| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mallika Tewari, Arvind Krishnamurthy, Hari S Shukl. Predictive markers of response to neoadjuvant chemotherapy in breast cancer. Surgical oncology. vol 17. issue 4. 2009-01-29. PMID:18467090. |
so far, several factors have been studied as predictors for response to cytotoxic treatment, viz., tumor size, hormone (estrogen and progesterone) receptor status, tumor type and differentiation, her2/cerb-2, tumor proliferation ki-67, apoptosis related genes p53, bcl-2 and bax; certain subgroups of breast cancer, and the latest in this category is gene expression profiling. |
2009-01-29 |
2023-08-12 |
human |
| C R Carvalho Pinto-Silva, S Moukha, W G Matias, E E Crepp. Domoic acid induces direct DNA damage and apoptosis in Caco-2 cells: recent advances. Environmental toxicology. vol 23. issue 6. 2009-01-28. PMID:18293405. |
this apoptosis is likely bax-dependent and occurred only at high concentrations of da, while lower concentrations upregulated both bax and bcl-2 at an apparent constant ratio until a sudden decrease of bcl-2 at 100 ng/ml and increase of bax. |
2009-01-28 |
2023-08-12 |
human |
| Roghieh Djafarzadeh, Valeria Milani, Nicole Rieth, Irene von Luettichau, Petra S Skrablin, Monika Hofstetter, Elfriede Noessner, Peter J Nelso. TIMP-1-GPI in combination with hyperthermic treatment of melanoma increases sensitivity to FAS-mediated apoptosis. Cancer immunology, immunotherapy : CII. vol 58. issue 3. 2009-01-28. PMID:18618109. |
the increased sensitivity to fas-induced apoptosis was linked to alterations in the apoptotic mediators bcl-2, bax, bcl-xl and apaf-1. |
2009-01-28 |
2023-08-12 |
Not clear |
| Agnieszka Pedrycz, Krystyna Czern. Immunohistochemical study of proteins linked to apoptosis in rat fetal kidney cells following prepregnancy adriamycin administration in the mother. Acta histochemica. vol 110. issue 6. 2009-01-27. PMID:18321562. |
immunolocalization of several proteins - p53, bax, apaf-1 and caspase 9 - which take part in the mitochondrial pathway of apoptosis and caspase 12, which takes part in the endoplasmic reticulum pathway of apoptosis, was determined. |
2009-01-27 |
2023-08-12 |
rat |
| Agnieszka Pedrycz, Krystyna Czern. Immunohistochemical study of proteins linked to apoptosis in rat fetal kidney cells following prepregnancy adriamycin administration in the mother. Acta histochemica. vol 110. issue 6. 2009-01-27. PMID:18321562. |
the results showed that adriamycin administered to the mother rat before pregnancy subsequently induced changes in fetal kidneys involving both the mitochondrial pathway of apoptosis, with increased labeling of the proteins p53, bax, apaf-1 and caspase 9, and the endoplasmic reticulum pathway of apoptosis, with increased labeling of caspase 12. |
2009-01-27 |
2023-08-12 |
rat |
| Susan M O'Brien, David F Claxton, Michael Crump, Stefan Faderl, Thomas Kipps, Michael J Keating, Jean Viallet, Bruce D Cheso. Phase I study of obatoclax mesylate (GX15-070), a small molecule pan-Bcl-2 family antagonist, in patients with advanced chronic lymphocytic leukemia. Blood. vol 113. issue 2. 2009-01-27. PMID:18931344. |
activation of bax and bak was demonstrated in peripheral blood mononuclear cells, and induction of apoptosis was related to overall obatoclax exposure, as monitored by the plasma concentration of oligonucleosomal dna/histone complexes. |
2009-01-27 |
2023-08-12 |
Not clear |
| Jerry E Chipuk, John C Fisher, Christopher P Dillon, Richard W Kriwacki, Tomomi Kuwana, Douglas R Gree. Mechanism of apoptosis induction by inhibition of the anti-apoptotic BCL-2 proteins. Proceedings of the National Academy of Sciences of the United States of America. vol 105. issue 51. 2009-01-27. PMID:19074266. |
