| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| b' Agnieszka Szuster-Ciesielska, Maria S\\xc5\\x82otwi\\xc5\\x84ska, Anna Stachura, Halina Marmurowska-Micha\\xc5\\x82owska, Halina Dubas-Slemp, Agnieszka Bojarska-Junak, Martyna Kandefer-Szersze\\xc5\\x8. Accelerated apoptosis of blood leukocytes and oxidative stress in blood of patients with major depression. Progress in neuro-psychopharmacology & biological psychiatry. vol 32. issue 3. 2008-07-02. PMID:18083280.' |
blood was taken from 29 patients with depression (age 48.2+/-11.2, 14 males, 15 females) and 30 healthy controls (age 41.3+/-4.1, 15 males, 15 females), and apoptosis was estimated by the cytometric method by measurements of annexin v binding, mitochondrial membrane potential (deltapsi), bcl-2, bax, and fas (cd95) expression in cd4+, cd8+ and cd14+ cells. |
2008-07-02 |
2023-08-12 |
cat |
| Guo-Ping Sun, Hua Wang, Shu-Ping Xu, Yu-Xian Shen, Qiang Wu, Zhen-Dong Chen, Wei We. Anti-tumor effects of paeonol in a HepA-hepatoma bearing mouse model via induction of tumor cell apoptosis and stimulation of IL-2 and TNF-alpha production. European journal of pharmacology. vol 584. issue 2-3. 2008-07-01. PMID:18329639. |
treatment of mice with 100, 200, or 400 mg/kg/day of paeonol significantly inhibited the growth of the hepa tumor in mice, induced hepa cell apoptosis as demonstrated by light microscopy and electron microscopy analyses, decreased the expression of bcl-2 and increased the expression of bax in hepa tumor tissues in a dose-related manner. |
2008-07-01 |
2023-08-12 |
mouse |
| Myung-Kwan Han, Eun-Kyung Song, Ying Guo, Xuan Ou, Charlie Mantel, Hal E Broxmeye. SIRT1 regulates apoptosis and Nanog expression in mouse embryonic stem cells by controlling p53 subcellular localization. Cell stem cell. vol 2. issue 3. 2008-07-01. PMID:18371449. |
endogenous ros triggered apoptosis of wild-type mes through mitochondrial translocation of p53 and bax but inhibited nanog expression of sirt1(-/-) mes, indicating that sirt1 makes mes cells sensitive to ros and inhibits p53-mediated suppression of nanog expression. |
2008-07-01 |
2023-08-12 |
mouse |
| Violeta Lamarca, Isabel Marzo, Antonio Sanz-Clemente, José A Carrodegua. Exposure of any of two proapoptotic domains of presenilin 1-associated protein/mitochondrial carrier homolog 1 on the surface of mitochondria is sufficient for induction of apoptosis in a Bax/Bak-independent manner. European journal of cell biology. vol 87. issue 5. 2008-07-01. PMID:18375015. |
overexpression of psap/mtch1 in cultured cells causes mitochondrial depolarization and apoptosis that does not depend on bax or bak, since apoptosis is induced in mouse embryonic fibroblasts lacking these two proteins. |
2008-07-01 |
2023-08-12 |
mouse |
| Mario Falchetti, Calogero Saieva, Ramona Lupi, Giovanna Masala, Piera Rizzolo, Ines Zanna, Ketty Ceccarelli, Francesco Sera, Renato Mariani-Costantini, Gabriella Nesi, Domenico Palli, Laura Ottin. Gastric cancer with high-level microsatellite instability: target gene mutations, clinicopathologic features, and long-term survival. Human pathology. vol 39. issue 6. 2008-07-01. PMID:18440592. |
we also investigated the msi-h-related genetic changes by analyzing coding repeats within target genes involved in pathways that control cell growth (tgfbetarii, igfiir, riz, tcf4, dp2), apoptosis (bax, bcl10, fas, caspase5, apaf1), and dna repair genes (hmsh6, hmsh3, med1, rad50, blm, atr, brca2, mre11). |
2008-07-01 |
2023-08-12 |
Not clear |
| Emanuela Mazzon, Salvatore Cuzzocre. Role of TNF-alpha in ileum tight junction alteration in mouse model of restraint stress. American journal of physiology. Gastrointestinal and liver physiology. vol 294. issue 5. 2008-06-30. PMID:18308862. |
