminal cell death is extensive and does not account for failed brainstem patterning. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 28. issue 14. 2008-05-19. PMID:18385316. |
drg11 heterozygote and bax(-/-) mice were crossed in an attempt to dissociate prv patterning anomalies from exuberant apoptosis in drg11(-/-) mice. |
2008-05-19 |
2023-08-12 |
mouse |