| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jonathan M Peterson, Yan Wang, Randall W Bryner, David L Williamson, Stephen E Alwa. Bax signaling regulates palmitate-mediated apoptosis in C(2)C(12) myotubes. American journal of physiology. Endocrinology and metabolism. vol 295. issue 6. 2009-02-11. PMID:18840766. |
bax signaling regulates palmitate-mediated apoptosis in c(2)c(12) myotubes. |
2009-02-11 |
2023-08-12 |
Not clear |
| Jonathan M Peterson, Yan Wang, Randall W Bryner, David L Williamson, Stephen E Alwa. Bax signaling regulates palmitate-mediated apoptosis in C(2)C(12) myotubes. American journal of physiology. Endocrinology and metabolism. vol 295. issue 6. 2009-02-11. PMID:18840766. |
however, the role of bax and bcl-2 in regulating palmitate-induced apoptosis has not been well studied. |
2009-02-11 |
2023-08-12 |
Not clear |
| Jonathan M Peterson, Yan Wang, Randall W Bryner, David L Williamson, Stephen E Alwa. Bax signaling regulates palmitate-mediated apoptosis in C(2)C(12) myotubes. American journal of physiology. Endocrinology and metabolism. vol 295. issue 6. 2009-02-11. PMID:18840766. |
therefore, the purpose of this study was to determine whether palmitate-induced apoptosis in c(2)c(12) myotubes is dependent on bax to bcl-2 binding. |
2009-02-11 |
2023-08-12 |
Not clear |
| Jonathan M Peterson, Yan Wang, Randall W Bryner, David L Williamson, Stephen E Alwa. Bax signaling regulates palmitate-mediated apoptosis in C(2)C(12) myotubes. American journal of physiology. Endocrinology and metabolism. vol 295. issue 6. 2009-02-11. PMID:18840766. |
last, the contribution of bax to palmitate-induced apoptosis was determined by treatment with bax sirna. |
2009-02-11 |
2023-08-12 |
Not clear |
| Sangnam Oh, Eunil Lee, Joohyun Lee, Yongchul Lim, Joonhee Kim, Samyong Wo. Comparison of the effects of 40% oxygen and two atmospheric absolute air pressure conditions on stress-induced premature senescence of normal human diploid fibroblasts. Cell stress & chaperones. vol 13. issue 4. 2009-02-09. PMID:18465208. |
among 26 statistically reliable genes, the expression of apoptosis related genes such as adam22, bax, bcl2l14, and ubd, as well as tumor suppressor-related genes like axin2 and atf, and also mitogen-activated protein kinase-related genes like mitogen-activated protein kinase kinase kinase 1, histamine receptor, and rab24, were significantly changed in cells responsive to pressure-induced oxidative stress. |
2009-02-09 |
2023-08-12 |
human |
| Xènia Garrofé-Ochoa, Raquel M Melero-Fernández de Mera, Franciso J Fernández-Gómez, Judit Ribas, Joaquín Jordán, Jacint Boi. BAX and BAK proteins are required for cyclin-dependent kinase inhibitory drugs to cause apoptosis. Molecular cancer therapeutics. vol 7. issue 12. 2009-02-09. PMID:19056676. |
bax and bak proteins are required for cyclin-dependent kinase inhibitory drugs to cause apoptosis. |
2009-02-09 |
2023-08-12 |
mouse |
| Xènia Garrofé-Ochoa, Raquel M Melero-Fernández de Mera, Franciso J Fernández-Gómez, Judit Ribas, Joaquín Jordán, Jacint Boi. BAX and BAK proteins are required for cyclin-dependent kinase inhibitory drugs to cause apoptosis. Molecular cancer therapeutics. vol 7. issue 12. 2009-02-09. PMID:19056676. |
in conclusion, olomoucine and roscovitine caused apoptosis through an intrinsic pathway, with bax and bak proteins being involved. |
2009-02-09 |
2023-08-12 |
mouse |
