| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jie Li, Gui-Zhi Sun, Hong-Sheng Lin, Ying-Xia Pei, Xin Qi, Cheng An, Jun Yu, Bao-Jin Hu. The herb medicine formula "Yang Wei Kang Liu" improves the survival of late stage gastric cancer patients and induces the apoptosis of human gastric cancer cell line through Fas/Fas ligand and Bax/Bcl-2 pathways. International immunopharmacology. vol 8. issue 9. 2008-10-03. PMID:18602065. |
in an approach of "serum pharmacology" in which sera were collected from rabbits orally administered with ywklf and examined for their anti-tumor cell activity in vitro, we observed that sera from rabbits administered with ywklf induced the apoptosis of mgc-803 cells by causing the loss of mitochondrial membrane potential, increasing the expression of fas protein and bax mrna, as well as down-regulating fas-l mrna. |
2008-10-03 |
2023-08-12 |
human |
| Chin-Cheng Su, Yi-Hsiang Li. Tanshinone IIA inhibits human breast cancer cells through increased Bax to Bcl-xL ratios. International journal of molecular medicine. vol 22. issue 3. 2008-10-03. PMID:18698495. |
one of the mechanisms may be through up-regulating the expression of bax but down-regulating bcl-2 expression and then inducing apoptosis. |
2008-10-03 |
2023-08-12 |
human |
| Lieven P Billen, Candis L Kokoski, Jonathan F Lovell, Brian Leber, David W Andrew. Bcl-XL inhibits membrane permeabilization by competing with Bax. PLoS biology. vol 6. issue 6. 2008-10-02. PMID:18547146. |
although bcl-xl and bax are structurally similar, activated bax forms large oligomers that permeabilize the outer mitochondrial membrane, thereby committing cells to apoptosis, whereas bcl-xl inhibits this process. |
2008-10-02 |
2023-08-12 |
Not clear |
| Walter Fries, Carmelo Muja, Carmela Crisafulli, Giuseppe Costantino, Giuseppe Longo, Salvatore Cuzzocrea, Emanuela Mazzo. Infliximab and etanercept are equally effective in reducing enterocyte APOPTOSIS in experimental colitis. International journal of medical sciences. vol 5. issue 4. 2008-10-01. PMID:18645606. |
circulating tnf-alpha levels were effectively reduced by ifx and etc (p<0.01, both) at 3 and 6 h. apoptosis of the ileal enterocytes, assessed by tunel staining, staining for fas-ligand, and bax, increased at 3 and 6h. |
2008-10-01 |
2023-08-12 |
mouse |
| Shu-chi Hsiung, Adrianne Tin, Hadassah Tamir, Thomas F Franke, Kuo-peing Li. Inhibition of 5-HT1A receptor-dependent cell survival by cAMP/protein kinase A: role of protein phosphatase 2A and Bax. Journal of neuroscience research. vol 86. issue 10. 2008-09-30. PMID:18459133. |
in contrast, increased camp levels enhanced bax translocation to the mitochondria, resulting in the release of cytochrome c, caspase-3 activation, and apoptosis induction. |
2008-09-30 |
2023-08-12 |
Not clear |
| J K Park, M Y Kang, Y H Kim, H C Jo, J K Shin, W J Choi, S A Lee, J H Lee, W S Choi, W Y Pai. PKC delta in preeclamptic placentas promotes Bax dissociation from 14-3-3 zeta through 14-3-3 zeta phosphorylation. Placenta. vol 29. issue 7. 2008-09-30. PMID:18472156. |
in addition, we explored the mechanism of bax dissociation from 14-3-3, hypothesizing that pkc-mediated phosphorylation of 14-3-3 results in dissociation of bax from 14-3-3 proteins, and leads to apoptosis. |
2008-09-30 |
2023-08-12 |
Not clear |
