| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Akhilesh Kumar, Saritha S D'Souza, S L Gaonkar, K M L Rai, Bharathi P Salimat. Growth inhibition and induction of apoptosis in MCF-7 breast cancer cells by a new series of substituted-1,3,4-oxadiazole derivatives. Investigational new drugs. vol 26. issue 5. 2009-01-13. PMID:18227972. |
although the derivatives induced apoptosis was associated with bax protein levels, negligible bcl-2 reduction was observed. |
2009-01-13 |
2023-08-12 |
Not clear |
| Jamie I Fletcher, Sarina Meusburger, Christine J Hawkins, David T Riglar, Erinna F Lee, W Douglas Fairlie, David C S Huang, Jerry M Adam. Apoptosis is triggered when prosurvival Bcl-2 proteins cannot restrain Bax. Proceedings of the National Academy of Sciences of the United States of America. vol 105. issue 47. 2009-01-07. PMID:18981409. |
apoptosis is triggered when prosurvival bcl-2 proteins cannot restrain bax. |
2009-01-07 |
2023-08-12 |
Not clear |
| Jamie I Fletcher, Sarina Meusburger, Christine J Hawkins, David T Riglar, Erinna F Lee, W Douglas Fairlie, David C S Huang, Jerry M Adam. Apoptosis is triggered when prosurvival Bcl-2 proteins cannot restrain Bax. Proceedings of the National Academy of Sciences of the United States of America. vol 105. issue 47. 2009-01-07. PMID:18981409. |
a central issue in the control of apoptosis is whether its essential mediators bax and bak must be restrained by bcl-2-like prosurvival relatives to prevent their damaging mitochondria and unleashing apoptosis. |
2009-01-07 |
2023-08-12 |
Not clear |
| Jamie I Fletcher, Sarina Meusburger, Christine J Hawkins, David T Riglar, Erinna F Lee, W Douglas Fairlie, David C S Huang, Jerry M Adam. Apoptosis is triggered when prosurvival Bcl-2 proteins cannot restrain Bax. Proceedings of the National Academy of Sciences of the United States of America. vol 105. issue 47. 2009-01-07. PMID:18981409. |
nevertheless, bcl-x(l) remained able to block apoptosis induced by bax d68r. |
2009-01-07 |
2023-08-12 |
Not clear |
| Jamie I Fletcher, Sarina Meusburger, Christine J Hawkins, David T Riglar, Erinna F Lee, W Douglas Fairlie, David C S Huang, Jerry M Adam. Apoptosis is triggered when prosurvival Bcl-2 proteins cannot restrain Bax. Proceedings of the National Academy of Sciences of the United States of America. vol 105. issue 47. 2009-01-07. PMID:18981409. |
whereas cells with sufficient bcl-x(l) tolerated expression of bax d68r, it provoked apoptosis when bcl-x(l) was absent, downregulated, or inactivated. |
2009-01-07 |
2023-08-12 |
Not clear |
| Paulina K Wrzal, Ahmed Bettaieb, Diana A Averill-Bate. Molecular mechanisms of apoptosis activation by heat shock in multidrug-resistant Chinese hamster cells. Radiation research. vol 170. issue 4. 2009-01-07. PMID:19024657. |
in the mitochondria-mediated pathway of heat-induced apoptosis, chrc5 cells showed higher mitochondrial levels of bax and tbid, more pronounced mitochondrial membrane depolarization, and increased apaf-1. |
2009-01-07 |
2023-08-12 |
Not clear |
| Zakaria Y Abd Elmageed, Rajiv L Gaur, Mandy Williams, Mohamed E Abdraboh, Prakash N Rao, Madhwa H G Raj, Fathi M Ismail, Allal Ouhti. Characterization of coordinated immediate responses by p16INK4A and p53 pathways in UVB-irradiated human skin cells. The Journal of investigative dermatology. vol 129. issue 1. 2009-01-06. PMID:18719612. |
in hacat cells, high uvb dose caused dramatic increase in p53 expression followed by upregulation of p21(cip1/waf1) and bax, and downregulation of bcl-2 leading to apoptosis. |