| Neha Saxena, Kausar M Ansari, Rahul Kumar, Alok Dhawan, Premendra D Dwivedi, Mukul Da. Patulin causes DNA damage leading to cell cycle arrest and apoptosis through modulation of Bax, p(53) and p(21/WAF1) proteins in skin of mice. Toxicology and applied pharmacology. vol 234. issue 2. 2009-02-06. PMID:19000704. |
patulin causes dna damage leading to cell cycle arrest and apoptosis through modulation of bax, p(53) and p(21/waf1) proteins in skin of mice. |
2009-02-06 |
2023-08-12 |
mouse |
| Yelena Janumyan, Qinghua Cui, Ling Yan, Courtney G Sansam, Mayda Valentin, Elizabeth Yan. G0 function of BCL2 and BCL-xL requires BAX, BAK, and p27 phosphorylation by Mirk, revealing a novel role of BAX and BAK in quiescence regulation. The Journal of biological chemistry. vol 283. issue 49. 2009-02-04. PMID:18818203. |
neither caspase inhibition nor abrogation of mitochondria-dependent apoptosis by bax and bak deletion fully recapitulated the g(0) effects of bcl2 or bcl-x(l), suggesting that mechanisms in addition to anti-apoptosis are involved in the cell cycle arrest function of bcl2 or bcl-x(l). |
2009-02-04 |
2023-08-12 |
Not clear |
| Nai Yang Fu, Sunil K Sukumaran, Sze Yen Kerk, Victor C Y. Baxbeta: a constitutively active human Bax isoform that is under tight regulatory control by the proteasomal degradation mechanism. Molecular cell. vol 33. issue 1. 2009-02-04. PMID:19150424. |
although mrnas of multiple isoforms of bax, which encodes a central regulator of apoptosis signaling, have been reported, only baxalpha protein has been well documented and studied. |
2009-02-04 |
2023-08-12 |
human |
| Nai Yang Fu, Sunil K Sukumaran, Sze Yen Kerk, Victor C Y. Baxbeta: a constitutively active human Bax isoform that is under tight regulatory control by the proteasomal degradation mechanism. Molecular cell. vol 33. issue 1. 2009-02-04. PMID:19150424. |
these observations underscore the plasticity of human bax in serving its role as a "gatekeeper" for apoptosis. |
2009-02-04 |
2023-08-12 |
human |
| Lydia Lartigue, Chantal Medina, Laura Schembri, Paul Chabert, Marion Zanese, Flora Tomasello, Renée Dalibart, Didier Thoraval, Marc Crouzet, François Ichas, Francesca De Giorg. An intracellular wave of cytochrome c propagates and precedes Bax redistribution during apoptosis. Journal of cell science. vol 121. issue Pt 21. 2009-02-03. PMID:18840646. |
an intracellular wave of cytochrome c propagates and precedes bax redistribution during apoptosis. |
2009-02-03 |
2023-08-12 |
Not clear |
| Lydia Lartigue, Chantal Medina, Laura Schembri, Paul Chabert, Marion Zanese, Flora Tomasello, Renée Dalibart, Didier Thoraval, Marc Crouzet, François Ichas, Francesca De Giorg. An intracellular wave of cytochrome c propagates and precedes Bax redistribution during apoptosis. Journal of cell science. vol 121. issue Pt 21. 2009-02-03. PMID:18840646. |
bax is considered to be pivotal in inducing cytochrome c release (ccr) from mitochondria during apoptosis. |
2009-02-03 |
2023-08-12 |
Not clear |
| Lydia Lartigue, Chantal Medina, Laura Schembri, Paul Chabert, Marion Zanese, Flora Tomasello, Renée Dalibart, Didier Thoraval, Marc Crouzet, François Ichas, Francesca De Giorg. An intracellular wave of cytochrome c propagates and precedes Bax redistribution during apoptosis. Journal of cell science. vol 121. issue Pt 21. 2009-02-03. PMID:18840646. |
