| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ru-Xiu Liu, Shuang Tan, Zhen-Yu Wu, Yun Zhang, Xi Huang, Zhi-Ming Li. [Effect of Qiangxin Fumai granule on myocyte apoptosis of sinus node and Bax, Bcl-2, Fas-L gene protein in rabbits of sinoatrial ischemia/reperfusion]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 33. issue 1. 2009-04-21. PMID:18338626. |
[effect of qiangxin fumai granule on myocyte apoptosis of sinus node and bax, bcl-2, fas-l gene protein in rabbits of sinoatrial ischemia/reperfusion]. |
2009-04-21 |
2023-08-12 |
Not clear |
| Dongqi Wang, Miao Liu, Huanjin Song, Min Wang, Kangping Yang, Yingang Zhan. [Expression of Bax and Caspase-3 and apoptosis in human lumbar intervertebral disc degeneration]. Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery. vol 22. issue 4. 2009-04-21. PMID:18575441. |
[expression of bax and caspase-3 and apoptosis in human lumbar intervertebral disc degeneration]. |
2009-04-21 |
2023-08-12 |
human |
| Xue-Song Li, Kan Gong, Guo-Feng Sun, Li-Qun Zhou, Zhi-Song He, Dian-Qi Xin, Yan-Qun Na, Yun-Yan Liang, Dai-Shu Wang, Ying-Lu Gu. [Differential transcription of Bcl-2 and Bax through the cell cycle in prostate cancer cell line]. Zhonghua wai ke za zhi [Chinese journal of surgery]. vol 46. issue 10. 2009-04-21. PMID:18953934. |
to investigate the differential expression of apoptosis associated gene bcl-2 and bax through cell cycle and its possible clinical meaning. |
2009-04-21 |
2023-08-12 |
Not clear |
| Peitan Liu, Baohuan Xu, Thomas A Cavalieri, Carl E Hoc. Inhibition of p53 by pifithrin-alpha reduces myocyte apoptosis and leukocyte transmigration in aged rat hearts following 24 hours of reperfusion. Shock (Augusta, Ga.). vol 30. issue 5. 2009-04-20. PMID:18317410. |
the protective effects of pft may involve the p53/bax-mediated apoptosis because treatment of mi/r rats with pft attenuated the ratio of bax to bcl2 (0.97 +/- 0.1 vs. 2.1 +/- 0.2, p < 0.05) and reduced myocyte apoptosis. |
2009-04-20 |
2023-08-12 |
rat |
| Eun Jeong Choi, Woong Shick Ah. Antiproliferative effects of dehydrocostuslactone through cell cycle arrest and apoptosis in human ovarian cancer SK-OV-3 cells. International journal of molecular medicine. vol 23. issue 2. 2009-04-20. PMID:19148545. |
following exposure to dehydrocostuslactone, there was a marked increase in the expression of the apoptotic protein bax and the downstream target p53, a tumor suppressor transcription factor protein, causing the release of cytochrome c. based on our findings, the mechanism by which dehydrocostuslactone causes cell cycle arrest is via cdk1 down-regulation, and its induction of apoptosis appears to be related to the activation of p53 and the release of cytochrome c. |
2009-04-20 |
2023-08-12 |
human |
| Nidhi Nigam, Sahdeo Prasad, Jasmine George, Yogeshwer Shukl. Lupeol induces p53 and cyclin-B-mediated G2/M arrest and targets apoptosis through activation of caspase in mouse skin. Biochemical and biophysical research communications. vol 381. issue 2. 2009-04-20. PMID:19232320. |
further lupeol-induced apoptosis was observed, as shown by an increased sub-g1 peak (28%) at 96 h, with upregulation of bax and caspase-3 genes and downregulation of anti-apoptotic bcl-2 and survivin genes. |
2009-04-20 |
2023-08-12 |
mouse |
| Jagat J Mukherjee, Suresh K Gupta, Harish Sikka, Subodh Kuma. Inhibition of benzopyrene-diol-epoxide (BPDE)-induced bax and caspase-9 by cadmium: role of mitogen activated protein kinase. Mutation research. vol 661. issue 1-2. 2009-04-16. PMID:19028507. |
erk1/2, p38 and jnk in hl-60 cells, and inhibition of bpde-induced apoptosis by cadmium is associated with down-regulation of pro-apoptotic bax induction/caspase-9 activation and up-regulation of erk phosphorylation, whereas p38 map kinase and c-jun phosphorylation (indicative of jnk activation) remain unaffected. |
2009-04-16 |
2023-08-12 |
human |
| Shuw-Yuan Lin, Wan-Wen Lai, Chin-Chin Ho, Fu-Shun Yu, Guang-Wei Chen, Jai-Sing Yang, Kuo-Ching Liu, Meng-Liang Lin, Ping-Ping Wu, Ming-Jen Fan, Jing-Gung Chun. Emodin induces apoptosis of human tongue squamous cancer SCC-4 cells through reactive oxygen species and mitochondria-dependent pathways. Anticancer research. vol 29. issue 1. 2009-04-16. PMID:19331169. |
