| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jennifer L Alabran, Adam Cheuk, Karen Liby, Michael Sporn, Javed Khan, John Letterio, Konstantin S Lesko. Human neuroblastoma cells rapidly enter cell cycle arrest and apoptosis following exposure to C-28 derivatives of the synthetic triterpenoid CDDO. Cancer biology & therapy. vol 7. issue 5. 2008-11-18. PMID:18277094. |
after treatment of human neuroblastoma cells with cddo-me, cell cycle studies show depletion of the s-phase, while apoptosis studies show conformational activation and mitochondrial translocation of bax protein, as well as activation of caspases -3 and -8. |
2008-11-18 |
2023-08-12 |
human |
| Xuesong Liu, Xu Luo, Yan Shi, Gui-Dong Zhu, Thomas Penning, Vincent L Giranda, Yan Lu. Poly (ADP-ribose) polymerase activity regulates apoptosis in HeLa cells after alkylating DNA damage. Cancer biology & therapy. vol 7. issue 6. 2008-11-18. PMID:18376143. |
bcl-2 family proteins regulate the release of cytochrome c. downregulation of bax and bak by their corresponding sirnas or overexpression of bcl-xl inhibited the release of cytochrome c from mitochondria to cytosol, and inhibited apoptosis induced by mnng/abt-888. |
2008-11-18 |
2023-08-12 |
human |
| Gang Luo, Xiaoling Guan, Liming Zho. Apoptotic effect of citrus fruit extract nobiletin on lung cancer cell line A549 in vitro and in vivo. Cancer biology & therapy. vol 7. issue 6. 2008-11-18. PMID:18379194. |
taken together, these results suggest that nobiletin could induce p53-mediated cell cycle arrest and apoptosis via modulated the bax:bcl-2 protein ratio, is effective as a potent antitumor agent on lung tumors. |
2008-11-18 |
2023-08-12 |
mouse |
| Su Young Kim, Young Lyun Oh, Kyung Mee Kim, Eun Goo Jeong, Min Sung Kim, Nam Jin Yoo, Sug Hyung Le. Decreased expression of Bax-interacting factor-1 (Bif-1) in invasive urinary bladder and gallbladder cancers. Pathology. vol 40. issue 6. 2008-11-18. PMID:18752120. |
bax-interacting factor-1 (bif-1) interacts with both bax and bak that are crucial for the intrinsic apoptosis signalling. |
2008-11-18 |
2023-08-12 |
Not clear |
| An-Heng Liu, Ya-Nan Cao, Hong-Tao Liu, Wei-Wei Zhang, Yan Liu, Tang-Wang Shi, Guo-Liang Jia, Xiao-Ming Wan. DIDS attenuates staurosporine-induced cardiomyocyte apoptosis by PI3K/Akt signaling pathway: activation of eNOS/NO and inhibition of Bax translocation. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. vol 22. issue 1-4. 2008-11-17. PMID:18769044. |
dids attenuates staurosporine-induced cardiomyocyte apoptosis by pi3k/akt signaling pathway: activation of enos/no and inhibition of bax translocation. |
2008-11-17 |
2023-08-12 |
Not clear |
| Xuefeng Wang, Honghai Li, Yao Chen, Jing Fu, Yibin Ren, Liwei Dong, Shanhua Tang, Shuqin Liu, Mengchao Wu, Hongyang Wan. p28GANK knockdown-derived reactive oxygen species induces apoptosis through mitochondrial dysfunction mediated by p38 in HepG2 cells. International journal of oncology. vol 33. issue 4. 2008-11-13. PMID:18813787. |
in this study, the activation of p38 was found to be critical for the p28gank knockdown-induced apoptosis, as suggested by the finding that pharmacological inhibition of p38 with sb203580 suppressed the redistribution of bax, the loss of deltapsim and the apoptosis. |
2008-11-13 |
2023-08-12 |
Not clear |
| P Mukherjee, Y S Devi, V S Chauha. Blood stage malaria antigens induce different activation-induced cell death programs in splenic CD4+T cells. Parasite immunology. vol 30. issue 10. 2008-11-12. PMID:18643960. |
while pfmsp-3 and ova-induced aicd was mediated through a death receptor-dependent apoptotic program, pfmsp-1(19) and pfag-induced aicd was via a mechanism dependent on the activation of mitochondria apoptosis signalling pathway through bax activation. |
