| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Madhavi Billam, Sandeep Mukhi, Lili Tang, Weimin Gao, Jia-Sheng Wan. Toxic response indicators of microcystin-LR in F344 rats following a single-dose treatment. Toxicon : official journal of the International Society on Toxinology. vol 51. issue 6. 2008-07-31. PMID:18339415. |
expression of apoptosis and cell cycle regulatory proteins like bax, bcl2, and bad showed a dose-dependent decrease. |
2008-07-31 |
2023-08-12 |
rat |
| So Young Eun, Im Sun Woo, Han-Su Jang, Hana Jin, Min Young Kim, Hye Jung Kim, Jae Heun Lee, Ki Churl Chang, Jin-Hoi Kim, Han Geuk Se. Identification of cytochrome c oxidase subunit 6A1 as a suppressor of Bax-induced cell death by yeast-based functional screening. Biochemical and biophysical research communications. vol 373. issue 1. 2008-07-31. PMID:18549809. |
our results demonstrate that yeast-based functional screening of human genes for inhibitors of bax-sensitivity in yeast identified a protein that not only suppresses the toxicity of bax in yeast, but also has a potential role in protecting mammalian cells from 4-hpr-induced apoptosis. |
2008-07-31 |
2023-08-12 |
human |
| Guo-Xiong Zhou, Xiao-Ling Ding, Jie-Fei Huang, Hong Zhang, Sheng-Bao Wu, Jian-Ping Cheng, Qun We. Apoptosis of human pancreatic cancer cells induced by Triptolide. World journal of gastroenterology. vol 14. issue 10. 2008-07-30. PMID:18330938. |
to investigate apoptosis in human pancreatic cancer cells induced by triptolide (tl), and the relationship between this apoptosis and expression of caspase-3' bcl-2 and bax. |
2008-07-30 |
2023-08-12 |
human |
| Hitomi Suzuki, Masayuki Tsuda, Makoto Kiso, Yumiko Sag. Nanos3 maintains the germ cell lineage in the mouse by suppressing both Bax-dependent and -independent apoptotic pathways. Developmental biology. vol 318. issue 1. 2008-07-30. PMID:18436203. |
differing from steel-null embryos, however, the bax elimination did not completely rescue pgc apoptosis in nanos3-null embryos, and only a portion of the pgcs survived in the double knockout embryo. |
2008-07-30 |
2023-08-12 |
mouse |
| Santiago Rello-Varona, Juan Carlos Stockert, Magdalena Cañete, Pilar Acedo, Angeles Villanuev. Mitotic catastrophe induced in HeLa cells by photodynamic treatment with Zn(II)-phthalocyanine. International journal of oncology. vol 32. issue 6. 2008-07-30. PMID:18497980. |
apoptosis was also confirmed by occurrence of parp cleavage and bax translocation to mitochondria. |
2008-07-30 |
2023-08-12 |
human |
| Zhentai Huang, Jianfei Jiang, Vladimir A Tyurin, Qing Zhao, Alexandra Mnuskin, Jin Ren, Natalia A Belikova, Weihong Feng, Igor V Kurnikov, Valerian E Kaga. Cardiolipin deficiency leads to decreased cardiolipin peroxidation and increased resistance of cells to apoptosis. Free radical biology & medicine. vol 44. issue 11. 2008-07-29. PMID:18375209. |
during actd-induced apoptosis, decreased cl peroxidation along with suppressed cytochrome (cyt) c release was observed in cl-deficient cells, whereas bax translocation to mitochondria remained similar to that in cl-sufficient hela cells. |
2008-07-29 |
2023-08-12 |
Not clear |
| J R Cross, A Postigo, K Blight, J Downwar. Viral pro-survival proteins block separate stages in Bax activation but changes in mitochondrial ultrastructure still occur. Cell death and differentiation. vol 15. issue 6. 2008-07-28. PMID:18274554. |
mitochondrial dysfunction mediated by bax and bak is a critical step in mammalian cell apoptosis. |
2008-07-28 |
2023-08-12 |
Not clear |
| J R Cross, A Postigo, K Blight, J Downwar. Viral pro-survival proteins block separate stages in Bax activation but changes in mitochondrial ultrastructure still occur. Cell death and differentiation. vol 15. issue 6. 2008-07-28. PMID:18274554. |
it is currently unclear whether mitochondria play a passive role in the initiation of apoptosis, remaining unaffected by cell stresses until bax and bak are active, or whether they actively participate in bax/bak activation. |
2008-07-28 |
2023-08-12 |
Not clear |
| J R Cross, A Postigo, K Blight, J Downwar. Viral pro-survival proteins block separate stages in Bax activation but changes in mitochondrial ultrastructure still occur. Cell death and differentiation. vol 15. issue 6. 2008-07-28. PMID:18274554. |
here, two viral proteins, e1b19k and bhrf1, are examined for their ability to block bax activation at different steps and thereby reveal the timing of mitochondrial changes during apoptosis. |
2008-07-28 |
2023-08-12 |
Not clear |
| J R Cross, A Postigo, K Blight, J Downwar. Viral pro-survival proteins block separate stages in Bax activation but changes in mitochondrial ultrastructure still occur. Cell death and differentiation. vol 15. issue 6. 2008-07-28. PMID:18274554. |
in this defined system we show that changes in mitochondrial ultrastructure, characteristic of cells undergoing apoptosis, precede bax activation and are not blocked by e1b19k and bhrf1. |
2008-07-28 |
2023-08-12 |
Not clear |
