| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yan-qiu Shi, Chang-jun Zhu, Hui-qing Yuan, Bo-qin Li, Jie Gao, Xian-jun Qu, Bin Sun, Yan-na Cheng, Song Li, Xia Li, Hong-Xiang Lo. Marchantin C, a novel microtubule inhibitor from liverwort with anti-tumor activity both in vivo and in vitro. Cancer letters. vol 276. issue 2. 2009-03-20. PMID:19095349. |
marchantin c-treated xenografts showed decreased microtubules, bcl-2 and increased cyclin b1, bax, caspase-3, indicating that marchantin c possess the same ability to induce microtubules depolymerization and tumor cell apoptosis in tumor-bearing mice as in vitro. |
2009-03-20 |
2023-08-12 |
mouse |
| Lu Yang, Dingfang Wu, Kewang Luo, Shihua Wu, Ping W. Andrographolide enhances 5-fluorouracil-induced apoptosis via caspase-8-dependent mitochondrial pathway involving p53 participation in hepatocellular carcinoma (SMMC-7721) cells. Cancer letters. vol 276. issue 2. 2009-03-20. PMID:19097688. |
andro alone induces smmc-7721 apoptosis with p53 expression, bax conformation and caspase-3,8,9 activation. |
2009-03-20 |
2023-08-12 |
human |
| Lu Yang, Dingfang Wu, Kewang Luo, Shihua Wu, Ping W. Andrographolide enhances 5-fluorouracil-induced apoptosis via caspase-8-dependent mitochondrial pathway involving p53 participation in hepatocellular carcinoma (SMMC-7721) cells. Cancer letters. vol 276. issue 2. 2009-03-20. PMID:19097688. |
surprisingly, the addition of andro to 5-fu induces synergistic apoptosis, which could be corroborated to the increased caspase-8, p53 activity and the significant changes of bax conformation in these cells, resulting in increased losses of mitochondrial membrane potential, increased release of cytochrome c, and activation of caspase-9 and caspase-3. |
2009-03-20 |
2023-08-12 |
human |
| C L Wang, T B Ng, X H Cao, Y Jiang, Z K Liu, T Y Wen, F Li. CLP induces apoptosis in human leukemia K562 cells through Ca(2+) regulating extracellular-related protein kinase ERK activation. Cancer letters. vol 276. issue 2. 2009-03-20. PMID:19100683. |
this erk phosphorylation subsequently activated bax, cytochrome c and caspase-3 leading to apoptosis. |
2009-03-20 |
2023-08-12 |
human |
| Luis F Z Batista, Wynand P Roos, Bernd Kaina, Carlos F M Menc. p53 mutant human glioma cells are sensitive to UV-C-induced apoptosis due to impaired cyclobutane pyrimidine dimer removal. Molecular cancer research : MCR. vol 7. issue 2. 2009-03-19. PMID:19208740. |
moreover, the results indicate that uv-c-induced apoptosis of p53 mutant glioma cells is executed through the intrinsic apoptotic pathway, with bcl-2 degradation and sustained bax and bak up-regulation. |
2009-03-19 |
2023-08-12 |
human |
| Jung-Mi Yun, Farrukh Afaq, Naghma Khan, Hasan Mukhta. Delphinidin, an anthocyanidin in pigmented fruits and vegetables, induces apoptosis and cell cycle arrest in human colon cancer HCT116 cells. Molecular carcinogenesis. vol 48. issue 3. 2009-03-18. PMID:18729103. |
we found that treatment of cells with delphinidin (30-240 microm; 48 h) resulted in (i) decrease in cell viability (ii) induction of apoptosis, (iii) cleavage of parp, (iv) activation of caspases-3, -8, and -9, (v) increase in bax with a concomitant decrease in bcl-2 protein, and (vi) g2/m phase cell cycle arrest. |
2009-03-18 |
2023-08-12 |
human |
| Jai-Sing Yang, Guang-Wei Chen, Te-Chun Hsia, Heng-Chien Ho, Chin-Chin Ho, Meng-Wei Lin, Song-Shei Lin, Ru-Duan Yeh, Siu-Wan Ip, Hsu-Fung Lu, Jing-Gung Chun. Diallyl disulfide induces apoptosis in human colon cancer cell line (COLO 205) through the induction of reactive oxygen species, endoplasmic reticulum stress, caspases casade and mitochondrial-dependent pathways. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 47. issue 1. 2009-03-16. PMID:19038304. |