taken together, these findings suggest that emodin mediated oxidative injury (dna damage) based on ros production and er stress based on the levels of gadd153 and grp78 that acts as an early and upstream change in the cell death cascade to caspase- and mitochondria-dependent signaling pathways, triggers mitochondrial dysfunction from bcl-2 and bax modulation, mitochondrial cytochrome c release and caspase activation, consequently leading to apoptosis in scc-4 cells. |
2009-04-16 |
2023-08-12 |
human |
| Tong Wang, Cun-Zhi Liu, Jian-Chun Yu, Wen Jiang, Jing-Xian Ha. Acupuncture protected cerebral multi-infarction rats from memory impairment by regulating the expression of apoptosis related genes Bcl-2 and Bax in hippocampus. Physiology & behavior. vol 96. issue 1. 2009-04-15. PMID:18938189. |
acupuncture protected cerebral multi-infarction rats from memory impairment by regulating the expression of apoptosis related genes bcl-2 and bax in hippocampus. |
2009-04-15 |
2023-08-12 |
rat |
| Tong Wang, Cun-Zhi Liu, Jian-Chun Yu, Wen Jiang, Jing-Xian Ha. Acupuncture protected cerebral multi-infarction rats from memory impairment by regulating the expression of apoptosis related genes Bcl-2 and Bax in hippocampus. Physiology & behavior. vol 96. issue 1. 2009-04-15. PMID:18938189. |
in this paper, we observed the effect of acupuncture on memory impairment, apoptosis and expression of bcl-2 and bax in hippocampus of cerebral multi-infarction rats. |
2009-04-15 |
2023-08-12 |
rat |
| Rita Ghosh, Manonmani Ganapathy, William L Alworth, Daniel C Chan, Addanki P Kuma. Combination of 2-methoxyestradiol (2-ME2) and eugenol for apoptosis induction synergistically in androgen independent prostate cancer cells. The Journal of steroid biochemistry and molecular biology. vol 113. issue 1-2. 2009-04-15. PMID:19084597. |
combining 2-me(2) with eugenol (i) inhibited growth of prostate cancer cells and induced apoptosis at lower concentrations than either single agent alone; (ii) analysis of the data using combination index (ci) showed ci values of 0.4 indicating strong synergistic interaction; (iii) increased population of cells g(2)/m phase by 4.5-fold (p=0.01); (iv) significantly reduced expression of antiapoptotic protein bcl-2 and enhanced expression of proapoptotic protein bax. |
2009-04-15 |
2023-08-12 |
human |
| Cheng-Yun Jin, Cheol Park, Jun-Hyuk Lee, Kyung Tae Chung, Taeg Kyu Kwon, Gi-Young Kim, Byung Tae Choi, Yung Hyun Cho. Naringenin-induced apoptosis is attenuated by Bcl-2 but restored by the small molecule Bcl-2 inhibitor, HA 14-1, in human leukemia U937 cells. Toxicology in vitro : an international journal published in association with BIBRA. vol 23. issue 2. 2009-04-14. PMID:19124070. |
additionally, bcl-2 overexpression attenuated naringenin-induced bax translocation and cytosolic release of cytochrome c. our results also indicated that co-administration of ha14-1 and naringenin increased apoptosis in bcl-2 overexpressing u937 cells by restoring mitochondrial dysfunction and activation of caspase-9 and caspase-3, as well as by cleavage of poly (adp-ribose) polymerase. |
2009-04-14 |
2023-08-12 |
human |
| Yi-Jing Zhou, Shi-Ping Zhang, Chang-Wei Liu, Yun-Qing Ca. The protection of selenium on ROS mediated-apoptosis by mitochondria dysfunction in cadmium-induced LLC-PK(1) cells. Toxicology in vitro : an international journal published in association with BIBRA. vol 23. issue 2. 2009-04-14. PMID:19135140. |
studies of pi and annexin v dual staining analysis demonstrated that 20 microm cd-induced apoptosis as early as 18 h. a concomitant by the generation of ros, the loss of mitochondrial membrane potential, cytochrome c (cyt c) release, activation of caspase-9, -3 and regulation of bcl-2 and bax were observed. |
2009-04-14 |
2023-08-12 |
Not clear |
