| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Anjali Naresh, Ann D Thor, Susan M Edgerton, Kathleen C Torkko, Rakesh Kumar, Frank E Jone. The HER4/4ICD estrogen receptor coactivator and BH3-only protein is an effector of tamoxifen-induced apoptosis. Cancer research. vol 68. issue 15. 2008-09-08. PMID:18676864. |
bcl-2 inhibition of tamoxifen-induced apoptosis and tamoxifen activation of bak, independent of bax, further supports a role for 4icd during tamoxifen-induced apoptosis. |
2008-09-08 |
2023-08-12 |
human |
| Xi-Min Fang, Ming-Zhen Chen, Ri-Ling Chen, Zhong-Lü Y. [Effect of cytochrome C on HL-60 cell apoptosis and its relationship with the relevant genes bcl-2 and bax]. Zhongguo shi yan xue ye xue za zhi. vol 13. issue 4. 2008-09-05. PMID:16129036. |
[effect of cytochrome c on hl-60 cell apoptosis and its relationship with the relevant genes bcl-2 and bax]. |
2008-09-05 |
2023-08-12 |
Not clear |
| Xi-Min Fang, Ming-Zhen Chen, Ri-Ling Chen, Zhong-Lü Y. [Effect of cytochrome C on HL-60 cell apoptosis and its relationship with the relevant genes bcl-2 and bax]. Zhongguo shi yan xue ye xue za zhi. vol 13. issue 4. 2008-09-05. PMID:16129036. |
to study the effect of cytochrome c on hl-60 cells in vitro and the mechanism of expression changes of relevant apoptotic genes, the inhibition rate of cytochrome c on hl-60 cells was detected by mtt, the morphology of hl-60 cells was observed by light microscopy and fluorescence microscopy, the changes of apoptosis rate and cell cycle were assayed by flow cytometry (fcm), dna ladder was investigated on electrophoresis, the expression changes of bax and bcl-2 mrna were examined by rt-pcr, when hl-60 cells were treated with different concentrations of cytochrome c for 24 hours. |
2008-09-05 |
2023-08-12 |
Not clear |
| Xi-Min Fang, Ming-Zhen Chen, Ri-Ling Chen, Zhong-Lü Y. [Effect of cytochrome C on HL-60 cell apoptosis and its relationship with the relevant genes bcl-2 and bax]. Zhongguo shi yan xue ye xue za zhi. vol 13. issue 4. 2008-09-05. PMID:16129036. |
the above metioned results suggested that at certain range of concentration of cytochrome c, apoptosis or necrosis can be induced by cytochrome c, and cell cycle arrests at g(1) phase in hl-60 cells, the percentage of apoptotic cells and the changes of expression of bax and bcl-2 depend on the dose of cytochrome c. the mechanism that cytochtome c induced apoptosis in hl-60 cells may be related to the activation of bax and inhibition of bcl-2. |
2008-09-05 |
2023-08-12 |
Not clear |
| Li-Rong Sun, Bin-Chang Ga. [Study on mechanism of apoptosis of HL-60 cells induced by cytarabine]. Zhongguo shi yan xue ye xue za zhi. vol 13. issue 4. 2008-09-05. PMID:16129037. |
to study the mechanism of apoptosis of hl-60 cells induced by cytarabine (ara-c), morphological changes of the hl-60 cells stained with giemsa were observed by microscopy; the dna fragments were detected by agarose gel electrophoresis; the expressions of bcl-2 and bax gene-related apoptosis were investigated by immunohistochemistry. |
2008-09-05 |
2023-08-12 |
Not clear |
| Li-Rong Sun, Bin-Chang Ga. [Study on mechanism of apoptosis of HL-60 cells induced by cytarabine]. Zhongguo shi yan xue ye xue za zhi. vol 13. issue 4. 2008-09-05. PMID:16129037. |
it is concluded that ara-c can effectively induce apoptosis of hl-60 cells and simultaneously decrease the level of expression of bcl-2 protein and elevate the level of expression of bax protein. |
2008-09-05 |
2023-08-12 |
Not clear |
| Hong-Yan Tong, Jie Jin, Wei-Lai Xu, Wen-Bin Qian, Mao-Fang Li. [Study on the mechanisms of telomerase regulations during apoptosis of the human MDS-RAEB cell line MUTZ-1 cells induced by arsenic trioxide]. Zhongguo shi yan xue ye xue za zhi. vol 13. issue 4. 2008-09-05. PMID:16129045. |
