| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kai Y Soo, Julie D Atkin, Malcolm K Horne, Phillip Nagle. Recruitment of mitochondria into apoptotic signaling correlates with the presence of inclusions formed by amyotrophic lateral sclerosis-associated SOD1 mutations. Journal of neurochemistry. vol 108. issue 3. 2009-02-24. PMID:19046404. |
furthermore, markers of mitochondrial apoptosis (activation and recruitment of bax, and cytochrome c redistribution) were observed in 30% of cells bearing msod1 inclusions but not in cells expressing dispersed sod1. |
2009-02-24 |
2023-08-12 |
Not clear |
| Wei-Hao Sun, Guo-Sheng Chen, Xi-Long Ou, Ye Yang, Cheng Luo, Yuan Zhang, Yun Shao, Hai-Chen Xu, Bin Xiao, Yi-Ping Xue, Su-Ming Zhou, Qin-Shi Zhao, Guo-Xian Din. Inhibition of COX-2 and activation of peroxisome proliferator-activated receptor gamma synergistically inhibits proliferation and induces apoptosis of human pancreatic carcinoma cells. Cancer letters. vol 275. issue 2. 2009-02-24. PMID:19056168. |
the combination of ns-398 and rosiglitazone exerted synergistic effects on proliferation inhibition, and apoptosis induction in sw1990 cells, with down-regulation of bcl-2 and up-regulation of bax expression. |
2009-02-24 |
2023-08-12 |
human |
| Takeshi Fukuda, Toshiyuki Sumi, Hiroyuki Nobeyama, Hiroyuki Yoshida, Yoshinari Matsumoto, Tomoyo Yasui, Ken-Ichi Honda, Osamu Ishik. Multiple organ failure of tumor-bearing rabbits in cancer cachexia is caused by apoptosis of normal organ cells. International journal of oncology. vol 34. issue 1. 2009-02-24. PMID:19082478. |
in cancer-bearing animals, we previously demonstrated that skeletal muscle apoptosis may be involved in muscle wasting and that bax may play a role in skeletal muscle cell apoptosis at an early stage. |
2009-02-24 |
2023-08-12 |
Not clear |
| Takeshi Fukuda, Toshiyuki Sumi, Hiroyuki Nobeyama, Hiroyuki Yoshida, Yoshinari Matsumoto, Tomoyo Yasui, Ken-Ichi Honda, Osamu Ishik. Multiple organ failure of tumor-bearing rabbits in cancer cachexia is caused by apoptosis of normal organ cells. International journal of oncology. vol 34. issue 1. 2009-02-24. PMID:19082478. |
in this study, we investigated the occurrence of apoptosis in the liver, kidney, spleen, lung and heart during cancer cachexia as well as the associations between apoptosis and the expression levels of bcl-2, bcl-xl and bax proteins. |
2009-02-24 |
2023-08-12 |
Not clear |
| Takeshi Fukuda, Toshiyuki Sumi, Hiroyuki Nobeyama, Hiroyuki Yoshida, Yoshinari Matsumoto, Tomoyo Yasui, Ken-Ichi Honda, Osamu Ishik. Multiple organ failure of tumor-bearing rabbits in cancer cachexia is caused by apoptosis of normal organ cells. International journal of oncology. vol 34. issue 1. 2009-02-24. PMID:19082478. |
the expression of bax increased in the tumor-bearing group and coincided with the occurrence of apoptosis. |
2009-02-24 |
2023-08-12 |
Not clear |
| Takeshi Fukuda, Toshiyuki Sumi, Hiroyuki Nobeyama, Hiroyuki Yoshida, Yoshinari Matsumoto, Tomoyo Yasui, Ken-Ichi Honda, Osamu Ishik. Multiple organ failure of tumor-bearing rabbits in cancer cachexia is caused by apoptosis of normal organ cells. International journal of oncology. vol 34. issue 1. 2009-02-24. PMID:19082478. |
these findings suggest the possibility that normal organ cell apoptosis related to bax not only causes body weight loss but also multiple organ failure in cancer cachexia. |
2009-02-24 |
2023-08-12 |