| T-H Hung, S-F Chen, J-D Liou, J-J Hsu, M-J Li, Y-L Yeh, T-T Hsie. Bax, Bak and mitochondrial oxidants are involved in hypoxia-reoxygenation-induced apoptosis in human placenta. Placenta. vol 29. issue 7. 2008-09-30. PMID:18472157. |
bax, bak and mitochondrial oxidants are involved in hypoxia-reoxygenation-induced apoptosis in human placenta. |
2008-09-30 |
2023-08-12 |
human |
| T-H Hung, S-F Chen, J-D Liou, J-J Hsu, M-J Li, Y-L Yeh, T-T Hsie. Bax, Bak and mitochondrial oxidants are involved in hypoxia-reoxygenation-induced apoptosis in human placenta. Placenta. vol 29. issue 7. 2008-09-30. PMID:18472157. |
our goal was studying expression of five bcl-2 proteins--bcl-2, bcl-xl, bax, bak, bad--and testing effects of diazoxide and cyclosporine a on oxidative stress and apoptosis in villous tissues subjected to hr. |
2008-09-30 |
2023-08-12 |
human |
| Cheng Gao, Xiangzhen Liu, Wei Liu, Huaizhang Shi, Zhenhuan Zhao, Huirong Chen, Shiguang Zha. Anti-apoptotic and neuroprotective effects of Tetramethylpyrazine following subarachnoid hemorrhage in rats. Autonomic neuroscience : basic & clinical. vol 141. issue 1-2. 2008-09-30. PMID:18558517. |
apoptosis of cerebral cortex was determined by tunel staining; caspase-3, bax and bcl-2 by western blotting; p53 expression by immunohistochemical staining. |
2008-09-30 |
2023-08-12 |
rat |
| Mark Wade, Luo Wei Rodewald, Joaquín M Espinosa, Geoffrey M Wah. BH3 activation blocks Hdmx suppression of apoptosis and cooperates with Nutlin to induce cell death. Cell cycle (Georgetown, Tex.). vol 7. issue 13. 2008-09-30. PMID:18604177. |
we show that sensitivity to apoptosis in cells with high hdmx levels is restored by combined treatment with nutlin and a bcl-2 family member antagonist to activate bax. |
2008-09-30 |
2023-08-12 |
human |
| Mark Wade, Luo Wei Rodewald, Joaquín M Espinosa, Geoffrey M Wah. BH3 activation blocks Hdmx suppression of apoptosis and cooperates with Nutlin to induce cell death. Cell cycle (Georgetown, Tex.). vol 7. issue 13. 2008-09-30. PMID:18604177. |
thus, selectively inhibiting hdm2 and activating bax is one effective strategy to induce apoptosis in tumors with high hdmx levels. |
2008-09-30 |
2023-08-12 |
human |
| Lorenzo Galluzzi, Eugenia Morselli, Oliver Kepp, Nicolas Tajeddine, Guido Kroeme. Targeting p53 to mitochondria for cancer therapy. Cell cycle (Georgetown, Tex.). vol 7. issue 13. 2008-09-30. PMID:18642442. |
since momp is commonly disabled in cancer cells, its pharmacological induction constitutes a therapeutic goal, and this has stimulated the design of mitochondriotropic inducers of apoptosis, both inhibitors of antiapoptotic bcl-2 family proteins (e.g., bcl-2, bcl-xl) or activators of their proapoptotic counterparts (e.g., bak, bax). |
2008-09-30 |
2023-08-12 |
mouse |
| Linda Struijk, Els van der Meijden, Siamaque Kazem, Jan Ter Schegget, Frank R de Gruijl, Renske D M Steenbergen, Mariet C W Feltkam. Specific betapapillomaviruses associated with squamous cell carcinoma of the skin inhibit UVB-induced apoptosis of primary human keratinocytes. The Journal of general virology. vol 89. issue Pt 9. 2008-09-30. PMID:18753241. |
the observed inhibition of uvb-induced apoptosis was mediated by e6 and coincided with reduced steady-state expression of the pro-apoptotic protein bax. |
2008-09-30 |
2023-08-12 |
human |
| Serena Catarzi, Tommaso Marcucci, Laura Papucci, Fabio Favilli, Martino Donnini, Francesco Tonelli, Maria Teresa Vincenzini, Teresa Iantomas. Apoptosis and Bax, Bcl-2, Mcl-1 expression in neutrophils of Crohn's disease patients. Inflammatory bowel diseases. vol 14. issue 6. 2008-09-26. PMID:18266233. |