2009-01-06 |
2023-08-12 |
human |
| Ching-Han Yu, Shu-Fen Kan, Hsiao-Fung Pu, Eileen Jea Chien, Paulus S Wan. Apoptotic signaling in bufalin- and cinobufagin-treated androgen-dependent and -independent human prostate cancer cells. Cancer science. vol 99. issue 12. 2009-01-06. PMID:19037992. |
these results suggest that bufalin and cinobufagin suppress cell proliferation and cause apoptosis in prostate cancer cells via a sequence of apoptotic modulators, including bax, cytochrome c, and caspases. |
2009-01-06 |
2023-08-12 |
human |
| Seung-Il Jeong, Beng Zhou, Jin-Beom Bae, Nam-Seok Kim, Sun-Geun Kim, Jin Kwon, Dae-Keun Kim, Tae-Yong Shin, Hoon Jeon, Jong-Phil Lim, Hongjun Kim, Ho Kyoung Kim, Chan-Ho O. Apoptosis-inducing effect of akebia saponin D from the roots of Dipsacus asper Wall in U937 cells. Archives of pharmacal research. vol 31. issue 11. 2009-01-05. PMID:19023535. |
taken together, these results strongly indicate that asd may exert apoptosis-inducing activity via induction of apoptosis through activation chiefly via the nitric oxide and apoptosis-related p53 and bax gene expression. |
2009-01-05 |
2023-08-12 |
human |
| Shigekuni Hosogi, Yoshinobu Iwasaki, Takahiro Yamada, Nobuyo Komatani-Tamiya, Atsushi Hiramatsu, Yoshihito Kohno, Mikio Ueda, Taichiro Arimoto, Yoshinori Marunak. Effect of inducible nitric oxide synthase on apoptosis in Candida-induced acute lung injury. Biomedical research (Tokyo, Japan). vol 29. issue 5. 2009-01-02. PMID:18997441. |
the augmented production of no increased fasl, tnf-alpha, and mrna production of bax of lung that induced apoptosis of alveolar epithelial cells. |
2009-01-02 |
2023-08-12 |
mouse |
| Arabinda Das, M Kelly Guyton, Denise D Matzelle, Swapan K Ray, Naren L Bani. Time-dependent increases in protease activities for neuronal apoptosis in spinal cords of Lewis rats during development of acute experimental autoimmune encephalomyelitis. Journal of neuroscience research. vol 86. issue 13. 2008-12-30. PMID:18521931. |
increases in the bax:bcl-2 ratio and activation of caspase-9 showed the involvement of mitochondria in apoptosis. |
2008-12-30 |
2023-08-12 |
rat |
| Xiaohua Li, Ying Zhang, Shanshan Cao, Xiong Chen, Yuanyuan Lu, Haifeng Jin, Shiren Sun, Bei Chen, Jie Liu, Jie Ding, Kaichun Wu, Daiming Fa. Reduction of TIP30 correlates with poor prognosis of gastric cancer patients and its restoration drastically inhibits tumor growth and metastasis. International journal of cancer. vol 124. issue 3. 2008-12-30. PMID:18972434. |
we also restored tip30 protein expression in human gastric cancer-derived cells ags and mkn28 lacking endogenous tip30 protein to study the effects of tip30 expression on cell proliferation, cell kinetics, tumorigenicity and metastasis in balb/c nude mice and found that adenoviral-mediated restoration of tip30 expression led to downregulation of cyclin d1, bcl-2, bcl-xl, but to upregulation of p27, bax, p53, caspase 3 and 9 expression, cell cycle g0/g1 arrest and apoptosis in vitro, and dramatic attenuation of tumor growth and abrogation of metastasis in animal models. |
2008-12-30 |
2023-08-12 |
mouse |
| Tsung-Chuan Ho, Show-Li Chen, Yuh-Cheng Yang, Chia-Yi Chen, Fang-Ping Feng, Jui-Wen Hsieh, Huey-Chuan Cheng, Yeou-Ping Tsa. 15-deoxy-Delta(12,14)-prostaglandin J2 induces vascular endothelial cell apoptosis through the sequential activation of MAPKS and p53. The Journal of biological chemistry. vol 283. issue 44. 2008-12-29. PMID:18718914. |