the genetic tnf-alpha inhibition significantly reduced the degree of 1) tnf-alpha production in ileum tissues; 2) the alteration of zonula occludens-1 (zo-1), claudin-2, claudin-4, claudin-5, and beta-catenin (immunohistochemistry); and 3) apoptosis (tunel staining, bax, bcl-2 expression). |
2008-06-30 |
2023-08-12 |
mouse |
| Jing Lu, Michael S Caplan, Dan Li, Tamas Jillin. Polyunsaturated fatty acids block platelet-activating factor-induced phosphatidylinositol 3 kinase/Akt-mediated apoptosis in intestinal epithelial cells. American journal of physiology. Gastrointestinal and liver physiology. vol 294. issue 5. 2008-06-30. PMID:18356536. |
we have shown earlier that platelet-activating factor (paf) causes apoptosis in enterocytes via a mechanism that involves bax translocation to mitochondria, followed by caspase activation and dna fragmentation. |
2008-06-30 |
2023-08-12 |
rat |
| Alex Philchenkov, Vitaliy Kaminskyy, Michael Zavelevich, Rostyslav Stoik. Apoptogenic activity of two benzophenanthridine alkaloids from Chelidonium majus L. does not correlate with their DNA damaging effects. Toxicology in vitro : an international journal published in association with BIBRA. vol 22. issue 2. 2008-06-27. PMID:18023322. |
apoptosis induction by che and san in these cells was accompanied by caspase-9 and -3 activation and an increase in the pro-apoptotic bax protein. |
2008-06-27 |
2023-08-12 |
human |
| L H Ho, S H Read, L Dorstyn, L Lambrusco, S Kuma. Caspase-2 is required for cell death induced by cytoskeletal disruption. Oncogene. vol 27. issue 24. 2008-06-24. PMID:18193089. |
we further found that caspase-2 mediates apoptosis via piddosome, bid and bax activation, and cytochrome c release. |
2008-06-24 |
2023-08-12 |
mouse |
| R A Eliseev, Y-F Dong, E Sampson, M J Zuscik, E M Schwarz, R J O'Keefe, R N Rosier, M H Driss. Runx2-mediated activation of the Bax gene increases osteosarcoma cell sensitivity to apoptosis. Oncogene. vol 27. issue 25. 2008-06-24. PMID:18223689. |
runx2-mediated activation of the bax gene increases osteosarcoma cell sensitivity to apoptosis. |
2008-06-24 |
2023-08-12 |
human |
| R A Eliseev, Y-F Dong, E Sampson, M J Zuscik, E M Schwarz, R J O'Keefe, R N Rosier, M H Driss. Runx2-mediated activation of the Bax gene increases osteosarcoma cell sensitivity to apoptosis. Oncogene. vol 27. issue 25. 2008-06-24. PMID:18223689. |
furthermore, bone morphogenetic protein-induced or vector-mediated expression of runx2 resulted in upregulation of bax expression, and subsequent increased sensitivity of saos2 cells to apoptosis. |
2008-06-24 |
2023-08-12 |
human |
| R A Eliseev, Y-F Dong, E Sampson, M J Zuscik, E M Schwarz, R J O'Keefe, R N Rosier, M H Driss. Runx2-mediated activation of the Bax gene increases osteosarcoma cell sensitivity to apoptosis. Oncogene. vol 27. issue 25. 2008-06-24. PMID:18223689. |
finally, the observed upregulation of bax expression and increased apoptosis were runx2 dependent as runx2 loss of function abrogated these effects. |
2008-06-24 |
2023-08-12 |
human |
| Wei-Hao Sun, Feng Zhu, Guo-Sheng Chen, Han Su, Cheng Luo, Qin-Shi Zhao, Yuan Zhang, Yun Shao, Jian Sun, Su-Ming Zhou, Guo-Xian Ding, Yun-Lin Chen. Blockade of cholecystokinin-2 receptor and cyclooxygenase-2 synergistically induces cell apoptosis, and inhibits the proliferation of human gastric cancer cells in vitro. Cancer letters. vol 263. issue 2. 2008-06-24. PMID:18258354. |
here, we demonstrated that the combination of ag-041r (a cck-2 receptor antagonist) plus ns-398 (a selective cox-2 inhibitor) treatment had synergistic effects on proliferation inhibition, apoptosis induction, down-regulation of bcl-2 and up-regulation of bax expression in mkn-45 cells. |
2008-06-24 |
2023-08-12 |
human |