our data show that the induction of apoptosis by inhibition of the anti-apoptotic bcl-2 repertoire requires "covert" levels of direct activators of bax and bak at the omm. |
2009-01-27 |
2023-08-12 |
Not clear |
| Eun Ji Kim, Soon Sung Lim, So Young Park, Hyun-Kyung Shin, Jong-Sang Kim, Jung Han Yoon Par. Apoptosis of DU145 human prostate cancer cells induced by dehydrocostus lactone isolated from the root of Saussurea lappa. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 46. issue 12. 2009-01-26. PMID:18848968. |
dhcl promoted apoptosis with increased activation of caspases 8, 9, 7, 3, enhanced parp cleavage, decreased bcl-xl expression and increased levels of bax, bak, bok, bik, bmf, and t-bid. |
2009-01-26 |
2023-08-12 |
human |
| Joon Hee Park, Cheng-Yun Jin, Bok Kyu Lee, Gi-Young Kim, Yung Hyun Choi, Yong Kee Jeon. Naringenin induces apoptosis through downregulation of Akt and caspase-3 activation in human leukemia THP-1 cells. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 46. issue 12. 2009-01-26. PMID:18930780. |
ngen-induced apoptosis was accompanied by increased hyperpolarization of the mitochondrial membrane potential, downregulation of bcl-2, upregulation of bax, activation of caspases and subsequent poly(adp-ribose)polymerase (parp) cleavages. |
2009-01-26 |
2023-08-12 |
human |
| Jung-Chang Lee, Manju Sharma, Young-Hee Lee, Nan-Hee Lee, Sun-Young Kim, Ji-Soo Yun, Sang-Yun Nam, Pyoung-Han Hwang, Eun-Chung Jhee, Ho-Keun Y. Pax9 mediated cell survival in oral squamous carcinoma cell enhanced by c-myb. Cell biochemistry and function. vol 26. issue 8. 2009-01-23. PMID:18979497. |
inhibition of pax9 caused the induction of apoptosis with enhanced cleavage of caspase-3 and parp, accelerated bax, and reduced bcl-2 expression. |
2009-01-23 |
2023-08-12 |
Not clear |
| Chung-Hsien Liu, Li-Jiau Huang, Sheng-Chu Kuo, Tsung-Hsien Lee, Kan-Jen Tsai, Hsu-Chin Cha. 4-Fluoro-N-butylphenylacetamide (H6) inhibits cell growth via cell-cycle arrest and apoptosis in human cervical cancer cells. Bioorganic & medicinal chemistry. vol 17. issue 1. 2009-01-23. PMID:19056280. |
furthermore, the decrease of bcl-2 and activation of bax, caspase-9/caspase-3 may be the effectors of h6-induced apoptosis. |
2009-01-23 |
2023-08-12 |
human |
| Hao-Ran Liu, Xiang-Dong Peng, Hai-Bo He, Yu-Hong Wang, Ya Li, Gui-Xia He, Ying-Lin Liu, Yan-Lai Li, Chun-Jiao Zen. Antiproliferative activity of the total saponin of Solanum lyratum Thunb in Hela cells by inducing apoptosis. Die Pharmazie. vol 63. issue 11. 2009-01-23. PMID:19069247. |
these results suggest that the induction of apoptosis by tsslt involves multiple pathways antigen including death receptor and mitochondrial pathway and strongly suggest that the mitochondrial pathway was mediated by low expression of bcl-2 and upregulation of bax, release of cyt c and subsequent activation of caspase-3 followed by down stream events leading to apoptotic cell death. |
2009-01-23 |
2023-08-12 |
human |
| C Tringali, B Lupo, F Cirillo, N Papini, L Anastasia, G Lamorte, P Colombi, R Bresciani, E Monti, G Tettamanti, B Venerand. Silencing of membrane-associated sialidase Neu3 diminishes apoptosis resistance and triggers megakaryocytic differentiation of chronic myeloid leukemic cells K562 through the increase of ganglioside GM3. Cell death and differentiation. vol 16. issue 1. 2009-01-22. PMID:18820643. |