2008-11-12 |
2023-08-12 |
mouse |
| Andrew J Steele, Archibald G Prentice, A Victor Hoffbrand, Birunthini C Yogashangary, Stephen M Hart, Elisabeth P Nacheva, Julie D Howard-Reeves, Veronique M Duke, Panagiotis D Kottaridis, Kate Cwynarski, Lyubomir T Vassilev, R Gitendra Wickremasingh. p53-mediated apoptosis of CLL cells: evidence for a transcription-independent mechanism. Blood. vol 112. issue 9. 2008-11-12. PMID:18682598. |
surprisingly, pifithrin alpha dramatically augmented apoptosis induction by p53-elevating agents and also accelerated the proapoptotic conformation change of the bax protein. |
2008-11-12 |
2023-08-12 |
Not clear |
| Lei Cai, Hua Wang, Qin Li, Yunfei Qian, Wenbing Ya. Salidroside inhibits H2O2-induced apoptosis in PC12 cells by preventing cytochrome c release and inactivating of caspase cascade. Acta biochimica et biophysica Sinica. vol 40. issue 9. 2008-11-12. PMID:18776992. |
in pc12 cells, h(2)o(2)-induced apoptosis was accompanied by the down-regulation of bcl-2, the up-regulation of bax, the release of mitochondrial cytochrome c to cytosol, and the activation of caspase-3, -8 and -9. |
2008-11-12 |
2023-08-12 |
rat |
| Azhar R Hussain, Maqbool Ahmed, Naif A Al-Jomah, Asma S Khan, Pulicat Manogaran, Mehar Sultana, Jehad Abubaker, Leonidas C Platanias, Khawla S Al-Kuraya, Shahab Uddi. Curcumin suppresses constitutive activation of nuclear factor-kappa B and requires functional Bax to induce apoptosis in Burkitt's lymphoma cell lines. Molecular cancer therapeutics. vol 7. issue 10. 2008-11-12. PMID:18852135. |
curcumin suppresses constitutive activation of nuclear factor-kappa b and requires functional bax to induce apoptosis in burkitt's lymphoma cell lines. |
2008-11-12 |
2023-08-12 |
Not clear |
| Azhar R Hussain, Maqbool Ahmed, Naif A Al-Jomah, Asma S Khan, Pulicat Manogaran, Mehar Sultana, Jehad Abubaker, Leonidas C Platanias, Khawla S Al-Kuraya, Shahab Uddi. Curcumin suppresses constitutive activation of nuclear factor-kappa B and requires functional Bax to induce apoptosis in Burkitt's lymphoma cell lines. Molecular cancer therapeutics. vol 7. issue 10. 2008-11-12. PMID:18852135. |
we provide evidence that curcumin, a natural compound isolated from rhizomes of plant curcuma longa, induces apoptosis in several burkitt's lymphoma cell lines expressing bax protein (as283a, kk124, and pa682pb), whereas it has no effects in cell lines with no bax expression (bml895 and ca46). |
2008-11-12 |
2023-08-12 |
Not clear |
| Theocharis Panaretakis, Linn Hjortsberg, Katja Pokrovskaja Tamm, Ann-Charlotte Björklund, Bertrand Joseph, Dan Grandé. Interferon alpha induces nucleus-independent apoptosis by activating extracellular signal-regulated kinase 1/2 and c-Jun NH2-terminal kinase downstream of phosphatidylinositol 3-kinase and mammalian target of rapamycin. Molecular biology of the cell. vol 19. issue 1. 2008-11-10. PMID:17942603. |
interferon (ifn)alpha induces apoptosis via bak and bax and the mitochondrial pathway. |
2008-11-10 |
2023-08-12 |
Not clear |
| Seungwoo Park, Sung Pil Hong, Tae Yoon Oh, Seungmin Bang, Jae Bock Chung, Si Young Son. Paclitaxel augments cytotoxic effect of photodynamic therapy using verteporfin in gastric and bile duct cancer cells. Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology. vol 7. issue 7. 2008-11-10. PMID:18597023. |
apoptotic changes were evaluated using dapi staining, dna fragmentation analysis, annexin v-fitc apoptosis assay, cell cycle analysis, and western blots for cytochrome c, bax, and bid. |
2008-11-10 |
2023-08-12 |
Not clear |
| Douglas R Green, Jerry E Chipu. Apoptosis: Stabbed in the BAX. Nature. vol 455. issue 7216. 2008-11-10. PMID:18948940. |