to investigate the mechanisms of the telomerase regulations during the apoptosis of the human mds-raeb cell line mutz-1 cells induced by arsenic trioxide (as(2)o(3)), telomerase activity was detected by trap-elisa and the expressions of mrnas of htert, trf1 (ttaggg repeat binding factor 1), trf2 (ttaggg repeat binding factor 2), bcl-2, and bax genes were detected by rt-pcr. |
2008-09-05 |
2023-08-12 |
human |
| Yue-Yong Zhu, De-Fu Ye, Jing-An Lin, Sheng-Mei Weng, Xiao-Hua Lian. [Anti-apoptosis effect of VEGF on the human chronic myelocytic leukemia cell line K562]. Zhongguo shi yan xue ye xue za zhi. vol 13. issue 5. 2008-09-05. PMID:16277841. |
to explore the effects of vascular endothelial growth factor (vegf) on the mechanisms of cml pathogenesis, the effect of vegf on k562 cell apoptosis induced by as(2)o(3) was analyzed through morphologic observation, dna fragmentation agarose gel electrophoresis and dna ploidy flow cytometry analysis, and the effect of vegf on the expression of bcl-x(l), bax and caspase-3 in k562 cells was determined by western blot, meanwhile the expression difference between bcl-x(l) and bax mrna in above conditions was detected by rt-pcr. |
2008-09-05 |
2023-08-12 |
human |
| HongYu Xue, LiJi Jin, Lei Jin, Peng Zhang, DanQing Li, YanQiu Xia, YaNan Lu, YongPing X. Neuroprotection of aucubin in primary diabetic encephalopathy. Science in China. Series C, Life sciences. vol 51. issue 6. 2008-09-03. PMID:18488169. |
rats were euthanized on day 87, and hippocampi were excised for visual (light and transmission electron microscopic) and immunochemical (western blot; immunohistochemical) assessments of the ca1 subfield for apoptosis and expression of regulatory proteins bcl-2 and bax. |
2008-09-03 |
2023-08-12 |
rat |
| HongYu Xue, LiJi Jin, Lei Jin, Peng Zhang, DanQing Li, YanQiu Xia, YaNan Lu, YongPing X. Neuroprotection of aucubin in primary diabetic encephalopathy. Science in China. Series C, Life sciences. vol 51. issue 6. 2008-09-03. PMID:18488169. |
these findings confirm the association of apoptosis with the encephalopathic effects of diabetes mellitus, and suggest a major role of the expression levels of bcl-2 and bax in the regulation of apoptotic cell death. |
2008-09-03 |
2023-08-12 |
rat |
| HongYu Xue, LiJi Jin, Lei Jin, Peng Zhang, DanQing Li, YanQiu Xia, YaNan Lu, YongPing X. Neuroprotection of aucubin in primary diabetic encephalopathy. Science in China. Series C, Life sciences. vol 51. issue 6. 2008-09-03. PMID:18488169. |
all of the results suggest that aucubin could effectively inhibit apoptosis by modulating the expressions of bcl-2 and bax genes. |
2008-09-03 |
2023-08-12 |
rat |
| Fernanda A Quinteros, Leticia I Machiavelli, Eliana A Miler, Jimena P Cabilla, Beatriz H Duvilansk. Mechanisms of chromium (VI)-induced apoptosis in anterior pituitary cells. Toxicology. vol 249. issue 2-3. 2008-09-03. PMID:18547707. |
the antioxidant n-acetyl-cysteine (nac) could prevent bax mrna increase and caspase 3 activation, confirming that cr (vi)-induced apoptosis involves oxidative stress generation. |
2008-09-03 |
2023-08-12 |
Not clear |
| Yong-Lie Zhou, Ya-Ping Lü, Lian-Nü Qiu, Wen-Song Wang, Hui-Jun Li. [Mechanism of sodium nitroprusside-induced apoptosis in K562 cell line]. Zhongguo shi yan xue ye xue za zhi. vol 13. issue 6. 2008-09-02. PMID:16403264. |
it is concluded that snp induces k562 cell apoptosis through increasing ros in cells, expressing the p53, bax, bad, fas protein and mitochondrial membrane protein and decreasing bcl-2 protein, opening the mitochondrial permeability transition pore and reducing deltapsim. |
2008-09-02 |
2023-08-12 |
human |