| Jau-Hong Lee, Yu-Ching Li, Siu-Wan Ip, Shu-Chun Hsu, Nai-Wen Chang, Nou-Ying Tang, Chun-Shu Yu, Su-Tze Chou, Song-Shei Lin, Chin-Chung Lino, Jai-Sing Yang, Jing-Gung Chun. The role of Ca2+ in baicalein-induced apoptosis in human breast MDA-MB-231 cancer cells through mitochondria- and caspase-3-dependent pathway. Anticancer research. vol 28. issue 3A. 2008-07-25. PMID:18630529. |
baicalein induced apoptosis in a time-dependent effect through the inhibition of bcl-2 expression, increased the levels of bax, reduced the level of deltapsim, and promoted the cytochrome c release and caspase-3 activation. |
2008-07-25 |
2023-08-12 |
human |
| Eunjin Park, Nam Ho Lee, Hong-Gu Joo, Youngheun Je. Modulation of apoptosis of eckol against ionizing radiation in mice. Biochemical and biophysical research communications. vol 372. issue 4. 2008-07-24. PMID:18522802. |
here, we ascertained that eckol protected the lymphocytes' viability and rescued intestinal cells from radiation-induced apoptosis by decreasing the amount of pro-apoptotic p53 and bax and increasing that of anti-apoptotic bcl-2. |
2008-07-24 |
2023-08-12 |
mouse |
| Viktor R Drel, Pal Pacher, Tayyeba K Ali, Jeho Shin, Ulrich Julius, Azza B El-Remessy, Irina G Obrosov. Aldose reductase inhibitor fidarestat counteracts diabetes-associated cataract formation, retinal oxidative-nitrosative stress, glial activation, and apoptosis. International journal of molecular medicine. vol 21. issue 6. 2008-07-23. PMID:18506358. |
apoptosis was assessed by tunel assay, nitrotyrosine and poly(adp-ribose) by immunocytochemistry, and bax and bcl-2 expression by western blot analyses. |
2008-07-23 |
2023-08-12 |
rat |
| Wen Xu, Jianwen Liu, Changlong Li, He-Zhen Wu, Yan-Wen Li. Kaempferol-7-O-beta-D-glucoside (KG) isolated from Smilax china L. rhizome induces G2/M phase arrest and apoptosis on HeLa cells in a p53-independent manner. Cancer letters. vol 264. issue 2. 2008-07-22. PMID:18343026. |
furthermore, inhibition of nf-kappab nuclear translocation, up-regulation of bax and down-regulation of bcl-2, were observed in hela cells treated with kg, which indicated that the mitochondrial pathway was involved in the apoptosis signal pathway. |
2008-07-22 |
2023-08-12 |
human |
| Chuanguang Qin, Yan Ding, Kaixun Huang, Huibi X. Protective effect of Misgurnus anguillicaudatus polysaccharide on immunological liver injury in mice. International immunopharmacology. vol 8. issue 5. 2008-07-22. PMID:18387502. |
the modulation influence of misgurnus anguillicaudatus polysaccharide on the expression of nitric oxide synthase (nos), b cell lymphoma/leukemia-2 (bcl-2, hepatocyte apoptosis inhibitor) and bcl-2 associated x protein (bax, hepatocyte apoptosis promoter) in mice's liver with immunological hepatic injury was studied. |
2008-07-22 |
2023-08-12 |
mouse |
| Radu Miha. The calcium sensing receptor: from understanding parathyroid calcium homeostasis to bone metastases. Annals of the Royal College of Surgeons of England. vol 90. issue 4. 2008-07-22. PMID:18492387. |
further work demonstrated that high [ca2+]i stimulates the expression of bcl-2 oncoprotein in cultured human parathyroid cells and that, in parathyroid adenomas, predominant expression of bcl-2 rather than bax oncoprotein might prevent apoptosis and explain the slow growth rate of these tumours. |
2008-07-22 |
2023-08-12 |
human |
| Lingdi Ma, Shihong Wen, Yan Zhan, Yujuan He, Xiaoshan Liu, Jikai Jian. Anticancer effects of the Chinese medicine matrine on murine hepatocellular carcinoma cells. Planta medica. vol 74. issue 3. 2008-07-21. PMID:18283616. |
morphological changes, flow cytometric analysis and expression of the proapoptotic protein bax indicated that this anticancer effect was mediated via apoptosis. |
2008-07-21 |
2023-08-12 |
mouse |
| Lingdi Ma, Shihong Wen, Yan Zhan, Yujuan He, Xiaoshan Liu, Jikai Jian. Anticancer effects of the Chinese medicine matrine on murine hepatocellular carcinoma cells. Planta medica. vol 74. issue 3. 2008-07-21. PMID:18283616. |
transmission electron microscope (tem) analysis and histoimmunochemical staining for bcl-2 and bax proteins also indicated induction of apoptosis in tumor tissues by matrine. |
2008-07-21 |
2023-08-12 |
mouse |
| Kissaou T Tchedre, Thomas Yori. sigma-1 receptors protect RGC-5 cells from apoptosis by regulating intracellular calcium, Bax levels, and caspase-3 activation. Investigative ophthalmology & visual science. vol 49. issue 6. 2008-07-18. PMID:18296662. |
sigma-1 receptors protect rgc-5 cells from apoptosis by regulating intracellular calcium, bax levels, and caspase-3 activation. |
2008-07-18 |
2023-08-12 |
Not clear |
| Xuefang Cao, Richard L Bennett, W Stratford Ma. c-Myc and caspase-2 are involved in activating Bax during cytotoxic drug-induced apoptosis. The Journal of biological chemistry. vol 283. issue 21. 2008-07-18. PMID:18375382. |
c-myc and caspase-2 are involved in activating bax during cytotoxic drug-induced apoptosis. |
2008-07-18 |
2023-08-12 |
human |