thus, the ccr wave not only questions the exact role of bax redistribution in cell death, but also indicates the existence of yet unidentified positive-feedback loops that ensure a spatiotemporal control of apoptosis at the subcellular scale. |
2009-02-03 |
2023-08-12 |
Not clear |
| Hyeyoung Park, Young Jun Lee, Tae Hyung Kim, Jaewon Lee, Sungpil Yoon, Wahn Soo Choi, Chang-Seon Myung, Hyung Sik Ki. Effects of trichostatin A, a histone deacetylase inhibitor, on the regulation of apoptosis in H-ras-transformed breast epithelial cells. International journal of molecular medicine. vol 22. issue 5. 2009-02-03. PMID:18949380. |
furthermore, the up-regulation of p53 promoted bax expression, which led to the activation of pro-caspase-3 and eventually to apoptosis in mcf10a-ras cells. |
2009-02-03 |
2023-08-12 |
human |
| Xia Zhang, Caifeng Bi, Yuhua Fan, Qiuzhi Cui, Di Chen, Yan Xiao, Q Ping Do. Induction of tumor cell apoptosis by taurine Schiff base copper complex is associated with the inhibition of proteasomal activity. International journal of molecular medicine. vol 22. issue 5. 2009-02-03. PMID:18949390. |
inhibition of tumor cellular proteasomal activity by compound 1 results in the accumulation of ubiquitinated protein and the proteasome target proteins p27 and bax, followed by the induction of apoptosis. |
2009-02-03 |
2023-08-12 |
human |
| Qun Wang, Quan-yan Liu, Zhi-Su Liu, Qun Qian, Quan Sun, Ding-yu Pa. Inhibition of hepatocelluar carcinoma MAT2A and MAT2beta gene expressions by single and dual small interfering RNA. Journal of experimental & clinical cancer research : CR. vol 27. 2009-02-03. PMID:19025580. |
results indicated that dual sirna could simultaneously inhibit the expression of mat2a and mat2beta gene by 89.5% and 97.8% respectively, in addition, dual sirna molecules were able to significantly suppress growth of hepatocelluar carcinoma cell in vitro as well as induce apoptosis which was involved in arrest cell cycle at the g1/s checkpoint and the expressions of p21, p27 and bax. |
2009-02-03 |
2023-08-12 |
Not clear |
| Hong-Wei Zhao, Feng Qin, Yi-Xia Liu, Xi Huang, Ping Re. Antiapoptotic mechanisms of Chinese medicine formula, Guan-Xin-Er-Hao, in the rat ischemic heart. The Tohoku journal of experimental medicine. vol 216. issue 4. 2009-02-03. PMID:19060445. |
bax promotes apoptosis, while bcl-2 inhibits apoptosis. |
2009-02-03 |
2023-08-12 |
rat |
| Hong-Wei Zhao, Feng Qin, Yi-Xia Liu, Xi Huang, Ping Re. Antiapoptotic mechanisms of Chinese medicine formula, Guan-Xin-Er-Hao, in the rat ischemic heart. The Tohoku journal of experimental medicine. vol 216. issue 4. 2009-02-03. PMID:19060445. |
taken together, gxeh tilted the balance between bax and bcl-2 toward an antiapoptotic state, decreased mitochondrial cytochrome c release, reduced caspase-9 activation, and attenuated subsequent caspase-3 activation and postischemic myocardial apoptosis in rats. |
2009-02-03 |
2023-08-12 |
rat |
| Ji Won Lee, Min Kyung Ch. Phenethyl isothiocyanate induced apoptosis via down regulation of Bcl-2/XIAP and triggering of the mitochondrial pathway in MCF-7 cells. Archives of pharmacal research. vol 31. issue 12. 2009-02-03. PMID:19099231. |
peitc also caused a decrease in the levels of bcl-2 with a concomitant increase in bax levels, which resulted in the release of cytochrome c. xiap suppression and smac translocation also contributed to the peitc-induced apoptosis. |
2009-02-03 |
2023-08-12 |
human |