| Ze-Ye Shao, Bao-An Chen, Jia-Hua Ding, Guo-Hua Xia, Huai-Gang Zhu, Xue-Zhi Ga. [Inhibition effect of vitamin K2 on human MDS-JSN04 cell line and its possible mechanism]. Zhongguo shi yan xue ye xue za zhi. vol 13. issue 6. 2008-09-02. PMID:16403273. |
the results showed that the typical apoptotic morphological features appeared in cells treated with vk(2) for 72 hours; vk(2) induced apoptosis of mds-jsn04 cells and in a dose-and-time-dependent manner, g(0)/g(1) cell arrest and significantly down-regulated the expression of bcl-2 and survivin, but had no effect on the expression of bax; the activity of caspase-3 significantly increased. |
2008-09-02 |
2023-08-12 |
human |
| Kwang Woon Kim, Luigi Moretti, Bo L. M867, a novel selective inhibitor of caspase-3 enhances cell death and extends tumor growth delay in irradiated lung cancer models. PloS one. vol 3. issue 5. 2008-09-02. PMID:18509530. |
although radiation is known to induce apoptosis, our recent study showed that knockdown of pro-apoptotic proteins bak and bax resulted in an increase in autophagic cell death and lung cancer radiosensitivity in vitro. |
2008-09-02 |
2023-08-12 |
Not clear |
| Yi-Hong Hsin, Chun-Feng Chen, Shing Huang, Tung-Sheng Shih, Ping-Shan Lai, Pin Ju Chue. The apoptotic effect of nanosilver is mediated by a ROS- and JNK-dependent mechanism involving the mitochondrial pathway in NIH3T3 cells. Toxicology letters. vol 179. issue 3. 2008-09-02. PMID:18547751. |
treatment with nanosilver induced the release of cytochrome c into the cytosol and translocation of bax to mitochondria, indicating that nanosilver-mediated apoptosis is mitochondria-dependent. |
2008-09-02 |
2023-08-12 |
Not clear |
| Mohammad A Islam, Young S Kim, Wook J Jang, Seon M Lee, Hoon G Kim, So Y Kim, Jeong O Kim, Yeong L H. A mixture of trans, trans conjugated linoleic acid induces apoptosis in MCF-7 human breast cancer cells with reciprocal expression of Bax and Bcl-2. Journal of agricultural and food chemistry. vol 56. issue 14. 2008-09-02. PMID:18570428. |
a mixture of trans, trans conjugated linoleic acid induces apoptosis in mcf-7 human breast cancer cells with reciprocal expression of bax and bcl-2. |
2008-09-02 |
2023-08-12 |
human |
| Farrukh Afaq, Najia Zaman, Naghma Khan, Deeba N Syed, Sami Sarfaraz, Mohammad Abu Zaid, Hasan Mukhta. Inhibition of epidermal growth factor receptor signaling pathway by delphinidin, an anthocyanidin in pigmented fruits and vegetables. International journal of cancer. vol 123. issue 7. 2008-09-02. PMID:18623129. |
treatment of au-565 cells with delphinidin resulted in (i) induction of apoptosis, (ii) cleavage of parp protein, (iii) activation of caspase-3 and (iv) downregulation of bcl-2 with an increase in the expression of bax. |
2008-09-02 |
2023-08-12 |
human |
| Ke Yu, Yuhe He, Leo W Y Yeung, Paul K S Lam, Rudolf S S Wu, Bingsheng Zho. DE-71-induced apoptosis involving intracellular calcium and the Bax-mitochondria-caspase protease pathway in human neuroblastoma cells in vitro. Toxicological sciences : an official journal of the Society of Toxicology. vol 104. issue 2. 2008-08-28. PMID:18453545. |
overall, our results indicate that de-71 induces the apoptosis of [ca(2+)](i) in sk-n-sh cells via bax insertion, cyt c release in the mitochondria, and the caspase activation pathway. |
2008-08-28 |
2023-08-12 |
human |
| Dragos Plesca, Suparna Mazumder, Alexandru Almasa. DNA damage response and apoptosis. Methods in enzymology. vol 446. 2008-08-28. PMID:18603118. |
finally, the bcl-2 family of proteins and the mitochondria that play a critical role in dna damage-induced apoptosis can be examined by translocation of bax and cytochrome c in and out of mitochondria. |
2008-08-28 |
2023-08-12 |
Not clear |