apoptosis: stabbed in the bax. |
2008-11-10 |
2023-08-12 |
Not clear |
| Evripidis Gavathiotis, Motoshi Suzuki, Marguerite L Davis, Kenneth Pitter, Gregory H Bird, Samuel G Katz, Ho-Chou Tu, Hyungjin Kim, Emily H-Y Cheng, Nico Tjandra, Loren D Walensk. BAX activation is initiated at a novel interaction site. Nature. vol 455. issue 7216. 2008-11-10. PMID:18948948. |
thus, we have now defined a bax interaction site for direct activation, establishing a new target for therapeutic modulation of apoptosis. |
2008-11-10 |
2023-08-12 |
human |
| M Mészárosová, A V Sirotkin, R Grossmann, K Darlak, F Valenzuel. The effect of obestatin on porcine ovarian granulosa cells. Animal reproduction science. vol 108. issue 1-2. 2008-11-06. PMID:17904772. |
the expression of intracellular peptides associated with proliferation (pcna, cyclin b1, map kinase), as well as markers of apoptosis (bax, p53, caspase 3), were detected using immunocytochemistry and western immunoblotting. |
2008-11-06 |
2023-08-12 |
Not clear |
| M Mészárosová, A V Sirotkin, R Grossmann, K Darlak, F Valenzuel. The effect of obestatin on porcine ovarian granulosa cells. Animal reproduction science. vol 108. issue 1-2. 2008-11-06. PMID:17904772. |
our results are the first demonstration that obestatin directly controls porcine ovarian cell functions: it can stimulate proliferation (accumulation of rpcna, cyclin b1 and mapk), apoptosis (expression of p53, caspase 3 and bax) and the secretion of progesterone. |
2008-11-06 |
2023-08-12 |
Not clear |
| Rachana Garg, Arvind Ingle, Girish Mar. Dietary turmeric modulates DMBA-induced p21ras, MAP kinases and AP-1/NF-kappaB pathway to alter cellular responses during hamster buccal pouch carcinogenesis. Toxicology and applied pharmacology. vol 232. issue 3. 2008-11-06. PMID:18687351. |
besides, buccal pouch of hamsters receiving turmeric diet showed significant alterations in dmba-induced effects: (a) decrease in cell proliferation (diminished pcna and bcl2 expression), (b) enhanced apoptosis (increased expression of bax, caspase-3 and apoptotic index), (c) decrease in inflammation (levels of cox-2, the downstream target of ap-1/nf-kappab, and pge2) and (d) aberrant expression of differentiation markers, the cytokeratins (1, 5, 8, and 18). |
2008-11-06 |
2023-08-12 |
Not clear |
| Arndt-Christian Müller, René Handrick, Simon Johannes Elsaesser, Justine Rudner, Guido Henke, Ute Ganswindt, Claus Belka, Verena Jendrosse. Importance of Bak for celecoxib-induced apoptosis. Biochemical pharmacology. vol 76. issue 9. 2008-11-05. PMID:18778687. |
to gain further insight into celecoxib-mediated apoptosis regulation at the level of the mitochondria we tested in how far the crucial pro-apoptotic bcl-2 proteins bak and bax were involved using clones of the bax-deficient jurkat t-lymphoma cell model either expressing bak (jurkat bak positive) or being negative for bak (jurkat bak negative), or overexpressing bcl-2 (jurkat bcl-2). |
2008-11-05 |
2023-08-12 |
Not clear |
| Jessica Barillari, Renato Iori, Alessio Papi, Marina Orlandi, Giovanna Bartolini, Simone Gabbanini, Gian Franco Pedulli, Luca Valgimigl. Kaiware Daikon (Raphanus sativus L.) extract: a naturally multipotent chemopreventive agent. Journal of agricultural and food chemistry. vol 56. issue 17. 2008-10-31. PMID:18665601. |
a 50 microm concentration of kde-itc had relevant apoptosis induction in all tested cancer cell lines, as confirmed by annexin v assay (e.g., 33% induction in lovo compared to control, p < 0.05), bax protein induction (e.g., +20% in ht-29, p < 0.05), and bcl2 downregulation (e.g.-20% in ht-29, p < 0.05), and induced caspase-1 and parp-1 activation in all cancer cells as shown by western blot analysis. |
2008-10-31 |
2023-08-12 |
human |