| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Liying Zhou, Donald C Chan. Dynamics and structure of the Bax-Bak complex responsible for releasing mitochondrial proteins during apoptosis. Journal of cell science. vol 121. issue Pt 13. 2008-12-22. PMID:18544634. |
using live cell imaging techniques, we showed here that bax underwent four distinct stages of dynamic redistribution during uv-induced apoptosis. |
2008-12-22 |
2023-08-12 |
Not clear |
| Katsuhiko Ohori, Tetsuji Miura, Masaya Tanno, Takayuki Miki, Takahiro Sato, Satoko Ishikawa, Yoshiyuki Horio, Kazuaki Shimamot. Ser9 phosphorylation of mitochondrial GSK-3beta is a primary mechanism of cardiomyocyte protection by erythropoietin against oxidant-induced apoptosis. American journal of physiology. Heart and circulatory physiology. vol 295. issue 5. 2008-12-22. PMID:18805899. |
these results suggest that the suppression of gsk-3beta activity by akt-mediated ser9 phosphorylation in the mitochondria affords cardiomyocytes tolerance against oxidant-induced apoptosis, possibly by inhibiting the access of bax to the mitochondria. |
2008-12-22 |
2023-08-12 |
Not clear |
| Yidan Lin, Xiangguo Liu, Ping Yue, Doris M Benbrook, K Darrell Berlin, Fadlo R Khuri, Shi-Yong Su. Involvement of c-FLIP and survivin down-regulation in flexible heteroarotinoid-induced apoptosis and enhancement of TRAIL-initiated apoptosis in lung cancer cells. Molecular cancer therapeutics. vol 7. issue 11. 2008-12-22. PMID:19001438. |
the hypothesis of this study was that the mechanism of sheta2-induced apoptosis requires modulation of additional proteins critical for regulation of apoptosis, including cellular flice-inhibitory protein (c-flip), survivin, x-linked inhibitor of apoptosis, bcl-2, bcl-x(l), bax, and bim. |
2008-12-22 |
2023-08-12 |
human |
| Louis Chesler, David D Goldenberg, Rodney Collins, Matt Grimmer, Grace E Kim, Tarik Tihan, Kim Nguyen, Slava Yakovenko, Katherine K Matthay, William A Weis. Chemotherapy-induced apoptosis in a transgenic model of neuroblastoma proceeds through p53 induction. Neoplasia (New York, N.Y.). vol 10. issue 11. 2008-12-19. PMID:18953436. |
treated tumors showed a prominent proliferation block, induction of p53 protein, and massive apoptosis proceeding through induction of the bcl-2 homology domain-3-only proteins puma and bim, leading to the activation of bax and cleavage of caspase-3 and -9. |
2008-12-19 |
2023-08-12 |
mouse |
| Sahdeo Prasad, Nidhi Nigam, Neetu Kalra, Yogeshwer Shukl. Regulation of signaling pathways involved in lupeol induced inhibition of proliferation and induction of apoptosis in human prostate cancer cells. Molecular carcinogenesis. vol 47. issue 12. 2008-12-16. PMID:18404669. |
further, on increase of lupeol exposure to pc-3 cells an induction of apoptosis was recorded, which was associated with upregulation of bax, caspase-3, -9, and apaf1 genes and down regulation of antiapoptotic bcl-2 gene. |
2008-12-16 |
2023-08-12 |
human |
| Arabinda Das, Naren L Banik, Swapan K Ra. N-(4-Hydroxyphenyl) retinamide induced both differentiation and apoptosis in human glioblastoma T98G and U87MG cells. Brain research. vol 1227. 2008-12-16. PMID:18602901. |
besides, apoptosis was associated with alterations in expression of pro-apoptotic bax and anti-apoptotic bcl-2 proteins resulting in an increase in bax:bcl-2 ratio, mitochondrial release of cytochrome c and smac, downregulation of selective baculoviral inhibitor-of-apoptosis repeat containing (birc) molecules, an increase in intracellular free [ca2+], and activation of calpain and caspase-3. |
2008-12-16 |
2023-08-12 |
human |