Not clear |
| Joseph George, Naren L Banik, Swapan K Ra. Bcl-2 siRNA augments taxol mediated apoptotic death in human glioblastoma U138MG and U251MG cells. Neurochemical research. vol 34. issue 1. 2009-02-23. PMID:18357521. |
western blotting demonstrated dramatic increases in the levels of bax, bak, tbid, active caspases, dna fragmentation factor-40 (dff40), cleaved fragments of lamin, fodrin, and poly(adp-ribose) polymerase (parp) during apoptosis. |
2009-02-23 |
2023-08-12 |
human |
| Arabinda Das, Naren L Banik, Swapan K Ra. Molecular mechanisms of the combination of retinoid and interferon-gamma for inducing differentiation and increasing apoptosis in human glioblastoma T98G and U87MG cells. Neurochemical research. vol 34. issue 1. 2009-02-23. PMID:18368485. |
besides, increases in bax:bcl-2 ratio and mitochondrial release of cytochrome c and smac into the cytosol activated caspase-9 and caspase-3 for apoptosis. |
2009-02-23 |
2023-08-12 |
human |
| Alessandra Valentini, Franco Conforti, Alessandra Crispini, Angelo De Martino, Rossella Condello, Chiara Stellitano, Giuseppe Rotilio, Mauro Ghedini, Giorgio Federici, Sergio Bernardini, Daniela Pucc. Synthesis, oxidant properties, and antitumoral effects of a heteroleptic palladium(II) complex of curcumin on human prostate cancer cells. Journal of medicinal chemistry. vol 52. issue 2. 2009-02-23. PMID:19113979. |
ros production induced by complex 1 treatment activated apoptosis through mitochondrial membrane depolarization in all prostate cancer cells, with up-regulation of bax and down-regulation of bcl-2 proteins. |
2009-02-23 |
2023-08-12 |
human |
| Xifa Lan, Hua Qu, Wenxiu Yao, Chaodong Zhan. Granulocyte-colony stimulating factor inhibits neuronal apoptosis in a rat model of diabetic cerebral ischemia. The Tohoku journal of experimental medicine. vol 216. issue 2. 2009-02-20. PMID:18832793. |
we analyzed the changes in neurological severity scores, infarct volume, number of apoptotic neurons, and the expression of g-csf receptor, phosphorylated signal transducer and activator of transcription 3 (pstat3), cellular inhibitor of apoptosis protein 2 (ciap2), bcl-2, and bax in the brain tissue. |
2009-02-20 |
2023-08-12 |
rat |
| A J Batchelder, A N Gordon-Weeks, R A Walke. Altered expression of anti-apoptotic proteins in non-involved tissue from cancer-containing breasts. Breast cancer research and treatment. vol 114. issue 1. 2009-02-17. PMID:18368476. |
using immunohistochemistry normal breast from 120 age-matched women (58 with breast cancer, 62 without) was analysed for proliferation, apoptosis, bcl2, bax, caspase 3, hsp27, hsp70, brca1, atm and bard1. |
2009-02-17 |
2023-08-12 |
Not clear |
| Katie Avery, Stuart Avery, Jill Shepherd, Paul R Heath, Harry Moor. Sphingosine-1-phosphate mediates transcriptional regulation of key targets associated with survival, proliferation, and pluripotency in human embryonic stem cells. Stem cells and development. vol 17. issue 6. 2009-02-17. PMID:18393631. |
s1p regulated apoptosis through several bcl-2 family members, including bax and bid, with increased expression of cell cycle progression genes associated with proliferation of hesc cultures. |
2009-02-17 |
2023-08-12 |
human |
| Jia-Ren Liu, Hong-Wei Dong, Bing-Qing Chen, Peng Zhao, Rui Hai Li. Fresh apples suppress mammary carcinogenesis and proliferative activity and induce apoptosis in mammary tumors of the Sprague-Dawley rat. Journal of agricultural and food chemistry. vol 57. issue 1. 2009-02-13. PMID:19072049. |