treatment of colo 205 cells with dads resulted in g2/m phase arrest and apoptosis occurrence through the mitochondrial-pathway (bcl-2, bcl-xl down-regulation and bak, bax up-regulation). |
2009-03-16 |
2023-08-12 |
human |
| DaLiao Xiao, Lubo Zhan. Upregulation of Bax and Bcl-2 following prenatal cocaine exposure induces apoptosis in fetal rat brain. International journal of medical sciences. vol 5. issue 6. 2009-03-13. PMID:18974856. |
upregulation of bax and bcl-2 following prenatal cocaine exposure induces apoptosis in fetal rat brain. |
2009-03-13 |
2023-08-12 |
rat |
| Ashwani Malhotra, Himanshu Vashistha, Virendra S Yadav, Michael G Dube, Satya P Kalra, Maha Abdellatif, Leonard G Megg. Inhibition of p66ShcA redox activity in cardiac muscle cells attenuates hyperglycemia-induced oxidative stress and apoptosis. American journal of physiology. Heart and circulatory physiology. vol 296. issue 2. 2009-03-12. PMID:19060130. |
these indexes of oxidative stress were accompanied by a 40% increase in apoptosis and the upregulation of cleaved caspase-3 and the apoptosis-related proteins p53 and bax. |
2009-03-12 |
2023-08-12 |
mouse |
| Balakrishna Shankar, Subramanian Krishnan, Vasantha Malladi, Arun Balakrishnan, Peter H William. Outer membrane proteins of wild-type and intimin-deficient enteropathogenic Escherichia coli induce Hep-2 cell death through intrinsic and extrinsic pathways of apoptosis. International journal of medical microbiology : IJMM. vol 299. issue 2. 2009-03-06. PMID:18771950. |
furthermore, apoptosis was associated with suppression of bcl-2 protein expression, up-regulation of bax mrna levels and increased cytochrome c release from mitochondria. |
2009-03-06 |
2023-08-12 |
Not clear |
| Hyungjin Kim, James J-D Hsieh, Emily H-Y Chen. Deadly splicing: Bax becomes Almighty. Molecular cell. vol 33. issue 2. 2009-03-04. PMID:19187757. |
activation of bax and bak by bh3-only molecules triggers mitochondrial apoptosis. |
2009-03-04 |
2023-08-12 |
Not clear |
| Huanchen Sha, Qingyong Ma, Rajiv Kumar Jha, Fuguo Xu, Liancai Wang, Zheng Wang, Yan Zhao, Fenling Fa. Resveratrol ameliorates hepatic injury via the mitochondrial pathway in rats with severe acute pancreatitis. European journal of pharmacology. vol 601. issue 1-3. 2009-03-03. PMID:18977215. |
we investigated cytochrome c released from mitochondria and used the rt-pcr (reverse transcription pcr), western blot technique to evaluate bax, bcl-2, and caspase-3 expression levels in hepatic tissue over the time course of apoptosis. |
2009-03-03 |
2023-08-12 |
rat |
| Chao-Xian Yang, Jun-Xiang Liu, Zhu-Lei Sun, Xiao-Qing Gao, Li Deng, Qiong-Lan Yua. [Effects of Ginsenoside RB1 on neural cell apoptosis and expressions of Bcl-2 and Bax in rats following subjected to cerebral ischemia-reperfusion]. Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition. vol 39. issue 2. 2009-02-27. PMID:18630686. |
[effects of ginsenoside rb1 on neural cell apoptosis and expressions of bcl-2 and bax in rats following subjected to cerebral ischemia-reperfusion]. |
2009-02-27 |
2023-08-12 |
rat |
| Chao-Xian Yang, Jun-Xiang Liu, Zhu-Lei Sun, Xiao-Qing Gao, Li Deng, Qiong-Lan Yua. [Effects of Ginsenoside RB1 on neural cell apoptosis and expressions of Bcl-2 and Bax in rats following subjected to cerebral ischemia-reperfusion]. Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition. vol 39. issue 2. 2009-02-27. PMID:18630686. |