the effects were as follows: (a) gangliosides gm3, gm1, and sialosylnorhexaosylceramide increased markedly; (b) cell growth and [(3)h]thymidine incorporation diminished relevantly; (c) as mrna, cyclin d2, and myc were much less expressed, whereas cyclin d1 was expressed more like its inhibitor p21; (d) as mrna, pro-apoptotic proteins bax and bad increased with concurrent decrease and increase in the anti-apoptotic proteins bcl-2 and bcl-xl, respectively; (e) the apoptosis inducers etoposide and staurosporine were active on neu3 silencing cells but not on mock cells; (f) as mrna, the megakaryocytic markers cd10, cd44, cd41, and cd61 increased similar to the case of mock cells stimulated with pma; (g) the signaling cascades mediated by plc-beta2, pkc, raf, erk1/2, rsk90, and jnk were largely activated. |
2009-01-22 |
2023-08-12 |
Not clear |
| Hirofumi Sawai, Naochika Doma. Differential roles for Bak in Triton X-100- and deoxycholate-induced apoptosis. Biochemical and biophysical research communications. vol 378. issue 3. 2009-01-22. PMID:19041633. |
we recently reported that bax activation occurs downstream of caspase activation in triton x-100 (tx)-induced apoptosis. |
2009-01-22 |
2023-08-12 |
Not clear |
| Hirofumi Sawai, Naochika Doma. Differential roles for Bak in Triton X-100- and deoxycholate-induced apoptosis. Biochemical and biophysical research communications. vol 378. issue 3. 2009-01-22. PMID:19041633. |
moreover, activation of both bak and bax was detected in apoptosis induced by deoxycholate, a physiological detergent in bile. |
2009-01-22 |
2023-08-12 |
Not clear |
| T R Wilson, M McEwan, K McLaughlin, C Le Clorennec, W L Allen, D A Fennell, P G Johnston, D B Longle. Combined inhibition of FLIP and XIAP induces Bax-independent apoptosis in type II colorectal cancer cells. Oncogene. vol 28. issue 1. 2009-01-21. PMID:18820704. |
flice-inhibitory protein (flip) blocks death receptor-mediated apoptosis by inhibiting caspase 8 activation; therefore, we assessed whether silencing flip could convert type ii cells into type i. flip silencing-induced caspase 8 activation in bax wild-type and null hct116 colorectal cancer cells; however, complete caspase 3 processing and apoptosis were only observed in bax wild-type cells. |
2009-01-21 |
2023-08-12 |
Not clear |
| T R Wilson, M McEwan, K McLaughlin, C Le Clorennec, W L Allen, D A Fennell, P G Johnston, D B Longle. Combined inhibition of FLIP and XIAP induces Bax-independent apoptosis in type II colorectal cancer cells. Oncogene. vol 28. issue 1. 2009-01-21. PMID:18820704. |
bax-null cells were also more resistant to chemotherapy and tumor necrosis factor-related apoptosis inducing ligand and, unlike the bax wild-type cells, were not sensitized to these agents by flip silencing. |
2009-01-21 |
2023-08-12 |
Not clear |
| Arabinda Das, Amogh Belagodu, Russel J Reiter, Swapan K Ray, Naren L Bani. Cytoprotective effects of melatonin on C6 astroglial cells exposed to glutamate excitotoxicity and oxidative stress. Journal of pineal research. vol 45. issue 2. 2009-01-14. PMID:18373557. |
western blot analyses showed alterations in bax and bcl-2 expression resulting in increased bax:bcl-2 ratio during apoptosis. |
2009-01-14 |
2023-08-12 |
rat |
| Arabinda Das, Amogh Belagodu, Russel J Reiter, Swapan K Ray, Naren L Bani. Cytoprotective effects of melatonin on C6 astroglial cells exposed to glutamate excitotoxicity and oxidative stress. Journal of pineal research. vol 45. issue 2. 2009-01-14. PMID:18373557. |
however, 15-min post-treatment of c6 cells with melatonin dramatically reduced bax:bcl-2 ratio and proteolytic activities, decreasing lga or h(2)o(2)-induced apoptosis. |
2009-01-14 |
2023-08-12 |
rat |
| Akhilesh Kumar, Saritha S D'Souza, S L Gaonkar, K M L Rai, Bharathi P Salimat. Growth inhibition and induction of apoptosis in MCF-7 breast cancer cells by a new series of substituted-1,3,4-oxadiazole derivatives. Investigational new drugs. vol 26. issue 5. 2009-01-13. PMID:18227972. |
furthermore, apoptosis in mcf-7 cell was induced by upregulation of proto-oncoprotein bax and activation of caspase-3 activated dnase. |
2009-01-13 |
2023-08-12 |
Not clear |