both 15d-pgj(2)-induced apoptosis and the induction of p21(waf1) and bax can be abolished by p53 small interfering rna but not by peroxisome proliferator-activated receptor gamma inhibitors. |
2008-12-29 |
2023-08-12 |
mouse |
| Tsung-Chuan Ho, Show-Li Chen, Yuh-Cheng Yang, Chia-Yi Chen, Fang-Ping Feng, Jui-Wen Hsieh, Huey-Chuan Cheng, Yeou-Ping Tsa. 15-deoxy-Delta(12,14)-prostaglandin J2 induces vascular endothelial cell apoptosis through the sequential activation of MAPKS and p53. The Journal of biological chemistry. vol 283. issue 44. 2008-12-29. PMID:18718914. |
jnk inhibitor (sp600125) or p38 mapk inhibitor (sb203580) pretreatment attenuated 15d-pgj(2)-mediated apoptosis and suppressed the p21(waf1) and bax expressions without affecting p53 protein accumulation. |
2008-12-29 |
2023-08-12 |
mouse |
| Gordon C Shore, Mai Nguye. Bcl-2 proteins and apoptosis: choose your partner. Cell. vol 135. issue 6. 2008-12-29. PMID:19070569. |
the bcl-2 family protein bax is a key effector of apoptosis. |
2008-12-29 |
2023-08-12 |
Not clear |
| Abha Sharma, Rajendra Sharma, Pankaj Chaudhary, Rit Vatsyayan, Virginia Pearce, Prince V S Jeyabal, Piotr Zimniak, Sanjay Awasthi, Yogesh C Awasth. 4-Hydroxynonenal induces p53-mediated apoptosis in retinal pigment epithelial cells. Archives of biochemistry and biophysics. vol 480. issue 2. 2008-12-24. PMID:18930016. |
p21 and bax, jnk, caspase3, and onset of apoptosis in treated rpe cells. |
2008-12-24 |
2023-08-12 |
mouse |
| Dragos Plesca, Suparna Mazumder, Vivian Gama, Shigemi Matsuyama, Alexandru Almasa. A C-terminal fragment of Cyclin E, generated by caspase-mediated cleavage, is degraded in the absence of a recognizable phosphodegron. The Journal of biological chemistry. vol 283. issue 45. 2008-12-23. PMID:18784078. |
blocking p18-cyclin e degradation with proteasome inhibitors increases levels of p18-cyclin e and enhances its association with ku70, thus leading to bax release, its activation, and apoptosis. |
2008-12-23 |
2023-08-12 |
Not clear |
| Jie Bai, Zong-hong Shao, Hong Liu, Jun Shi, Yan-ran Cao, Mei-feng Tu, Yu-hong Wu, Hai-rong Jia, Juan Sun, Zhen-zhu Cui, Lin-sheng Qian, Chong-li Yan. [Expression of apoptosis related proteins in CD34 positive bone marrow cells of patients with polycythemia vera]. Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi. vol 25. issue 10. 2008-12-22. PMID:15634597. |
to investigate the expression of apoptosis receptor fas (cd95) and apoptosis related protein bcl-2 and bax in cd34 positive bone marrow cells of the patients with polycythemia vera (pv). |
2008-12-22 |
2023-08-12 |
Not clear |
| Valeria Merico, Gabriela Diaz de Barboza, Chiara Vasco, Ruben Ponce, Valeria Rodriguez, Silvia Garagna, Nori Tolosa de Talamon. A mitochondrial mechanism is involved in apoptosis of Robertsonian mouse male germ cells. Reproduction (Cambridge, England). vol 135. issue 6. 2008-12-22. PMID:18502894. |
for histological evaluation of apoptosis, tunel labelling and immunohistochemistry were used to localise bax and cytochrome c. expression of calbindin d(28k) (cb), an anti-apoptotic molecule, was also analysed by immunohistochemistry and immunoblotting. |
2008-12-22 |
2023-08-12 |
mouse |
| Liying Zhou, Donald C Chan. Dynamics and structure of the Bax-Bak complex responsible for releasing mitochondrial proteins during apoptosis. Journal of cell science. vol 121. issue Pt 13. 2008-12-22. PMID:18544634. |
bax and bak are known to play a central role in facilitating the release of mitochondrial intermembrane proteins during apoptosis. |
2008-12-22 |
2023-08-12 |
Not clear |