| Sangita Manna, Tridib Chakraborty, Balaram Ghosh, Mary Chatterjee, Amalendu Panda, Sunil Srivastava, Ajay Rana, Malay Chatterje. Dietary fish oil associated with increased apoptosis and modulated expression of Bax and Bcl-2 during 7,12-dimethylbenz(alpha)anthracene-induced mammary carcinogenesis in rats. Prostaglandins, leukotrienes, and essential fatty acids. vol 79. issue 1-2. 2008-12-16. PMID:18614344. |
dietary fish oil associated with increased apoptosis and modulated expression of bax and bcl-2 during 7,12-dimethylbenz(alpha)anthracene-induced mammary carcinogenesis in rats. |
2008-12-16 |
2023-08-12 |
rat |
| Sangita Manna, Tridib Chakraborty, Balaram Ghosh, Mary Chatterjee, Amalendu Panda, Sunil Srivastava, Ajay Rana, Malay Chatterje. Dietary fish oil associated with increased apoptosis and modulated expression of Bax and Bcl-2 during 7,12-dimethylbenz(alpha)anthracene-induced mammary carcinogenesis in rats. Prostaglandins, leukotrienes, and essential fatty acids. vol 79. issue 1-2. 2008-12-16. PMID:18614344. |
treatment was continued 25 weeks, studying histopathology, expression of bax and bcl-2 proteins by immunohistochemistry and apoptosis by tunel assay and morphological study at 36 weeks. |
2008-12-16 |
2023-08-12 |
rat |
| Ming Li, Jide Wang, Samuel S M Ng, Chu-Yan Chan, Amy C Chen, Hong Ping Xia, David T Yew, Benjamin C Y Wong, Zhu Chen, Hsiang-Fu Kung, Marie Chia-Mi Li. The four-and-a-half-LIM protein 2 (FHL2) is overexpressed in gliomas and associated with oncogenic activities. Glia. vol 56. issue 12. 2008-12-16. PMID:18615633. |
overexpression of fhl2 increased the tumorigenicity of glioblastoma cells in nude mice and decreased the mrna levels of p53 and its downstream proapoptotic genes, including p21, bcl2-associated protein x (bax), and p53-upregulated modulator of apoptosis. |
2008-12-16 |
2023-08-12 |
mouse |
| F Martínez-Arribas, E Martín-Garabato, I Zapardiel, J Sánchez, A R Lucas, A Tejerina, J Schneide. Bax expression in untreated breast cancer: an immunocytometric study of 255 cases. Anticancer research. vol 28. issue 5A. 2008-12-16. PMID:19035283. |
bax is one of the main effectors of apoptosis in breast cancer. |
2008-12-16 |
2023-08-12 |
Not clear |
| Ruifen Zhang, Ian Humphreys, Ravi P Sahu, Yan Shi, Sanjay K Srivastav. In vitro and in vivo induction of apoptosis by capsaicin in pancreatic cancer cells is mediated through ROS generation and mitochondrial death pathway. Apoptosis : an international journal on programmed cell death. vol 13. issue 12. 2008-12-15. PMID:19002586. |
tumors from capsaicin treated mice demonstrated increased apoptosis, which was related to the activation of jnk and increased cytosolic protein expression of bax, cytochrome c, aif and cleaved caspase-3, as compared with controls. |
2008-12-15 |
2023-08-12 |
mouse |
| Wei Zhao, Qi Zhao, Jia Liu, Xin-Yun Xu, Wei-Wei Sun, Xue Zhou, Su Liu, Ting-Hua Wan. Electro-acupuncture reduces neuronal apoptosis linked to Bax and Bcl-2 expression in the spinal cords of cats subjected to partial dorsal root ganglionectomy. Neurochemical research. vol 33. issue 11. 2008-12-12. PMID:18401708. |
electro-acupuncture reduces neuronal apoptosis linked to bax and bcl-2 expression in the spinal cords of cats subjected to partial dorsal root ganglionectomy. |
2008-12-12 |
2023-08-12 |
cat |
| Wei Zhao, Qi Zhao, Jia Liu, Xin-Yun Xu, Wei-Wei Sun, Xue Zhou, Su Liu, Ting-Hua Wan. Electro-acupuncture reduces neuronal apoptosis linked to Bax and Bcl-2 expression in the spinal cords of cats subjected to partial dorsal root ganglionectomy. Neurochemical research. vol 33. issue 11. 2008-12-12. PMID:18401708. |