to observe the effects of ginsenoside rb1 (grb1) on neuronal cell apoptosis and the expressions of bcl-2 and bax in rats after cerebral ischemia-reperfusion so as to investigate the neuroprotective mechanism of grb1. |
2009-02-27 |
2023-08-12 |
rat |
| Chao-Xian Yang, Jun-Xiang Liu, Zhu-Lei Sun, Xiao-Qing Gao, Li Deng, Qiong-Lan Yua. [Effects of Ginsenoside RB1 on neural cell apoptosis and expressions of Bcl-2 and Bax in rats following subjected to cerebral ischemia-reperfusion]. Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition. vol 39. issue 2. 2009-02-27. PMID:18630686. |
tunel and immunohistochemical method were used to analyze the cell apoptosis and expressions of bcl-2 and bax, respectively. |
2009-02-27 |
2023-08-12 |
rat |
| Fang Liu, Chih-Chang Wei, Shyh-Jong Wu, Isabelle Chenier, Shao-Ling Zhang, Janos G Filep, Julie R Ingelfinger, John S D Cha. Apocynin attenuates tubular apoptosis and tubulointerstitial fibrosis in transgenic mice independent of hypertension. Kidney international. vol 75. issue 2. 2009-02-27. PMID:18923387. |
untreated transgenic mice had significant elevations of their systolic blood pressure, albuminuria, reactive oxygen species production, nadph oxidase activity, tubular apoptosis, active caspase-3, bax, transforming growth factor-beta1, plasminogen activator inhibitor-1, extracellular matrix proteins, collagen type iv, and phosphorylated p47phox expression compared to untreated non-transgenic mice. |
2009-02-27 |
2023-08-12 |
mouse |
| Julie L Lefebvre, Yifeng Zhang, Markus Meister, Xiaozhong Wang, Joshua R Sane. gamma-Protocadherins regulate neuronal survival but are dispensable for circuit formation in retina. Development (Cambridge, England). vol 135. issue 24. 2009-02-26. PMID:19029044. |
blocking apoptosis by deletion of the pro-apoptotic gene bax showed that even neurons destined to die formed qualitatively and quantitatively appropriate connections. |
2009-02-26 |
2023-08-12 |
mouse |
| Tuhina Prasad, Xiaozhong Wang, Paul A Gray, Joshua A Weine. A differential developmental pattern of spinal interneuron apoptosis during synaptogenesis: insights from genetic analyses of the protocadherin-gamma gene cluster. Development (Cambridge, England). vol 135. issue 24. 2009-02-26. PMID:19029045. |
we show that this represents an exacerbation of a normal, underlying developmental pattern: the extent of each population's decrease in pcdh-gamma mutants is precisely commensurate both with the extent of its loss during normal embryogenesis and with the extent of its increase in bax(-/-) mice, in which apoptosis is genetically blocked. |
2009-02-26 |
2023-08-12 |
mouse |
| Bo Peng, Qin Hu, Xinmin Liu, Liwei Wang, Qi Chang, Jianrong Li, Jintian Tang, Ning Wang, Yuqi Wan. Duchesnea phenolic fraction inhibits in vitro and in vivo growth of cervical cancer through induction of apoptosis and cell cycle arrest. Experimental biology and medicine (Maywood, N.J.). vol 234. issue 1. 2009-02-25. PMID:19064947. |
dpf could induce apoptosis in tumor tissues as evidenced by increased tunel-positive cells, activation of caspase-3, up-regulation of bax and down-regulation of bcl-2. |
2009-02-25 |
2023-08-12 |
mouse |
| Zhong-Jian Shen, Stephane Esnault, Anna Schinzel, Christoph Borner, James S Malte. The peptidyl-prolyl isomerase Pin1 facilitates cytokine-induced survival of eosinophils by suppressing Bax activation. Nature immunology. vol 10. issue 3. 2009-02-25. PMID:19182807. |
inhibition of bax resulted in less eosinophil apoptosis, even in the absence of cytokines. |
2009-02-25 |
2023-08-12 |
human |