apoptosis and bax, bcl-2, mcl-1 expression in neutrophils of crohn's disease patients. |
2008-09-26 |
2023-08-12 |
Not clear |
| Danielle Haack, Henry Luu, Jaehoon Cho, Michael J Chen, Amelia Russo-Neustad. Exercise reverses chronic stress-induced Bax oligomer formation in the cerebral cortex. Neuroscience letters. vol 438. issue 3. 2008-09-26. PMID:18487019. |
bax is a key protein of the b-cell lymphoma (bcl) family that complexes within the mitochondrial membrane and forms pores to initiate cellular apoptosis. |
2008-09-26 |
2023-08-12 |
Not clear |
| Danielle Haack, Henry Luu, Jaehoon Cho, Michael J Chen, Amelia Russo-Neustad. Exercise reverses chronic stress-induced Bax oligomer formation in the cerebral cortex. Neuroscience letters. vol 438. issue 3. 2008-09-26. PMID:18487019. |
we reveal that chronic, but not acute, stress increases cortical levels of bax oligomer 270, a complex revealed in previous studies to be associated with apoptosis. |
2008-09-26 |
2023-08-12 |
Not clear |
| Li-Hui Wang, Jing-Yu Yang, Wei Cui, Young Kee Shin, Chun-Fu W. Involvement of promyelocytic leukemia protein in the ethanol-induced apoptosis in mouse embryo fibroblasts. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan. vol 128. issue 7. 2008-09-26. PMID:18591875. |
in this study, using wild-type mouse embryo fibroblasts (mef) and pml null mef cells, we found that (1) ethanol (100 mm and 200 mm) could obviously induce apoptosis of wild-type mef cells, whereas, in pml null mef cells, the pro-apoptotic function of ethanol was partially blocked; (2) the expression levels of phosphorylated p53 and two of its target genes, p21 and bax, could be significantly up-regulated by ethanol (200 mm) in wild-type mef cells in a time-dependent manner, but not in pml null mef cells. |
2008-09-26 |
2023-08-12 |
mouse |
| Nicole Doudican, Adrianna Rodriguez, Iman Osman, Seth J Orlo. Mebendazole induces apoptosis via Bcl-2 inactivation in chemoresistant melanoma cells. Molecular cancer research : MCR. vol 6. issue 8. 2008-09-26. PMID:18667591. |
phosphorylation of bcl-2 in melanoma cells prevents its interaction with proapoptotic bax, thereby promoting apoptosis. |
2008-09-26 |
2023-08-12 |
Not clear |
| Zhong-Fang Lai, Yu-Zhen Chen, Li-Ping Feng, Xian-Min Meng, Jin-Feng Ding, Lai-Yuan Wang, Jue Ye, Ping Li, Xiao-Shu Cheng, Yasunori Kitamoto, Koshiro Monzen, Issei Komuro, Nobuo Sakaguchi, Shokei Kim-Mitsuyam. Overexpression of TNNI3K, a cardiac-specific MAP kinase, promotes P19CL6-derived cardiac myogenesis and prevents myocardial infarction-induced injury. American journal of physiology. Heart and circulatory physiology. vol 295. issue 2. 2008-09-25. PMID:18552163. |
tnni3k suppressed phosphorylation of cardiac troponin i, annexin-v(+) cells, bax protein, and p38/jnk-mediated apoptosis. |
2008-09-25 |
2023-08-12 |
mouse |
| Takeshi Miyasou, A-Hon Kwon, Katsushige Tsuji, Zeyu Qiu, Tadayoshi Okumura, Yasuo Kamiyam. Edaravone prevents Fas-induced fulminant hepatic failure in mice by regulating mitochondrial Bcl-xL and Bax. Shock (Augusta, Ga.). vol 30. issue 2. 2008-09-23. PMID:18180697. |
in conclusion, edaravone might protect hepatocytes from fas-induced mitochondria-dependent apoptosis by regulating mitochondrial bcl-xl and bax. |
2008-09-23 |
2023-08-12 |
mouse |