| R J S Viana, A F Nunes, R E Castro, R M Ramalho, J Meyerson, S Fossati, J Ghiso, A Rostagno, C M P Rodrigue. Tauroursodeoxycholic acid prevents E22Q Alzheimer's Abeta toxicity in human cerebral endothelial cells. Cellular and molecular life sciences : CMLS. vol 66. issue 6. 2009-04-14. PMID:19189048. |
comparative assessment of structural parameters and cell death mechanisms elicited in primary human cerebral endothelial cells by abetae22q and wild-type abeta revealed that only abetae22q triggered the bax mitochondrial pathway of apoptosis. |
2009-04-14 |
2023-08-12 |
human |
| Takayuki Iriyama, Yoshimasa Kamei, Shiro Kozuma, Yuji Taketan. Bax-inhibiting peptide protects glutamate-induced cerebellar granule cell death by blocking Bax translocation. Neuroscience letters. vol 451. issue 1. 2009-04-13. PMID:19110033. |
bax, a member of the bcl-2 family proteins, plays a key role in the promotion of apoptosis by translocation from the cytosol to the mitochondria and the release of apoptogenic factors such as cytochrome c. recently, bax-inhibiting peptide (bip), a novel membrane-permeable peptide which can bind bax in the cytosol and inhibit its translocation to the mitochondria, was developed. |
2009-04-13 |
2023-08-12 |
Not clear |
| Shaojin Duan, Lin Wan, Wenjiang J Fu, Hong Pan, Qi Ding, Chang Chen, Peiwei Han, Xiaoyan Zhu, Liying Du, Hongxiao Liu, Yuxia Chen, Ximing Liu, Xiting Yan, Minghua Deng, Minping Qia. Nonlinear cooperation of p53-ING1-induced bax expression and protein S-nitrosylation in GSNO-induced thymocyte apoptosis: a quantitative approach with cross-platform validation. Apoptosis : an international journal on programmed cell death. vol 14. issue 2. 2009-04-10. PMID:19082896. |
nonlinear cooperation of p53-ing1-induced bax expression and protein s-nitrosylation in gsno-induced thymocyte apoptosis: a quantitative approach with cross-platform validation. |
2009-04-10 |
2023-08-12 |
Not clear |
| Takuma Uo, Timothy D Veenstra, Richard S Morriso. Histone deacetylase inhibitors prevent p53-dependent and p53-independent Bax-mediated neuronal apoptosis through two distinct mechanisms. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 29. issue 9. 2009-04-10. PMID:19261878. |
moreover, hdacis also prevented caspase-3 cleavage in postnatal cortical neurons treated with staurosporine, 3-nitropropionic acid and a bcl-2 inhibitor, all of which require the presence of bax but not p53 to promote apoptosis. |
2009-04-10 |
2023-08-12 |
mouse |
| Mohamad A Mikati, Michele Zeinieh, Ralph Abi Habib, Jimmy El Hokayem, Amal Rahmeh, Marwan El Sabban, Julnar Usta, Ghassan Dbaib. Changes in sphingomyelinases, ceramide, Bax, Bcl(2), and caspase-3 during and after experimental status epilepticus. Epilepsy research. vol 81. issue 2-3. 2009-04-09. PMID:18603412. |
we studied ceramide, a known mediator of apoptosis in multiple models, sphingomyelinases (smases), enzymes that break down sphingomyelin and increase ceramide thus leading to apoptosis in many models, bcl(2), bax, and caspase-3. |
2009-04-09 |
2023-08-12 |
Not clear |
| Matthew A King, Christoph G Goemans, Farida Hafiz, Jochen H M Prehn, Andreas Wyttenbach, Aviva M Tolkovsk. Cytoplasmic inclusions of Htt exon1 containing an expanded polyglutamine tract suppress execution of apoptosis in sympathetic neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 28. issue 53. 2009-04-09. PMID:19118173. |
by treating the neurons with combined cytosine arabinoside and ngf withdrawal, we demonstrate that q97 confers a powerful resistance to apoptosis at multiple levels: despite normal proapoptotic signaling (elevation of p-ser15-p53 and bimel), there is no increase of puma mrna or bax activation, both necessary for apoptosis. |
2009-04-09 |
2023-08-12 |
human |
| Matthew A King, Christoph G Goemans, Farida Hafiz, Jochen H M Prehn, Andreas Wyttenbach, Aviva M Tolkovsk. Cytoplasmic inclusions of Htt exon1 containing an expanded polyglutamine tract suppress execution of apoptosis in sympathetic neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 28. issue 53. 2009-04-09. PMID:19118173. |
even restoration of bax translocation with overexpressed puma does not activate apoptosis. |
2009-04-09 |
2023-08-12 |
human |