the expression of proliferating cell nuclear antigen (pcna), cyclin d1, and bcl-2 decreased, and bax expression and apoptosis increased with increasing apple extracts. |
2009-02-13 |
2023-08-12 |
rat |
| Kai Li, Yuanyuan Lu, Jie Liang, Guanhong Luo, Gui Ren, Xin Wang, Daiming Fa. RhoE enhances multidrug resistance of gastric cancer cells by suppressing Bax. Biochemical and biophysical research communications. vol 379. issue 2. 2009-02-13. PMID:19101510. |
in brief, our study demonstrated that rhoe may promote the multidrug resistance phenotype of gastric cancer cells by decreasing the expression of bax at posttranscriptional level, thus inhibiting vincristine-induced apoptosis. |
2009-02-13 |
2023-08-12 |
Not clear |
| Mary E Shawgo, Shary N Shelton, John D Robertso. Caspase-mediated Bak activation and cytochrome c release during intrinsic apoptotic cell death in Jurkat cells. The Journal of biological chemistry. vol 283. issue 51. 2009-02-12. PMID:18927073. |
although this process is generally accepted to require the activation of bak or bax, the underlying mechanism responsible for their activation during true intrinsic apoptosis is not well understood. |
2009-02-12 |
2023-08-12 |
Not clear |
| Alexander Bank, Jian Yu, Lin Zhan. NSAIDs downregulate Bcl-X(L) and dissociate BAX and Bcl-X(L) to induce apoptosis in colon cancer cells. Nutrition and cancer. vol 60 Suppl 1. 2009-02-12. PMID:19003586. |
nsaids downregulate bcl-x(l) and dissociate bax and bcl-x(l) to induce apoptosis in colon cancer cells. |
2009-02-12 |
2023-08-12 |
Not clear |
| Alexander Bank, Jian Yu, Lin Zhan. NSAIDs downregulate Bcl-X(L) and dissociate BAX and Bcl-X(L) to induce apoptosis in colon cancer cells. Nutrition and cancer. vol 60 Suppl 1. 2009-02-12. PMID:19003586. |
our previous study demonstrated that nsaids require the proapoptotic b-cell non-hodgkin lymphoma-2 (bcl-2) family member bcl-2-associated x protein (bax) to induce apoptosis and inhibit the expression of antiapoptotic basal cell lymphoma-extra large (bcl-x(l)) in colon cancer cells. |
2009-02-12 |
2023-08-12 |
Not clear |
| Alexander Bank, Jian Yu, Lin Zhan. NSAIDs downregulate Bcl-X(L) and dissociate BAX and Bcl-X(L) to induce apoptosis in colon cancer cells. Nutrition and cancer. vol 60 Suppl 1. 2009-02-12. PMID:19003586. |
in this study, we further investigated how bax and bcl-x(l) mediate nsaid-induced apoptosis. |
2009-02-12 |
2023-08-12 |
Not clear |
| Alexander Bank, Jian Yu, Lin Zhan. NSAIDs downregulate Bcl-X(L) and dissociate BAX and Bcl-X(L) to induce apoptosis in colon cancer cells. Nutrition and cancer. vol 60 Suppl 1. 2009-02-12. PMID:19003586. |
furthermore, we found that only wild-type bax, but not a mutant bax deficient in either protein-protein interaction or mitochondrial localization, was able to restore nsaid-induced apoptosis in the bax-knockout colon cancer cells. |
2009-02-12 |
2023-08-12 |
Not clear |
| Alexander Bank, Jian Yu, Lin Zhan. NSAIDs downregulate Bcl-X(L) and dissociate BAX and Bcl-X(L) to induce apoptosis in colon cancer cells. Nutrition and cancer. vol 60 Suppl 1. 2009-02-12. PMID:19003586. |
these results suggest that nsaids induce apoptosis in colon cancer cells by dissociating bax and bcl-x(l), thereby promoting bax mitochondrial translocation and multimerization. |
2009-02-12 |
2023-08-12 |
Not clear |