the present findings suggest that ea could inhibit neuronal apoptosis in dorsal root deafferentated cat spinal cords, possibly by bax downregulation and bcl-2 upregulation. |
2008-12-12 |
2023-08-12 |
cat |
| Yan-Jie Zhang, Qiang Dai, Shu-Ming Wu, Hong-Yin Zhu, Guan-Feng Shen, En-Ling Li, Shu-Dong Xia. Susceptibility for NSAIDs-induced apoptosis correlates to p53 gene status in gastric cancer cells. Cancer investigation. vol 26. issue 9. 2008-12-12. PMID:18798056. |
apoptosis in gastric cancer cells expressing wild-type p53 is induced through up-regulation of bax and down-regulation of bcl-2 and that regulation of the bax-bcl-2 heterodimer may be a major target of nsaids. |
2008-12-12 |
2023-08-12 |
Not clear |
| Yuan-peng Huang, Jian Du, Zhen-feng Hon. [Effect of Kangquan Recipe on apoptosis regulatory genes bax and bcl-2 mRNA in prostate of rats]. Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine. vol 27. issue 8. 2008-12-10. PMID:17879535. |
[effect of kangquan recipe on apoptosis regulatory genes bax and bcl-2 mrna in prostate of rats]. |
2008-12-10 |
2023-08-12 |
rat |
| Yuan-peng Huang, Jian Du, Zhen-feng Hon. [Effect of Kangquan Recipe on apoptosis regulatory genes bax and bcl-2 mRNA in prostate of rats]. Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine. vol 27. issue 8. 2008-12-10. PMID:17879535. |
to investigate the effect of kangquan recipe (kqr) on apoptosis regulatory genes bax and bcl-2 mrna in prostate of rats. |
2008-12-10 |
2023-08-12 |
rat |
| K M Ahmed, M Fan, D Nantajit, N Cao, J J L. Cyclin D1 in low-dose radiation-induced adaptive resistance. Oncogene. vol 27. issue 53. 2008-12-10. PMID:18695676. |
these results demonstrate the evidence that cytosolic cyclin d1 is able to regulate apoptosis by interaction with bax in ldir-induced adaptive resistance. |
2008-12-10 |
2023-08-12 |
human |
| Tiziana Genovese, Emanuela Mazzon, Emanuela Esposito, Rosanna Di Paola, Rocco Caminiti, Rosaria Meli, Placido Bramanti, Salvatore Cuzzocre. Effect of thalidomide on signal transduction pathways and secondary damage in experimental spinal cord trauma. Shock (Augusta, Ga.). vol 30. issue 3. 2008-12-09. PMID:18197140. |
thalidomide treatment significantly reduced the degree of: 1) spinal cord inflammation and tissue injury (histological score); 2) neutrophil infiltration (myeloperoxidase evaluation); 3) inos, nitrotyrosine, lipid peroxidation, and cytokine expression (tnf-alpha and il-1beta); 4) apoptosis (terminal deoxynucleotidyltransferase-mediated utp end labeling staining, and bax and bcl-2 expression); and 5) nuclear factor-kappab activation. |
2008-12-09 |
2023-08-12 |
mouse |
| Robert M Pasternack, Zhen Qian, Jing-Yi Zheng, Dimitris N Metaxas, Eileen White, Nada N Boustan. Measurement of subcellular texture by optical Gabor-like filtering with a digital micromirror device. Optics letters. vol 33. issue 19. 2008-12-09. PMID:18830354. |
our method showed significantly rounder structures within apoptosis-defective cells lacking the proapoptotic mitochondrial effectors bax and bak, when compared with bax/bak expressing cells functional for apoptosis, consistent with reported differences in mitochondrial shape in these cells. |
2008-12-09 |
2023-08-12 |
Not clear |
| Jie Liu, Wen Zhou, Shao-Shun Li, Zhe Sun, Bingzhen Lin, Yuan-Yuan Lang, Jia-You He, Xihua Cao, Tingdong Yan, Li Wang, Jiongming Lu, Young-Hoon Han, Yu Cao, Xiao-kun Zhang, Jin-Zhang Zen. Modulation of orphan nuclear receptor Nur77-mediated apoptotic pathway by acetylshikonin and analogues. Cancer research. vol 68. issue 21. 2008-12-08. PMID:18974131. |
our data also showed that sk07-induced apoptosis was associated with a bcl-2 conformational change and bax activation. |
2008-12-08 |
2023-08-12 |
Not clear |