| Hideshi Ishii, Koshi Mimori, Kazuhiro Ishikawa, Hiroshi Okumura, Flavia Pichiorri, Teresa Druck, Hiroshi Inoue, Andrea Vecchione, Toshiyuki Saito, Masaki Mori, Kay Huebne. Fhit-deficient hematopoietic stem cells survive hydroquinone exposure carrying precancerous changes. Cancer research. vol 68. issue 10. 2008-06-24. PMID:18483248. |
comparative immunohistochemical analyses of bone marrow transplants showed relative absence of bax in fhit-deficient bone marrow, suggesting insensitivity to apoptosis; assessment of dna damage showed that occurrence of the oxidized base 8-hydroxyguanosine, a marker of dna damage, was also reduced in fhit-deficient bone marrow, as was production of intracellular reactive oxygen species. |
2008-06-24 |
2023-08-12 |
mouse |
| Wenguang Sun, Qi Wang, Bingqing Chen, Jiaren Liu, Huikun Liu, Weili X. Gamma-tocotrienol-induced apoptosis in human gastric cancer SGC-7901 cells is associated with a suppression in mitogen-activated protein kinase signalling. The British journal of nutrition. vol 99. issue 6. 2008-06-23. PMID:18081943. |
furthermore, gamma-tocotrienol-induced apoptosis was accompanied by down regulation of bcl-2, up regulation of bax, activation of caspase-3, and subsequent poly (adp-ribose) polymerase cleavage. |
2008-06-23 |
2023-08-12 |
human |
| Arwed Hostmann, Kerstin Jasse, Gundula Schulze-Tanzil, Yohan Robinson, Andreas Oberholzer, Wolfgang Ertel, Sven K Tschoek. Biphasic onset of splenic apoptosis following hemorrhagic shock: critical implications for Bax, Bcl-2, and Mcl-1 proteins. Critical care (London, England). vol 12. issue 1. 2008-06-23. PMID:18211685. |
biphasic onset of splenic apoptosis following hemorrhagic shock: critical implications for bax, bcl-2, and mcl-1 proteins. |
2008-06-23 |
2023-08-12 |
Not clear |
| Kyung-No Son, Robert P Becker, Patricia Kallio, Howard L Lipto. Theiler's virus-induced intrinsic apoptosis in M1-D macrophages is Bax mediated and restricts virus infectivity: a mechanism for persistence of a cytolytic virus. Journal of virology. vol 82. issue 9. 2008-06-23. PMID:18287228. |
theiler's virus-induced intrinsic apoptosis in m1-d macrophages is bax mediated and restricts virus infectivity: a mechanism for persistence of a cytolytic virus. |
2008-06-23 |
2023-08-12 |
mouse |
| Mayank Singh, Neeta Sing. Induction of apoptosis by hydrogen peroxide in HPV 16 positive human cervical cancer cells: involvement of mitochondrial pathway. Molecular and cellular biochemistry. vol 310. issue 1-2. 2008-06-20. PMID:18060474. |
we demonstrate, here, that in hpv 16 positive cell lines apoptosis is triggered by upregulation of p73, which causes activation of pro-apoptotic bax accompanied by down regulation of anti-apoptotic bcl xl, release of cytochrome c from mitochondria and activation of caspases-9 and -3. |
2008-06-20 |
2023-08-12 |
human |
| Un-Ho Jin, Kwon-Ho Song, Muneo Motomura, Ikukatsu Suzuki, Yeun-Hwa Gu, Yun-Jeong Kang, Tae-Chul Moon, Cheorl-Ho Ki. Caffeic acid phenethyl ester induces mitochondria-mediated apoptosis in human myeloid leukemia U937 cells. Molecular and cellular biochemistry. vol 310. issue 1-2. 2008-06-20. PMID:18060475. |
apoptotic action of the cape was accompanied by release of cytochrome c, reduction of bcl-2 expression, increase of bax expression, activation/cleavage of caspase-3 and activation/cleavage of parp in u937 cells, but not by fas protein, an initial mediator in the death signaling, or by phospho-eif2 alpha and chop, crucial mediators in er-mediated apoptosis. |
2008-06-20 |
2023-08-12 |
human |
| Kerstin Reimers, Claudia Y U Choi, Vesna Bucan, Peter M Vog. The Bax Inhibitor-1 (BI-1) family in apoptosis and tumorigenesis. Current molecular medicine. vol 8. issue 2. 2008-06-20. PMID:18336295. |
the bax inhibitor-1 (bi-1) family in apoptosis and tumorigenesis. |
2008-06-20 |
2023-08-12 |
Not clear |